Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs.

PubWeight™: 1.54‹?› | Rank: Top 4%

🔗 View Article (PMID 17805544)

Published in Semin Immunopathol on September 06, 2007

Authors

Christine E Becker1, Luke A J O'Neill

Author Affiliations

1: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland. beckerc@tcd.ie

Articles citing this

Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet (2008) 3.11

How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol (2009) 2.46

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis (2010) 1.84

In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses. Proc Natl Acad Sci U S A (2009) 1.84

Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock. Clin Microbiol Rev (2009) 1.49

TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis. Gastroenterology (2011) 1.39

Optimized subunit vaccine protects against experimental leishmaniasis. Vaccine (2009) 1.39

Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol (2009) 1.31

Toll-like receptors in chronic pain. Exp Neurol (2011) 1.29

Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nat Med (2009) 1.29

The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J Biol Chem (2011) 1.27

Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes. PLoS One (2011) 1.26

Toll-like receptor 4 has an essential role in early skin wound healing. J Invest Dermatol (2012) 1.19

The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis. Trends Parasitol (2014) 1.10

Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease. World J Gastroenterol (2011) 1.08

Serum interleukin-33 levels in patients with gastric cancer. Dig Dis Sci (2011) 1.07

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells. Front Cell Neurosci (2014) 1.05

Pattern recognition receptor-dependent mechanisms of acute lung injury. Mol Med (2009) 1.04

Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. Clin Exp Immunol (2009) 1.03

Understanding diversity of human innate immunity receptors: analysis of surface features of leucine-rich repeat domains in NLRs and TLRs. BMC Immunol (2009) 1.02

Uric acid induces trophoblast IL-1β production via the inflammasome: implications for the pathogenesis of preeclampsia. Am J Reprod Immunol (2011) 1.00

Association of Toll-like receptor signaling and reactive oxygen species: a potential therapeutic target for posttrauma acute lung injury. Mediators Inflamm (2010) 0.92

Network analysis of inflammatory genes and their transcriptional regulators in coronary artery disease. PLoS One (2014) 0.90

Interplay of protease-activated receptors and NOD pattern recognition receptors in epithelial innate immune responses to bacteria. Immunol Lett (2010) 0.89

Association between the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 and inflammatory bowel disease: a meta-analysis. PLoS One (2012) 0.88

8-Prenylkaempferol Suppresses Influenza A Virus-Induced RANTES Production in A549 Cells via Blocking PI3K-Mediated Transcriptional Activation of NF-κB and IRF3. Evid Based Complement Alternat Med (2011) 0.87

Roles of TLR7 in activation of NF-κB signaling of keratinocytes by imiquimod. PLoS One (2013) 0.87

The role of Toll-like receptors in age-associated lung diseases. J Gerontol A Biol Sci Med Sci (2012) 0.83

Redox signaling in acute pancreatitis. Redox Biol (2015) 0.82

Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort. PLoS One (2013) 0.80

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation. Mol Cell Endocrinol (2014) 0.79

Toll-like receptor 4-interacting SPA4 peptide suppresses the NLRP3 inflammasome in response to LPS and ATP stimuli. J Leukoc Biol (2015) 0.78

Determination of the Relationship Between rs4986790 and rs4986791 Variants of TLR4 Gene and Lung Cancer. Inflammation (2016) 0.77

Association Between Helicobacter pylori cagA, babA2 Virulence Factors and Gastric Mucosal Interleukin-33 mRNA Expression and Clinical Outcomes in Dyspeptic Patients. Int J Mol Cell Med (2015) 0.77

Interleukin-18 increases TLR4 and mannose receptor expression and modulates cytokine production in human monocytes. Mediators Inflamm (2015) 0.77

Neuroinflammation and copper in Alzheimer's disease. Int J Alzheimers Dis (2013) 0.77

Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling. Front Immunol (2015) 0.76

Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection. PLoS One (2015) 0.76

Aspartate attenuates intestinal injury and inhibits TLR4 and NODs/NF-κB and p38 signaling in weaned pigs after LPS challenge. Eur J Nutr (2016) 0.75

Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease. Inflamm Res (2016) 0.75

Periodontal Disease-Induced Atherosclerosis and Oxidative Stress. Antioxidants (Basel) (2015) 0.75

The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms. Sci Rep (2016) 0.75

Microbiota, Immune Subversion, and Chronic Inflammation. Front Immunol (2017) 0.75

TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women. Pathog Dis (2015) 0.75

Expression profiles of Toll-like receptors 1, 2 and 5 in selected organs of commercial and indigenous chickens. J Appl Genet (2013) 0.75

Recombinant Salmonella expressing SspH2-EscI fusion protein limits its colonization in mice. BMC Immunol (2017) 0.75

