Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study.

PubWeight™: 2.37‹?› | Rank: Top 2%

🔗 View Article (PMC 2771565)

Published in Am J Psychiatry on September 01, 2007

Authors

Christian Otte1, Jeanne McCaffery, Sadia Ali, Mary A Whooley

Author Affiliations

1: Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. otte@uke.uni-hamburg.de

Articles citing this

The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry (2011) 6.66

Depression in older adults. Annu Rev Clin Psychol (2009) 3.07

A prospective cohort study investigating factors associated with depression during medical internship. Arch Gen Psychiatry (2010) 2.41

Health care insurance, financial concerns in accessing care, and delays to hospital presentation in acute myocardial infarction. JAMA (2010) 2.33

Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. Brain Behav Immun (2009) 1.61

Association of functional polymorphisms from brain-derived neurotrophic factor and serotonin-related genes with depressive symptoms after a medical stressor in older adults. PLoS One (2015) 1.42

The serotonin transporter polymorphism (5-HTTLPR): allelic variation and links with depressive symptoms. Depress Anxiety (2010) 1.22

Genetic variation in 5HTTLPR is associated with emotional resilience. Am J Med Genet B Neuropsychiatr Genet (2009) 1.19

The heritability of hedonic capacity and perceived stress: a twin study evaluation of candidate depressive phenotypes. Psychol Med (2008) 1.08

Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers. Brain Behav Immun (2007) 1.03

Platelets and depression in cardiovascular disease: A brief review of the current literature. World J Psychiatry (2012) 0.96

Ontogeny and regulation of the serotonin transporter: providing insights into human disorders. Pharmacol Ther (2011) 0.96

Individual differences in delay discounting under acute stress: the role of trait perceived stress. Front Psychol (2012) 0.93

Depression and coronary heart disease: more pieces of the puzzle. Am J Psychiatry (2007) 0.92

Genetic predictors of depressive symptoms in cardiac patients. Am J Med Genet B Neuropsychiatr Genet (2009) 0.91

Comorbidity of depression with physical disorders: research and clinical implications. Chonnam Med J (2015) 0.89

Monoamine transporters: vulnerable and vital doorkeepers. Prog Mol Biol Transl Sci (2011) 0.87

Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application. Transl Psychiatry (2014) 0.86

Emotion regulation moderates the risk associated with the 5-HTT gene and stress in children. Emotion (2014) 0.86

Response to psychosocial treatment in poststroke depression is associated with serotonin transporter polymorphisms. Stroke (2011) 0.82

Persistent versus transient depressive symptoms in relation to platelet hyperactivation: a longitudinal analysis of dementia caregivers. J Affect Disord (2009) 0.81

Pharmacogenetics of major depression: insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. Mol Diagn Ther (2008) 0.80

Depression and the Link with Cardiovascular Disease. Front Psychiatry (2016) 0.80

The 5-HTTLPR polymorphism in South African healthy populations: a global comparison. J Neural Transm (Vienna) (2008) 0.80

Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging. Psychosom Med (2010) 0.79

Gene-environment interactions in geriatric depression. Psychiatr Clin North Am (2011) 0.79

Inflammatory vulnerability associated with the rh5-HTTLPR genotype in juvenile rhesus monkeys. Genes Brain Behav (2013) 0.78

Clinical implications of genetic variation in the serotonin transporter promoter region: a review. Prim Care Companion J Clin Psychiatry (2009) 0.78

Association of depressive and anxiety symptoms with 24-hour urinary catecholamines in individuals with untreated high blood pressure. Psychosom Med (2015) 0.78

Glucocorticoid receptor gene and depression in patients with coronary heart disease: the Heart and Soul Study-2009 Curt Richter Award Winner. Psychoneuroendocrinology (2009) 0.77

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Mol Psychiatry (2017) 0.76

Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma. Rev Bras Psiquiatr (2010) 0.76

The St. Louis African American health-heart study: methodology for the study of cardiovascular disease and depression in young-old African Americans. BMC Cardiovasc Disord (2013) 0.76

The "S" Allele of the Serotonin Transporter Is Not Associated with Major Depression in a Sample OF Veterans. Adv Genet Res (2015) 0.75

Elevated cardiac risk in patients with major depressive disorder. Am J Psychiatry (2008) 0.75

The "S" Allele of the Serotonin Transporter Is Not Associated with Major Depression or Alcohol Use Disorders in a Veteran Sample. Int J Med Biol Front (2015) 0.75

Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. Behav Genet (2015) 0.75

Association between a serotonin transporter gene variant and hopelessness among men in the Heart and Soul Study. J Gen Intern Med (2010) 0.75

Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction. Am J Cardiol (2015) 0.75

Perceived stress and poly-tobacco product use across adolescence: Patterns of association and gender differences. J Psychiatr Res (2017) 0.75

Articles cited by this

A global measure of perceived stress. J Health Soc Behav (1983) 56.90

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (2003) 28.61

National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. Arch Gen Psychiatry (1981) 18.92

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science (1996) 16.04

Allelic variation of human serotonin transporter gene expression. J Neurochem (1996) 7.08

Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA (2003) 7.01

Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med (1984) 6.74

Social supports and serotonin transporter gene moderate depression in maltreated children. Proc Natl Acad Sci U S A (2004) 4.42

The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry (2005) 3.96

Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure Trial (Val-HeFT). Circulation (2003) 3.78

Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry (2004) 3.54

What makes a good genetic association study? Lancet (2005) 3.46

Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry (2006) 3.44

Life events, first depression onset and the serotonin transporter gene. Br J Psychiatry (2006) 3.32

Treatment of mood disorders. Nat Neurosci (2002) 3.13

Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B Neuropsychiatr Genet (2004) 3.11

Detection of depressive disorder for patients receiving prepaid or fee-for-service care. Results from the Medical Outcomes Study. JAMA (1989) 2.79

The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry (2000) 2.46

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol Med (2005) 2.45

Evidence of a selective increase in cardiac sympathetic activity in patients with sustained ventricular arrhythmias. N Engl J Med (1991) 2.44

Depression and cardiovascular disease: healing the broken-hearted. JAMA (2006) 2.44

Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol Psychiatry (2005) 2.35

A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry (2000) 2.32

Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet (1999) 2.16

Common genetic vulnerability to depressive symptoms and coronary artery disease: a review and development of candidate genes related to inflammation and serotonin. Psychosom Med (2006) 2.13

Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Mol Psychiatry (2005) 2.06

Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction. Am Heart J (2005) 1.86

Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression. Arch Gen Psychiatry (2006) 1.74

Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression. Arch Gen Psychiatry (2004) 1.54

Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study. Biol Psychiatry (2004) 1.39

The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. Biol Psychiatry (2005) 1.31

Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. Am J Med Genet (2002) 1.28

Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene. Endocrinology (2002) 1.23

Neuroimaging studies of serotonin gene polymorphisms: exploring the interplay of genes, brain, and behavior. Cogn Affect Behav Neurosci (2006) 1.21

Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study. Am J Psychiatry (2005) 1.16

Allelic variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cardiovascular reactivity in young adult male and female twins of European-American descent. Psychosom Med (2003) 1.07

Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. Am J Geriatr Psychiatry (2005) 1.06

Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease. Mol Psychiatry (2001) 1.05

Serotonin transporter gene promoter region polymorphism associated with poststroke major depression. J Neuropsychiatry Clin Neurosci (2006) 0.96

Depression and anxiety in Parkinson's disease: possible effect of genetic variation in the serotonin transporter. J Geriatr Psychiatry Neurol (1999) 0.92

Articles by these authors

Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA (2003) 7.01

Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA (2008) 6.50

Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy: results from the Heart and Estrogen/Progestin Replacement Study (HERS) trial. JAMA (2002) 5.07

The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study. Ann Intern Med (2010) 4.89

Depression screening and patient outcomes in cardiovascular care: a systematic review. JAMA (2008) 3.55

Six-minute walk test as a prognostic tool in stable coronary heart disease: data from the heart and soul study. Arch Intern Med (2012) 3.50

Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc (2002) 3.03

B-type natriuretic peptide and ischemia in patients with stable coronary disease: data from the Heart and Soul study. Circulation (2003) 2.82

Additive effects of cognitive function and depressive symptoms on mortality in elderly community-living adults. J Gerontol A Biol Sci Med Sci (2003) 2.82

Depression and heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study. Arch Gen Psychiatry (2005) 2.73

N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP), cardiovascular events, and mortality in patients with stable coronary heart disease. JAMA (2007) 2.67

Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul Study. Circulation (2006) 2.61

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53

Depression and inflammation in patients with coronary heart disease: findings from the Heart and Soul Study. Biol Psychiatry (2007) 2.44

Blood pressure reactivity to psychological stress predicts hypertension in the CARDIA study. Circulation (2004) 2.39

Development of an echocardiographic risk-stratification index to predict heart failure in patients with stable coronary artery disease: the Heart and Soul study. JACC Cardiovasc Imaging (2009) 2.38

