Published in Adv Protein Chem on January 01, 2007
Conformational selection or induced fit: a flux description of reaction mechanism. Proc Natl Acad Sci U S A (2009) 3.03
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function. Physiology (Bethesda) (2010) 2.05
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes. Nature (2010) 1.79
Two distinct conformations of helix 6 observed in antagonist-bound structures of a beta1-adrenergic receptor. Proc Natl Acad Sci U S A (2011) 1.59
The structural basis of G-protein-coupled receptor signaling (Nobel Lecture). Angew Chem Int Ed Engl (2013) 1.25
Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis. J Biol Chem (2008) 1.19
Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques. PLoS Comput Biol (2011) 1.12
Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties. PLoS Comput Biol (2012) 1.10
Critical features for biosynthesis, stability, and functionality of a G protein-coupled receptor uncovered by all-versus-all mutations. Proc Natl Acad Sci U S A (2012) 1.09
Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discovery. Comput Struct Biotechnol J (2013) 0.95
Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process. J Biol Chem (2009) 0.92
Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch. J Biol Chem (2014) 0.89
Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor. PLoS One (2010) 0.87
Superagonism at G protein-coupled receptors and beyond. Br J Pharmacol (2015) 0.84
Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions? Biochemistry (2016) 0.82
Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation. Neuropharmacology (2008) 0.81
Stabilization of G protein-coupled receptors by point mutations. Front Pharmacol (2015) 0.81
Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probes. PLoS One (2012) 0.80
Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices. Proc Natl Acad Sci U S A (2016) 0.80
Engineering a G protein-coupled receptor for structural studies: stabilization of the BLT1 receptor ground state. Protein Sci (2009) 0.79
Advances in methods to characterize ligand-induced ionic lock and rotamer toggle molecular switch in G protein-coupled receptors. Methods Enzymol (2013) 0.77
Regulation of ethanol-related behavior and ethanol metabolism by the Corazonin neurons and Corazonin receptor in Drosophila melanogaster. PLoS One (2014) 0.77
Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity. Am J Physiol Cell Physiol (2011) 0.75
Anti-Inflammatory Effects of β2-Receptor Agonists Salbutamol and Terbutaline Are Mediated by MKP-1. PLoS One (2016) 0.75
The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands. PLoS One (2016) 0.75
The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket. Sci Rep (2017) 0.75
Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor. PLoS One (2017) 0.75
Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work. Front Endocrinol (Lausanne) (2017) 0.75
Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther (2006) 7.03
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A (2007) 6.04
Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor. Nat Chem Biol (2006) 3.76
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proc Natl Acad Sci U S A (2009) 2.86
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nat Methods (2010) 2.77
Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. J Biol Chem (2005) 2.64
Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem (2002) 2.06
Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies. J Biol Chem (2007) 1.85
Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc Natl Acad Sci U S A (2005) 1.65
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J (2008) 1.50
Using synthetic lipids to stabilize purified beta2 adrenoceptor in detergent micelles. Anal Biochem (2005) 1.49
A new era of GPCR structural and chemical biology. Nat Chem Biol (2012) 1.41
Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells. Biochemistry (2005) 1.34
Plasmon-waveguide resonance studies of ligand binding to the human beta 2-adrenergic receptor. Biochemistry (2004) 1.32
The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. Proc Natl Acad Sci U S A (2003) 1.32
Protecting the myocardium: a role for the beta2 adrenergic receptor in the heart. Crit Care Med (2004) 1.28
Allosteric modulation of beta2-adrenergic receptor by Zn(2+). Mol Pharmacol (2002) 1.25
The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes. J Biol Chem (2002) 1.15
Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice. Am J Physiol Heart Circ Physiol (2002) 1.12
Tandem facial amphiphiles for membrane protein stabilization. J Am Chem Soc (2010) 1.05
Toward understanding GPCR dimers. Nat Struct Mol Biol (2004) 0.93
Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study. Chem Commun (Camb) (2013) 0.93
Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal. Traffic (2010) 0.92
Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor. J Biol Chem (2002) 0.90
Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery. Methods Mol Biol (2009) 0.83
International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? J Recept Signal Transduct Res (2010) 0.82
The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors. J Biol Chem (2001) 0.82
PDZ-domain arrays for identifying components of GPCR signaling complexes. Trends Pharmacol Sci (2006) 0.79
Q&A: Brian Kobilka. Stuck on structure. Nature (2014) 0.77
Brian Kobilka: chipping away at the β2-adrenergic receptor. Interview by Ruth Williams. Circ Res (2013) 0.75