Published in Nat Rev Cancer on October 01, 2007
Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34
Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev (2008) 4.80
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol (2009) 4.39
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol (2009) 4.04
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell (2011) 3.23
Classifying collective cancer cell invasion. Nat Cell Biol (2012) 2.83
The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis (2008) 2.82
Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer (2011) 2.64
Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci U S A (2010) 2.62
Mouse models of advanced spontaneous metastasis for experimental therapeutics. Nat Rev Cancer (2011) 2.42
Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol (2008) 2.39
Matrix nanotopography as a regulator of cell function. J Cell Biol (2012) 2.20
3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood. Biomed Microdevices (2011) 2.10
Crossing the endothelial barrier during metastasis. Nat Rev Cancer (2013) 2.00
A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas. Br J Cancer (2011) 1.95
Spontaneous migration of cancer cells under conditions of mechanical confinement. Integr Biol (Camb) (2009) 1.81
In vivo identification of regulators of cell invasion across basement membranes. Sci Signal (2010) 1.77
In vivo imaging in cancer. Cold Spring Harb Perspect Biol (2010) 1.76
Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci (2010) 1.67
Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination. Cancer Res (2009) 1.63
Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition. Mol Cancer (2014) 1.59
Homeostatic competition drives tumor growth and metastasis nucleation. HFSP J (2009) 1.55
Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment. Clin Exp Metastasis (2008) 1.51
AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res (2010) 1.50
Metastasis: tumor cells becoming MENAcing. Trends Cell Biol (2010) 1.44
Impact of tumor cell cytoskeleton organization on invasiveness and migration: a microchannel-based approach. PLoS One (2010) 1.43
Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer? Breast Cancer Res Treat (2008) 1.41
Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion. J Biol Chem (2009) 1.23
Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors. Intravital (2013) 1.22
Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis. Hepatology (2012) 1.21
Mechanisms of tumor cell extravasation in an in vitro microvascular network platform. Integr Biol (Camb) (2013) 1.19
Intravital imaging illuminates transforming growth factor beta signaling switches during metastasis. Cancer Res (2010) 1.18
In vivo nano-imaging of membrane dynamics in metastatic tumor cells using quantum dots. J Biol Chem (2009) 1.17
Polymer particles that switch shape in response to a stimulus. Proc Natl Acad Sci U S A (2010) 1.16
The role of immunoglobulin superfamily cell adhesion molecules in cancer metastasis. Int J Cell Biol (2012) 1.15
Adhesion dynamics at a glance. J Cell Sci (2011) 1.13
Evolution of cell motility in an individual-based model of tumour growth. J Theor Biol (2009) 1.13
RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. J Cell Biol (2013) 1.13
A transcription co-factor integrates cell adhesion and motility with the p53 response. Proc Natl Acad Sci U S A (2009) 1.11
R-Ras regulates migration through an interaction with filamin A in melanoma cells. PLoS One (2010) 1.11
Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device. Lab Chip (2013) 1.10
The potential of optical proteomic technologies to individualize prognosis and guide rational treatment for cancer patients. Target Oncol (2009) 1.10
Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion. Am J Pathol (2009) 1.09
Shining new light on 3D cell motility and the metastatic process. Trends Cell Biol (2009) 1.09
Invading cancer cells are predominantly in G0/G1 resulting in chemoresistance demonstrated by real-time FUCCI imaging. Cell Cycle (2014) 1.09
p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol (2010) 1.08
Semaphorin 3A suppresses tumor growth and metastasis in mice melanoma model. PLoS One (2012) 1.05
The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition. J Transl Med (2016) 1.03
Caveolin-1 modulates the ability of Ewing's sarcoma to metastasize. Mol Cancer Res (2010) 1.01
Microfabricated physical spatial gradients for investigating cell migration and invasion dynamics. PLoS One (2011) 1.00
Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model. Oncogene (2010) 1.00
Caught in the act: revealing the metastatic process by live imaging. Dis Model Mech (2013) 0.99
The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation. EMBO Mol Med (2013) 0.99
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration. J Biol Chem (2011) 0.99
Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway. Br J Cancer (2010) 0.99
Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis. J Biol Chem (2011) 0.98
Scavenger receptor B1 is a potential biomarker of human nasopharyngeal carcinoma and its growth is inhibited by HDL-mimetic nanoparticles. Theranostics (2013) 0.98
Influence of diet on metastasis and tumor dormancy. Clin Exp Metastasis (2008) 0.97
The molecular biology of brain metastasis. J Oncol (2012) 0.96
Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapy. PLoS Comput Biol (2015) 0.96
Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape. Proc Natl Acad Sci U S A (2011) 0.95
The ADAMTS1 protease gene is required for mammary tumor growth and metastasis. Am J Pathol (2011) 0.95
Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions. Cell Commun Signal (2010) 0.95
Cell migration. Compr Physiol (2012) 0.94
A transient parabiosis skin transplantation model in mice. Nat Protoc (2012) 0.94
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. Proc Natl Acad Sci U S A (2010) 0.94
Cancer cell invasion: treatment and monitoring opportunities in nanomedicine. Adv Drug Deliv Rev (2011) 0.93
The evolution of tumor metastases during clonal expansion. J Theor Biol (2009) 0.93
Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8. Clin Exp Metastasis (2010) 0.92
BLT2 up-regulates interleukin-8 production and promotes the invasiveness of breast cancer cells. PLoS One (2012) 0.92
Hypoxia modulates A431 cellular pathways association to tumor radioresistance and enhanced migration revealed by comprehensive proteomic and functional studies. Mol Cell Proteomics (2012) 0.92
Illuminating breast cancer invasion: diverse roles for cell-cell interactions. Curr Opin Cell Biol (2014) 0.91
Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms. J Nat Prod (2009) 0.91
Arkadia regulates tumor metastasis by modulation of the TGF-β pathway. Cancer Res (2013) 0.91
Suppression of mitochondrial complex I influences cell metastatic properties. PLoS One (2013) 0.90
Krüppel-like factors in cancer progression: three fingers on the steering wheel. Oncotarget (2014) 0.90
Systems microscopy approaches to understand cancer cell migration and metastasis. Cell Mol Life Sci (2010) 0.89
LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice. Clin Exp Metastasis (2012) 0.89
Detection of disseminated tumor cells in the bone marrow of breast cancer patients using multiplex gene expression measurements identifies new therapeutic targets in patients at high risk for the development of metastatic disease. Breast Cancer Res Treat (2012) 0.89
Development of a high-throughput three-dimensional invasion assay for anti-cancer drug discovery. PLoS One (2013) 0.88
Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer. Mol Cancer Ther (2014) 0.87
Multivalent pseudopeptides targeting cell surface nucleoproteins inhibit cancer cell invasion through tissue inhibitor of metalloproteinases 3 (TIMP-3) release. J Biol Chem (2012) 0.87
Early detection in head and neck cancer - current state and future perspectives. GMS Curr Top Otorhinolaryngol Head Neck Surg (2010) 0.86
DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems. Angew Chem Int Ed Engl (2012) 0.86
A microfluidic platform for quantitative analysis of cancer angiogenesis and intravasation. Biomicrofluidics (2014) 0.86
Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins. Sci Rep (2015) 0.86
Natural history of hepatic metastases from colorectal cancer--pathobiological pathways with clinical significance. World J Gastroenterol (2014) 0.86
Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells. Cell Commun Signal (2014) 0.85
Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated metastasis and invasion in cervical cancer. PLoS One (2013) 0.85
Periostin Is a Key Niche Component for Wound Metastasis of Melanoma. PLoS One (2015) 0.85
Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells. BMC Cancer (2012) 0.84
Microenvironment of tumor-draining lymph nodes: opportunities for liposome-based targeted therapy. Int J Mol Sci (2014) 0.84
Invadopodia and basement membrane invasion in vivo. Cell Adh Migr (2014) 0.83
Comparable ecological dynamics underlie early cancer invasion and species dispersal, involving self-organizing processes. J Theor Biol (2008) 0.83
Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment. Expert Rev Mol Med (2015) 0.83
Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling. Cell Commun Signal (2013) 0.83
Oxidative and nitrosative stress in the metastatic microenvironment. Cancers (Basel) (2010) 0.83
Clinico-pathological correlation of E-cadherin expression at the invasive tumor front of Indian oral squamous cell carcinomas: An immunohistochemical study. J Oral Maxillofac Pathol (2014) 0.83
Intravital microscopy in the mouse dorsal chamber model for the study of solid tumors. Am J Cancer Res (2011) 0.83