Published in Structure on November 01, 2007
Chemistry and biology of vision. J Biol Chem (2011) 1.73
Functional and behavioral restoration of vision by gene therapy in the guanylate cyclase-1 (GC1) knockout mouse. PLoS One (2010) 1.33
Mg2+/Ca2+ cation binding cycle of guanylyl cyclase activating proteins (GCAPs): role in regulation of photoreceptor guanylyl cyclase. Mol Cell Biochem (2009) 1.28
Signal transducing membrane complexes of photoreceptor outer segments. Vision Res (2008) 1.25
Molecular structure and target recognition of neuronal calcium sensor proteins. Biochim Biophys Acta (2011) 1.12
A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res (2008) 1.12
Effects of Ca2+, Mg2+, and myristoylation on guanylyl cyclase activating protein 1 structure and stability. Biochemistry (2009) 1.11
Binding of guanylyl cyclase activating protein 1 (GCAP1) to retinal guanylyl cyclase (RetGC1). The role of individual EF-hands. J Biol Chem (2008) 1.06
Ca2+ -dependent regulation of phototransduction. Photochem Photobiol (2008) 1.05
Structure of a Ca2+-myristoyl switch protein that controls activation of a phosphatidylinositol 4-kinase in fission yeast. J Biol Chem (2011) 1.05
Rhizobial and fungal symbioses show different requirements for calmodulin binding to calcium calmodulin-dependent protein kinase in Lotus japonicus. Plant Cell (2012) 1.04
Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi. J Biol Chem (2008) 1.02
The diversity of calcium sensor proteins in the regulation of neuronal function. Cold Spring Harb Perspect Biol (2010) 1.00
Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J Mol Biol (2012) 0.98
Retracted Molecular structure and target recognition of neuronal calcium sensor proteins. Front Mol Neurosci (2012) 0.96
Understanding the physiological roles of the neuronal calcium sensor proteins. Mol Brain (2012) 0.95
A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem (2009) 0.91
A calcium-relay mechanism in vertebrate phototransduction. ACS Chem Neurosci (2013) 0.90
Focus on molecules: guanylate cyclase-activating proteins (GCAPs). Exp Eye Res (2009) 0.89
Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1. Front Mol Neurosci (2014) 0.87
Neuronal calcium sensor-1 (Ncs1p) is up-regulated by calcineurin to promote Ca2+ tolerance in fission yeast. J Biol Chem (2009) 0.86
Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure (2010) 0.85
GCAP1 mutations associated with autosomal dominant cone dystrophy. Adv Exp Med Biol (2010) 0.84
Ca(2+)-sensors and ROS-GC: interlocked sensory transduction elements: a review. Front Mol Neurosci (2012) 0.84
Protein and Signaling Networks in Vertebrate Photoreceptor Cells. Front Mol Neurosci (2015) 0.83
Identification of target binding site in photoreceptor guanylyl cyclase-activating protein 1 (GCAP1). J Biol Chem (2014) 0.82
EF hand-mediated Ca- and cGMP-signaling in photoreceptor synaptic terminals. Front Mol Neurosci (2012) 0.82
Interaction of GCAP1 with retinal guanylyl cyclase and calcium: sensitivity to fatty acylation. Front Mol Neurosci (2012) 0.82
Interaction between the D2 dopamine receptor and neuronal calcium sensor-1 analyzed by fluorescence anisotropy. Biochemistry (2011) 0.81
GPS-Lipid: a robust tool for the prediction of multiple lipid modification sites. Sci Rep (2016) 0.80
Antithetical modes of and the Ca(2+) sensors targeting in ANF-RGC and ROS-GC1 membrane guanylate cyclases. Front Mol Neurosci (2012) 0.80
The presence of membranes or micelles induces structural changes of the myristoylated guanylate-cyclase activating protein-2. Eur Biophys J (2011) 0.80
Heterogeneous N-terminal acylation of retinal proteins results from the retina's unusual lipid metabolism. Biochemistry (2011) 0.79
Structural insights for activation of retinal guanylate cyclase by GCAP1. PLoS One (2013) 0.79
Structure of Guanylyl Cyclase Activator Protein 1 (GCAP1) Mutant V77E in a Ca2+-free/Mg2+-bound Activator State. J Biol Chem (2015) 0.79
Chemistry and biology of the initial steps in vision: the Friedenwald lecture. Invest Ophthalmol Vis Sci (2014) 0.79
Backbone (1)H, (13)C, and (15)N resonance assignments of guanylyl cyclase activating protein-1, GCAP1. Biomol NMR Assign (2012) 0.79
The myristoylation of guanylate cyclase-activating protein-2 causes an increase in thermodynamic stability in the presence but not in the absence of Ca²⁺. Protein Sci (2011) 0.77
(1)H, (15)N, and (13)C chemical shift assignments of neuronal calcium sensor-1 homolog from fission yeast. Biomol NMR Assign (2009) 0.77
Calcium-induced conformational changes in the regulatory domain of the human mitochondrial ATP-Mg/Pi carrier. Biochim Biophys Acta (2015) 0.77
¹H, ¹³C, and ¹⁵N chemical shift assignments of neuronal calcium sensor protein, hippocalcin. Biomol NMR Assign (2012) 0.76
Allosteric communication pathways routed by Ca(2+)/Mg(2+) exchange in GCAP1 selectively switch target regulation modes. Sci Rep (2016) 0.75
Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome. Proc Natl Acad Sci U S A (2017) 0.75
Calcium regulation of the human mitochondrial ATP-Mg/Pi carrier SLC25A24 uses a locking pin mechanism. Sci Rep (2017) 0.75
Structure and Calcium Binding Properties of a Neuronal Calcium-Myristoyl Switch Protein, Visinin-Like Protein 3. PLoS One (2016) 0.75
