The role of biofilms in otolaryngologic infections: update 2007.

Medical biofilms. Biotechnol Bioeng (2008) 1.70

Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling. MBio (2010) 1.59

Characterization of mucosal Candida albicans biofilms. PLoS One (2009) 1.51

Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates. BMC Genomics (2011) 1.18

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections. Pathogens (2013) 1.15

Intracellular persisting Staphylococcus aureus is the major pathogen in recurrent tonsillitis. PLoS One (2010) 1.07

Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media. Paediatr Respir Rev (2012) 1.05

RbsB (NTHI_0632) mediates quorum signal uptake in nontypeable Haemophilus influenzae strain 86-028NP. Mol Microbiol (2011) 0.99

Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein. PLoS One (2013) 0.98

The Etiology and Pathogenesis of Chronic Rhinosinusitis: a Review of Current Hypotheses. Curr Allergy Asthma Rep (2015) 0.91

Pathogenesis of mucosal biofilm infections: challenges and progress. Expert Rev Anti Infect Ther (2008) 0.90

Role of biofilm in children with recurrent upper respiratory tract infections. Eur J Clin Microbiol Infect Dis (2014) 0.89

Haemophilus responses to nutritional immunity: epigenetic and morphological contribution to biofilm architecture, invasion, persistence and disease severity. PLoS Pathog (2013) 0.87

SapF-mediated heme-iron utilization enhances persistence and coordinates biofilm architecture of Haemophilus. Front Cell Infect Microbiol (2012) 0.86

Postoperative complications in cochlear implants: a retrospective analysis of 438 consecutive cases. Eur Arch Otorhinolaryngol (2011) 0.85

Nasal cytology: the "infectious spot", an expression of a morphological-chromatic biofilm. Eur J Clin Microbiol Infect Dis (2011) 0.84

Interspecies bacterial communication as a target for therapy in otitis media. Expert Rev Anti Infect Ther (2010) 0.83

Association of adenoid hyperplasia and bacterial biofilm formation in children with adenoiditis in Taiwan. Eur Arch Otorhinolaryngol (2011) 0.79

Immune mediators of sea-cucumber Holothuria tubulosa (Echinodermata) as source of novel antimicrobial and anti-staphylococcal biofilm agents. AMB Express (2013) 0.78

Innate immunity and the role of defensins in otitis media. Curr Allergy Asthma Rep (2011) 0.78

Biofilm formation by otopathogenic strains of Pseudomonas aeruginosa is not consistently inhibited by ethylenediaminetetraacetic acid. Otol Neurotol (2012) 0.78

Infectious causes of cholesteatoma and treatment of infected ossicles prior to reimplantation by hydrostatic high-pressure inactivation. Biomed Res Int (2015) 0.78

In vitro efficacy of N-acetylcysteine on bacteria associated with chronic suppurative otitis media. J Otolaryngol Head Neck Surg (2014) 0.75

Bacterial biofilm formation in the middle-ear mucosa of chronic otitis media patients. Indian J Otolaryngol Head Neck Surg (2012) 0.75

Determinants of chronic otitis media with effusion in preschool children: a case-control study. BMC Pediatr (2017) 0.75

Surgery of the ear and the lateral skull base: pitfalls and complications. GMS Curr Top Otorhinolaryngol Head Neck Surg (2013) 0.75

Role of Acetic Acid Irrigation in Medical Management of Chronic Suppurative Otitis Media: A Comparative Study. Indian J Otolaryngol Head Neck Surg (2014) 0.75

A novel streptococcal cell-cell communication peptide promotes pneumococcal virulence and biofilm formation. Mol Microbiol (2017) 0.75

Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? Eur Arch Otorhinolaryngol (2017) 0.75

Antibiofilm effects of topical corticosteroids and intranasal saline in patients with chronic rhinosinusitis with nasal polyps depend on bacterial species and their biofilm-forming capacity. Eur Arch Otorhinolaryngol (2017) 0.75

Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol (2004) 18.85

Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm. J Bacteriol (2002) 6.98

Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. JAMA (2006) 4.53

Evolving concepts in biofilm infections. Cell Microbiol (2009) 3.90

Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome. J Bacteriol (2007) 3.62

Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains. Genome Biol (2007) 3.29

Biofilm formation and dispersal and the transmission of human pathogens. Trends Microbiol (2005) 2.80

Insights into the genome of large sulfur bacteria revealed by analysis of single filaments. PLoS Biol (2007) 2.69

Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species. Genome Biol (2010) 2.60

Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa in biofilms. Antimicrob Agents Chemother (2004) 2.51

Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms. Infect Immun (2002) 2.32

The malarial host-targeting signal is conserved in the Irish potato famine pathogen. PLoS Pathog (2006) 2.10

Phenotypic characterization of Streptococcus pneumoniae biofilm development. J Bacteriol (2006) 1.93

Bacterial biofilms: a diagnostic and therapeutic challenge. Expert Rev Anti Infect Ther (2003) 1.77

Bacterial plurality as a general mechanism driving persistence in chronic infections. Clin Orthop Relat Res (2005) 1.67

The malaria secretome: from algorithms to essential function in blood stage infection. PLoS Pathog (2008) 1.67

Generation of genic diversity among Streptococcus pneumoniae strains via horizontal gene transfer during a chronic polyclonal pediatric infection. PLoS Pathog (2010) 1.66

Biofilms and chronic infections. JAMA (2008) 1.65

Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates. BMC Microbiol (2008) 1.64

Characterization, distribution, and expression of novel genes among eight clinical isolates of Streptococcus pneumoniae. Infect Immun (2006) 1.55

The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities. Anal Bioanal Chem (2006) 1.49

Direct demonstration of viable Staphylococcus aureus biofilms in an infected total joint arthroplasty. A case report. J Bone Joint Surg Am (2008) 1.46

Developmental regulation of microbial biofilms. Curr Opin Biotechnol (2002) 1.45

Towards diagnostic guidelines for biofilm-associated infections. FEMS Immunol Med Microbiol (2012) 1.43

Identification, distribution, and expression of novel genes in 10 clinical isolates of nontypeable Haemophilus influenzae. Infect Immun (2005) 1.39

Viscoelasticity of Staphylococcus aureus biofilms in response to fluid shear allows resistance to detachment and facilitates rolling migration. Appl Environ Microbiol (2005) 1.35

Molecular and imaging techniques for bacterial biofilms in joint arthroplasty infections. Clin Orthop Relat Res (2005) 1.34

Successful identification of pathogens by polymerase chain reaction (PCR)-based electron spray ionization time-of-flight mass spectrometry (ESI-TOF-MS) in culture-negative periprosthetic joint infection. J Bone Joint Surg Am (2012) 1.34

Arginine or nitrate enhances antibiotic susceptibility of Pseudomonas aeruginosa in biofilms. Antimicrob Agents Chemother (2006) 1.27

The distributed genome hypothesis as a rubric for understanding evolution in situ during chronic bacterial biofilm infectious processes. FEMS Immunol Med Microbiol (2010) 1.27

Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chem Biol (2011) 1.26

Viscoelastic properties of a mixed culture biofilm from rheometer creep analysis. Biofouling (2003) 1.25

Diagnosis of periprosthetic joint infection. J Arthroplasty (2013) 1.24

The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection. BMC Infect Dis (2013) 1.23

Tonsillolith: not just a stone but a living biofilm. Otolaryngol Head Neck Surg (2009) 1.21

Extensive genomic plasticity in Pseudomonas aeruginosa revealed by identification and distribution studies of novel genes among clinical isolates. Infect Immun (2006) 1.20

Chronic surgical site infection due to suture-associated polymicrobial biofilm. Surg Infect (Larchmt) (2009) 1.19

Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates. BMC Genomics (2011) 1.18

Common infection strategies of pathogenic eukaryotes. Nat Rev Microbiol (2006) 1.17

Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis. BMC Microbiol (2010) 1.16

Engineering approaches for the detection and control of orthopaedic biofilm infections. Clin Orthop Relat Res (2005) 1.15