Articles cited by this

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40

Biologic basis for interleukin-1 in disease. Blood (1996) 16.04

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature (2004) 14.80

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity (2004) 13.55

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol (2006) 10.55

Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol (2005) 9.70

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol (2006) 9.64

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem (2003) 9.37

TLR signaling. Cell Death Differ (2006) 9.24

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J (2006) 8.12

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49

Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol (2007) 7.23

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet (2006) 6.89

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol (2007) 6.36

Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med (2002) 6.00

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature (2001) 5.95

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95

Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem (2001) 5.74

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol (2004) 5.74

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature (2005) 5.37

Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science (2003) 4.80

Toll-like receptors in the pathogenesis of human disease. Nat Immunol (2004) 4.40

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet (2007) 4.23

NLRs join TLRs as innate sensors of pathogens. Trends Immunol (2005) 4.12

TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol (2006) 3.75

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri. EMBO Rep (2001) 3.55

RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol (2007) 3.43

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol (2006) 3.41

How Toll-like receptors signal: what we know and what we don't know. Curr Opin Immunol (2005) 3.40

CATERPILLERs, pyrin and hereditary immunological disorders. Nat Rev Immunol (2006) 3.37

Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci U S A (2005) 3.35

A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med (2003) 3.30

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. J Biol Chem (2002) 3.28

TLR signaling. Curr Top Microbiol Immunol (2006) 3.22

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem (2006) 3.20

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet (2005) 2.93

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A (2004) 2.89

Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis (2002) 2.76

Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol (2007) 2.73

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS Lett (2002) 2.66

Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep (2004) 2.64

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem (2003) 2.61

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature (2002) 2.60

TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology (2003) 2.58

The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci (2005) 2.56

Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis. J Immunol (2005) 2.49

Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties. J Immunol (2003) 2.48

The role of innate immunity in acute allograft rejection after lung transplantation. Am J Respir Crit Care Med (2003) 2.44

The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. Eur Respir J (2004) 2.38

Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. Hum Mol Genet (2004) 2.23

Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun (2005) 2.23

The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem (2005) 2.21

Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J Immunol (2002) 2.11

Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms. J Immunol (2004) 2.08

Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture. Cell Microbiol (2005) 2.07

NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. PLoS Pathog (2005) 2.04

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol (2005) 2.03

Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes. Eur J Immunol (2004) 1.99

Innate immune response in Th1- and Th2-dominant mouse strains. Shock (2004) 1.95

The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. J Leukoc Biol (2000) 1.94

Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study. Cancer Res (2004) 1.91

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol (2005) 1.90

Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol Med Microbiol (2001) 1.77

TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. J Mol Med (Berl) (2005) 1.61

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A (2007) 1.54

A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin. J Exp Med (2007) 1.51

Synergistic enhancement of Toll-like receptor responses by NOD1 activation. Eur J Immunol (2005) 1.37

Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem (2004) 1.31

Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. Gut (2005) 1.30

Inherited disorders of human Toll-like receptor signaling: immunological implications. Immunol Rev (2005) 1.28

TIR, CARD and PYRIN: three domains for an antimicrobial triad. Cell Death Differ (2006) 1.26

The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE (2000) 1.25

Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease. Neurosci Lett (2005) 1.19

Sensing of bacteria: NOD a lonely job. Curr Opin Microbiol (2006) 1.14

NOD-like receptors and human diseases. Microbes Infect (2007) 1.08

Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. Diabetes Care (2004) 1.03

Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome. Biochem Soc Trans (2003) 1.03

Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity. J Biol Chem (2005) 1.03

Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. Genes Immun (2004) 1.00

Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling? Immunol Lett (2004) 0.98

Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus. Clin Diagn Lab Immunol (2004) 0.90

Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages. J Vet Med Sci (2006) 0.88

Battling enteroinvasive bacteria: Nod1 comes to the rescue. Trends Microbiol (2004) 0.83

Ectodermal dysplasia and immunodeficiency. Arch Dis Child (1995) 0.76

Articles by these authors

(truncated to the top 100)

Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol (2005) 9.70

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol (2010) 6.64

Resolution of inflammation: state of the art, definitions and terms. FASEB J (2007) 5.12

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol (2009) 5.05

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet (2007) 4.23

The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE (2003) 4.14

Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology (2004) 4.09

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol (2006) 3.94

TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol (2006) 3.75

Targeting Toll-like receptors: emerging therapeutics? Nat Rev Drug Discov (2010) 3.35

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol (2004) 3.19

Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol (2006) 3.00

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J Exp Med (2003) 2.85

A long noncoding RNA mediates both activation and repression of immune response genes. Science (2013) 2.85

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation? Nat Immunol (2012) 2.59

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med (2012) 2.49

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. Proc Natl Acad Sci U S A (2009) 2.42

Signalling adaptors used by Toll-like receptors: an update. Cytokine (2008) 2.22

Genetic variation in Toll-like receptors and disease susceptibility. Nat Immunol (2012) 2.09

Localisation and trafficking of Toll-like receptors: an important mode of regulation. Curr Opin Immunol (2010) 2.08

Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. Circulation (2009) 1.94

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J Biol Chem (2003) 1.91

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88. J Biol Chem (2003) 1.81

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem (2006) 1.77

A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS One (2007) 1.73

Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production. J Immunol (2012) 1.71

