Published in Cancer Res on November 01, 2007
Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife (2013) 1.22
Wealth of opportunity - the C1 domain as a target for drug development. Curr Drug Targets (2008) 1.21
RasGRP Ras guanine nucleotide exchange factors in cancer. Front Biol (Beijing) (2013) 1.04
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis. Sci Signal (2013) 0.98
Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells. Front Immunol (2013) 0.95
Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. Nat Commun (2015) 0.87
RasGRP1 transgenic mice develop cutaneous squamous cell carcinomas in response to skin wounding: potential role of granulocyte colony-stimulating factor. Am J Pathol (2009) 0.84
RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes. J Biol Chem (2010) 0.79
Targeted deletion of RasGRP1 impairs skin tumorigenesis. Carcinogenesis (2014) 0.77
Protein kinase C in cancer: The top five unanswered questions. Mol Carcinog (2017) 0.75
A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife (2017) 0.75
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature (1986) 6.14
Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer (2007) 5.71
RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol (2000) 4.28
Multistage carcinogenesis in mouse skin. Pharmacol Ther (1992) 2.79
RasGRP links T-cell receptor signaling to Ras. Blood (2000) 2.46
v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc Natl Acad Sci U S A (1990) 2.16
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell (1990) 2.16
C1 domains exposed: from diacylglycerol binding to protein-protein interactions. Biochim Biophys Acta (2006) 1.98
FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis (1993) 1.95
RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J Immunol (2005) 1.70
Competitive inhibition by diacylglycerol of specific phorbol ester binding. Proc Natl Acad Sci U S A (1984) 1.60
Modelling cancer in human skin tissue. Nat Rev Cancer (2006) 1.46
CalDAG-GEFIII activation of Ras, R-ras, and Rap1. J Biol Chem (2000) 1.40
Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals. Curr Opin Neurobiol (2004) 1.31
Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene (2002) 1.30
The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters. Mol Pharmacol (2000) 1.24
Phorbol esters modulate the Ras exchange factor RasGRP3. Cancer Res (2001) 1.24
Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin. J Invest Dermatol (1990) 1.23
Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors. Proc Natl Acad Sci U S A (1990) 1.20
Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors. Proc Natl Acad Sci U S A (1992) 1.20
Non-kinase second-messenger signaling: new pathways with new promise. Bioessays (2004) 1.17
An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med (2006) 1.15
The wild-type Ras: road ahead. FASEB J (2005) 1.02
Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin. Cancer Res (2007) 0.98
Identification of novel genetic loci contributing to 12-O-tetradecanoylphorbol-13-acetate skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice. Cancer Res (2003) 0.98
RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes. J Biol Chem (2003) 0.97
Differential gene expression in epidermis of mice sensitive and resistant to phorbol ester skin tumor promotion. Mol Carcinog (2005) 0.91
Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s. Bioorg Med Chem (2004) 0.90
Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes. Mol Cancer Ther (2006) 0.90
Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation. Mol Carcinog (2000) 0.82
Tumor promotion by regenerative epidermal hyperplasia in mouse skin. J Cutan Pathol (1982) 0.81
Low incidence of Ha-ras oncogene mutations in human epidermal tumors. Cancer Lett (1991) 0.81
Further analysis of c-Ha-ras mutations in papillomas initiated by several polycyclic aromatic hydrocarbons and papillomas from uninitiated, promoter-treated skin in SENCAR mice. Mol Carcinog (1993) 0.80
SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene. Carcinogenesis (1994) 0.77
Distribution of ras guanyl releasing protein (RasGRP) mRNA in the adult rat central nervous system. J Neurocytol (2000) 0.76
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest (2007) 2.26
Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology (2005) 1.69
Behavioral stress accelerates prostate cancer development in mice. J Clin Invest (2013) 1.52
Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition. Fertil Steril (2006) 1.46
Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model. Menopause (2007) 1.45
Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Menopause (2012) 1.42
Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone. Menopause (2009) 1.42
Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Res (2007) 1.28
