Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008.

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Published in Intensive Care Med on December 04, 2007

Authors

R Phillip Dellinger1, Mitchell M Levy, Jean M Carlet, Julian Bion, Margaret M Parker, Roman Jaeschke, Konrad Reinhart, Derek C Angus, Christian Brun-Buisson, Richard Beale, Thierry Calandra, Jean-Francois Dhainaut, Herwig Gerlach, Maurene Harvey, John J Marini, John Marshall, Marco Ranieri, Graham Ramsay, Jonathan Sevransky, B Taylor Thompson, Sean Townsend, Jeffrey S Vender, Janice L Zimmerman, Jean-Louis Vincent

Author Affiliations

1: Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden 08103, NJ, USA. Dellinger-Phil@CooperHealth.edu

Associated clinical trials:

Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock (SSS) | NCT02473263

Comparing USCOM and Echocardiographic Hemodynamic Measurements in Children (CUE Study) | NCT02083172

Hemodynamic Resuscitation and Monitoring in Early Sepsis (HERMES) | NCT04143035

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Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery--a prospective sequential analysis*. Crit Care Med (2013) 5.88

Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med (2002) 5.84

Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA (2010) 5.80