Involvement of notch signaling in wound healing.

Analysis of αSMA-labeled progenitor cell commitment identifies notch signaling as an important pathway in fracture healing. J Bone Miner Res (2014) 1.66

MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination. Proc Natl Acad Sci U S A (2013) 1.60

Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately. Stem Cell Res Ther (2015) 1.57

Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages. J Immunol (2010) 1.49

Cutaneous wound healing: recruiting developmental pathways for regeneration. Cell Mol Life Sci (2012) 1.40

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis. Front Oncol (2015) 1.15

Preventive effect of Notch signaling inhibition by a gamma-secretase inhibitor on peritoneal dialysis fluid-induced peritoneal fibrosis in rats. Am J Pathol (2010) 1.07

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state. Elife (2014) 1.04

Notch pathway modulation on bone marrow-derived vascular precursor cells regulates their angiogenic and wound healing potential. PLoS One (2008) 1.01

Promoting angiogenesis via manipulation of VEGF responsiveness with notch signaling. Biomaterials (2009) 1.00

The wound healing, chronic fibrosis, and cancer progression triad. Physiol Genomics (2014) 0.99

Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration. J Orthop Res (2011) 0.98

The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke. Neuroscience (2008) 0.98

Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo. PLoS One (2010) 0.97

Systemic inhibition of canonical Notch signaling results in sustained callus inflammation and alters multiple phases of fracture healing. PLoS One (2013) 0.96

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis. Arthritis Rheum (2011) 0.94

Notch signaling promotes the corneal epithelium wound healing. Mol Vis (2012) 0.93

Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype. Proc Natl Acad Sci U S A (2015) 0.91

Suppression of colon carcinogenesis by targeting Notch signaling. Carcinogenesis (2013) 0.90

Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer. Cancer Growth Metastasis (2015) 0.90

New insights into the mechanism of notch signalling in fibrosis. Open Rheumatol J (2012) 0.89

Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials (2010) 0.88

Expression of HES and HEY genes in infantile hemangiomas. Vasc Cell (2011) 0.86

Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesis. PLoS One (2012) 0.84

A potential role for notch signaling in the pathogenesis and regulation of hemangiomas. J Craniofac Surg (2009) 0.83

Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring. Am J Pathol (2014) 0.83

A synthetic uric acid analog accelerates cutaneous wound healing in mice. PLoS One (2010) 0.81

New insights into glomerular parietal epithelial cell activation and its signaling pathways in glomerular diseases. Biomed Res Int (2015) 0.77

Epidermal stem cells (ESCs) accelerate diabetic wound healing via the Notch signalling pathway. Biosci Rep (2016) 0.76

Epidermal Notch1 recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair. Nat Commun (2016) 0.76

Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury. Biol Open (2016) 0.75

Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration. Sci Rep (2017) 0.75

Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain. Oncotarget (2016) 0.75

JMJD3 and NF-κB-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing. Sci Rep (2017) 0.75

Angiogenesis in cancer and other diseases. Nature (2000) 28.28

Mechanisms of angiogenesis. Nature (1997) 18.04

Wound healing--aiming for perfect skin regeneration. Science (1997) 16.08

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature (1999) 10.36

Notch signaling. Science (1995) 7.22

Notch signalling controls pancreatic cell differentiation. Nature (1999) 7.18

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature (2006) 7.01

Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature (2006) 6.56

Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet (1997) 5.58

Notch signalling regulates stem cell numbers in vitro and in vivo. Nature (2006) 5.49

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29

Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet (1999) 4.55

Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol (2005) 4.53

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem (2001) 4.45

Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol (2005) 2.81

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ (2002) 2.60

Notch signaling in vascular development. Arterioscler Thromb Vasc Biol (2003) 2.31

Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28

Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border. Cell (1998) 2.17

Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix. Microsc Res Tech (2003) 2.02

Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB J (2005) 1.92

Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91

Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells. J Immunol (2001) 1.84

Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med (2006) 1.82

High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Dev Cell (2004) 1.78

Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A (2004) 1.77

Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. J Clin Invest (2006) 1.76

TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J Immunol (2003) 1.75

Notch-1 up-regulation and signaling following macrophage activation modulates gene expression patterns known to affect antigen-presenting capacity and cytotoxic activity. J Immunol (2006) 1.65

Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Am J Pathol (2001) 1.61

Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. J Immunol (1992) 1.40

Abnormal blood vessel development in mice lacking presenilin-1. Mech Dev (2003) 1.31

