Published in Methods Mol Biol on January 01, 2007
Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet (2008) 26.79
Decanalization and the origin of complex disease. Nat Rev Genet (2009) 3.12
Comprehensive approach to analyzing rare genetic variants. PLoS One (2010) 2.93
Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80
The genetic contribution to non-syndromic human obesity. Nat Rev Genet (2009) 2.70
Genetical genomics: spotlight on QTL hotspots. PLoS Genet (2008) 2.63
HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). Hum Genet (2012) 2.18
Design of association studies with pooled or un-pooled next-generation sequencing data. Genet Epidemiol (2010) 2.06
Interpretation of association signals and identification of causal variants from genome-wide association studies. Am J Hum Genet (2010) 2.06
Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies. Annu Rev Public Health (2010) 1.88
Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. Am J Hum Genet (2009) 1.71
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain (2010) 1.67
A variational Bayes algorithm for fast and accurate multiple locus genome-wide association analysis. BMC Bioinformatics (2010) 1.63
Approaches for evaluating rare polymorphisms in genetic association studies. Hum Hered (2010) 1.30
Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility. J Allergy Clin Immunol (2009) 1.25
The genetics of autism: key issues, recent findings, and clinical implications. Psychiatr Clin North Am (2010) 1.21
High-throughput, high-accuracy array-based resequencing. Proc Natl Acad Sci U S A (2009) 1.14
Methodological Issues in Multistage Genome-wide Association Studies. Stat Sci (2009) 1.06
Genomic convergence of genome-wide investigations for complex traits. Ann Hum Genet (2009) 1.01
Genome-wide association studies: hypothesis-"free" or "engaged"? Transl Res (2009) 0.99
Domain duplication, divergence, and loss events in vertebrate Msx paralogs reveal phylogenomically informed disease markers. BMC Evol Biol (2009) 0.98
Power of family-based association designs to detect rare variants in large pedigrees using imputed genotypes. Genet Epidemiol (2013) 0.98
Variants in exon 11 of MEF2A gene and coronary artery disease: evidence from a case-control study, systematic review, and meta-analysis. PLoS One (2012) 0.97
Genetic [corrected] insights into the causes and classification of [corrected] cerebral palsies. Lancet Neurol (2012) 0.95
Identifying rare variants associated with complex traits via sequencing. Curr Protoc Hum Genet (2013) 0.95
Combining family- and population-based imputation data for association analysis of rare and common variants in large pedigrees. Genet Epidemiol (2014) 0.93
Encore: Genetic Association Interaction Network centrality pipeline and application to SLE exome data. Genet Epidemiol (2013) 0.92
An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases. Am J Hum Genet (2014) 0.88
Use of a targeted, combinatorial next-generation sequencing approach for the study of bicuspid aortic valve. BMC Med Genomics (2014) 0.86
Identifying rare disease variants in the Genetic Analysis Workshop 17 simulated data: a comparison of several statistical approaches. BMC Proc (2011) 0.86
Genetics and genomics of primary biliary cirrhosis. Clin Liver Dis (2008) 0.86
Elevated blood pressure: Our family's fault? The genetics of essential hypertension. World J Cardiol (2014) 0.82
Perspective: a systems approach to diabetes research. Front Genet (2013) 0.82
Combining effects from rare and common genetic variants in an exome-wide association study of sequence data. BMC Proc (2011) 0.81
Gene-based multiple trait analysis for exome sequencing data. BMC Proc (2011) 0.80
Database of genetic studies of bipolar disorder. Psychiatr Genet (2011) 0.80
A goodness-of-fit association test for whole genome sequencing data. BMC Proc (2014) 0.80
Gene-based analysis of rare and common variants to determine association with blood pressure. BMC Proc (2014) 0.80
Two-stage design of sequencing studies for testing association with rare variants. Hum Hered (2011) 0.80
I Believe I Can Fly!: Use of Drosophila as a Model Organism in Neuropsychopharmacology Research. Neuropsychopharmacology (2015) 0.79
Combined cis-regulator elements as important mechanism affecting FXII plasma levels. Thromb Res (2009) 0.79
Higher criticism approach to detect rare variants using whole genome sequencing data. BMC Proc (2014) 0.78
Comparison of haplotype-based statistical tests for disease association with rare and common variants. Brief Bioinform (2015) 0.78
Genetics in psychiatry: common variant association studies. Mol Autism (2010) 0.78
A comparison of two collapsing methods in different approaches. BMC Proc (2014) 0.77
Detecting rare variants in case-parents association studies. PLoS One (2013) 0.77
Colitis-associated colon cancer: Is it in your genes? World J Gastroenterol (2015) 0.77
A clustering approach to identify rare variants associated with hypertension. BMC Proc (2016) 0.75
Genetic factors for alcohol dependence and schizophrenia: common and rare variants. Austin J Drug Abuse Addict (2014) 0.75