Physiology and Endocrinology of the Ovarian Cycle in Macaques. Toxicol Pathol (2008) 1.14
Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One (2010) 1.13
A 2-substituted prodiginine, 2-(p-hydroxybenzyl)prodigiosin, from Pseudoalteromonas rubra. J Nat Prod (2008) 1.05
Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res (2012) 1.04
Characterization and experimental transmission of an oncogenic papillomavirus in female macaques. J Virol (2007) 1.02
Mammographic density and epithelial histopathologic markers. BMC Cancer (2009) 1.00
Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis. Endocrinology (2002) 0.99
Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin. Cancer Res (2007) 0.98
RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes. J Biol Chem (2003) 0.97
Intrathecal ketorolac in dogs and rats. Toxicol Sci (2004) 0.96
Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Nutr Cancer (2006) 0.95
Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys. Psychoneuroendocrinology (2007) 0.92
Cyclic changes in the mammary gland of cynomolgus macaques. Fertil Steril (2004) 0.92
In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids. J Biol Chem (2008) 0.92
Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys. Breast Cancer Res Treat (2007) 0.91
Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys. Carcinogenesis (2006) 0.91
The placenta in toxicology. Part II: Systemic and local immune adaptations in pregnancy. Toxicol Pathol (2013) 0.91
Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey. Cancer Immunol Immunother (2004) 0.90
Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes. Mol Cancer Ther (2006) 0.90
Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys. J Clin Endocrinol Metab (2004) 0.90
Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Clin Cancer Res (2010) 0.90
Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo. Biochem J (2006) 0.89
Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys. Leuk Lymphoma (2004) 0.88
Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast. Cancer Res (2006) 0.88
A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates. Radiat Res (2011) 0.88
The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain. J Biol Chem (2006) 0.88
Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys. Menopause (2012) 0.87
Progestin effects on cell proliferation pathways in the postmenopausal mammary gland. Breast Cancer Res (2013) 0.87
Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat (2011) 0.87
Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biol Reprod (2006) 0.87
Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring. Am J Primatol (2009) 0.86
Contrasting effects of two hormone replacement therapies on the cardiovascular and mammary gland outcomes in surgically postmenopausal monkeys. Am J Obstet Gynecol (2003) 0.85
Transcriptional profiles of progestogen effects in the postmenopausal breast. Breast Cancer Res Treat (2008) 0.85
Soy consumption and histopathologic markers in breast tissue using tissue microarrays. Nutr Cancer (2009) 0.85
Accelerated mammary tumor onset in a HER2/Neu mouse model exposed to DDT metabolites locally delivered to the mammary gland. Environ Health Perspect (2012) 0.85
Effects of soy on the mammary glands of premenopausal female monkeys. Fertil Steril (2006) 0.85
The effects of hormone replacement on the biomechanical properties of the uterosacral and round ligaments in the monkey model. Am J Obstet Gynecol (2005) 0.84
Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland. Lab Invest (2008) 0.84
RasGRP1 transgenic mice develop cutaneous squamous cell carcinomas in response to skin wounding: potential role of granulocyte colony-stimulating factor. Am J Pathol (2009) 0.84
Hippocampal volume in postmenopausal cynomolgus macaques with behavioral depression. Menopause (2011) 0.83
Do variations in mast cell hyperplasia account for differences in radiation-induced lung injury among different mouse strains, rats and nonhuman primates? Radiat Res (2013) 0.81
Histopathology of the urinary bladders of cynomolgus monkeys treated with PPAR agonists. Toxicol Pathol (2008) 0.81
DMP1β, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer. J Pathol (2015) 0.81
Effects of two novel selective estrogen receptor modulators, raloxifene, tamoxifen, and ethinyl estradiol on the uterus, vagina and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis). Am J Obstet Gynecol (2007) 0.81
STP position paper: ovarian follicular counting in the assessment of rodent reproductive toxicity. Toxicol Pathol (2005) 0.81
Health issues in postmenopausal women who drink. Alcohol Res Health (2002) 0.81
Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis). J Nutr (2007) 0.81
Mammary gland development in early pubertal female macaques. Toxicol Pathol (2007) 0.81
