Published in Ann Oncol on June 01, 1991
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev (1998) 5.60
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science (1995) 5.46
p19ARF links the tumour suppressor p53 to Ras. Nature (1998) 4.89
Randomised trial of endoscopic sphincterotomy with gallbladder left in situ versus open surgery for common bileduct calculi in high-risk patients. Lancet (1996) 3.81
[Yield of laboratory tests in the detection of excessive drinkers in the work place]. Med Clin (Barc) (1993) 2.64
Mutations and altered expression of p16INK4 in human cancer. Proc Natl Acad Sci U S A (1994) 2.64
Correlation of the highest-energy cosmic rays with nearby extragalactic objects. Science (2007) 2.57
Tumor susceptibility of p21(Waf1/Cip1)-deficient mice. Cancer Res (2001) 2.37
Deletion of the p16 and p15 genes in human bladder tumors. J Natl Cancer Inst (1995) 2.25
Tumor suppressors and oncogenes in cellular senescence. Exp Gerontol (2000) 2.17
Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene (1995) 2.05
Biodegradation and biological treatments of cellulose, hemicellulose and lignin: an overview. Int Microbiol (2002) 2.00
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene (1999) 2.00
Busulfan plus cyclophosphamide followed by autologous blood stem-cell transplantation for patients with acute myeloblastic leukemia in first complete remission: a report from a single institution. J Clin Oncol (1993) 1.96
Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J Biol Chem (2000) 1.88
Histone macroH2A isoforms predict the risk of lung cancer recurrence. Oncogene (2009) 1.78
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene (2008) 1.78
Mutations associated with familial melanoma impair p16INK4 function. Nat Genet (1995) 1.69
Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature (1998) 1.61
Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation. J Cell Biochem (2000) 1.59
Diagnostic value of Alt a 1, fungal enolase and manganese-dependent superoxide dismutase in the component-resolved diagnosis of allergy to Pleosporaceae. Clin Exp Allergy (2011) 1.56
Induction of senescence by oncogenic Ras. Methods Enzymol (2001) 1.52
Hemorrhagic proctosigmoiditis and Blastocystis hominis infection. Ann Intern Med (1996) 1.48
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J (1999) 1.48
The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. Cancer Res (2001) 1.46
Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase. Proc Natl Acad Sci U S A (1989) 1.45
In vitro activities of 10 antifungal drugs against 508 dermatophyte strains. Antimicrob Agents Chemother (2001) 1.44
The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development. Nat Med (2000) 1.43
Cancer dissemination during laparoscopic surgery: tubes, gas, and cells. World J Surg (1998) 1.42
[Diffuse mediastinal lipomatosis and exogenous obesity]. Rev Clin Esp (1993) 1.39
Fahr's syndrome presenting with pure and progressive presenile dementia. Neurol Sci (2005) 1.39
[Phosphocalcium metabolism disorders in patients with active pulmonary tuberculosis]. Med Clin (Barc) (1991) 1.39
Hepatic and splanchnic perfusion and oxygenation after transjugular intrahepatic portosystemic shunt. Rev Esp Enferm Dig (2000) 1.38
[Non-Hodgkin's lymphomas associated with the acquired immunodeficiency syndrome. A multicenter clinical study of 77 cases]. Med Clin (Barc) (1995) 1.38
Mercurialis annua pollen: a new source of allergic sensitization and respiratory disease. J Allergy Clin Immunol (1992) 1.38
Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma. Oncogene (2006) 1.32
Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications. Blood (1998) 1.28
Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood (2001) 1.26
Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res (1995) 1.23
Interaction of the bacteriophage phi 29 protein p6 with double-stranded DNA. Proc Natl Acad Sci U S A (1988) 1.21
Regression of gastric high grade mucosa associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication. Gut (2001) 1.21
Gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma. Clinicopathological study and evaluation of the prognostic factors in 143 patients. Ann Oncol (1995) 1.17
Waldeyer ring lymphomas. A clinicopathological study of 79 cases. Histopathology (1994) 1.16
Identification of genes involved in imatinib resistance in CML: a gene-expression profiling approach. Leukemia (2006) 1.13
Acute necrotizing esophagitis. Gastrointest Endosc (2001) 1.11
[Brucellosis of the kidney: description of 3 cases]. Rev Clin Esp (1979) 1.11
SIRT1 stabilizes PML promoting its sumoylation. Cell Death Differ (2010) 1.10
17Beta-oestradiol reduces cardiac leukocyte accumulation in myocardial ischaemia reperfusion injury in rat. Eur J Pharmacol (1997) 1.10
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues. Aging (Albany NY) (2013) 1.09
Detection of feline infectious peritonitis virus-like antigen in ferrets. Vet Rec (2006) 1.09
[Treatment of low-grade gastric MALT lymphoma with Helicobacter pylori eradication. Follow-up of the histological and molecular response]. Med Clin (Barc) (1998) 1.08
p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol Cell Biol (1996) 1.08
Early infections in adult patients undergoing unrelated donor cord blood transplantation. Bone Marrow Transplant (2002) 1.07
Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression. Oncogene (2006) 1.07
Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas. Oncogene (1997) 1.07
A prospective study of astrovirus diarrhea of infancy in Mexico City. Pediatr Infect Dis J (1998) 1.07
Mutational effects on the p16INK4a tumor suppressor protein. Cancer Res (1995) 1.06
[Invasive fungal infections in patients with blood disorders]. Med Clin (Barc) (1998) 1.06
The spilled stone. A potential danger after laparoscopic cholecystectomy. Surg Endosc (1995) 1.06
Effect of long-term administration of cross-sex hormone therapy on serum and urinary uric acid in transsexual persons. J Clin Endocrinol Metab (2008) 1.05
SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency. Oncogene (2012) 1.05
In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. Biochem Biophys Res Commun (1997) 1.04
Inhibition of African swine fever infection in the presence of immune sera in vivo and in vitro. Am J Vet Res (1986) 1.03
Low grade gastric B-cell MALT lymphoma progressing into high grade lymphoma. Clonal identity of the two stages of the tumour, unusual bone involvement and leukemic dissemination. Histopathology (1995) 1.03
Regulation of the tumor suppressor PTEN by SUMO. Cell Death Dis (2012) 1.02
A case of endocarditis due to Granulicatella adiacens. Clin Microbiol Infect (2003) 1.01
A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in Rasa Aragonesa sheep. Anim Genet (2008) 1.01
Helicobacter pylori eradication for the treatment of low-grade gastric MALT lymphoma: follow-up together with sequential molecular studies. Ann Oncol (1997) 1.01
Chronic pancreatitis associated with systemic lupus erythematosus in a young girl. Pancreas (2003) 1.01
Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes. Biochem Biophys Res Commun (2000) 1.00
NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration. Br J Cancer (2010) 1.00
Purification and characterization of a new alpha-amylase of intermediate thermal stability from the yeast Lipomyces kononenkoae. Biochem Cell Biol (1995) 1.00
Benign parotid hypertrophy on +HIV patients: limited late failures after external radiation. Int J Radiat Oncol Biol Phys (1999) 1.00
Hemorrhagic dengue with spontaneous splenic rupture: case report and review. Clin Infect Dis (1997) 0.99
[Temporal variation of genotypes and serotypes of enterohemorrhagic E Coli isolated from Chilean children with intestinal infections or hemolytic uremic syndrome]. Rev Med Chil (1997) 0.98
Evidence for cooperative effects in human liver arginase. Biochim Biophys Acta (1982) 0.98
A major cysteine proteinase is developmentally regulated in Trypanosoma cruzi. FEMS Microbiol Lett (1990) 0.98
Clinicoepidemiologic characteristics, prognostic factors, and survival analysis of patients coinfected with human immunodeficiency virus and Leishmania in an area of Madrid, Spain. Am J Trop Med Hyg (1998) 0.98
Utility of flow cytometric analysis of mast cells in the diagnosis and classification of adult mastocytosis. Leuk Res (2001) 0.98
Factors predicting mortality in severe acute pancreatitis. Pancreatology (2003) 0.97
Laparoscopic resection of a retroperitoneal cystic lymphangioma. Surg Endosc (1994) 0.97
Detection and identification of bacterial DNA in serum from patients with acute pancreatitis. Gut (2005) 0.96
Richter's transformation of chronic lymphocytic leukemia. The possible role of fludarabine and the Epstein-Barr virus in its pathogenesis. Leuk Res (2005) 0.96
Hodgkin's disease in patients with antibodies to human immunodeficiency virus. A study of 22 patients. Cancer (1990) 0.96
Some kinetic properties of a cysteine proteinase (cruzipain) from Trypanosoma cruzi. Biochim Biophys Acta (1990) 0.95
Normal and clonal B lineage cells can be distinguished by their differential expression of B cell antigens and adhesion molecules in peripheral blood from multiple myeloma (MM) patients--diagnostic and clinical implications. Clin Exp Immunol (1998) 0.95
Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy. Hum Mol Genet (2013) 0.95
Primary sclerosing cholangitis associated with systemic sclerosis. Postgrad Med J (1991) 0.95
Molecular characterization of American cockroach tropomyosin (Periplaneta americana allergen 7), a cross-reactive allergen. J Immunol (1999) 0.94
Activation of replication origins in phi29-related phages requires the recognition of initiation proteins to specific nucleoprotein complexes. J Biol Chem (1996) 0.94
Inborn errors of metabolism and motor disturbances in children. J Inherit Metab Dis (2009) 0.94
Metastatic carcinoma of the prostate presenting as a superior vena cava syndrome. Chest (1993) 0.93
Acute promyelocytic leukemia. Therapy results and prognostic factors. Cancer (1988) 0.93
Proliferation centers in chronic lymphocytic leukemia: the niche where NF-kappaB activation takes place. Leukemia (2010) 0.93
Conservative laparoscopic treatment of a posttraumatic splenic cyst. Surg Endosc (1995) 0.92
Cytomegalovirus maculopapular eruption in a kidney transplant patient. Transpl Infect Dis (2001) 0.92
estA, a gene coding for a cell-bound esterase from Paenibacillus sp. BP-23, is a new member of the bacterial subclass of type B carboxylesterases. Res Microbiol (2000) 0.92