Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice.

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Published in Genes Brain Behav on August 03, 2007

Authors

E J Young1, T Lipina, E Tam, A Mandel, S J Clapcote, A R Bechard, J Chambers, H T J Mount, P J Fletcher, J C Roder, L R Osborne

Author Affiliations

1: Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

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Src potentiation of NMDA receptors in hippocampal and spinal neurons is not mediated by reducing zinc inhibition. J Neurosci (1999) 1.03