The nature of telomere fusion and a definition of the critical telomere length in human cells.

PubWeight™: 1.88‹?› | Rank: Top 3%

🔗 View Article (PMC 1993879)

Published in Genes Dev on October 01, 2007


Rebecca Capper1, Bethan Britt-Compton, Maira Tankimanova, Jan Rowson, Boitelo Letsolo, Stephen Man, Michele Haughton, Duncan M Baird

Author Affiliations

1: Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom.

Articles citing this

A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol (2008) 2.75

Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One (2011) 2.61

Telomere dysfunction and tumour suppression: the senescence connection. Nat Rev Cancer (2008) 2.54

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination. Nature (2015) 2.03

ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol Cell Biol (2008) 1.88

The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J (2010) 1.83

Telomere shortening and survival in free-living corvids. Proc Biol Sci (2009) 1.76

DNA damage response at functional and dysfunctional telomeres. Genes Dev (2008) 1.75

Telomere dysfunction and chromosome instability. Mutat Res (2011) 1.51

Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage. PLoS One (2010) 1.50

Human RAP1 inhibits non-homologous end joining at telomeres. EMBO J (2009) 1.49

Chromothripsis and Kataegis Induced by Telomere Crisis. Cell (2015) 1.49

Blood cell telomere length is a dynamic feature. PLoS One (2011) 1.41

Nestling telomere shortening, but not telomere length, reflects developmental stress and predicts survival in wild birds. Proc Biol Sci (2014) 1.25

Comparative biology of telomeres: where plants stand. FEBS Lett (2010) 1.23

Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Res (2009) 1.23

Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Res (2009) 1.19

Alternative end-joining mechanisms: a historical perspective. Front Genet (2013) 1.13

Taming the tiger by the tail: modulation of DNA damage responses by telomeres. EMBO J (2009) 1.12

End joining at Caenorhabditis elegans telomeres. Genetics (2008) 1.01

DNA synthesis generates terminal duplications that seal end-to-end chromosome fusions. Science (2011) 1.01

Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction. Nucleic Acids Res (2012) 1.00

Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis. Cell Rep (2012) 0.98

Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere. J Biol Chem (2012) 0.98

Complex interactions between the DNA-damage response and mammalian telomeres. Nat Struct Mol Biol (2015) 0.97

Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells. DNA Repair (Amst) (2008) 0.95

Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis. J Am Soc Nephrol (2009) 0.94

Stop pulling my strings - what telomeres taught us about the DNA damage response. Nat Rev Mol Cell Biol (2016) 0.93

Diet-related telomere shortening and chromosome stability. Mutagenesis (2011) 0.92

Dicentric breakage at telomere fusions. Genes Dev (2010) 0.92

Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair. DNA Repair (Amst) (2011) 0.92

Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris. Proc Natl Acad Sci U S A (2015) 0.91

Markers of cellular senescence. Telomere shortening as a marker of cellular senescence. Aging (Albany NY) (2016) 0.88

Telomere deficiencies on chromosomes 9p, 15p, 15q and Xp: potential biomarkers for breast cancer risk. Hum Mol Genet (2010) 0.88

Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol (2012) 0.87

The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion. Mol Cell (2010) 0.86

Mre11 modulates the fidelity of fusion between short telomeres in human cells. Nucleic Acids Res (2011) 0.86

The role of dicentric chromosome formation and secondary centromere deletion in the evolution of myeloid malignancy. Genet Res Int (2011) 0.85

Repeated stressors in adulthood increase the rate of biological ageing. Front Zool (2015) 0.85

DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome. Curr Opin Cell Biol (2015) 0.85

Telomere organization in the ligninolytic basidiomycete Pleurotus ostreatus. Appl Environ Microbiol (2008) 0.84

Human subtelomeric copy number variations. Cytogenet Genome Res (2009) 0.84

Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence. Genes Dev (2013) 0.84

No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells. DNA Repair (Amst) (2008) 0.84

Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients. Mol Oncol (2015) 0.83

Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. Nat Commun (2015) 0.83

The presence of telomere fusion in sporadic colon cancer independently of disease stage, TP53/KRAS mutation status, mean telomere length, and telomerase activity. Neoplasia (2014) 0.82

Cancer: Trouble upstream. Nature (2013) 0.82

Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity. PLoS One (2015) 0.82

The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line. PLoS Genet (2013) 0.81

CGGBP1 phosphorylation constitutes a telomere-protection signal. Cell Cycle (2013) 0.81

Frequency of chromosomally-integrated human herpesvirus 6 in children with acute lymphoblastic leukemia. PLoS One (2013) 0.81

Telomeres in cancer: tumour suppression and genome instability. Nat Rev Mol Cell Biol (2017) 0.80

Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis. BMC Gastroenterol (2014) 0.80

Stem cell expansion during carcinogenesis in stem cell-depleted conditional telomeric repeat factor 2 null mutant mice. Oncogene (2012) 0.79

Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells. Nucleic Acids Res (2013) 0.79

