Published in Blood on November 30, 2007
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Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J Exp Med (2010) 4.56
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CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes. Immunity (2011) 1.99
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Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal Immunol (2011) 1.32
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Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor. Nat Immunol (2015) 1.23
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IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors. Blood (2012) 1.19
The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. Immunity (2014) 1.11
IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia. Cancer Res (2011) 1.05
L-Myc expression by dendritic cells is required for optimal T-cell priming. Nature (2014) 0.98
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IFN regulatory factor 8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation. J Immunol (2015) 0.96
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A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages. Genes Dev (2015) 0.94
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Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection. Infect Immun (2014) 0.91
Resident CD11b(+)Ly6C(-) lung dendritic cells are responsible for allergic airway sensitization to house dust mite in mice. PLoS One (2012) 0.90
The small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activation. J Immunol (2012) 0.90
The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2. J Exp Med (2016) 0.88
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Differential requirement for irf8 in formation of embryonic and adult macrophages in zebrafish. PLoS One (2015) 0.88
The role of the vascular dendritic cell network in atherosclerosis. Am J Physiol Cell Physiol (2013) 0.87
Cutting edge: IRF8 regulates Bax transcription in vivo in primary myeloid cells. J Immunol (2011) 0.86
A Hitchhiker's Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System. Front Immunol (2015) 0.85
CD8α dendritic cells drive establishment of HSV-1 latency. PLoS One (2014) 0.83
Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets. Front Immunol (2015) 0.83
miR-22 controls Irf8 mRNA abundance and murine dendritic cell development. PLoS One (2012) 0.83
Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci Rep (2016) 0.82
Are mouse models of human mycobacterial diseases relevant? Genetics says: 'yes!'. Immunology (2011) 0.82
Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation. Blood (2014) 0.82
Dendritic cells and multiple sclerosis: disease, tolerance and therapy. Int J Mol Sci (2012) 0.82
Innate immune regulation by STAT-mediated transcriptional mechanisms. Immunol Rev (2014) 0.81
IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes. Nat Commun (2015) 0.81
Pulmonary dendritic cell development and antigen acquisition. Immunol Res (2013) 0.80
Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells. Immunobiology (2014) 0.80
Coregulatory interactions among CD8α dendritic cells, the latency-associated transcript, and programmed death 1 contribute to higher levels of herpes simplex virus 1 latency. J Virol (2014) 0.80
Dendritic cell development: a choose-your-own-adventure story. Adv Hematol (2013) 0.80
Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3. PLoS One (2013) 0.80
Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development. J Immunol (2013) 0.79
A STATus report on DC development. J Leukoc Biol (2012) 0.79
IRF4 and IRF8: Governing the virtues of B Lymphocytes. Front Biol (Beijing) (2014) 0.79
SLE-associated risk factors affect DC function. Immunol Rev (2016) 0.78
Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection. J Immunol (2016) 0.77
CD8+ T Cells Play a Bystander Role in Mice Latently Infected with Herpes Simplex Virus 1. J Virol (2016) 0.76
β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage. J Immunol (2016) 0.76
MMP3-mediated tumor progression is controlled transcriptionally by a novel IRF8-MMP3 interaction. Oncotarget (2015) 0.76
Dendritic cell analysis in primary immunodeficiency. Curr Opin Allergy Clin Immunol (2016) 0.75
TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity. Proc Natl Acad Sci U S A (2017) 0.75
Lipopolysaccharide Attenuates Induction of Proallergic Cytokines, Thymic Stromal Lymphopoietin, and Interleukin 33 in Respiratory Epithelial Cells Stimulated with PolyI:C and Human Parechovirus. Front Immunol (2016) 0.75
CD1a(+) survivin(+) dendritic cell infiltration in dermal lesions of systemic sclerosis. Arthritis Res Ther (2015) 0.75
Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines. J Leukoc Biol (2017) 0.75
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IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol (2006) 7.98
Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol (2006) 6.62
Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol (2006) 4.55
Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med (2006) 3.49
Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol (2005) 3.47
IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol (2005) 3.15
ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J Exp Med (2002) 2.92
Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol (2003) 2.91
Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells. Blood (2002) 2.77
Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells. J Immunol (2003) 2.21
Production of type I interferons: plasmacytoid dendritic cells and beyond. J Exp Med (2005) 2.14
Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development. Proc Natl Acad Sci U S A (2004) 2.08
Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. J Immunol (2002) 1.98
Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns. J Immunol (2003) 1.76
A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice. J Exp Med (2005) 1.74
The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J Exp Med (2004) 1.71
The interferon regulatory factor family in host defense: mechanism of action. J Biol Chem (2007) 1.67
ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro. Blood (2002) 1.47
Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. Blood (2005) 1.44
The role of the interferon regulatory factor (IRF) family in dendritic cell development and function. Cytokine Growth Factor Rev (2007) 1.38
ICSBP/IRF-8 transactivation: a tale of protein-protein interaction. J Interferon Cytokine Res (2002) 1.32
Genetic control of myeloproliferation in BXH-2 mice. Blood (2003) 0.98
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell (2005) 8.95
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell (2005) 8.92
A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09