New insights into the regulation of TLR signaling. J Leukoc Biol (2006) 1.68

IL-10 inhibits miR-155 induction by toll-like receptors. J Biol Chem (2010) 1.65

The Warburg effect then and now: from cancer to inflammatory diseases. Bioessays (2013) 1.64

TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia. J Immunol (2012) 1.63

Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs. Circ Cardiovasc Interv (2012) 1.62

Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. Immunol Cell Biol (2007) 1.56

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A (2007) 1.54

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Nat Immunol (2009) 1.52

Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. Biochem J (2009) 1.52

Adaptor usage and Toll-like receptor signaling specificity. FEBS Lett (2005) 1.50

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. J Biol Chem (2004) 1.50

What the Myddosome structure tells us about the initiation of innate immunity. Trends Immunol (2011) 1.45

MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3. J Immunol (2009) 1.44

Signalling of toll-like receptors. Handb Exp Pharmacol (2008) 1.40

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. J Biol Chem (2005) 1.37

New insights into the regulation of signalling by toll-like receptors and nod-like receptors. J Innate Immun (2010) 1.35

The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Immunol (2004) 1.34

Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci U S A (2006) 1.33

Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem (2007) 1.32

The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. J Biol Chem (2004) 1.30

How important are Toll-like receptors for antimicrobial responses? Cell Microbiol (2007) 1.28

The inflammasome in atherosclerosis and type 2 diabetes. Sci Transl Med (2011) 1.26

Listeria monocytogenes infection in the face of innate immunity. Cell Microbiol (2009) 1.25

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A (2009) 1.25

How metabolism generates signals during innate immunity and inflammation. J Biol Chem (2013) 1.22

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments. Curr Opin Immunol (2013) 1.19

The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS One (2011) 1.19

Biochemical regulation of the inflammasome. Crit Rev Biochem Mol Biol (2012) 1.18

Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa. J Biol Chem (2003) 1.16

Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1. J Biol Chem (2001) 1.16

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome. Trends Mol Med (2011) 1.15

Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction. J Biol Chem (2002) 1.12

New developments in Toll-like receptor targeted therapeutics. Curr Opin Pharmacol (2012) 1.10

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation. Nat Commun (2012) 1.09

Diversity and regulation in the NF-kappaB system. Trends Biochem Sci (2007) 1.09

Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis. Br J Haematol (2007) 1.09

High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity. Biochemistry (2003) 1.08

Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation. J Biol Chem (2008) 1.07

NLRP3 at the interface of metabolism and inflammation. Immunol Rev (2015) 1.06

The role of toll-like receptors in macrophages. Front Biosci (2008) 1.04

Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components. Mol Cell Proteomics (2007) 1.02

Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6. J Biol Chem (2011) 1.01

Genetic variation in Toll-like receptor signalling and the risk of inflammatory and immune diseases. J Innate Immun (2009) 1.01

TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB. J Biol Chem (2009) 1.00

Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling? Immunol Lett (2004) 0.98

The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. J Leukoc Biol (2007) 0.98

The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3. FEBS Lett (2011) 0.98

Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion. J Biol Chem (2009) 0.97

'Fine tuning' TLR signaling. Nat Immunol (2008) 0.97

TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain. J Immunol (2009) 0.96

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). J Biol Chem (2010) 0.96

TLRs play good cop, bad cop in the lung. Nat Med (2005) 0.94

Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence. J Gen Virol (2007) 0.93

The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10. J Biol Chem (2013) 0.93

Both TLR2 and TRIF contribute to interferon-β production during Listeria infection. PLoS One (2012) 0.92

IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. J Neurochem (2008) 0.92

IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65. J Biol Chem (2006) 0.92

SIGIRR puts the brakes on Toll-like receptors. Nat Immunol (2003) 0.87

Regulators of TLR4 signaling by endotoxins. Subcell Biochem (2010) 0.85

Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin. PLoS One (2013) 0.85

Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury? J Cell Biochem (2005) 0.84

How NOD-ing off leads to Crohn disease. Nat Immunol (2004) 0.84

Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL). J Biol Chem (2011) 0.83

A feed-forward loop involving hyaluronic acid and toll-like receptor-4 as a treatment for colitis? Gastroenterology (2009) 0.82

DisSARMing Toll-like receptor signaling. Nat Immunol (2006) 0.81

HIF1α and metabolic reprogramming in inflammation. J Clin Invest (2016) 0.81

Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene. Biochem J (2004) 0.81

Bacteria fight back against Toll-like receptors. Nat Med (2008) 0.80

MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. Am J Physiol Gastrointest Liver Physiol (2014) 0.80

Toll-like receptors in the spotlight. Nat Immunol (2003) 0.79

The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling. J Biol Chem (2013) 0.79

Spotlight on new anti-inflammatory drug targets in the immune system. Curr Opin Pharmacol (2003) 0.79

Outfoxing Foxo1 with miR-182. Nat Immunol (2010) 0.77

Synergism between NOD-like receptors and Toll-like receptors in human B lymphocytes. J Leukoc Biol (2011) 0.76