Mucosal biofilm formation on middle-ear mucosa in a nonhuman primate model of chronic suppurative otitis media. Laryngoscope (2005) 1.15

Pan-genome analysis provides much higher strain typing resolution than multi-locus sequence typing. Microbiology (2009) 1.14

New methods for the detection of orthopedic and other biofilm infections. FEMS Immunol Med Microbiol (2011) 1.14

Comparative genomic analyses of 17 clinical isolates of Gardnerella vaginalis provide evidence of multiple genetically isolated clades consistent with subspeciation into genovars. J Bacteriol (2012) 1.13

What makes pathogens pathogenic. Genome Biol (2008) 1.12

Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media. PLoS One (2008) 1.12

The role of biofilms in otolaryngologic infections. Curr Opin Otolaryngol Head Neck Surg (2004) 1.12

Unique challenges of obtaining regulatory approval for a multicenter protocol to study the genetics of RRP and suggested remedies. Otolaryngol Head Neck Surg (2006) 1.11

Influence of the hydrodynamic environment on quorum sensing in Pseudomonas aeruginosa biofilms. J Bacteriol (2007) 1.11

Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae using a modification of the finite supragenome model. BMC Genomics (2011) 1.11

Prevention of staphylococcal biofilm-associated infections by the quorum sensing inhibitor RIP. Clin Orthop Relat Res (2005) 1.10

Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4. Environ Microbiol (2011) 1.09

Deletion and acquisition of genomic content during early stage adaptation of Pseudomonas aeruginosa to a human host environment. Environ Microbiol (2012) 1.09

An erythrocyte vesicle protein exported by the malaria parasite promotes tubovesicular lipid import from the host cell surface. PLoS Pathog (2008) 1.09

Diagnosis of periprosthetic joint infection. J Orthop Res (2014) 1.08

Identification of adenoid biofilms with middle ear pathogens in otitis-prone children utilizing SEM and FISH. Int J Pediatr Otorhinolaryngol (2009) 1.07

Characterization of bacterial communities in venous insufficiency wounds by use of conventional culture and molecular diagnostic methods. J Clin Microbiol (2011) 1.06

Multifunctional role of human SPLUNC1 in Pseudomonas aeruginosa infection. Infect Immun (2012) 1.06

Population-level virulence factors amongst pathogenic bacteria: relation to infection outcome. Future Microbiol (2008) 1.05

Orthopaedic biofilm infections. Curr Orthop Pract (2011) 1.04

Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages. J Bacteriol (2009) 1.04

Modular spectral imaging system for discrimination of pigments in cells and microbial communities. Appl Environ Microbiol (2008) 1.03

Identification of differentially expressed genes in fibroblasts derived from patients with Dupuytren's Contracture. BMC Med Genomics (2008) 1.02

Can we trust intraoperative culture results in nonunions? J Orthop Trauma (2014) 1.02

Characterization of a mixed MRSA/MRSE biofilm in an explanted total ankle arthroplasty. FEMS Immunol Med Microbiol (2011) 1.01

Lipid rafts and malaria parasite infection of erythrocytes. Mol Membr Biol (2006) 1.01

Biofilms in periprosthetic orthopedic infections. Future Microbiol (2014) 0.99

Role of biofilms in neurosurgical device-related infections. Neurosurg Rev (2005) 0.98

Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity. Kidney Int (2004) 0.96

Real-time microsensor measurement of local metabolic activities in ex vivo dental biofilms exposed to sucrose and treated with chlorhexidine. Appl Environ Microbiol (2010) 0.96

Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis. Antimicrob Agents Chemother (2003) 0.96

Fluorescence "in situ" hybridization for the detection of biofilm in the middle ear and upper respiratory tract mucosa. Methods Mol Biol (2009) 0.95

In vivo capsular switch in Streptococcus pneumoniae--analysis by whole genome sequencing. PLoS One (2012) 0.95

Statistical quantification of detachment rates and size distributions of cell clumps from wild-type (PAO1) and cell signaling mutant (JP1) Pseudomonas aeruginosa biofilms. Appl Environ Microbiol (2004) 0.95