Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring.

PubWeight™: 1.99‹?› | Rank: Top 2%

🔗 View Article (PMC 2234383)

Published in J Exp Med on January 07, 2008

Authors

Ryoichi Mori1, Tanya J Shaw, Paul Martin

Author Affiliations

1: Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.

Associated clinical trials:

3-D Imaging Assessment of Scar Formation and Would Healing in Fat Grafted vs Non-Fat Grafted Facial Reconstruction Wound Sites | NCT01750424

Articles citing this

Macrophage diversity in renal injury and repair. J Clin Invest (2008) 4.41

Wound repair at a glance. J Cell Sci (2009) 2.53

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology (2010) 2.37

Inflammation and wound healing: the role of the macrophage. Expert Rev Mol Med (2011) 2.13

Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med (2014) 1.87

The myofibroblast matrix: implications for tissue repair and fibrosis. J Pathol (2013) 1.73

Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts. Cancer Res (2009) 1.65

Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis. Eur Heart J (2015) 1.63

The role of osteopontin in inflammatory processes. J Cell Commun Signal (2009) 1.57

Mammalian fetal cardiac regeneration after myocardial infarction is associated with differential gene expression compared with the adult. Ann Thorac Surg (2014) 1.39

Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates. PLoS One (2012) 1.38

Metchnikoff's policemen: macrophages in development, homeostasis and regeneration. Trends Mol Med (2011) 1.34

Skin wound healing modulation by macrophages. Int J Clin Exp Pathol (2010) 1.34

Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc Natl Acad Sci U S A (2010) 1.33

The effect of age on thymic function. Front Immunol (2013) 1.20

Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology. Am J Pathol (2011) 1.19

Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts. J Clin Invest (2009) 1.15

Alveolar macrophage dysregulation in Hermansky-Pudlak syndrome type 1. Am J Respir Crit Care Med (2009) 1.15

Osteopontin as two-sided mediator of intestinal inflammation. J Cell Mol Med (2008) 1.14

Epithelial-mesenchymal transition, TGF-β, and osteopontin in wound healing and tissue remodeling after injury. J Burn Care Res (2012) 1.12

Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans. Hepatology (2012) 1.09

Engineering biomaterials to integrate and heal: the biocompatibility paradigm shifts. Biotechnol Bioeng (2012) 1.09

IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice. Am J Physiol Heart Circ Physiol (2009) 1.08

Induction of specific microRNAs inhibits cutaneous wound healing. J Biol Chem (2012) 1.04

Alterations in osteopontin modify muscle size in females in both humans and mice. Med Sci Sports Exerc (2013) 1.03

The immunology of fibrosis: innate and adaptive responses. Trends Immunol (2010) 1.01

Age dependent increase in the levels of osteopontin inhibits skeletal muscle regeneration. Aging (Albany NY) (2012) 0.99

Osteopontin deficiency delays inflammatory infiltration and the onset of muscle regeneration in a mouse model of muscle injury. Dis Model Mech (2012) 0.98

The role of osteopontin (OPN/SPP1) haplotypes in the susceptibility to Crohn's disease. PLoS One (2011) 0.98

Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly? Front Pharmacol (2012) 0.97

Tissues use resident dendritic cells and macrophages to maintain homeostasis and to regain homeostasis upon tissue injury: the immunoregulatory role of changing tissue environments. Mediators Inflamm (2012) 0.96

Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus. Arthritis Res Ther (2013) 0.95

Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound. Adv Wound Care (New Rochelle) (2016) 0.94

Disclosure of the Culprits: Macrophages-Versatile Regulators of Wound Healing. Adv Wound Care (New Rochelle) (2013) 0.94

Dendritic epidermal T cells regulate skin antimicrobial barrier function. J Clin Invest (2013) 0.94

Macrophage-targeted therapy: CD64-based immunotoxins for treatment of chronic inflammatory diseases. Toxins (Basel) (2012) 0.91

Regenerative healing following foetal myocardial infarction. Eur J Cardiothorac Surg (2010) 0.90

A microarray analysis of temporal gene expression profiles in thermally injured human skin. Burns (2009) 0.90

Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol (2015) 0.90

Osteopontin, inflammation and myogenesis: influencing regeneration, fibrosis and size of skeletal muscle. J Cell Commun Signal (2013) 0.89

Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice. Toxicol Lett (2013) 0.89

Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study. Clin Orthop Relat Res (2013) 0.88

Pathological axes of wound repair: gastrulation revisited. Theor Biol Med Model (2010) 0.87

Therapeutic improvement of scarring: mechanisms of scarless and scar-forming healing and approaches to the discovery of new treatments. Dermatol Res Pract (2010) 0.87

