HIF-dependent antitumorigenic effect of antioxidants in vivo.

PubWeight™: 4.81‹?› | Rank: Top 1%

🔗 View Article (PMC 2084208)

Published in Cancer Cell on September 01, 2007

Authors

Ping Gao1, Huafeng Zhang, Ramani Dinavahi, Feng Li, Yan Xiang, Venu Raman, Zaver M Bhujwalla, Dean W Felsher, Linzhao Cheng, Jonathan Pevsner, Linda A Lee, Gregg L Semenza, Chi V Dang

Author Affiliations

1: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Articles citing this

(truncated to the top 100)

Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature (2009) 13.28

Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet (2007) 10.78

MYC on the path to cancer. Cell (2012) 8.65

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene (2009) 8.01

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature (2009) 5.32

HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev (2009) 5.24

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A (2010) 4.97

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci (2012) 4.96

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A (2008) 4.79

Oxidative stress inhibits distant metastasis by human melanoma cells. Nature (2015) 3.87

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest (2013) 3.55

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol (2007) 3.51

ROS function in redox signaling and oxidative stress. Curr Biol (2014) 3.35

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis. Mod Pathol (2008) 3.18

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci (2010) 3.17

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle (2010) 3.15

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity. Cancer Immunol Immunother (2010) 3.00

Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res (2009) 2.90

Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50

Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol (2007) 2.45

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci U S A (2009) 2.33

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol (2009) 2.27

The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle (2010) 2.26

Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha. Blood (2008) 2.09

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One (2010) 2.05

Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat Cell Biol (2009) 1.99

Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs. Cancer Res (2008) 1.98

Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. Proc Natl Acad Sci U S A (2009) 1.91

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? Nat Rev Cancer (2014) 1.89

Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta (2012) 1.89

Vitamin C is dispensable for oxygen sensing in vivo. Blood (2011) 1.68

Mitochondrial dysfunction in cancer. Front Oncol (2013) 1.57

Facilitating replication under stress: an oncogenic function of MYC? Nat Rev Cancer (2009) 1.56

Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels. Mol Cell Biol (2011) 1.54

Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J Biol Chem (2008) 1.51

Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis. J Biol Chem (2011) 1.48

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.46

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. Cancer Metab (2014) 1.45

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc Natl Acad Sci U S A (2014) 1.43

The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A (2008) 1.42

Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis. Mol Cell Biol (2011) 1.42

SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J (2009) 1.41

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities. Amino Acids (2010) 1.41

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. Trends Mol Med (2012) 1.33

Hereditary leiomyomatosis and renal cell cancer: update on clinical and molecular characteristics. Fam Cancer (2011) 1.30

Oxidative stress, tumor microenvironment, and metabolic reprogramming: a diabolic liaison. Int J Cell Biol (2012) 1.29

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol Rev Camb Philos Soc (2014) 1.27

Multiscale models of angiogenesis. IEEE Eng Med Biol Mag (2009) 1.26

Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci U S A (2010) 1.25

Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia (2008) 1.23

Mitochondrial respiration protects against oxygen-associated DNA damage. Nat Commun (2010) 1.23

Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1alpha. Cancer Chemother Pharmacol (2010) 1.21

Mitochondrial reactive oxygen species and cancer. Cancer Metab (2014) 1.20

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. Free Radic Biol Med (2009) 1.17

The role of cellular oxidative stress in regulating glycolysis energy metabolism in hepatoma cells. Mol Cancer (2009) 1.15

Mitochondrial autophagy: life and breath of the cell. Autophagy (2008) 1.13

Frequent gene products and molecular pathways altered in prostate cancer- and metastasis-initiating cells and their progenies and novel promising multitargeted therapies. Mol Med (2011) 1.13

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo. PLoS One (2010) 1.10

Role of hypoxia-inducible factors in breast cancer metastasis. Future Oncol (2013) 1.09

Overexpression of the c-myc oncogene inhibits nonsense-mediated RNA decay in B lymphocytes. J Biol Chem (2011) 1.08

Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model. Cancer Res (2009) 1.08

A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways. Cell Cycle (2010) 1.07

Myeloid suppressor cells and immune modulation in lung cancer. Immunotherapy (2012) 1.07

Molecular mechanisms underlying chronic inflammation-associated cancers. Cancer Lett (2013) 1.06

Microenvironment and radiation therapy. Biomed Res Int (2012) 1.06

Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells. Cancer Res (2011) 1.06

