Published in Nature on December 20, 2007
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol (2012) 3.90
Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B. Science (2010) 3.07
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy (2010) 2.99
Orchestrating nuclear envelope disassembly and reassembly during mitosis. Nat Rev Mol Cell Biol (2009) 2.66
Molecular control of animal cell cytokinesis. Nat Cell Biol (2012) 2.45
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J (2012) 2.34
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell (2010) 2.33
Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly. J Cell Sci (2009) 2.23
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat Struct Mol Biol (2011) 2.23
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat Cell Biol (2011) 2.15
Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly. Dev Cell (2013) 2.09
Valosin-containing protein disease: inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia. Neuromuscul Disord (2009) 1.94
Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. Mol Cell (2011) 1.91
Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell (2013) 1.89
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell (2009) 1.82
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry (2009) 1.78
Polyubiquitin chains: functions, structures, and mechanisms. Cell Mol Life Sci (2008) 1.75
Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations. Nat Cell Biol (2011) 1.69
Feedback control of chromosome separation by a midzone Aurora B gradient. Science (2014) 1.66
Ku80 removal from DNA through double strand break-induced ubiquitylation. J Cell Biol (2008) 1.64
The nuclear envelope. Cold Spring Harb Perspect Biol (2010) 1.64
ESCRT-III controls nuclear envelope reformation. Nature (2015) 1.63
Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int J Cell Biol (2012) 1.52
Ubiquitin signals proteolysis-independent stripping of transcription factors. Mol Cell (2014) 1.49
Reorganization of the nuclear envelope during open mitosis. Curr Opin Cell Biol (2008) 1.46
A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction. Mol Cell (2011) 1.41
Cell division: control of the chromosomal passenger complex in time and space. Chromosoma (2013) 1.34
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis. J Cell Sci (2014) 1.32
A ubiquitin-selective AAA-ATPase mediates transcriptional switching by remodelling a repressor-promoter DNA complex. Nat Cell Biol (2009) 1.31
Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci U S A (2008) 1.29
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J Cell Biol (2009) 1.29
The life cycle of the metazoan nuclear envelope. Curr Opin Cell Biol (2008) 1.24
AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization. Proc Natl Acad Sci U S A (2012) 1.22
Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nat Commun (2012) 1.21
The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group. PLoS One (2010) 1.21
Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction. Nat Cell Biol (2013) 1.20
RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. Mol Biol Cell (2008) 1.19
Polyubiquitylation of histone H2B. Mol Biol Cell (2008) 1.17
The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell (2009) 1.15
Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1. Development (2011) 1.15
The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins. EMBO J (2012) 1.15
Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma. PLoS One (2011) 1.14
SUMOylation modulates the function of Aurora-B kinase. J Cell Sci (2010) 1.10
Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. J Biol Chem (2012) 1.09
The p97 ATPase associates with EEA1 to regulate the size of early endosomes. Cell Res (2011) 1.09
The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis. Front Cell Dev Biol (2015) 1.08
Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity. Nat Commun (2014) 1.08
Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy. Cell Res (2011) 1.07
Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control. J Cell Sci (2012) 1.06
Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. J Cell Biol (2012) 1.03
Importin beta regulates the seeding of chromatin with initiation sites for nuclear pore assembly. Mol Biol Cell (2009) 1.00
Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation. Chromosoma (2012) 0.97
Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A (2012) 0.97
Altered cofactor regulation with disease-associated p97/VCP mutations. Proc Natl Acad Sci U S A (2015) 0.97
The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP. Genes Dev (2013) 0.96
p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association? Genes Cancer (2010) 0.96
The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. J Cell Biol (2013) 0.95
Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development. Cell (2012) 0.94
Structure and function of the AAA+ ATPase p97/Cdc48p. Gene (2016) 0.94
Role of p97/VCP (Cdc48) in genome stability. Front Genet (2013) 0.94
The p97 ATPase dislocates MHC class I heavy chain in US2-expressing cells via a Ufd1-Npl4-independent mechanism. J Biol Chem (2010) 0.94
Destroying the ring: Freeing DNA from Ku with ubiquitin. FEBS Lett (2011) 0.93
Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infection. J Virol (2012) 0.91
Valosin containing protein associated fronto-temporal lobar degeneration: clinical presentation, pathologic features and pathogenesis. Curr Alzheimer Res (2011) 0.91
An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2. Dev Cell (2008) 0.89
Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1. J Cell Sci (2013) 0.89
Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. Proc Natl Acad Sci U S A (2011) 0.89
Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion. Nat Struct Mol Biol (2014) 0.88
Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase. Proc Natl Acad Sci U S A (2011) 0.87
Termination of DNA replication forks: "Breaking up is hard to do". Nucleus (2015) 0.86
Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly. Nucleus (2012) 0.85
The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes. Proc Natl Acad Sci U S A (2014) 0.85
Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor. Mol Biol Cell (2011) 0.84
Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy. Open Biol (2014) 0.84
The ESCRT machinery: new roles at new holes. Curr Opin Cell Biol (2016) 0.83
Molecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins. EMBO Mol Med (2014) 0.83
Using in vivo biotinylated ubiquitin to describe a mitotic exit ubiquitome from human cells. Mol Cell Proteomics (2014) 0.83
Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Nat Commun (2014) 0.82
Decoding ubiquitin for mitosis. Genes Cancer (2012) 0.82
Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication. Chromosoma (2016) 0.81
Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin. Front Genet (2016) 0.81
TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity. Immunol Rev (2015) 0.81
Revoking the cellular license to replicate: yet another AAA assignment. Mol Cell (2011) 0.81
Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response. PLoS One (2013) 0.81
Regulation of the Aurora B chromosome passenger protein complex during oocyte maturation in Xenopus laevis. Mol Cell Biol (2008) 0.81
Another VCP interactor: NF is enough. J Clin Invest (2011) 0.80
Border Safety: Quality Control at the Nuclear Envelope. Trends Cell Biol (2015) 0.80
The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B. Nucleic Acids Res (2014) 0.79
Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin. J Biol Chem (2016) 0.79
Nucleosome functions in spindle assembly and nuclear envelope formation. Bioessays (2015) 0.79
Emerging mechanisms of mRNP remodeling regulation. Wiley Interdiscip Rev RNA (2014) 0.78
Late mitotic functions of Aurora kinases. Chromosoma (2016) 0.78
Aurora B-mediated localized delays in nuclear envelope formation facilitate inclusion of late-segregating chromosome fragments. Mol Biol Cell (2015) 0.78
Monoubiquitination of EEA1 regulates endosome fusion and trafficking. Cell Biosci (2013) 0.78
A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells. PLoS One (2011) 0.77
Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction. J Biol Chem (2015) 0.77
A non-canonical role of the p97 complex in RIG-I antiviral signaling. EMBO J (2015) 0.77
Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1. Exp Cell Res (2012) 0.77
Coordinate to guard: crosstalk of phosphorylation, sumoylation, and ubiquitylation in DNA damage response. Front Oncol (2012) 0.76
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol (2003) 4.35
Ubiquitin interactions of NZF zinc fingers. EMBO J (2004) 2.72
The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cell (2003) 1.84
Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation. J Cell Biol (2010) 1.83
Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J Biol Chem (2003) 1.72
VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J Cell Biol (2004) 1.55
Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans. J Cell Biol (2007) 1.50
The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. J Biol Chem (2004) 1.41
Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8. Curr Biol (2004) 1.33
Role(s) of Cdc48/p97 in mitosis. Biochem Soc Trans (2008) 1.23
Structural insights into the p97-Ufd1-Npl4 complex. Proc Natl Acad Sci U S A (2007) 1.22
Mitotic spindle (DIS)orientation and DISease: cause or consequence? J Cell Biol (2012) 1.21
URI-1 is required for DNA stability in C. elegans. Development (2006) 1.16
Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem (2002) 1.15
A genomewide screen for suppressors of par-2 uncovers potential regulators of PAR protein-dependent cell polarity in Caenorhabditis elegans. Genetics (2006) 1.15
A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning. Dev Cell (2008) 1.13
Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells. J Cell Sci (2011) 1.11
NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extracts. J Cell Sci (2007) 1.00
Detailed structural insights into the p97-Npl4-Ufd1 interface. J Biol Chem (2007) 0.99
Cell polarity and asymmetric cell division: the C. elegans early embryo. Essays Biochem (2012) 0.97
Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A (2012) 0.97
Heterotrimeric G proteins and regulation of size asymmetry during cell division. Curr Opin Cell Biol (2005) 0.95
The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. J Cell Biol (2013) 0.95
Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain. J Biol Chem (2003) 0.93
SPAT-1/Bora acts with Polo-like kinase 1 to regulate PAR polarity and cell cycle progression. Development (2010) 0.92
MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo. Genetics (2009) 0.92
Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1. Mech Ageing Dev (2010) 0.90
High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. Biochemistry (2010) 0.90
Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? Open Biol (2013) 0.87
Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration. J Cell Sci (2012) 0.87
Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function. FEBS J (2014) 0.84
Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span. Mech Ageing Dev (2010) 0.84
Low level sequence variant analysis of recombinant proteins: an optimized approach. PLoS One (2012) 0.83
Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry. Mech Ageing Dev (2012) 0.83
Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d). Biol Chem (2006) 0.82
Characterization of a new AAA+ protein from archaea. J Struct Biol (2006) 0.81
Differential proteomic analysis of mouse macrophages exposed to adsorbate-loaded heavy fuel oil derived combustion particles using an automated sample-preparation workflow. Anal Bioanal Chem (2015) 0.81
LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline. J Cell Sci (2010) 0.80
Aggregation and chemical modification of monoclonal antibodies under upstream processing conditions. Pharm Res (2013) 0.79
Aurora A in cell division: kinase activity not required. Nat Cell Biol (2011) 0.78
Another transistor-based revolution: on-chip qPCR. Nat Methods (2013) 0.78
The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo. Dev Biol (2012) 0.78
Coordinating cell polarity with cell division in space and time. Trends Cell Biol (2011) 0.77
Cdk1 plays matchmaker for the Polo-like kinase and its activator SPAT-1/Bora. Cell Cycle (2015) 0.75
When the Swiss clock goes wrong: regulation of Aurora A by UBXN-2/CDC-48. Cell Cycle (2013) 0.75