Rare Cytogenetic Abnormalities and Alteration of microRNAs in Acute Myeloid Leukemia and Response to Therapy. Oncol Rev (2015) 0.79

Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human. Proc Natl Acad Sci U S A (2016) 0.77

Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4. Genome Res (2016) 0.77

Postmyocardial infarct remodeling and heart failure: potential contributions from pro- and antiaging factors. Cardiol Res Pract (2011) 0.76

Stabilization of telomere G-quadruplexes interferes with human herpesvirus 6A chromosomal integration. J Virol (2017) 0.76

Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence. Sci Rep (2017) 0.76

How do telomeres and NHEJ coexist? Mol Cell Oncol (2014) 0.75

Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia. PLoS One (2017) 0.75

The histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenance. Epigenetics (2016) 0.75

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux. Cell Rep (2016) 0.75

Fibroblasts from Werner syndrome patients: cancer cells derived by experimental introduction of oncogenes maintain malignant properties despite entering crisis. Oncol Rep (2010) 0.75

Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia. Int J Cancer Oncol (2015) 0.75

Acentric chromosome ends are prone to fusion with functional chromosome ends through a homology-directed rearrangement. Nucleic Acids Res (2015) 0.75

Short telomere length and its correlation with gene mutations in myelodysplastic syndrome. J Hematol Oncol (2016) 0.75

Different effects of accelerated development and enhanced growth on oxidative stress and telomere shortening in amphibian larvae. Sci Rep (2017) 0.75

HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B. Viruses (2017) 0.75

Telomeres and telomerase in prostate cancer development and therapy. Nat Rev Urol (2017) 0.75

Articles cited by this

Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol (1977) 41.93

Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17

Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97

A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55

A human cell line from a pleural effusion derived from a breast carcinoma. J Natl Cancer Inst (1973) 10.64

TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13

DNA damage foci at dysfunctional telomeres. Curr Biol (2003) 9.08

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature (2000) 7.28

Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell (1999) 6.98

Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (2001) 6.95

The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell (2001) 5.98

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol (2005) 5.49

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet (1997) 4.95

A human telomeric protein. Science (1995) 4.77

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J (1996) 4.58

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr Biol (2002) 3.95

Characterization of a new human diploid cell strain, IMR-90. Science (1977) 3.89

Characteristics of a human diploid cell designated MRC-5. Nature (1970) 3.77

Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet (2003) 3.77

Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol Cell Biol (2003) 3.32

Properties of a non-tumorigenic human cervical keratinocyte cell line. Int J Cancer (1989) 3.30

Human papillomavirus types 16 and 18 sequences in carcinoma cell lines of the cervix. Virology (1985) 3.22

Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell (2002) 3.06

EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev (2002) 3.05

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet (2001) 2.92

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc Natl Acad Sci U S A (2001) 2.91

Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res (2001) 2.65

Strand-specific postreplicative processing of mammalian telomeres. Science (2001) 2.64

Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nat Genet (1998) 2.56

Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism. Genetics (2001) 2.46

DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining. Nucleic Acids Res (2000) 2.29

[Principle of marginotomy in template synthesis of polynucleotides]. Dokl Akad Nauk SSSR (1971) 2.26

E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene (1993) 2.25

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol (2001) 2.21

TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J (1999) 2.20


A mechanistic basis for Mre11-directed DNA joining at microhomologies. Proc Natl Acad Sci U S A (2000) 2.05

Tumor antigen and human chorionic gonadotropin in CaSki cells: a new epidermoid cervical cancer cell line. Science (1977) 2.00

Protection of telomeres by the Ku protein in fission yeast. Mol Biol Cell (2000) 1.94

George Otto Gey. (1899-1970). The HeLa cell and a reappraisal of its origin. Obstet Gynecol (1971) 1.93

Studies on a new human cell line (SiHa) derived from carcinoma of uterus. I. Its establishment and morphology. Proc Soc Exp Biol Med (1970) 1.80

Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining. EMBO J (2004) 1.72

Ku-dependent and Ku-independent end-joining pathways lead to chromosomal rearrangements during double-strand break repair in Saccharomyces cerevisiae. Genetics (2003) 1.64

Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes. Cancer Res (2004) 1.56

Telomere instability in the male germline. Hum Mol Genet (2005) 1.55

Rejoining of DNA double-strand breaks in vitro by single-strand annealing. Eur J Biochem (1998) 1.49

Telomere length dynamics in telomerase-positive immortal human cell populations. Exp Cell Res (1998) 1.47

Clinical significance of cytogenetic findings in solid tumors. Cancer Genet Cytogenet (1997) 1.46

DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol (2006) 1.39

Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry (2002) 1.38

Telomerase activity in normal and malignant murine tissues. Oncogene (1995) 1.34

End resection initiates genomic instability in the absence of telomerase. Mol Cell Biol (2003) 1.32

Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans. Hum Mol Genet (2006) 1.30

Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis. Mol Cell Biol (1999) 1.23

Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human Xp/Yp telomere. EMBO J (1995) 1.23