An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro. J Biol Chem (1996) 1.30

Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling. Immunity (2006) 1.22

Control of epidermal stem cell clusters by Notch-mediated lateral induction. Dev Biol (2003) 1.20

The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration. J Biol Chem (2004) 1.15

Physiology of wound healing. Adv Skin Wound Care (2000) 1.10

Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors. Eur J Pharmacol (2005) 1.04

Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. Blood (2002) 1.01

Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells. Microvasc Res (2000) 1.00

Soluble form of Jagged1: unique product of epithelial keratinocytes and a regulator of keratinocyte differentiation. J Cell Biochem (2004) 0.99

Chimeric VEGF-ENZ7/PlGF specifically binding to VEGFR-2 accelerates skin wound healing via enhancement of neovascularization. Arterioscler Thromb Vasc Biol (2006) 0.86

Evolutionary origins of Notch signaling in early development. Cell Cycle (2006) 0.85

Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division. J Cell Physiol (2000) 0.82

Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron (2003) 14.03

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science (2005) 8.86

Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation (2006) 4.61

Superoxide flashes in single mitochondria. Cell (2008) 4.08

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med (2002) 4.04

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A (2007) 3.91

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 3.61

Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke (2009) 3.55

Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell (2013) 3.32

Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem (2002) 3.27

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci (2008) 3.25

AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat Neurosci (2008) 3.11

Notch promotes radioresistance of glioma stem cells. Stem Cells (2010) 3.07

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82

Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol (2005) 2.81

"Control" laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A (2010) 2.50

Targeting Notch to target cancer stem cells. Clin Cancer Res (2010) 2.46

Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. J Neurochem (2002) 2.45

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus (2008) 2.44

Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg (2007) 2.43

c-Myc is required for maintenance of glioma cancer stem cells. PLoS One (2008) 2.41

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev (2008) 2.39

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol (2007) 2.37

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci U S A (2003) 2.35

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med (2006) 2.35

A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A (2013) 2.35

Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med (2006) 2.32

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake. Nat Neurosci (2013) 2.30

Calcium orchestrates apoptosis. Nat Cell Biol (2003) 2.27

Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer Res (2005) 2.27

Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett (2011) 2.24

Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med (2012) 2.21

Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res (2008) 2.19

Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. Oncogene (2003) 2.16

A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr (2007) 2.16

Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation. J Exp Med (2005) 2.15

Toll-like receptors in neurodegeneration. Brain Res Rev (2008) 2.15

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A (2009) 2.15

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci (2002) 2.14

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis (2007) 2.08

Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis. Proc Natl Acad Sci U S A (2010) 2.05

Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Exp Neurol (2007) 2.04

Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell (2011) 2.04

Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol (2008) 2.03

Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci (2011) 2.01

Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron (2004) 1.99

Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J Neurochem (2002) 1.99

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med (2011) 1.97

Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res (2006) 1.97

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97

Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells (2009) 1.97

Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res Rev (2006) 1.94

Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells. J Cell Biochem (2011) 1.94

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92

Toll-like receptors in ischemia-reperfusion injury. Shock (2009) 1.92

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci (2003) 1.91

Modulation of taste sensitivity by GLP-1 signaling. J Neurochem (2008) 1.89

Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung. Cancer Res (2007) 1.88

Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia. Ann Neurol (2004) 1.87

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.86

p53 in neuronal apoptosis. Biochem Biophys Res Commun (2005) 1.85

Evidence for CALM in directing VAMP2 trafficking. Traffic (2007) 1.84

Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus (2009) 1.84

Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med (2006) 1.82

Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal (2010) 1.77

Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A (2004) 1.77

Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell (2011) 1.77

TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J Immunol (2003) 1.75

When neurogenesis encounters aging and disease. Trends Neurosci (2010) 1.73

Membrane properties of rat embryonic multipotent neural stem cells. J Neurochem (2004) 1.73

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J Neurochem (2002) 1.71

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol (2010) 1.71

Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood (2008) 1.69

Age and energy intake interact to modify cell stress pathways and stroke outcome. Ann Neurol (2010) 1.68

Inducible proteopathies. Trends Neurosci (2006) 1.67

Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene (2005) 1.63

Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease. Neuromolecular Med (2002) 1.63

Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem (2007) 1.61

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. Ann Neurol (2002) 1.61