Self-reported medication adherence and cardiovascular events in patients with stable coronary heart disease: the heart and soul study. Arch Intern Med (2007) 2.34

Vitamin D deficiency and cardiovascular events in patients with coronary heart disease: data from the Heart and Soul Study. Am J Epidemiol (2014) 2.30

Central nervous system active medications and risk for fractures in older women. Arch Intern Med (2003) 2.30

Depression and medication adherence in outpatients with coronary heart disease: findings from the Heart and Soul Study. Arch Intern Med (2005) 2.28

Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study. Circulation (2006) 2.27

Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study. Circulation (2007) 2.23

Screening for depression in patients with coronary heart disease (data from the Heart and Soul Study). Am J Cardiol (2005) 2.18

Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. PLoS One (2010) 2.10

Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease:The Heart and Soul Study. Arch Gen Psychiatry (2010) 1.99

Urinary creatinine excretion rate and mortality in persons with coronary artery disease: the Heart and Soul Study. Circulation (2010) 1.97

Differential associations between specific depressive symptoms and cardiovascular prognosis in patients with stable coronary heart disease. J Am Coll Cardiol (2010) 1.96

Fractional excretion of phosphorus modifies the association between fibroblast growth factor-23 and outcomes. J Am Soc Nephrol (2013) 1.95

Depressive symptoms, health behaviors, and subsequent inflammation in patients with coronary heart disease: prospective findings from the heart and soul study. Am J Psychiatry (2011) 1.92

Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: data from the Heart and Soul Study. Arterioscler Thromb Vasc Biol (2008) 1.92

Blood pressure reactivity to psychological stress and coronary calcification in the Coronary Artery Risk Development in Young Adults Study. Hypertension (2006) 1.86

Relation of sex and estrogen therapy to serum fibroblast growth factor 23, serum phosphorus, and urine phosphorus: the Heart and Soul Study. Am J Kidney Dis (2011) 1.83

A twin registry study of the relationship between posttraumatic stress disorder and nicotine dependence in men. Arch Gen Psychiatry (2005) 1.75

Prognostic significance of increased left ventricular mass index to mortality and sudden death in patients with stable coronary heart disease (from the Heart and Soul Study). Am J Cardiol (2008) 1.75

Early life stress and morphometry of the adult anterior cingulate cortex and caudate nuclei. Biol Psychiatry (2006) 1.74

Association between renal insufficiency and inducible ischemia in patients with coronary artery disease: the heart and soul study. J Am Soc Nephrol (2003) 1.72

Maintaining large weight losses: the role of behavioral and psychological factors. J Consult Clin Psychol (2008) 1.72

Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA (2010) 1.71

High-sensitivity cardiac troponin T levels and secondary events in outpatients with coronary heart disease from the Heart and Soul Study. JAMA Intern Med (2013) 1.62

Is B-type natriuretic peptide a useful screening test for systolic or diastolic dysfunction in patients with coronary disease? Data from the Heart and Soul Study. Am J Med (2004) 1.56

Prognostic value of low-level cardiac troponin-I elevations in patients without definite acute coronary syndromes. Am Heart J (2004) 1.55

Effects of sustained audit/feedback on self-reported health status of primary care patients. Am J Med (2004) 1.52

Fibroblast growth factor-23 and early decrements in kidney function: the Heart and Soul Study. Nephrol Dial Transplant (2009) 1.51

Alcohol consumption and 5-year change in left atrial volume among patients with coronary heart disease: results from the Heart and Soul study. J Card Fail (2013) 1.50

Depression and leukocyte telomere length in patients with coronary heart disease: data from the Heart and Soul Study. Psychosom Med (2011) 1.49

Differential association of cognitive and somatic depressive symptoms with heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study. Psychosom Med (2007) 1.46

Association of blood pressure and heart rate response during exercise with cardiovascular events in the Heart and Soul Study. J Hypertens (2010) 1.45

Lack of association of chromosome 9p21.3 genotype with cardiovascular structure and function in persons with stable coronary artery disease: The Heart and Soul Study. Atherosclerosis (2008) 1.45

Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul Study. Am J Med (2008) 1.45

Usefulness of left atrial volume index to predict heart failure hospitalization and mortality in ambulatory patients with coronary heart disease and comparison to left ventricular ejection fraction (from the Heart and Soul Study). Am J Cardiol (2008) 1.44

Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: the Heart and Soul Study. Atherosclerosis (2010) 1.43