Effects of social status and moderate alcohol consumption on mammary gland and endometrium of surgically postmenopausal monkeys. Menopause (2004) 0.80
Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Menopause (2013) 0.80
Cystic mammary adenocarcinoma associated with a prolactin-secreting pituitary adenoma in a New Zealand white rabbit (Oryctolagus cuniculus). Comp Med (2008) 0.80
The placenta in toxicology. Part I: Animal models in toxicology: placental morphology and tolerance molecules in the cynomolgus monkey (Macaca fascicularis). Toxicol Pathol (2013) 0.80
Pathology of fractionated whole-brain irradiation in rhesus monkeys ( Macaca mulatta ). Radiat Res (2015) 0.79
Mammographic density and matrix metalloproteinases in breast tissue. Cancer Microenviron (2009) 0.79
RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes. J Biol Chem (2010) 0.79
Structural basis of RasGRP binding to high-affinity PKC ligands. J Med Chem (2002) 0.79
Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates. Cancer Prev Res (Phila) (2013) 0.79
The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Maturitas (2012) 0.79
Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes. Comp Med (2009) 0.79
Receptors for thyrotropin-releasing hormone, thyroid-stimulating hormone, and thyroid hormones in the macaque uterus: effects of long-term sex hormone treatment. Menopause (2012) 0.78
Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene. Evid Based Complement Alternat Med (2012) 0.78
Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein. J Agric Food Chem (2011) 0.78
Comparative effects of oral conjugated equine estrogens and micronized 17beta-estradiol on breast proliferation: a retrospective analysis. Menopause (2008) 0.78
The effects of adenocaine (adenosine and lidocaine) on early post-resuscitation cardiac and neurological dysfunction in a porcine model of cardiac arrest. Resuscitation (2013) 0.78
Tamoxifen-DNA adduct formation in monkey and human reproductive organs. Carcinogenesis (2014) 0.78
Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys. J Clin Endocrinol Metab (2004) 0.78
Phorbol esters as probes for the study of protein kinase C function. Methods Mol Biol (2003) 0.77
Targeted deletion of RasGRP1 impairs skin tumorigenesis. Carcinogenesis (2014) 0.77
Inhibition of Neu-induced mammary carcinogenesis in transgenic mice expressing ERΔ3, a dominant negative estrogen receptor α variant. Horm Cancer (2012) 0.77
Endocrine profile of an ovariectomized cynomolgus monkey (Macaca fascicularis) with a supernumerary ovary. Comp Med (2011) 0.77
Past oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis). Cancer Epidemiol Biomarkers Prev (2008) 0.77
Type 2 Diabetes is a Delayed Late Effect of Whole-Body Irradiation in Nonhuman Primates. Radiat Res (2015) 0.77
Effect of hormone replacement and selective estrogen receptor modulators (SERMs) on the biomechanics and biochemistry of pelvic support ligaments in the cynomolgus monkey (Macaca fascicularis). Am J Obstet Gynecol (2010) 0.76
Effect of long-term treatment with steroid hormones or tamoxifen on the progesterone receptor and androgen receptor in the endometrium of ovariectomized cynomolgus macaques. Reprod Biol Endocrinol (2003) 0.76
Expression of p53 and markers for apoptosis in breast tissue during long-term hormone therapy in cynomolgus monkeys. Am J Obstet Gynecol (2005) 0.76
Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. Int J Radiat Biol (2015) 0.76
Endogenous and exogenous equol are antiestrogenic in reproductive tissues of apolipoprotein e-null mice. J Nutr (2012) 0.76
Effects of tibolone on estrogen biosynthesis in the mammary tissue of postmenopausal monkeys. Menopause (2006) 0.76
Lessons to be learned from animal studies on hormones and the breast. Maturitas (2004) 0.76
Novel In Vivo model for combinatorial fluorescence labeling in mouse prostate. Prostate (2015) 0.76
Effects of hormonally active agents on steroid hormone receptor expression and cell proliferation in the myometrium of ovariectomized macaques. Toxicol Pathol (2011) 0.75
The placenta in toxicology. Part IV: Battery of toxicological test systems based on human placenta. Toxicol Pathol (2013) 0.75
Distribution of cyclooxygenases 1 and 2 in the uterus and breast of cynomolgus monkeys-effects of hormone treatment. Menopause (2011) 0.75
Estrogen replacement therapy induces telomerase RNA expression in the macaque endometrium. Fertil Steril (2002) 0.75
Use of the progestin challenge test in nonhuman primates (Macaca fascicularis). Fertil Steril (2002) 0.75
Value of the micropig model of menopause in the assessment of benefits and risks of postmenopausal therapies for cardiovascular and reproductive tissues. Fertil Steril (2003) 0.75
Effects of long-term tibolone treatment on nuclear sex steroid hormone receptors and G-protein-coupled estrogen receptor-1 expression in the macaque uterus. Menopause (2012) 0.75