The neglected significance of "antioxidative stress". Oxid Med Cell Longev (2012) 1.06

Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy. Oncoimmunology (2015) 1.03

Effects of manganese superoxide dismutase silencing on androgen receptor function and gene regulation: implications for castration-resistant prostate cancer. Clin Cancer Res (2008) 1.02

Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease. Blood (2008) 1.02

Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function. Annu Rev Nutr (2013) 1.02

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol (2015) 1.01

Mitochondria in cancer: at the crossroads of life and death. Chin J Cancer (2011) 1.01

Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction. J Natl Cancer Inst (2013) 0.98

Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species. PLoS One (2012) 0.98

Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function. FASEB J (2012) 0.98

Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors. Front Aging Neurosci (2010) 0.98

The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes. J Biol Chem (2011) 0.98

Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins. J Am Assoc Lab Anim Sci (2008) 0.97

Antimalarial therapy prevents Myc-induced lymphoma. J Clin Invest (2008) 0.97

Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4. Cell Cycle (2013) 0.97

HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs). Breast Cancer Res (2013) 0.96

Myeloid derived suppressor cells: Targets for therapy. Oncoimmunology (2013) 0.94

The fate of chemoresistance in triple negative breast cancer (TNBC). BBA Clin (2015) 0.94

ROS homeostasis and metabolism: a dangerous liason in cancer cells. Cell Death Dis (2016) 0.94

The role of antioxidants in skin cancer prevention and treatment. Oxid Med Cell Longev (2014) 0.94

Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs. Cancer Chemother Pharmacol (2010) 0.94

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression. J Clin Invest (2012) 0.94

Vascular cell-adhesion molecule-1 plays a central role in the proangiogenic effects of oxidative stress. Proc Natl Acad Sci U S A (2011) 0.94

A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis. Proc Natl Acad Sci U S A (2012) 0.93

Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance. Cell Div (2012) 0.93

Hypoxia-inducible factor 1 and breast cancer metastasis. J Zhejiang Univ Sci B (2015) 0.92

Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition. Matrix Biol (2012) 0.92

Hydrogen peroxide - production, fate and role in redox signaling of tumor cells. Cell Commun Signal (2015) 0.91

Suppression of mitochondrial complex I influences cell metastatic properties. PLoS One (2013) 0.90

A role for virally induced reactive oxygen species in Kaposi's sarcoma herpesvirus tumorigenesis. Antioxid Redox Signal (2012) 0.89

c-MYC-induced genomic instability. Cold Spring Harb Perspect Med (2014) 0.89

The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity. J Biol Chem (2013) 0.88

Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. Endocr Relat Cancer (2014) 0.88

Articles cited by this

Targeting HIF-1 for cancer therapy. Nat Rev Cancer (2003) 28.01

Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature (2006) 8.16

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol (2003) 8.12

The antioxidant function of the p53 tumor suppressor. Nat Med (2005) 7.57

A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med (2006) 7.42

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J (2003) 6.44

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell (2007) 6.16

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell (2007) 6.06

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab (2005) 5.61

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell (2002) 5.47

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature (2006) 4.57

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J (2004) 4.26

Control of cell growth by c-Myc in the absence of cell division. Curr Biol (1999) 3.90

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res (2003) 3.34

Proline hydroxylation and gene expression. Annu Rev Biochem (2005) 3.23

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell (2007) 3.09

HIF-1 as a target for drug development. Nat Rev Drug Discov (2003) 3.07

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res (2006) 3.05

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol Cell (2005) 2.82

Hypoxia signalling controls metabolic demand. Curr Opin Cell Biol (2007) 2.49

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem (2005) 2.19

Developmental context determines latency of MYC-induced tumorigenesis. PLoS Biol (2004) 2.05

Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Res (2003) 1.99

Ascorbic acid and cancer: a review. Cancer Res (1979) 1.88

Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations. Blood (2002) 1.84

HIFs, hypoxia, and vascular development. Curr Top Dev Biol (2004) 1.60

Persistent oxidative stress in chromosomally unstable cells. Cancer Res (2003) 1.53

c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus. Proc Natl Acad Sci U S A (2005) 1.43

Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice. Cancer Res (2004) 1.43

Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model. Cancer Res (2006) 1.41

Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress. J Mol Med (Berl) (2003) 1.38

