p53 is regulated by the lysine demethylase LSD1.

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Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency. Nat Med (2009) 2.51

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Emerging roles for chromatin as a signal integration and storage platform. Nat Rev Mol Cell Biol (2013) 1.65

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer (2010) 1.64

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor. Proc Natl Acad Sci U S A (2014) 1.63

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Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J (2009) 1.54

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat Struct Mol Biol (2010) 1.52

Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability. Mol Cell Biol (2010) 1.51

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Structural insights into histone lysine demethylation. Curr Opin Struct Biol (2010) 1.44

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms. Mol Cell (2016) 1.44

G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression. Nat Commun (2016) 1.43

A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.41

Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling. J Biol Chem (2008) 1.38

Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer. Mol Carcinog (2011) 1.37

Epigenetics in breast cancer: what's new? Breast Cancer Res (2011) 1.36

Protein methylation: a new mechanism of p53 tumor suppressor regulation. Histol Histopathol (2008) 1.34

Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS Pathog (2011) 1.31

Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. Mol Cell Biol (2009) 1.29

G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta. J Biol Chem (2008) 1.28

Surf the post-translational modification network of p53 regulation. Int J Biol Sci (2012) 1.25

Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell (2012) 1.23

FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat Commun (2012) 1.21

SET7/9 mediated methylation of non-histone proteins in mammalian cells. Epigenetics (2009) 1.16

Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro Oncol (2011) 1.16

Substrate and product specificities of SET domain methyltransferases. Epigenetics (2011) 1.15

p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol (2008) 1.15

AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function. Cell Res (2010) 1.14

The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression. J Biol Chem (2010) 1.13

Protein post-translational modifications and regulation of pluripotency in human stem cells. Cell Res (2013) 1.12

Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion. Cancer Res (2012) 1.11

An unexpected journey: lysine methylation across the proteome. Biochim Biophys Acta (2014) 1.11

The functional diversity of protein lysine methylation. Mol Syst Biol (2014) 1.11

Histone modifiers in cancer: friends or foes? Genes Cancer (2011) 1.10

Lysine methylation of promoter-bound transcription factors and relevance to cancer. Cell Res (2010) 1.10

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nat Struct Mol Biol (2012) 1.09

LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer. Br J Cancer (2013) 1.09

The motility of a human parasite, Toxoplasma gondii, is regulated by a novel lysine methyltransferase. PLoS Pathog (2011) 1.08

USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation. Nucleic Acids Res (2011) 1.07

Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem (2009) 1.06

Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex. Structure (2011) 1.06

Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PLoS One (2012) 1.06

Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation. Proc Natl Acad Sci U S A (2013) 1.05

Histone demethylases and cancer. Adv Cancer Res (2009) 1.05

Metabostemness: a new cancer hallmark. Front Oncol (2014) 1.05

The roles of Jumonji-type oxygenases in human disease. Epigenomics (2014) 1.05

Keeping p53 in check: a high-stakes balancing act. Cell (2010) 1.04

Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. J Mol Biol (2011) 1.04

Lysine-specific modifications of p53: a matter of life and death? Oncotarget (2013) 1.03

Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biol (2010) 1.03

Targets in epigenetics: inhibiting the methyl writers of the histone code. Curr Chem Genomics (2011) 1.03

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output. EMBO J (2010) 1.03

Confining euchromatin/heterochromatin territory: jumonji crosses the line. Genes Dev (2010) 1.03

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells. Leukemia (2014) 1.03

Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. PLoS One (2012) 1.02

UniPrime: a workflow-based platform for improved universal primer design. Nucleic Acids Res (2008) 1.01

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc Natl Acad Sci U S A (2014) 1.01

Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing. J Biol Chem (2013) 1.01

Cabin1 restrains p53 activity on chromatin. Nat Struct Mol Biol (2009) 0.99

Epigenetic regulation in cancer progression. Cell Biosci (2014) 0.99

Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1. Biochemistry (2009) 0.99

High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients. BMC Cancer (2014) 0.98

Nuclear receptor coregulators as a new paradigm for therapeutic targeting. Adv Drug Deliv Rev (2010) 0.98

Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics. Cell Cycle (2013) 0.98

Roles of p53 in herpes simplex virus 1 replication. J Virol (2013) 0.98

Structural and functional coordination of DNA and histone methylation. Cold Spring Harb Perspect Biol (2014) 0.98

Targeting protein lysine methylation and demethylation in cancers. Acta Biochim Biophys Sin (Shanghai) (2012) 0.98

Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain. Curr Opin Struct Biol (2011) 0.97

The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70

The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res (2012) 15.41

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44

Long noncoding RNAs with enhancer-like function in human cells. Cell (2010) 13.00

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell (2005) 9.27

Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25

Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16

Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45

IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95

Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat Struct Mol Biol (2005) 7.49

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41

Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11

The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10

The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01

An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature (2005) 5.89

Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet (2002) 5.86

Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J (2002) 5.33

Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep (2006) 5.19

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13

Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06

Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science (2003) 4.74

Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science (2006) 4.54

Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51

An epigenetic road map for histone lysine methylation. J Cell Sci (2003) 4.43

MicroRNA biogenesis and cancer. Cancer Res (2005) 4.41

MicroRNA silencing through RISC recruitment of eIF6. Nature (2007) 4.37

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A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol (2004) 4.23

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Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature (2013) 3.98

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89

Retracted A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2009) 3.88

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86

Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64

Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59

Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51

Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet (2001) 3.46

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell (2008) 3.42

RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex. EMBO Rep (2007) 3.40

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev (2006) 3.24

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A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol (2006) 3.15

Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. J Biol Chem (2006) 3.14

H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome. Genome Res (2008) 3.09

Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev (2004) 3.08

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science (2010) 3.05

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Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00

Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell (2009) 2.99

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97

The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell (2007) 2.94

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Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome. Mol Cell (2007) 2.69

Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27. EMBO J (2006) 2.68

Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell (2007) 2.66

G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64

The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem (2001) 2.63

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Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A (2003) 2.50

Genome-wide and caste-specific DNA methylomes of the ants Camponotus floridanus and Harpegnathos saltator. Curr Biol (2012) 2.50

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev (2008) 2.48

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H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol Cell (2007) 2.32

Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell (2007) 2.29

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol (2005) 2.27

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24