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
DaliLite workbench for protein structure comparison. Bioinformatics (2000) 10.53
SOLVE and RESOLVE: automated structure solution and density modification. Methods Enzymol (2003) 6.96
Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency. Protein Eng (2001) 5.71
Molecular mechanics of calcium-myristoyl switches. Nature (1997) 3.36
The neuronal calcium sensor family of Ca2+-binding proteins. Biochem J (2001) 2.85
Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling. Nat Rev Neurosci (2007) 2.79
Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein. Neuron (1994) 2.47
Purification and characterization of yeast myristoyl CoA:protein N-myristoyltransferase. Proc Natl Acad Sci U S A (1987) 2.36
The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem (2007) 2.31
Turned on by Ca2+! The physiology and pathology of Ca(2+)-binding proteins in the retina. Trends Neurosci (1996) 2.24
Cloning, sequencing, and expression of a 24-kDa Ca(2+)-binding protein activating photoreceptor guanylyl cyclase. J Biol Chem (1995) 2.10
A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1. Hum Mol Genet (1998) 1.81
Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function. Trends Neurosci (2004) 1.77
Ca(2+)-binding proteins in the retina: structure, function, and the etiology of human visual diseases. Bioessays (2000) 1.69
Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction. J Biol Chem (1995) 1.62
Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci (2002) 1.52
Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun (2002) 1.51
Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction. J Biol Chem (2002) 1.51
Constitutive activation of photoreceptor guanylate cyclase by Y99C mutant of GCAP-1. Possible role in causing human autosomal dominant cone degeneration. J Biol Chem (1998) 1.49
Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases. J Biol Chem (1999) 1.47
Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. J Biol Chem (1999) 1.47
Calcium binding, but not a calcium-myristoyl switch, controls the ability of guanylyl cyclase-activating protein GCAP-2 to regulate photoreceptor guanylyl cyclase. J Biol Chem (1997) 1.43
GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy. Mol Cell (1998) 1.38
Changes in biological activity and folding of guanylate cyclase-activating protein 1 as a function of calcium. Biochemistry (1998) 1.33
Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae. Biochemistry (2000) 1.32
Crystal structure of recombinant bovine neurocalcin. Nat Struct Biol (1999) 1.28
Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase-activating protein 1. Biochemistry (1997) 1.27
Amino-terminal myristoylation induces cooperative calcium binding to recoverin. J Biol Chem (1995) 1.27
A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD). Invest Ophthalmol Vis Sci (2005) 1.12
Calcium- and myristoyl-dependent properties of guanylate cyclase-activating protein-1 and protein-2. Biochemistry (2002) 1.09
Mapping sites in guanylyl cyclase activating protein-1 required for regulation of photoreceptor membrane guanylyl cyclases. J Biol Chem (1999) 1.08
The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. J Mol Biol (2006) 1.06
Structure, topology, and dynamics of myristoylated recoverin bound to phospholipid bilayers. Biochemistry (2003) 1.04
Regulation of photoreceptor membrane guanylyl cyclases by guanylyl cyclase activator proteins. Methods (1999) 1.03
Guanylate-cyclase-inhibitory protein is a frog retinal Ca2+-binding protein related to mammalian guanylate-cyclase-activating proteins. Eur J Biochem (1998) 0.96
Identification of functional regions of guanylate cyclase-activating protein 1 (GCAP1) using GCAP1/GCIP chimeras. Biol Chem (2001) 0.96
The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association. Neuroscience (2000) 0.93
Ca2+-dependent conformational changes in bovine GCAP-2. Protein Sci (1998) 0.92
Identification of a domain in guanylyl cyclase-activating protein 1 that interacts with a complex of guanylyl cyclase and tubulin in photoreceptors. J Biol Chem (1999) 0.91
Guanylate cyclase activating proteins, guanylate cyclase and disease. Adv Exp Med Biol (2002) 0.89
Identification of residues that determine the absence of a Ca(2+)/myristoyl switch in neuronal calcium sensor-1. J Biol Chem (2004) 0.86
Structure and membrane-targeting mechanism of retinal Ca2+-binding proteins, recoverin and GCAP-2. Adv Exp Med Biol (2002) 0.86
Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature (2003) 5.85
Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther (2005) 4.74
Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A (2006) 4.33
Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc Natl Acad Sci U S A (2005) 4.04
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol (2007) 3.86
Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem (2003) 3.16
Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Invest Ophthalmol Vis Sci (2004) 2.72
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev (2007) 2.62
Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci (2004) 2.62
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem (2007) 2.59