ROS: really involved in oxygen sensing. Cell Metab (2005) 1.37

Chemical-induced DNA damage and human cancer risk. Nat Rev Cancer (2004) 1.34

Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice. DNA Repair (Amst) (2006) 1.32

N-acetylcysteine -- passe-partout or much ado about nothing? Br J Clin Pharmacol (2006) 1.23

Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets. Curr Cancer Drug Targets (2006) 1.12

Biological relevance of adduct detection to the chemoprevention of cancer. Clin Cancer Res (2004) 1.08

Comparative genomic hybridization on mouse cDNA microarrays and its application to a murine lymphoma model. Oncogene (2005) 0.93

Effect of dietary ascorbic acid on the incidence of spontaneous mammary tumors in RIII mice. Proc Natl Acad Sci U S A (1985) 0.87

Articles by these authors

c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81

Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science (2002) 17.38

Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature (2009) 13.28

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab (2006) 13.22

Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet (2007) 10.78

Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer (2011) 9.68

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47

Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell (2009) 8.97

A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell (2010) 7.94

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem (2008) 7.71

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell (2011) 7.33

Cancer's molecular sweet tooth and the Warburg effect. Cancer Res (2006) 7.24

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell (2007) 6.31

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell (2007) 6.06

The c-Myc target gene network. Semin Cancer Biol (2006) 5.98

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood (2004) 5.71

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 5.63

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature (2004) 5.61

Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell (2009) 5.49

Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A (2006) 5.27

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell (2010) 5.02

Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol (2005) 4.99

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A (2010) 4.97

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab (2012) 4.80

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A (2008) 4.79

Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell (2003) 4.55

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol (2003) 4.49

MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell (2009) 4.47

Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene. PLoS Genet (2010) 4.29

Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med (2013) 4.26

Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood (2009) 4.22

Activation of innate immune antiviral responses by Nod2. Nat Immunol (2009) 4.19

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat Genet (2002) 4.06

Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat Genet (2010) 3.99

Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol (2006) 3.98

Artificial reporter gene providing MRI contrast based on proton exchange. Nat Biotechnol (2007) 3.87

Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc Natl Acad Sci U S A (2004) 3.85

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A (2009) 3.76

MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer (2010) 3.64

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res (2011) 3.58

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol (2007) 3.51

DNA methylation signatures within the human brain. Am J Hum Genet (2007) 3.50

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem (2002) 3.50

Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer (2003) 3.47

Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood (2011) 3.43

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation. Proc Natl Acad Sci U S A (2007) 3.37

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res (2003) 3.34

CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell (2010) 3.33

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovasc Res (2007) 3.31

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res (2010) 3.30

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol (2002) 3.23

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting. Blood (2011) 3.21

Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells (2008) 3.14

Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol (2006) 3.12

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell (2007) 3.09

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene (2005) 3.05

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res (2006) 3.05

Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell (2011) 3.05

Advanced materials for energy storage. Adv Mater (2010) 3.04

Multifaceted roles of glycolytic enzymes. Trends Biochem Sci (2005) 3.01

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem (2002) 2.95

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95

Genetic evidence supports demic diffusion of Han culture. Nature (2004) 2.92

MRI of the tumor microenvironment. J Magn Reson Imaging (2002) 2.87

Choline metabolism in malignant transformation. Nat Rev Cancer (2011) 2.85

Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells. Circ Res (2006) 2.82

Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem Cells (2005) 2.81

Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol (2006) 2.80

Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene (2003) 2.71

SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis. Bioinformatics (2002) 2.69

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation (2003) 2.68

Fatty liver and the metabolic syndrome among Shanghai adults. J Gastroenterol Hepatol (2005) 2.67

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res (2003) 2.66

Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. J Clin Oncol (2002) 2.56

HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene (2005) 2.53

Mechanism of induction and suppression of antiviral immunity directed by virus-derived small RNAs in Drosophila. Cell Host Microbe (2008) 2.48

Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol (2002) 2.45

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res (2007) 2.43

Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Arabidopsis is associated with drastically reduced accumulation of three classes of viral small interfering RNAs. Plant Cell (2007) 2.43

Molecular causes of the aberrant choline phospholipid metabolism in breast cancer. Cancer Res (2004) 2.43

PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning. Circ Res (2005) 2.43

Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission. J Infect Dis (2007) 2.42

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem (2006) 2.39