Advances in the genetics of schizophrenia: will high-risk copy number variants be useful in clinical genetics or diagnostics? F1000 Med Rep (2009) 0.75
Detecting functional rare variants by collapsing and incorporating functional annotation in Genetic Analysis Workshop 17 mini-exome data. BMC Proc (2011) 0.75
Detecting multiple variants associated with disease based on sequencing data of case-parent trios. J Hum Genet (2016) 0.75
A powerful association test of multiple genetic variants using a random-effects model. Stat Med (2013) 0.75
A stochastic inference of de novo CNV detection and association test in multiplex schizophrenia families. Front Genet (2013) 0.75
Optimal two-stage genotyping in population-based association studies. Genet Epidemiol (2003) 6.01
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46
Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A (2010) 3.78
Improved power by use of a weighted score test for linkage disequilibrium mapping. Am J Hum Genet (2006) 3.36
Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences. Hum Hered (2003) 3.33
Choosing an optimal method to combine P-values. Stat Med (2009) 3.15
A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet (2008) 3.00
Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet (2003) 2.92
Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80
Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Hum Mol Genet (2005) 2.80
Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet (2004) 2.36
Linkage analysis of a complex disease through use of admixed populations. Am J Hum Genet (2004) 2.21
Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes. Am J Hum Genet (2008) 2.20
Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am J Hum Genet (2005) 2.18
A powerful method of combining measures of association and Hardy-Weinberg disequilibrium for fine-mapping in case-control studies. Stat Med (2006) 2.18
Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions. Bioinformatics (2006) 2.08
Whole genome scan for obstructive sleep apnea and obesity in African-American families. Am J Respir Crit Care Med (2004) 2.03
The Family Investigation of Nephropathy and Diabetes (FIND): design and methods. J Diabetes Complications (2005) 1.87
Self-reported race and genetic admixture. N Engl J Med (2006) 1.85
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci U S A (2003) 1.84
The meaning of interaction. Hum Hered (2010) 1.83
EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet (2009) 1.82
A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet (2002) 1.81
Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes (2007) 1.79
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes (2007) 1.61
A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies. Am J Hum Genet (2008) 1.57
Improving power in contrasting linkage-disequilibrium patterns between cases and controls. Am J Hum Genet (2007) 1.55
A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study. Am J Hum Genet (2003) 1.53
A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population. BMC Genet (2003) 1.50
Log-linear model-based multifactor dimensionality reduction method to detect gene gene interactions. Bioinformatics (2007) 1.44
Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis. Genet Epidemiol (2002) 1.44
Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS). Genet Epidemiol (2011) 1.43
Sampling correction in linkage analysis. Genet Epidemiol (2004) 1.43
Genome scan of M. tuberculosis infection and disease in Ugandans. PLoS One (2008) 1.41
Plasma aldosterone is independently associated with the metabolic syndrome. Hypertension (2006) 1.40
Are linkage analysis and the collection of family data dead? Prospects for family studies in the age of genome-wide association. Hum Hered (2007) 1.39
Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients. Cancer Res (2009) 1.38
Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading. Am J Hum Genet (2004) 1.36
Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. Hum Mol Genet (2005) 1.36
A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. Am J Hum Genet (2006) 1.31
Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci (2008) 1.29
Statistical interaction in human genetics: how should we model it if we are looking for biological interaction? Nat Rev Genet (2010) 1.28
Two-level Haseman-Elston regression for general pedigree data analysis. Genet Epidemiol (2005) 1.28
Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study. Proc Natl Acad Sci U S A (2004) 1.27
The power of independent types of genetic information to detect association in a case-control study design. Genet Epidemiol (2008) 1.24
CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt. Hypertension (2007) 1.23
Adaptive two-stage analysis of genetic association in case-control designs. Hum Hered (2007) 1.23
Single-marker and two-marker association tests for unphased case-control genotype data, with a power comparison. Genet Epidemiol (2010) 1.22
A sarcoidosis genetic linkage consortium: the sarcoidosis genetic analysis (SAGA) study. Sarcoidosis Vasc Diffuse Lung Dis (2005) 1.18
A partial least-square approach for modeling gene-gene and gene-environment interactions when multiple markers are genotyped. Genet Epidemiol (2009) 1.18
