Published in Proc Natl Acad Sci U S A on December 19, 2007
Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discov Today (2009) 1.47
Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine. Dalton Trans (2009) 1.10
Controlling Platinum, Ruthenium and Osmium Reactivity for Anticancer Drug Design. Adv Inorg Chem (2009) 1.01
Unusual DNA binding modes for metal anticancer complexes. Biochimie (2009) 0.95
Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry (2013) 0.91
Photoinduced reactions of cis,trans,cis-[Pt(IV)(N3)2(OH)2(NH3)2) with 1-methylimidazole. Chemistry (2009) 0.89
Photocytotoxic trans-diam(m)ine platinum(IV) diazido complexes more potent than their cis isomers. Chem Res Toxicol (2010) 0.88
Synthesis, characterization, and photophysical properties of three platinum(II) complexes bearing fluorescent analogues of the Di-2-pyridylmethane ligand. Inorg Chem (2010) 0.87
Synthesis, characterisation and photochemistry of Pt(IV) pyridyl azido acetato complexes. Dalton Trans (2009) 0.83
Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand. Sci Rep (2016) 0.81
Potentiating effect of UVA irradiation on anticancer activity of Carboplatin derivatives involving 7-azaindoles. PLoS One (2015) 0.80
Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. J Inorg Biochem (2010) 0.79
Antitumor carboplatin is more toxic in tumor cells when photoactivated: enhanced DNA binding. J Biol Inorg Chem (2012) 0.79
DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects. J Biol Inorg Chem (2008) 0.78
De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angew Chem Int Ed Engl (2013) 0.78
Insights into the acid-base properties of Pt(IV)-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry (2011) 0.78
Photodissociation of a ruthenium(II) arene complex and its subsequent interactions with biomolecules: a density functional theory study. J Mol Model (2012) 0.76
Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chem Sci (2016) 0.75
Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light. Chemistry (2016) 0.75
Comprehensive Vibrational Spectroscopic Investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) Diazido Anticancer Prodrug Candidate. Inorg Chem (2016) 0.75
Bringing inorganic chemistry to life with inspiration from R. J. P. Williams. J Biol Inorg Chem (2016) 0.75
Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene (2003) 10.74
The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol (2004) 4.95
Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett (1985) 3.50
DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues. Proc Natl Acad Sci U S A (1993) 1.65
Interaction of trans-diamminedichloroplatinum(II) with DNA: formation of monofunctional adducts and their reaction with glutathione. Biochemistry (1987) 1.33
Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay. Clin Cancer Res (1999) 1.28
DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent. Biochemistry (1999) 1.28
Photodynamic therapy in the treatment of cancer: current state of the art. Drugs (1999) 1.22
Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin. Nucleic Acids Res (2007) 1.22
Photoactivatable platinum complexes. Anticancer Agents Med Chem (2007) 1.08
A photoactivated trans-diammine platinum complex as cytotoxic as cisplatin. Chemistry (2006) 1.05
Current status of structure-activity relationships of platinum anticancer drugs: activation of the trans geometry. Met Ions Biol Syst (1996) 1.00
Detection of oxaliplatin-induced DNA crosslinks in vitro and in cancer patients using the alkaline comet assay. DNA Repair (Amst) (2005) 0.99
Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires. J Am Chem Soc (2005) 0.94
Light-activated destruction of cancer cell nuclei by platinum diazide complexes. Chem Biol (2006) 0.94
Nucleotide cross-linking induced by photoreactions of platinum(IV)-azide complexes. Angew Chem Int Ed Engl (2003) 0.92
cis-[Rh2(mu-O2CCH3)2(CH3CN)6]2+ as a photoactivated cisplatin analog. J Am Chem Soc (2006) 0.92
Formation of platinated GG cross-links on DNA by photoactivation of a platinum(IV) azide complex. J Biol Inorg Chem (2003) 0.91
Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross-linking. Biochemistry (1999) 0.89
DNA adducts of antitumor trans-[PtCl2 (E-imino ether)2]. Nucleic Acids Res (1996) 0.86