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry (2003) 2.42
Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem (2008) 2.35
The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem (2007) 2.31
Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem (2005) 2.28
Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol (2004) 2.24
Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A (2007) 2.21
Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A (2003) 2.21
Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda) (2010) 2.18
Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem (2005) 2.15
Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem (2002) 2.11
G protein-coupled receptor rhodopsin: a prospectus. Annu Rev Physiol (2002) 2.08
Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol (2006) 2.03
Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry (2004) 2.03
Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc Natl Acad Sci U S A (2009) 2.01
Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem (2009) 2.01
Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography. J Cell Biol (2007) 1.92
A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci (2004) 1.92
Structure and flexibility of the complete periplasmic domain of BamA: the protein insertion machine of the outer membrane. Structure (2010) 1.92
Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci (2002) 1.86
Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med (2005) 1.83
Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle. Proc Natl Acad Sci U S A (2005) 1.83
Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci (2008) 1.76
Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem (2013) 1.76
Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A (2002) 1.72
ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet (2008) 1.69
Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proc Natl Acad Sci U S A (2009) 1.65
RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metab (2008) 1.64
Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem (2004) 1.64
Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem (2008) 1.62
Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem (2005) 1.58
Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem (2006) 1.58
Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. Biomed Opt Express (2010) 1.58
Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem (2004) 1.57
Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem (2011) 1.55
Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem (2011) 1.55
Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A (2009) 1.54
Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc Natl Acad Sci U S A (2007) 1.53
Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci (2002) 1.52
Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun (2002) 1.51
Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem (2008) 1.51
GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J (2002) 1.49
Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol (2004) 1.45
Phototransduction: crystal clear. Trends Biochem Sci (2003) 1.45
A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J (2010) 1.45
Rhodopsin phosphorylation: 30 years later. Prog Retin Eye Res (2003) 1.45
Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II. J Biol Chem (2002) 1.43
The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci (2010) 1.42
Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo. J Neurochem (2003) 1.42
Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. Annu Rev Pharmacol Toxicol (2008) 1.41
Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat Chem Biol (2011) 1.40
Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Invest Ophthalmol Vis Sci (2006) 1.39
The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev (2011) 1.39
Rhodopsin self-associates in asolectin liposomes. Proc Natl Acad Sci U S A (2006) 1.39
Functional and structural characterization of rhodopsin oligomers. J Biol Chem (2006) 1.39
Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Mol Pharmacol (2006) 1.38
Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem (2011) 1.38
Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A (2013) 1.36
Visual rhodopsin sees the light: structure and mechanism of G protein signaling. J Biol Chem (2007) 1.35
The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem (2008) 1.33
Structure of cone photoreceptors. Prog Retin Eye Res (2009) 1.32
A critical role of CaBP4 in the cone synapse. Invest Ophthalmol Vis Sci (2005) 1.31
Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci (2009) 1.31
Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle. J Biol Chem (2005) 1.29
Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J (2011) 1.29
Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci (2007) 1.29
Chemistry of the retinoid (visual) cycle. Chem Rev (2013) 1.28
Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta (2011) 1.28
Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors. Mol Pharmacol (2008) 1.28
The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. Annu Rev Biophys Biomol Struct (2003) 1.27
The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol (2010) 1.25