Published in J Cell Biol on December 17, 2007
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell (2010) 2.56
Segregation and activation of myosin IIB creates a rear in migrating cells. J Cell Biol (2008) 2.15
Chemotaxis, chemokine receptors and human disease. Cytokine (2008) 1.63
The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils. Am J Physiol Cell Physiol (2012) 1.57
The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol (2009) 1.53
Regulation of RhoGEF proteins by G12/13-coupled receptors. Br J Pharmacol (2009) 1.45
Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors. Mol Pharmacol (2009) 1.38
Cellular responses to extracellular guidance cues. EMBO J (2010) 1.25
GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. Cell Res (2011) 1.21
Review series: TOR kinase complexes and cell migration. J Cell Biol (2011) 1.19
Microfluidic technologies for temporal perturbations of chemotaxis. Annu Rev Biomed Eng (2010) 1.12
Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity (2010) 1.10
Network crosstalk dynamically changes during neutrophil polarization. Cell (2012) 1.09
Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility. Proc Natl Acad Sci U S A (2010) 1.05
Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium. Development (2010) 1.00
Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion. Mol Biol Cell (2012) 0.94
Regulation and physiological functions of G12/13-mediated signaling pathways. Neurosignals (2009) 0.93
Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep (2013) 0.88
Multiple roles for RhoA during T cell transendothelial migration. Small GTPases (2010) 0.88
Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. J Cell Sci (2015) 0.85
Structural and functional insights on the Myosin superfamily. Bioinform Biol Insights (2012) 0.83
Helicobacter pylori CagA disrupts epithelial patterning by activating myosin light chain. PLoS One (2011) 0.81
Rac[e] to the pole: setting up polarity in endothelial cells. Small GTPases (2014) 0.80
Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils. EMBO Rep (2015) 0.79
Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient. J Exp Med (2015) 0.78
Cellular mechanism of bile acid-accelerated hepatocyte polarity. Small GTPases (2011) 0.78
Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration. Dev Cell (2016) 0.75
Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration. Mol Biol Cell (2016) 0.75
A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. Sci Rep (2016) 0.75
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol (2005) 10.44
Cell migration: Rho GTPases lead the way. Dev Biol (2004) 8.20
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93
Spatiotemporal dynamics of RhoA activity in migrating cells. Nature (2006) 6.84
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell (2003) 6.46
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science (2000) 6.26
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol (2002) 4.64
Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science (2000) 4.61
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol (2003) 4.02
Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell (2003) 3.66
Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol (2003) 3.31
Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron (2002) 2.59
Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner. Curr Biol (2004) 2.53
Use and properties of ROCK-specific inhibitor Y-27632. Methods Enzymol (2000) 2.19
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol (2006) 2.10
A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem (1999) 2.08
Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Res (2004) 2.05
Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol Cell Biol (2003) 1.94
A membrane-permeant ester of phosphatidylinositol 3,4, 5-trisphosphate (PIP(3)) is an activator of human neutrophil migration. FEBS Lett (2000) 1.93
Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proc Natl Acad Sci U S A (2006) 1.89
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J Cell Biol (2006) 1.86
Neutrophil microtubules suppress polarity and enhance directional migration. Proc Natl Acad Sci U S A (2005) 1.81
Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion. Biol Res (2002) 1.63
Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. Proc Natl Acad Sci U S A (2002) 1.60
Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis. Int J Biochem Cell Biol (2002) 1.58
Microtubule-disruption-induced and chemotactic-peptide-induced migration of human neutrophils: implications for differential sets of signalling pathways. J Cell Sci (2003) 1.49
Behaviour of neutrophil leucocytes in uniform concentrations of chemotactic factors: contraction waves, cell polarity and persistence. J Cell Sci (1985) 1.33
New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia. Development (2007) 1.26
Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood (2005) 1.16
B plexins activate Rho through PDZ-RhoGEF. FEBS Lett (2002) 1.11
Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton. Mol Biol Cell (2004) 1.07
Budding roles for myosin II on the Golgi. Trends Cell Biol (1998) 1.04
Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. J Biol Chem (2003) 1.03
Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member. FEBS Lett (1999) 1.03
Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity. J Biol Chem (2006) 0.92
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell (2003) 6.46
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol (2002) 4.64
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol (2003) 4.02
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol (2006) 2.10
Multipotent and unipotent progenitors contribute to prostate postnatal development. Nat Cell Biol (2012) 1.89
Neutrophil microtubules suppress polarity and enhance directional migration. Proc Natl Acad Sci U S A (2005) 1.81
Iceberg alert for NIH. Science (2012) 1.60
Bound attractant at the leading vs. the trailing edge determines chemotactic prowess. Proc Natl Acad Sci U S A (2007) 1.54
Polarity reveals intrinsic cell chirality. Proc Natl Acad Sci U S A (2007) 1.48
Morphology matters in immune cell chemotaxis: membrane asymmetry affects amplification. Phys Biol (2006) 0.99
Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic (2002) 0.98
Rac and cell migration: CDM proteins integrate signals. Nat Cell Biol (2005) 0.83
[Identification of basal cell carcinoma initiating cells]. Med Sci (Paris) (2010) 0.75