ID genes mediate tumor reinitiation during breast cancer lung metastasis.

PubWeight™: 2.85‹?› | Rank: Top 1%

🔗 View Article (PMC 2148319)

Published in Proc Natl Acad Sci U S A on November 28, 2007

Authors

Gaorav P Gupta1, Jonathan Perk, Swarnali Acharyya, Paola de Candia, Vivek Mittal, Katia Todorova-Manova, William L Gerald, Edi Brogi, Robert Benezra, Joan Massagué

Author Affiliations

1: Cancer Biology and Genetics Program, Molecular Cytology Core Facility, Human Oncology and Pathogenesis Program, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Articles citing this

TGFbeta in Cancer. Cell (2008) 17.44

Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17

Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34

p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer (2009) 9.21

Molecular basis of metastasis. N Engl J Med (2008) 8.19

Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res (2009) 7.98

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell (2008) 7.60

The metastatic niche: adapting the foreign soil. Nat Rev Cancer (2009) 5.28

A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res (2009) 2.84

The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell (2012) 2.84

Tumor metastasis: moving new biological insights into the clinic. Nat Med (2013) 2.71

Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer (2011) 2.64

KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol (2009) 1.97

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nat Cell Biol (2010) 1.93

Mechanisms governing metastatic dormancy and reactivation. Cell (2013) 1.81

GATA3 in development and cancer differentiation: cells GATA have it! J Cell Physiol (2010) 1.80

The TGF-beta paradox in human cancer: an update. Future Oncol (2009) 1.79

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response. Proc Natl Acad Sci U S A (2008) 1.58

Modeling metastasis in the mouse. Curr Opin Pharmacol (2010) 1.46

ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancer. Cancer Biol Ther (2010) 1.44

Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions. J Biol Chem (2011) 1.33

TGF-β signaling in breast cancer cell invasion and bone metastasis. J Mammary Gland Biol Neoplasia (2011) 1.28

Targeting metastasis. Nat Rev Cancer (2016) 1.26

TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition. Cell Rep (2013) 1.24

Recent advances in anti-angiogenic therapy of cancer. Oncotarget (2011) 1.22

NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer. PLoS One (2011) 1.19

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat (2010) 1.14

ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling. Mol Cell Biol (2011) 1.11

Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F. Cancer Res (2010) 1.09

Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex. J Biol Chem (2009) 1.06

Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions. Am J Pathol (2009) 1.05

New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment. Front Pharmacol (2012) 1.05

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype. Sci Rep (2015) 1.04

p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation. Cytokine Growth Factor Rev (2008) 1.03

ID1 enhances docetaxel cytotoxicity in prostate cancer cells through inhibition of p21. Cancer Res (2010) 1.01

Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. J Biol Chem (2008) 0.97

ID4: a new player in the cancer arena. Oncotarget (2010) 0.97

Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization. Cell Rep (2015) 0.96

Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B. Cancer Med (2012) 0.95

Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines. PLoS One (2013) 0.93

ID1 promotes breast cancer metastasis by S100A9 regulation. Mol Cancer Res (2014) 0.92

Id1 and Id3 co-expression correlates with clinical outcome in stage III-N2 non-small cell lung cancer patients treated with definitive chemoradiotherapy. J Transl Med (2013) 0.91

Distinctive properties of metastasis-initiating cells. Genes Dev (2016) 0.91

Arkadia regulates tumor metastasis by modulation of the TGF-β pathway. Cancer Res (2013) 0.91

Surviving at a distance: organ specific metastasis. Trends Cancer (2015) 0.90

Krüppel-like factors in cancer progression: three fingers on the steering wheel. Oncotarget (2014) 0.90

DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer. PLoS One (2014) 0.89

Regulation of the unfolded protein response by eif2Bdelta isoforms. J Biol Chem (2010) 0.89

E47 and Id1 interplay in epithelial-mesenchymal transition. PLoS One (2013) 0.88

Id1 promotes tumor cell migration in nonsmall cell lung cancers. J Oncol (2010) 0.88

Progression of cutaneous melanoma: implications for treatment. Clin Exp Metastasis (2012) 0.87

Identification of novel metastasis suppressor signaling pathways for breast cancer. Cell Cycle (2012) 0.86

ID3 contributes to cerebrospinal fluid seeding and poor prognosis in medulloblastoma. BMC Cancer (2013) 0.85

Activated β-catenin forces N2A cell-derived neurons back to tumor-like neuroblasts and positively correlates with a risk for human neuroblastoma. Int J Biol Sci (2012) 0.85

Targeting Breast Cancer Metastasis. Breast Cancer (Auckl) (2015) 0.85

A genetic strategy for combined screening and localized imaging of breast cancer. Mol Imaging Biol (2011) 0.84

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis. PLoS One (2009) 0.84

Preclinical efficacy of cystatin C to target the oncogenic activity of transforming growth factor Beta in breast cancer. Transl Oncol (2009) 0.84

Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells. Oncotarget (2015) 0.83

Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Br J Pharmacol (2014) 0.82

ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities. Mol Ther (2014) 0.82

Metformin attenuates transforming growth factor beta (TGF-β) mediated oncogenesis in mesenchymal stem-like/claudin-low triple negative breast cancer. Cell Cycle (2016) 0.82

A personalized committee classification approach to improving prediction of breast cancer metastasis. Bioinformatics (2014) 0.81

The use of chemokine-releasing tissue engineering scaffolds in a model of inflammatory response-mediated melanoma cancer metastasis. Biomaterials (2011) 0.81

ID1 regulates U87 human cell proliferation and invasion. Oncol Lett (2013) 0.80

Increased potency of the PHSCN dendrimer as an inhibitor of human prostate cancer cell invasion, extravasation, and lung colony formation. Clin Exp Metastasis (2010) 0.80

Inhibitor of differentiation 1 (Id1) and Id3 proteins play different roles in TGFβ effects on cell proliferation and migration in prostate cancer cells. Prostate (2012) 0.80

Contribution of xanthine oxidoreductase to mammary epithelial and breast cancer cell differentiation in part modulates inhibitor of differentiation-1. Mol Cancer Res (2011) 0.80

Conductive interstitial thermal therapy (CITT) inhibits recurrence and metastasis in rabbit VX2 carcinoma model. Int J Hyperthermia (2009) 0.79

The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids. J Neuroimmune Pharmacol (2015) 0.79

Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesis. Oncotarget (2015) 0.79

Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis. BMC Cancer (2014) 0.78

Stratification and therapeutic potential of PML in metastatic breast cancer. Nat Commun (2016) 0.77

Effects of upregulation of Id3 in human lung adenocarcinoma cells on proliferation, apoptosis, mobility and tumorigenicity. Cancer Gene Ther (2015) 0.77

The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks. Biochim Biophys Acta (2016) 0.77

p53 and ΔNp63α Coregulate the Transcriptional and Cellular Response to TGFβ and BMP Signals. Mol Cancer Res (2015) 0.77

Id1 overexpression is independent of repression and epigenetic silencing of tumor suppressor genes in melanoma. Epigenetics (2010) 0.76

Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells. Biomater Sci (2015) 0.76

GCIP functions as a tumor suppressor in non-small cell lung cancer by suppressing Id1-mediated tumor promotion. Oncotarget (2014) 0.76

GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment. Nat Commun (2016) 0.75

Id Proteins Contribute to Tumor Development and Metastatic Colonization in a Model of Bladder Carcinogenesis. Bladder Cancer (2015) 0.75

Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression. Cancer Lett (2016) 0.75

The role of the cell-cell interactions in cancer progression. J Cell Mol Med (2015) 0.75

Molecular culprits generating brain tumor stem cells. Brain Tumor Res Treat (2013) 0.75

ID1 upregulation and FoxO3a downregulation by Epstein-Barr virus-encoded LMP1 in Hodgkin's lymphoma. Mol Clin Oncol (2016) 0.75

New insights into the role of ID proteins in breast cancer metastasis: a MET affair. Breast Cancer Res (2014) 0.75

Glucocorticoid Receptor-Targeted Liposomal Codelivery of Lipophilic Drug and Anti-Hsp90 Gene: Strategy to Induce Drug-Sensitivity, EMT-Reversal, and Reduced Malignancy in Aggressive Tumors. Mol Pharm (2016) 0.75

Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun (2017) 0.75

DNA Methylation Patterns in Rat Mammary Carcinomas Induced by Pre- and Post-Pubertal Irradiation. PLoS One (2016) 0.75

ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82. Oncogene (2017) 0.75

Emerging role of DUBs in tumor metastasis and apoptosis: Therapeutic implication. Pharmacol Ther (2017) 0.75

Articles cited by this

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer (2003) 22.78

Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85

Cancer metastasis: building a framework. Cell (2006) 19.67

A multigenic program mediating breast cancer metastasis to bone. Cancer Cell (2003) 16.86

Purification and unique properties of mammary epithelial stem cells. Nature (2006) 15.98

Concordance among gene-expression-based predictors for breast cancer. N Engl J Med (2006) 13.50

Molecular definition of breast tumor heterogeneity. Cancer Cell (2007) 12.67

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol (2007) 10.49

Applying the principles of stem-cell biology to cancer. Nat Rev Cancer (2003) 8.95

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature (2007) 7.05

Specific protection against breast cancers by cyclin D1 ablation. Nature (2001) 6.94

Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Mod Pathol (2006) 6.86

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature (1999) 6.50

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell (1988) 6.48

Genetic determinants of cancer metastasis. Nat Rev Genet (2007) 6.38

Prognostic markers in triple-negative breast cancer. Cancer (2007) 6.28

Self-renewal and cancer of the gut: two sides of a coin. Science (2005) 5.44

Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science (2006) 4.79

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A (2003) 4.69

Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci U S A (2007) 3.92

Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer (2005) 3.80

The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc Natl Acad Sci U S A (2004) 2.53

Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am J Pathol (2002) 2.26

Sorting out breast-cancer gene signatures. N Engl J Med (2007) 2.22

A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1. Mol Cell Biol (1998) 1.70

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer. Mol Cell Biol (2001) 1.68

Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci U S A (2003) 1.68

Helix-loop-helix proteins in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia (2003) 1.57

Reassessment of id1 protein expression in human mammary, prostate, and bladder cancers using a monospecific rabbit monoclonal anti-id1 antibody. Cancer Res (2006) 1.56

Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Res (2005) 1.46

Articles by these authors

Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94

Integrative genomic profiling of human prostate cancer. Cancer Cell (2010) 23.61

Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85

Cancer metastasis: building a framework. Cell (2006) 19.67

A multigenic program mediating breast cancer metastasis to bone. Cancer Cell (2003) 16.86

Endogenous human microRNAs that suppress breast cancer metastasis. Nature (2008) 14.37

Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17

Role of transposable elements in heterochromatin and epigenetic control. Nature (2004) 10.51

Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med (2008) 10.12

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer (2003) 8.35

Genes that mediate breast cancer metastasis to the brain. Nature (2009) 8.23

Molecular basis of metastasis. N Engl J Med (2008) 8.19

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell (2008) 7.60

Epithelial-mesenchymal transitions: twist in development and metastasis. Cell (2004) 7.14

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature (2007) 7.05

Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Am J Pathol (2004) 6.95

Tumor self-seeding by circulating cancer cells. Cell (2009) 6.66

Genetic determinants of cancer metastasis. Nat Rev Genet (2007) 6.38

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell (2004) 6.35

Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest (2005) 6.10

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell (2006) 5.88

Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet (2009) 5.31

Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature (2002) 5.25

Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell (2009) 5.24

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest (2007) 5.17

Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat Rev Cancer (2002) 5.02

A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell (2012) 4.89

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell (2009) 4.81

Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science (2006) 4.79

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature (2010) 4.78

Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science (2008) 4.71

Gene expression profiling predicts clinical outcome of prostate cancer. J Clin Invest (2004) 4.59

Id proteins in development, cell cycle and cancer. Trends Cell Biol (2003) 4.53

Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell (2009) 4.52

Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell (2008) 4.51

TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell (2005) 4.46

Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res (2002) 4.42

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature (2004) 4.41

Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest (2006) 4.37

Roles of TGFbeta in metastasis. Cell Res (2009) 4.35

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med (2011) 4.25

Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci U S A (2005) 4.20

Subtle variations in Pten dose determine cancer susceptibility. Nat Genet (2010) 4.19

Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Invest (2008) 4.13

An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science (2007) 4.00

Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer (2010) 3.95

Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases. Mod Pathol (2011) 3.92

Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci U S A (2007) 3.92

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell (2002) 3.87

Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer. Proc Natl Acad Sci U S A (2007) 3.84

Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer (2005) 3.80

Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays. Clin Cancer Res (2005) 3.79

WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell (2009) 3.76

Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res (2007) 3.63

Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci U S A (2003) 3.61

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell (2003) 3.57

A gene expression signature predicts survival of patients with stage I non-small cell lung cancer. PLoS Med (2006) 3.37

Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell (2013) 3.33

Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer Res (2006) 3.32

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell (2006) 3.31

Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis. Am J Surg Pathol (2008) 3.30

VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell (2011) 3.23

Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell (2007) 3.23

Is cancer a disease of self-seeding? Nat Med (2006) 3.19

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev (2011) 3.04

Nomogram for predicting the risk of local recurrence after breast-conserving surgery for ductal carcinoma in situ. J Clin Oncol (2010) 2.97

Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell (2011) 2.96

Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat Med (2012) 2.95

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer Cell (2012) 2.94

C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell (2006) 2.87

The role of SPINK1 in ETS rearrangement-negative prostate cancers. Cancer Cell (2008) 2.87

The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell (2012) 2.84

Integration of gene expression profiling and clinical variables to predict prostate carcinoma recurrence after radical prostatectomy. Cancer (2005) 2.78

TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proc Natl Acad Sci U S A (2010) 2.72

Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell (2011) 2.64

A FoxO-Smad synexpression group in human keratinocytes. Proc Natl Acad Sci U S A (2006) 2.60

Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev (2007) 2.60

ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev (2009) 2.59

Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent. Nat Biotechnol (2010) 2.54

Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells. Science (2004) 2.53

Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors. Cancer Cell (2003) 2.53

Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma. Cancer Cell (2012) 2.50

Origins of metastatic traits. Cancer Cell (2013) 2.49

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell (2009) 2.45

TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomy. Cancer Res (2009) 2.42