Structural characterization, DNA interactions, and cytotoxicity of new transplatin analogues containing one aliphatic and one planar heterocyclic amine ligand. J Med Chem (2006) 0.86
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand. Biochem Pharmacol (2004) 0.85
Recognition of DNA modified by trans-[PtClNH(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex. FEBS J (2006) 0.85
The second ECVAM workshop on phototoxicity testing. The report and recommendations of ECVAM workshop 42. Altern Lab Anim (2001) 0.83
Photogenotoxicity of hypericin in HaCaT keratinocytes: implications for St. John's Wort supplements and high dose UVA-1 therapy. Toxicol Lett (2005) 0.83
A temporal constraint structure for extracting temporal information from clinical narrative. J Biomed Inform (2005) 4.42
The evaluation of a temporal reasoning system in processing clinical discharge summaries. J Am Med Inform Assoc (2007) 3.71
System architecture for temporal information extraction, representation and reasoning in clinical narrative reports. AMIA Annu Symp Proc (2005) 2.93
Modeling electronic discharge summaries as a simple temporal constraint satisfaction problem. J Am Med Inform Assoc (2004) 2.88
Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme. Proc Natl Acad Sci U S A (2005) 2.31
Inter-patient distance metrics using SNOMED CT defining relationships. J Biomed Inform (2006) 2.12
New trends for metal complexes with anticancer activity. Curr Opin Chem Biol (2008) 2.06
Structures of piperazine, piperidine and morpholine. Acta Crystallogr B (2004) 1.95
A potent trans-diimine platinum anticancer complex photoactivated by visible light. Angew Chem Int Ed Engl (2010) 1.74
A novel protein-mineral interface. Nat Struct Biol (2003) 1.69
Optically pure, water-stable metallo-helical 'flexicate' assemblies with antibiotic activity. Nat Chem (2011) 1.61
Highly luminescent, triple- and quadruple-stranded, dinuclear Eu, Nd, and Sm(III) lanthanide complexes based on bis-diketonate ligands. J Am Chem Soc (2004) 1.53
Periodic iron nanomineralization in human serum transferrin fibrils. Angew Chem Int Ed Engl (2008) 1.52
Metal complexes as DNA intercalators. Acc Chem Res (2011) 1.47
Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discov Today (2009) 1.47
Effect of pressure on the crystal structure of salicylaldoxime-I, and the structure of salicylaldoxime-II at 5.93 GPa. Acta Crystallogr B (2006) 1.45
Organometallic half-sandwich iridium anticancer complexes. J Med Chem (2011) 1.40
Chloro half-sandwich osmium(II) complexes: influence of chelated N,N-ligands on hydrolysis, guanine binding, and cytotoxicity. Inorg Chem (2007) 1.40
Enhancing SMM properties in a family of [Mn6] clusters. Chem Commun (Camb) (2007) 1.39
Ligand-selective photodissociation from [Ru(bpy)(4AP)4]2+: a spectroscopic and computational study. Inorg Chem (2009) 1.35
Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes. Chem Commun (Camb) (2005) 1.34
Zinc(II) complexes of constrained antiviral macrocycles. Dalton Trans (2012) 1.28
DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464. Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair. J Biol Chem (2002) 1.28
Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor. J Am Chem Soc (2002) 1.26
Organometallic ruthenium(II) diamine anticancer complexes: arene-nucleobase stacking and stereospecific hydrogen-bonding in guanine adducts. J Am Chem Soc (2002) 1.26
DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media. Biochemistry (2003) 1.25
Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities. Biochem J (2004) 1.24
Phenylazo-pyridine and phenylazo-pyrazole chlorido ruthenium(II) arene complexes: arene loss, aquation, and cancer cell cytotoxicity. Inorg Chem (2006) 1.22
Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin. Nucleic Acids Res (2007) 1.22
Exploration of the medical periodic table: towards new targets. Chem Commun (Camb) (2013) 1.18
Highly selective binding of organometallic ruthenium ethylenediamine complexes to nucleic acids: novel recognition mechanisms. J Am Chem Soc (2003) 1.18
How to modify 7-azaindole to form cytotoxic Pt(II) complexes: highly in vitro anticancer effective cisplatin derivatives involving halogeno-substituted 7-azaindole. J Inorg Biochem (2012) 1.17
Toward a magnetostructural correlation for a family of Mn6 SMMs. J Am Chem Soc (2007) 1.16
Isotopic polymorphism in pyridine. Angew Chem Int Ed Engl (2009) 1.13