Telomerase activity in gynecological tumors. Clin Cancer Res (1996) 0.94

Lack of reciprocal translocations in carcinomas. Cancer Genet Cytogenet (1986) 0.94

Telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas. Br J Cancer (2004) 0.84

Articles by these authors

Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet (2003) 3.77

Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis. Blood (2010) 2.16

Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. J Invest Dermatol (2008) 1.93

Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis. J Natl Cancer Inst (2012) 1.82

Telomere instability in the male germline. Hum Mol Genet (2005) 1.55

Immunological responses in women with human papillomavirus type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination. Clin Cancer Res (2004) 1.51

Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage. PLoS One (2010) 1.50

Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans. Hum Mol Genet (2006) 1.30

On the origin of trisomy 21 Down syndrome. Mol Cytogenet (2008) 1.29

Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression. Clin Cancer Res (2011) 1.25

Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. J Gerontol A Biol Sci Med Sci (2005) 1.24

Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Res (2009) 1.19

Competition between CTL narrows the immune response induced by prime-boost vaccination protocols. J Immunol (2002) 1.18

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease. Br J Haematol (2014) 1.07

Short telomeres are preferentially elongated by telomerase in human cells. FEBS Lett (2009) 1.07

The naphthalene catabolic (nag) genes of Ralstonia sp. strain U2 are an operon that is regulated by NagR, a LysR-type transcriptional regulator. J Bacteriol (2003) 0.99

Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability. J Natl Cancer Inst (2013) 0.98

Identification of HLA-DR1- and HLA-DR15-restricted human papillomavirus type 16 (HPV16) and HPV18 E6 epitopes recognized by CD4+ T cells from healthy young women. J Gen Virol (2007) 0.97

Telomere dysfunction and its role in haematological cancer. Br J Haematol (2012) 0.93

Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen. Blood (2004) 0.93

Activation of CD40 in cervical carcinoma cells facilitates CTL responses and augments chemotherapy-induced apoptosis. J Immunol (2005) 0.92

T-cell receptor tetramer binding or the lack there of does not necessitate antigen reactivity in T-cell receptor transduced T cells. Cancer Immunol Immunother (2005) 0.91

Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Hum Mol Genet (2004) 0.90

Telomere length maintenance in stem cell populations. Biochim Biophys Acta (2009) 0.89

Epitope specificity and longevity of a vaccine-induced human T cell response against HPV18. Int Immunol (2004) 0.89

DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase. Mutat Res (2010) 0.88

Strain-specific telomere length revealed by single telomere length analysis in Caenorhabditis elegans. Nucleic Acids Res (2004) 0.88

Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation. Exp Cell Res (2004) 0.86

Mre11 modulates the fidelity of fusion between short telomeres in human cells. Nucleic Acids Res (2011) 0.86

A novel tumor antigen derived from enhanced degradation of bax protein in human cancers. Cancer Res (2011) 0.85

Blinatumomab induces autologous T-cell killing of chronic lymphocytic leukemia cells. Haematologica (2013) 0.85

Definition of an HPV18/45 cross-reactive human T-cell epitope after DNA immunisation of HLA-A2/KB transgenic mice. Int J Cancer (2006) 0.84

Telomere dynamics during replicative senescence are not directly modulated by conditions of oxidative stress in IMR90 fibroblast cells. Biogerontology (2009) 0.84

Activated B cells mediate efficient expansion of rare antigen-specific T cells. Hum Immunol (2007) 0.83

Anti-viral cytotoxic T cells inhibit the growth of cancer cells with antibody targeted HLA class I/peptide complexes in SCID mice. Int J Cancer (2002) 0.83

Cross-typic specificity and immunotherapeutic potential of a human HPV16 E7-specific CTL line. Int J Cancer (2005) 0.82

Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death. Genes Chromosomes Cancer (2012) 0.82

Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression. Exp Cell Res (2003) 0.81

Decreased HPV-specific T cell responses and accumulation of immunosuppressive influences in oropharyngeal cancer patients following radical therapy. Cancer Immunol Immunother (2013) 0.81

Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence. Mech Ageing Dev (2010) 0.80

T-cell response to human papillomavirus type 58 L1, E6, And E7 peptides in women with cleared infection, cervical intraepithelial neoplasia, or invasive cancer. Clin Vaccine Immunol (2010) 0.79

HPV16 E6 29-38-specific T cells kill cervical carcinoma cells despite partial evasion of T-cell effector function. Int J Cancer (2008) 0.79

T-cell response to human papillomavirus type 52 L1, E6, and E7 peptides in women with transient infection, cervical intraepithelial neoplasia, and invasive cancer. J Med Virol (2011) 0.79

Promiscuous behavior of HPV16E6 specific T cell receptor beta chains hampers functional expression in TCR transgenic T cells, which can be restored in part by genetic modification. Cell Oncol (2010) 0.76

CD8(+) T-cell recognition of a synthetic epitope formed by t-butyl modification. Immunology (2014) 0.75

Shortened telomeres: a driving force behind leukemia? Future Oncol (2010) 0.75