P-selectin 1087G/A polymorphism is associated with neuropsychological test performance in older adults with cardiovascular disease. Stroke (2009) 1.43

Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul Study. Am Heart J (2007) 1.42

Predicting heart failure hospitalization and mortality by quantitative echocardiography: is body surface area the indexing method of choice? The Heart and Soul Study. J Am Soc Echocardiogr (2010) 1.42

C-reactive protein and ischemia in users and nonusers of beta-blockers and statins: data from the Heart and Soul Study. Circulation (2003) 1.40

Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study. Biol Psychiatry (2004) 1.39

Association of chronic kidney disease and anemia with physical capacity: the heart and soul study. J Am Soc Nephrol (2004) 1.35

Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study. Nephrol Dial Transplant (2006) 1.34

Post-traumatic stress disorder is associated with poor health behaviors: findings from the heart and soul study. Health Psychol (2011) 1.27

Depression predicts mortality and hospitalization in patients with myocardial infarction complicated by heart failure. Am Heart J (2005) 1.27

Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study. Nephrol Dial Transplant (2007) 1.27

Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation. Nicotine Tob Res (2007) 1.26

A functional polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, dysfunction, and ischemia: data from the heart and soul study. PLoS One (2010) 1.25

Depressive symptoms and perceived doctor-patient communication in the Heart and Soul study. J Gen Intern Med (2009) 1.24

Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: The Heart and Soul Study. Atherosclerosis (2008) 1.22

Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul Study. J Card Fail (2006) 1.21

Prevalence and prognosis of asymptomatic left ventricular diastolic dysfunction in ambulatory patients with coronary heart disease. Am J Cardiol (2007) 1.18

Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study. Am J Psychiatry (2005) 1.16

Elevated pulmonary artery pressure by Doppler echocardiography predicts hospitalization for heart failure and mortality in ambulatory stable coronary artery disease: the Heart and Soul Study. J Am Coll Cardiol (2006) 1.15

Depression, stress, and quality of life in persons with chronic kidney disease: the Heart and Soul Study. Nephron Clin Pract (2005) 1.14

Depressive symptoms and rates of bone loss at the hip in older women. J Am Geriatr Soc (2007) 1.13

Prognostic value of left ventricular end-systolic volume index as a predictor of heart failure hospitalization in stable coronary artery disease: data from the Heart and Soul Study. J Am Soc Echocardiogr (2008) 1.13

Posttraumatic stress disorder and health-related quality of life in patients with coronary heart disease: findings from the Heart and Soul Study. Arch Gen Psychiatry (2009) 1.13

Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study. Circ Cardiovasc Qual Outcomes (2010) 1.13

Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. J Am Coll Cardiol (2012) 1.12

Higher dietary intake of long-chain omega-3 polyunsaturated fatty acids is inversely associated with depressive symptoms in women. Nutrition (2009) 1.11

Relation of low socioeconomic status to C-reactive protein in patients with coronary heart disease (from the heart and soul study). Am J Cardiol (2005) 1.11

C-reactive protein, diastolic dysfunction, and risk of heart failure in patients with coronary disease: Heart and Soul Study. Eur J Heart Fail (2007) 1.10

The PHQ-9 versus the PHQ-8--is item 9 useful for assessing suicide risk in coronary artery disease patients? Data from the Heart and Soul Study. J Psychosom Res (2012) 1.07

Psychological risk factors and the metabolic syndrome in patients with coronary heart disease: findings from the Heart and Soul Study. Psychiatry Res (2009) 1.05

Association of cystatin C with poor exercise capacity and heart rate recovery: data from the heart and soul study. Am J Kidney Dis (2007) 1.05

Optimizing detection of major depression among patients with coronary artery disease using the patient health questionnaire: data from the heart and soul study. J Gen Intern Med (2008) 1.04

Early life stress and adult emotional experience: an international perspective. Int J Psychiatry Med (2006) 1.04

Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proc Natl Acad Sci U S A (2007) 1.04

The CHADS2 score predicts ischemic stroke in the absence of atrial fibrillation among subjects with coronary heart disease: data from the Heart and Soul Study. Am Heart J (2011) 1.03

Association of metabolic syndrome with exercise capacity and heart rate recovery in patients with coronary heart disease in the heart and soul study. Am J Cardiol (2005) 1.02

Depression and cardiovascular disease. Prog Cardiovasc Dis (2013) 1.01

Pulmonary regurgitation end-diastolic gradient is a Doppler marker of cardiac status: data from the Heart and Soul Study. J Am Soc Echocardiogr (2005) 1.01