Combined theoretical and computational study of interstrand DNA guanine-guanine cross-linking by trans-[Pt(pyridine)2] derived from the photoactivated prodrug trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorg Chem (2012) 1.11
Configurationally restricted bismacrocyclic CXCR4 receptor antagonists. J Med Chem (2006) 1.10
Synthetic and structural studies of cobalt-pivalate complexes. Chemistry (2003) 1.10
Medicinal organometallic chemistry: designing metal arene complexes as anticancer agents. Chem Asian J (2008) 1.10
Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine. Dalton Trans (2009) 1.10
Multiple bacteria encode metallothioneins and SmtA-like zinc fingers. Mol Microbiol (2002) 1.09
Kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts. Chemistry (2003) 1.09
Interdomain zinc site on human albumin. Proc Natl Acad Sci U S A (2003) 1.08
Synergistic anion and metal binding to the ferric ion-binding protein from Neisseria gonorrhoeae. J Biol Chem (2002) 1.08
Photoactivatable platinum complexes. Anticancer Agents Med Chem (2007) 1.08
A record anisotropy barrier for a single-molecule magnet. J Am Chem Soc (2007) 1.07
Cyclam complexes and their applications in medicine. Chem Soc Rev (2004) 1.07
DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes. Nucleic Acids Res (2003) 1.06
Transport of metal salts by zwitterionic ligands; simple but highly efficient salicylaldoxime extractants. Chem Commun (Camb) (2008) 1.06
Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands. J Med Chem (2006) 1.06
A photoactivated trans-diammine platinum complex as cytotoxic as cisplatin. Chemistry (2006) 1.05
Microwave-assisted synthesis of a hexanuclear Mn(III) single-molecule magnet. Inorg Chem (2006) 1.05
Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Proc Natl Acad Sci U S A (2003) 1.04
A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464. J Biol Inorg Chem (2002) 1.04
Anti-viral cyclam macrocycles : rapid zinc uptake at physiological pH. Chem Commun (Camb) (2004) 1.03
Albumin as a zinc carrier: properties of its high-affinity zinc-binding site. Biochem Soc Trans (2008) 1.02
Horseshoes, rings, and distorted rings: studies of cyclic chromium-fluoride cages. Angew Chem Int Ed Engl (2003) 1.02
Configurations of nickel-cyclam antiviral complexes and protein recognition. Chemistry (2007) 1.02
Role of Tyr84 in controlling the reactivity of Cys34 of human albumin. FEBS J (2005) 1.02
Controlling Platinum, Ruthenium and Osmium Reactivity for Anticancer Drug Design. Adv Inorg Chem (2009) 1.01
Tuning the reactivity of osmium(II) and ruthenium(II) arene complexes under physiological conditions. J Am Chem Soc (2006) 1.01
Designing organometallic compounds for catalysis and therapy. Chem Commun (Camb) (2012) 1.00
Photoactivatable metal complexes: from theory to applications in biotechnology and medicine. Philos Trans A Math Phys Eng Sci (2013) 1.00
Gold(III)-dithiocarbamato complexes induce cancer cell death triggered by thioredoxin redox system inhibition and activation of ERK pathway. Chem Biol (2007) 1.00
Handling implicit and uncertain temporal information in medical text. AMIA Annu Symp Proc (2006) 1.00
Osmium(II) and ruthenium(II) arene maltolato complexes: rapid hydrolysis and nucleobase binding. Chemistry (2007) 1.00
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines. Biochemistry (2003) 1.00
Recognition of major DNA adducts of enantiomeric cisplatin analogs by HMG box proteins and nucleotide excision repair of these adducts. Chem Biol (2002) 1.00
Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity. Proc Natl Acad Sci U S A (2005) 1.00
Investigating the effect of hydrogen bonding environments in amide cleavage reactions at zinc(II) complexes with intramolecular amide oxygen co-ordination. Dalton Trans (2004) 0.99
Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity. Chem Biol (2005) 0.98
An Asymmetric Enzyme-Catalyzed Retro-Claisen Reaction for the Desymmetrization of Cyclic beta-Diketones This work was supported by the BBSRC (grants to N.J.T. and S.L.F.) and the European Commission (grant to J.G.). We also thank Mr. J. Millar and Dr. D. Uhrin for assistance with NMR spectroscopy. Angew Chem Int Ed Engl (2001) 0.98
Quantifying the relative contribution of hydrogen bonding and hydrophobic environments, and coordinating groups, in the zinc(II)-water acidity by synthetic modelling chemistry. Dalton Trans (2004) 0.97