Published in Nat Genet on November 04, 2007
A HapMap harvest of insights into the genetics of common disease. J Clin Invest (2008) 18.31
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet (2008) 7.63
Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07
Multiple common variants for celiac disease influencing immune gene expression. Nat Genet (2010) 6.90
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet (2008) 6.42
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet (2009) 5.75
Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet (2009) 4.79
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet (2008) 4.33
Progress and promise of genome-wide association studies for human complex trait genetics. Genetics (2010) 3.81
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet (2011) 3.68
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet (2009) 3.52
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet (2009) 3.36
Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate. Rheumatology (Oxford) (2009) 3.33
The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity (2008) 3.19
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet (2008) 3.18
Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet (2008) 2.94
A20: central gatekeeper in inflammation and immunity. J Biol Chem (2008) 2.83
Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res (2009) 2.63
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet (2011) 2.54
A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol (2012) 2.47
Recent advances in the genetics of autoimmune disease. Annu Rev Immunol (2009) 2.41
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet (2010) 2.34
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet (2012) 2.31
Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol (2013) 2.20
Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies. Arthritis Rheum (2009) 2.19
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature (2014) 2.10
Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy. Arthritis Rheum (2010) 2.08
Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet (2008) 2.08
Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One (2009) 2.03
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat Genet (2011) 1.95
Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations. Arthritis Rheum (2009) 1.92
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. Ann Rheum Dis (2010) 1.90
Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis. Nat Rev Rheumatol (2012) 1.78
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet (2011) 1.78
Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol (2011) 1.77
The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings. J Invest Dermatol (2012) 1.71
Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. Mol Med (2008) 1.69
A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis. Cancer Res (2009) 1.64
Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets. Arthritis Res Ther (2008) 1.61
Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol (2008) 1.59
Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations. J Med Genet (2008) 1.59
Recent advances in the genetics of rheumatoid arthritis. Curr Opin Rheumatol (2010) 1.58
Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia. Cancer Res (2009) 1.57
Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Hum Mol Genet (2009) 1.55
Quantifying missing heritability at known GWAS loci. PLoS Genet (2013) 1.55
Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk. Ann Rheum Dis (2010) 1.53
A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2. PLoS Genet (2008) 1.53
STAT4: genetics, mechanisms, and implications for autoimmunity. Curr Allergy Asthma Rep (2008) 1.53
African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity. J Immunol (2010) 1.52
Unraveling the genetics of autoimmunity. Cell (2010) 1.51
GRM7 variants confer susceptibility to age-related hearing impairment. Hum Mol Genet (2008) 1.49
Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nat Immunol (2011) 1.46
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med (2011) 1.42
Genome-wide searching of rare genetic variants in WTCCC data. Hum Genet (2010) 1.39
Psoriasis genetics: breaking the barrier. Trends Genet (2010) 1.38
Developments in the scientific understanding of rheumatoid arthritis. Arthritis Res Ther (2009) 1.38
Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet (2009) 1.37
Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis (2010) 1.36
New insights into the pathogenesis and genetics of psoriatic arthritis. Nat Clin Pract Rheumatol (2009) 1.35
Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility. Arthritis Res Ther (2009) 1.35
Recent advances in the genetics of systemic lupus erythematosus. Expert Rev Clin Immunol (2010) 1.35
Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans. Arthritis Rheum (2010) 1.34
Rheumatoid arthritis: a view of the current genetic landscape. Genes Immun (2008) 1.32
Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants. Hum Mol Genet (2012) 1.32
Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Ann Rheum Dis (2010) 1.31
The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1. Arthritis Rheum (2010) 1.28
A comprehensive review of the genetics of juvenile idiopathic arthritis. Pediatr Rheumatol Online J (2008) 1.27
Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations. Genes Immun (2009) 1.25
Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. Ann Rheum Dis (2010) 1.25
Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases. Genes Immun (2011) 1.24
Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia (2008) 1.23
Visualization of shared genomic regions and meiotic recombination in high-density SNP data. PLoS One (2009) 1.23
Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. Nat Rev Neurosci (2012) 1.22
Genetics and visceral leishmaniasis: of mice and man. Parasite Immunol (2009) 1.21
Genetics of rheumatoid arthritis: what have we learned? Immunogenetics (2011) 1.21
MHC-resident variation affects risks after unrelated donor hematopoietic cell transplantation. Sci Transl Med (2012) 1.21
The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. Hum Genet (2009) 1.20
Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis. Arthritis Rheum (2009) 1.20
Recent findings on genetics of systemic autoimmune diseases. Curr Opin Immunol (2010) 1.19
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. Nat Genet (2013) 1.19
Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study. Arthritis Res Ther (2010) 1.17
Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. Neurobiol Aging (2010) 1.16
The inextricable link between atherosclerosis and prototypical inflammatory diseases rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res Ther (2009) 1.15
Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis. Genes Immun (2009) 1.14
High-throughput, high-accuracy array-based resequencing. Proc Natl Acad Sci U S A (2009) 1.14
Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae. Proc Natl Acad Sci U S A (2009) 1.13
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet (2015) 1.13
Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity (2013) 1.13
A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme. J Exp Med (2009) 1.12
Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. Mol Psychiatry (2008) 1.11
TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis. J Invest Dermatol (2011) 1.10
Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. Ann Rheum Dis (2009) 1.10
Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis. Nat Rev Rheumatol (2010) 1.09
A new methodology to associate SNPs with human diseases according to their pathway related context. PLoS One (2011) 1.09
Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis. Arthritis Rheum (2009) 1.09
Power consequences of linkage disequilibrium variation between populations. Genet Epidemiol (2009) 1.08
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Genomic control for association studies. Biometrics (1999) 64.39
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Efficiency and power in genetic association studies. Nat Genet (2005) 25.56
Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet (2005) 25.34
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18
Assessing the impact of population stratification on genetic association studies. Nat Genet (2004) 16.28
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
The effects of human population structure on large genetic association studies. Nat Genet (2004) 14.88
Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet (2007) 14.37
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 13.71
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science (2000) 10.98
Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet (2006) 7.49
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet (1994) 7.04
European population substructure: clustering of northern and southern populations. PLoS Genet (2006) 5.27
The New York Cancer Project: rationale, organization, design, and baseline characteristics. J Urban Health (2004) 5.21
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci U S A (2007) 4.71
Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann Rheum Dis (2003) 4.36
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem (1990) 3.41
Epidemiology and genetics of rheumatoid arthritis. Arthritis Res (2002) 3.37
WHAP: haplotype-based association analysis. Bioinformatics (2006) 3.36
Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles. Arthritis Rheum (2005) 2.88
Clustering of disease features within 512 multicase rheumatoid arthritis families. Arthritis Rheum (2004) 2.00
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord. Genes Dev (2005) 1.66
The validity of a rheumatoid arthritis medical records-based index of severity compared with the DAS28. Arthritis Res Ther (2006) 1.43
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res (2010) 97.51
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
The structure of haplotype blocks in the human genome. Science (2002) 50.88
Population structure and eigenanalysis. PLoS Genet (2006) 37.21
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96
Structure validation by Calpha geometry: phi,psi and Cbeta deviation. Proteins (2003) 32.38
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Strong association of de novo copy number mutations with autism. Science (2007) 27.84
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Efficiency and power in genetic association studies. Nat Genet (2005) 25.56
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Detecting recent positive selection in the human genome from haplotype structure. Nature (2002) 22.00
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Initial genome sequencing and analysis of multiple myeloma. Nature (2011) 17.28
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27