Two-marker association tests yield new disease associations for coronary artery disease and hypertension. Hum Genet (2011) 1.16
Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m. Proc Natl Acad Sci U S A (2004) 1.16
Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. J Infect Dis (2003) 1.16
Regression models for linkage: issues of traits, covariates, heterogeneity, and interaction. Hum Hered (2003) 1.15
Heritability of renal function in hypertensive families of African descent in the Seychelles (Indian Ocean). Kidney Int (2005) 1.13
Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Biol Psychiatry (2008) 1.13
Detecting genetic interactions for quantitative traits with U-statistics. Genet Epidemiol (2011) 1.13
The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activity. Am J Hum Genet (2003) 1.11
Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet (2008) 1.10
Mapping susceptibility loci for alcohol consumption using number of grams of alcohol consumed per day as a phenotype measure. BMC Genet (2003) 1.10
In silico gene prioritization by integrating multiple data sources. PLoS One (2011) 1.10
GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients: absence of protease resistance at 48 weeks. AIDS (2004) 1.08
Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study. Am J Nephrol (2011) 1.07
Haplotype-based quantitative trait mapping using a clustering algorithm. BMC Bioinformatics (2006) 1.07
Robust asymptotic sampling theory for correlations in pedigrees. Stat Med (2003) 1.07
Evidence for a major gene influence on tumor necrosis factor-alpha expression in tuberculosis: path and segregation analysis. Hum Hered (2005) 1.05
Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis (2008) 1.05
Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. Biol Psychiatry (2006) 1.05
Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes. Hum Genet (2007) 1.04
Complement factor H and hemicentin-1 in age-related macular degeneration and renal phenotypes. Hum Mol Genet (2007) 1.03
The distribution of long range admixture linkage disequilibrium in an African-American population. Hum Hered (2002) 1.03
A modified revisited Haseman-Elston method to further improve power. Hum Hered (2004) 1.02
A framework for structural equation models in general pedigrees. Hum Hered (2011) 1.02
Structural equation model-based genome scan for the metabolic syndrome. BMC Genet (2003) 1.02
High heritability of ambulatory blood pressure in families of East African descent. Hypertension (2005) 1.02
A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology. Int J Epidemiol (2007) 1.01
Fine mapping functional sites or regions from case-control data using haplotypes of multiple linked SNPs. Ann Hum Genet (2005) 1.01
A likelihood ratio-based Mann-Whitney approach finds novel replicable joint gene action for type 2 diabetes. Genet Epidemiol (2012) 1.00
The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium. Am J Hum Genet (2006) 1.00
Identification of gene-gene interactions in the presence of missing data using the multifactor dimensionality reduction method. Genet Epidemiol (2009) 1.00
Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data. BMC Syst Biol (2012) 1.00
Evaluation of removable statistical interaction for binary traits. Stat Med (2012) 0.99
Distribution and magnitude of type I error of model-based multipoint lod scores: implications for multipoint mod scores. Genet Epidemiol (2006) 0.98
Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak. Genet Epidemiol (2006) 0.97
Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers. Genetics (2003) 0.97
Immunoglobulin allotypes influence IgG antibody responses to hepatitis C virus envelope proteins E1 and E2. Hum Immunol (2008) 0.97
A non-parametric method for building predictive genetic tests on high-dimensional data. Hum Hered (2011) 0.96
A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Am J Epidemiol (2007) 0.96
Genetic markers of IgG influence the outcome of infection with hepatitis C virus. J Infect Dis (2008) 0.95
Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus. Am J Hum Genet (2006) 0.94
Genome-wide linkage scan for genes affecting longitudinal trends in systolic blood pressure. BMC Genet (2003) 0.93
Linkage analysis of plasma dopamine β-hydroxylase activity in families of patients with schizophrenia. Hum Genet (2011) 0.92
Capability of common SNPs to tag rare variants. BMC Proc (2011) 0.92
Using the optimal robust receiver operating characteristic (ROC) curve for predictive genetic tests. Biometrics (2009) 0.91
Comparison of microsatellites, single-nucleotide polymorphisms (SNPs) and composite markers derived from SNPs in linkage analysis. BMC Genet (2005) 0.91
Heritability and intrafamilial aggregation of arterial characteristics. J Hypertens (2008) 0.91
Examination of association with candidate genes for diabetic nephropathy in a Mexican American population. Clin J Am Soc Nephrol (2010) 0.91
Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. PLoS One (2013) 0.91
A variance component based multi-marker association test using family and unrelated data. BMC Genet (2013) 0.90