Published in J Biol Chem on August 21, 2007
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization. J Biol Chem (2009) 1.16
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell (2014) 1.11
CHK2 kinase in the DNA damage response and beyond. J Mol Cell Biol (2014) 1.05
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol Cell Biol (2008) 0.98
DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer. Biomolecules (2015) 0.88
Pirh2: an E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation. Cell Cycle (2013) 0.88
The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover. Cell Death Differ (2013) 0.87
Autoinhibition and autoactivation of the DNA replication checkpoint kinase Cds1. J Biol Chem (2009) 0.87
RhoB promotes γH2AX dephosphorylation and DNA double-strand break repair. Mol Cell Biol (2014) 0.86
Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem (2014) 0.80
CHK2 stability is regulated by the E3 ubiquitin ligase SIAH2. Oncogene (2016) 0.76
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med (2010) 27.12
Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
Mutant p53: one name, many proteins. Genes Dev (2012) 4.33
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A (2010) 4.18
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. J Clin Oncol (2009) 4.05
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell (2007) 3.56
Transcriptional regulation by p53. Cold Spring Harb Perspect Biol (2010) 3.16
TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15
Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics. Nature (2013) 2.98
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell (2009) 2.50
Structural convergence between Cryo-EM and NMR reveals intersubunit interactions critical for HIV-1 capsid function. Cell (2009) 2.32
P53 and prognosis: new insights and further complexity. Cell (2005) 2.28
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J (2006) 2.21
p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev (2004) 2.07
p53 linear diffusion along DNA requires its C terminus. Mol Cell (2004) 2.03
Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol Cell (2009) 2.00
Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. Am J Respir Crit Care Med (2006) 1.98
The Chk2 protein kinase. DNA Repair (Amst) (2004) 1.85
Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem (2013) 1.76
Unleashing the power of p53: lessons from mice and men. Genes Dev (2006) 1.76
Homozygosity haplotype allows a genomewide search for the autosomal segments shared among patients. Am J Hum Genet (2007) 1.76
APC/C(Cdc20) targets E2F1 for degradation in prometaphase. Cell Cycle (2010) 1.62
Preoperative masked renal damage in Japanese patients with primary aldosteronism: identification of predictors for chronic kidney disease manifested after adrenalectomy. Int J Urol (2012) 1.61
Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell (2002) 1.57
Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes Dev (2013) 1.57
p53-Dependent induction of PVT1 and miR-1204. J Biol Chem (2011) 1.56
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation. Mol Cell Biol (2005) 1.56
Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities. Cell Cycle (2009) 1.55
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating. J Virol (2012) 1.52
Mechanism of allosteric activation of SAMHD1 by dGTP. Nat Struct Mol Biol (2013) 1.49
Solid-state NMR studies of HIV-1 capsid protein assemblies. J Am Chem Soc (2010) 1.49
Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein. Mol Cell Biol (2002) 1.43
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev (2009) 1.42
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis. Proc Natl Acad Sci U S A (2008) 1.40
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol Cell (2003) 1.39
Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. Am J Pathol (2011) 1.39
p73alpha regulation by Chk1 in response to DNA damage. Mol Cell Biol (2003) 1.36
NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity. Nat Commun (2013) 1.36
The C terminus of p53 binds the N-terminal domain of MDM2. Nat Struct Mol Biol (2010) 1.35
p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer. Clin Cancer Res (2003) 1.35
The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells. Oncogene (2002) 1.35
First-line gefitinib in patients aged 75 or older with advanced non-small cell lung cancer harboring epidermal growth factor receptor mutations: NEJ 003 study. J Thorac Oncol (2012) 1.33
Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A (2012) 1.30
Questioning the role of checkpoint kinase 2 in the p53 DNA damage response. J Biol Chem (2003) 1.29
Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. J Biol Chem (2006) 1.28
Motions on the millisecond time scale and multiple conformations of HIV-1 capsid protein: implications for structural polymorphism of CA assemblies. J Am Chem Soc (2012) 1.28
Mutational analysis of the p53 core domain L1 loop. J Biol Chem (2006) 1.25
p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation. J Cell Sci (2008) 1.24
Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network. PLoS One (2013) 1.22
p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled. Mol Cell Biol (2006) 1.20
The S phase checkpoint: when the crowd meets at the fork. Semin Cell Dev Biol (2005) 1.20
Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans. J Clin Invest (2011) 1.20
MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci U S A (2013) 1.19
Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Mol Cell (2012) 1.19
Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces. PLoS Pathog (2011) 1.15
Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding. J Mol Biol (2010) 1.14
NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1. Am J Pathol (2006) 1.14
1H-13C/1H-15N heteronuclear dipolar recoupling by R-symmetry sequences under fast magic angle spinning for dynamics analysis of biological and organic solids. J Am Chem Soc (2011) 1.14
Spin diffusion driven by R-symmetry sequences: applications to homonuclear correlation spectroscopy in MAS NMR of biological and organic solids. J Am Chem Soc (2011) 1.13
A prospective PCR-based screening for the EML4-ALK oncogene in non-small cell lung cancer. Clin Cancer Res (2012) 1.12
Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Mol Biol Cell (2010) 1.10
p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation. Proc Natl Acad Sci U S A (2011) 1.10
Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner. Cell Cycle (2008) 1.09
Mutant p53 gain of function: the NF-Y connection. Cancer Cell (2006) 1.08
Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. PLoS Pathog (2013) 1.08
Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.08
Protease cleavage leads to formation of mature trimer interface in HIV-1 capsid. PLoS Pathog (2012) 1.07
Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects. Retrovirology (2012) 1.06
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem (2003) 1.05
Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions. J Cell Mol Med (2012) 1.05
P53 and aging: A fresh look at an old paradigm. Aging (Albany NY) (2010) 1.05
p53 in the cytoplasm: a question of overkill? Cell (2004) 1.05
Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation. J Biol Chem (2002) 1.04
Interaction of HIV-1 reverse transcriptase ribonuclease H with an acylhydrazone inhibitor. Chem Biol Drug Des (2010) 1.04
Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation. Cancer Sci (2008) 1.03
Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proc Natl Acad Sci U S A (2013) 1.01
HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation. J Biol Chem (2013) 1.01
Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties. Nucleic Acids Res (2013) 1.01
A quantitatively-modeled homozygosity mapping algorithm, qHomozygosityMapping, utilizing whole genome single nucleotide polymorphism genotyping data. BMC Bioinformatics (2010) 1.00
Inhibition of TFII-I-dependent cell cycle regulation by p53. Mol Cell Biol (2005) 1.00
Recoupling of chemical shift anisotropy by R-symmetry sequences in magic angle spinning NMR spectroscopy. J Chem Phys (2012) 1.00
Magic angle spinning NMR reveals sequence-dependent structural plasticity, dynamics, and the spacer peptide 1 conformation in HIV-1 capsid protein assemblies. J Am Chem Soc (2013) 0.99
Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. J Immunol (2011) 0.99
DECOD: fast and accurate discriminative DNA motif finding. Bioinformatics (2011) 0.98
p53 and Metabolism: The GAMT Connection. Mol Cell (2009) 0.98
p53 and p73 display common and distinct requirements for sequence specific binding to DNA. Nucleic Acids Res (2006) 0.98
Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response. J Biol Chem (2009) 0.97
Prediction of the pathogens that are the cause of pneumonia by the battlefield hypothesis. PLoS One (2011) 0.96
Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block. J Biol Chem (2003) 0.96
p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner. J Cell Sci (2008) 0.95
Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov (2011) 0.94