The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc Natl Acad Sci U S A (2003) 5.59
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood (2002) 4.88
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol (2004) 4.43
Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins. Mol Cell Biol (2004) 4.41
Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell (2004) 4.38
TRIM family proteins and their emerging roles in innate immunity. Nat Rev Immunol (2008) 4.21
New genes involved in cancer identified by retroviral tagging. Nat Genet (2002) 4.14
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature (2009) 3.86
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol (2008) 3.74
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell (2005) 3.38
Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription. Mol Biol Cell (2009) 3.29
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules. Proc Natl Acad Sci U S A (2008) 3.27
IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol (2005) 3.15
Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. Mol Cell (2004) 2.99
ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J Exp Med (2002) 2.92
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity (2009) 2.89
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest (2008) 2.88
AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79
Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells. Blood (2002) 2.77
The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Semin Cancer Biol (2002) 2.66
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A (2002) 2.62
PNPASE regulates RNA import into mitochondria. Cell (2010) 2.54
Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity. Cancer Res (2002) 2.52
A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. Mol Cell Biol (2002) 2.51
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A (2009) 2.46
The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase. J Biol Chem (2008) 2.40
Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells. J Immunol (2003) 2.21
Bromodomain 4 activation predicts breast cancer survival. Proc Natl Acad Sci U S A (2008) 2.15
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein. J Exp Med (2005) 2.00
ICSBP/IRF-8: its regulatory roles in the development of myeloid cells. J Interferon Cytokine Res (2002) 1.99
BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc Natl Acad Sci U S A (2012) 1.93
Interaction of bovine papillomavirus E2 protein with Brd4 stabilizes its association with chromatin. J Virol (2005) 1.87
Immunoglobulin class switch recombination is impaired in Atm-deficient mice. J Exp Med (2004) 1.87
The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4. J Virol (2005) 1.86
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Cancer Res (2005) 1.83
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med (2009) 1.81
Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. Mol Biol Cell (2005) 1.81
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol (2012) 1.81
Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages. J Immunol (2007) 1.80
Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol Immunother (2010) 1.79
Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. Proc Natl Acad Sci U S A (2010) 1.79
Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery. PLoS Pathog (2009) 1.78
Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+ T cells. Eur J Immunol (2013) 1.76
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci U S A (2008) 1.75
Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J Immunol (2009) 1.73
IRF8 regulates myeloid and B lymphoid lineage diversification. Immunol Res (2009) 1.68
The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming. Mol Cell Biol (2004) 1.64
The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. Proc Natl Acad Sci U S A (2003) 1.62
IRF family proteins and type I interferon induction in dendritic cells. Cell Res (2006) 1.61
Axon growth and guidance genes identify T-dependent germinal centre B cells. Immunol Cell Biol (2007) 1.60
Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein. J Biol Chem (2004) 1.60
IL-6 transgenic mouse model for extraosseous plasmacytoma. Proc Natl Acad Sci U S A (2002) 1.55
Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4. J Biol Chem (2006) 1.54
IRF8 regulates B-cell lineage specification, commitment, and differentiation. Blood (2008) 1.53
The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8. Immunity (2007) 1.53
IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways. J Biol Chem (2006) 1.52
Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. Mol Cell Biol (2004) 1.47
ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro. Blood (2002) 1.47
Immune cell-specific amplification of interferon signaling by the IRF-4/8-PU.1 complex. J Interferon Cytokine Res (2005) 1.46
Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells. J Immunol (2004) 1.45
Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J Biol Chem (2008) 1.44
Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. Blood (2005) 1.44
Biallelic mutations in IRF8 impair human NK cell maturation and function. J Clin Invest (2016) 1.39
The role of the interferon regulatory factor (IRF) family in dendritic cell development and function. Cytokine Growth Factor Rev (2007) 1.38
High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas. Cancer Res (2004) 1.38
Inducible deposition of the histone variant H3.3 in interferon-stimulated genes. J Biol Chem (2009) 1.36
Precancerous stem cells have the potential for both benign and malignant differentiation. PLoS One (2007) 1.36
BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes. Mol Cell Biol (2013) 1.35
Interferon regulatory factor family of transcription factors and regulation of oncogenesis. Cancer Sci (2008) 1.35
A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. Proc Natl Acad Sci U S A (2009) 1.35
Interaction of histone acetylases and deacetylases in vivo. Mol Cell Biol (2003) 1.35
Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. Biotechniques (2002) 1.33
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes. Proc Natl Acad Sci U S A (2009) 1.31
Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma. J Exp Med (2003) 1.29
IFN consensus sequence binding protein/IFN regulatory factor-8 guides bone marrow progenitor cells toward the macrophage lineage. J Immunol (2002) 1.29
Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen. Proc Natl Acad Sci U S A (2005) 1.28
Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells. Cancer Res (2007) 1.27
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. Proc Natl Acad Sci U S A (2002) 1.26
The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity. J Immunol (2009) 1.26
Structural basis for acetylated histone H4 recognition by the human BRD2 bromodomain. J Biol Chem (2010) 1.24