Anti-inflammatory polymeric coatings for implantable biomaterials and devices. J Diabetes Sci Technol (2008) 0.87

Osteopontin in systemic sclerosis and its role in dermal fibrosis. J Invest Dermatol (2012) 0.86

Loss of discoidin domain receptor 2 promotes hepatic fibrosis after chronic carbon tetrachloride through altered paracrine interactions between hepatic stellate cells and liver-associated macrophages. Am J Pathol (2011) 0.86

Matricellular proteins and biomaterials. Matrix Biol (2014) 0.86

Osteopontin overproduction is associated with progression of glomerular fibrosis in a rat model of anti-glomerular basement membrane glomerulonephritis. Am J Nephrol (2010) 0.85

The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice. J Diet Suppl (2010) 0.84

A small peptide with potential ability to promote wound healing. PLoS One (2014) 0.83

Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring. Am J Pathol (2014) 0.83

The alarmin HMGB-1 influences healing outcomes in fetal skin wounds. Wound Repair Regen (2013) 0.83

Improved repair of dermal wounds in mice lacking microRNA-155. J Cell Mol Med (2014) 0.83

Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: reduction of oxidant levels. J Cell Physiol (2013) 0.82

Persistent inflammation and angiogenesis during wound healing in K14-directed Hoxb13 transgenic mice. J Invest Dermatol (2009) 0.82

Human gingival fibroblasts display a non-fibrotic phenotype distinct from skin fibroblasts in three-dimensional cultures. PLoS One (2014) 0.82

Embryonic wound healing: a primer for engineering novel therapies for tissue repair. Birth Defects Res C Embryo Today (2012) 0.82

Lumican Accelerates Wound Healing by Enhancing α2β1 Integrin-Mediated Fibroblast Contractility. PLoS One (2013) 0.82

The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity. J Surg Res (2011) 0.82

Blockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis. Am J Nephrol (2010) 0.81

The four-herb Chinese medicine ANBP enhances wound healing and inhibits scar formation via bidirectional regulation of transformation growth factor pathway. PLoS One (2014) 0.81

Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents. Arch Toxicol (2015) 0.80

The LIM-only protein FHL2 attenuates lung inflammation during bleomycin-induced fibrosis. PLoS One (2013) 0.79

Elevated levels of full-length and thrombin-cleaved osteopontin during acute dengue virus infection are associated with coagulation abnormalities. Thromb Res (2014) 0.79

Associations Between Elastography Findings and Clinicopathological Factors in Breast Cancer. Medicine (Baltimore) (2015) 0.78

The molecular basis of hypertrophic scars. Burns Trauma (2016) 0.78

Resolution mediator chemerin15 reprograms the wound microenvironment to promote repair and reduce scarring. Curr Biol (2014) 0.78

Osteopontin is not crucial to protective immunity during murine tuberculosis. Immunology (2009) 0.77

Differential Gene Expression Profiling of Dystrophic Dog Muscle after MuStem Cell Transplantation. PLoS One (2015) 0.77

Knockdown of osteopontin reduces the inflammatory response and subsequent size of postsurgical adhesions in a murine model. Am J Pathol (2012) 0.76

Purinergic signaling in scarring. FASEB J (2015) 0.76

The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors. PLoS One (2016) 0.76

Macrophages are necessary for epimorphic regeneration in African spiny mice. Elife (2017) 0.75

Effects of streptolysin o on extracellular matrix gene expression in normal human epidermal keratinocytes. Dose Response (2011) 0.75

Monocyte Chemotactic Protein-1-Interleukin-6-Osteopontin Pathway of Intra-Aneurysmal Tissue Healing. Stroke (2017) 0.75

Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice. Environ Health Perspect (2016) 0.75

Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages. EMBO Mol Med (2016) 0.75

Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix. Proc Natl Acad Sci U S A (2017) 0.75

Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation. NPJ Regen Med (2016) 0.75

Osteopontin activates mesenchymal stem cells to repair skin wound. PLoS One (2017) 0.75

A novel role for SALL4 during scar-free wound healing in axolotl. NPJ Regen Med (2016) 0.75

Articles cited by this

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest (2005) 8.58

Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. Science (1988) 6.77

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest (2001) 4.63

Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol (2005) 4.53

Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 3.70

Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci (1995) 3.68

Altered wound healing in mice lacking a functional osteopontin gene (spp1). J Clin Invest (1998) 3.56

Procollagen trafficking, processing and fibrillogenesis. J Cell Sci (2005) 3.54

Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. PLoS Med (2005) 3.15

Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis Rheum (2007) 3.02

Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells. Curr Biol (2003) 2.87

Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1. J Biol Chem (2002) 2.26

Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors. Proc Natl Acad Sci U S A (1987) 2.17

Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy. Hypertension (2004) 2.10

Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo. Am J Pathol (1998) 1.83

Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltration. FASEB J (2002) 1.76

Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing. Am J Pathol (2006) 1.70

Imatinib as a novel antifibrotic agent in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med (2005) 1.68

The regulation and role of osteopontin in malignant transformation and cancer. Cytokine Growth Factor Rev (2006) 1.59

Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing. J Biol Chem (1996) 1.59

Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice. Genome Biol (2004) 1.46

Effects and regulation of osteopontin in rat hepatic stellate cells. Biochem Pharmacol (2004) 1.25

Mast cell involvement in normal human skin wound healing: expression of monocyte chemoattractant protein-1 is correlated with recruitment of mast cells which synthesize interleukin-4 in vivo. J Pathol (2000) 1.20

Mast cells modulate the inflammatory but not the proliferative response in healing wounds. Wound Repair Regen (2003) 1.12

Mechanisms and mediators of pulmonary fibrosis. Crit Rev Immunol (2005) 1.08

Effect of recombinant platelet-derived growth factor (Regranex) on wound closure in genetically diabetic mice. J Burn Care Res (2006) 1.06

Structural and functional domains of osteopontin. Ann N Y Acad Sci (1995) 1.05

Insights into the mechanisms of renal fibrosis: is it possible to achieve regression? Am J Physiol Renal Physiol (2005) 1.05

Differential regulation of angiogenic genes in diabetic wound healing. J Invest Dermatol (2006) 1.00

Osteopontin overexpression inhibits in vitro re-endothelialization via integrin engagement. J Biol Chem (2007) 0.85

Articles by these authors

(truncated to the top 100)

National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant (2005) 19.83

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90

hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics (2007) 4.62

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46

Differentiation of the major Listeria monocytogenes serovars by multiplex PCR. J Clin Microbiol (2004) 4.32

Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C. N Engl J Med (2009) 4.21

AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models. Mol Cancer Ther (2007) 4.16

Measuring therapeutic response in chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group report. Biol Blood Marrow Transplant (2006) 4.09

Wound healing recapitulates morphogenesis in Drosophila embryos. Nat Cell Biol (2002) 4.04

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet (2009) 3.52

Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood (2002) 3.45

Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation. PLoS Biol (2010) 2.99

A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update. Clin Gastroenterol Hepatol (2008) 2.97

Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B. Gastroenterology (2004) 2.97

Randomized study comparing banding and propranolol to prevent initial variceal hemorrhage in cirrhotics with high-risk esophageal varices. Gastroenterology (2005) 2.90

Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis. Ann Intern Med (2005) 2.68

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet (2013) 2.60

c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev Cell (2003) 2.59

The role of social scientists in synthetic biology. Science & Society Series on Convergence Research. EMBO Rep (2009) 2.57

Wound repair at a glance. J Cell Sci (2009) 2.53

Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J Cell Biol (2005) 2.38

New aspects regarding evolution and virulence of Listeria monocytogenes revealed by comparative genomics and DNA arrays. Infect Immun (2004) 2.31

Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B. Gastroenterology (2006) 2.22

An explicit quality indicator set for measurement of quality of care in patients with cirrhosis. Clin Gastroenterol Hepatol (2010) 2.18

Hepatitis C-related hepatocellular carcinoma in the United States: influence of ethnic status. Am J Gastroenterol (2003) 2.18

Dynamic analysis of dorsal closure in Drosophila: from genetics to cell biology. Dev Cell (2002) 2.06

Treatment of hepatitis C after kidney transplant: a pooled analysis of observational studies. J Med Virol (2014) 2.03

Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure. Development (2008) 2.03

Peginterferon alfa-2a for hepatitis C after liver transplantation: two randomized, controlled trials. Hepatology (2005) 1.97

6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology (2003) 1.95

Wound healing and inflammation: embryos reveal the way to perfect repair. Philos Trans R Soc Lond B Biol Sci (2004) 1.94

A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: an update. Clin Gastroenterol Hepatol (2006) 1.92

Evaluation for liver transplantation in adults: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation. Hepatology (2014) 1.91

Recent US Food and Drug Administration warnings on hepatitis B reactivation with immune-suppressing and anticancer drugs: just the tip of the iceberg? Hepatology (2015) 1.87

Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report. Biol Blood Marrow Transplant (2006) 1.86

Blood and marrow transplant clinical trials network toxicity committee consensus summary: thrombotic microangiopathy after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (2005) 1.85

Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease. Arthritis Res Ther (2010) 1.85

The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair. J Invest Dermatol (2007) 1.85

Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE₂. Curr Biol (2012) 1.80

Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation. Cell Motil Cytoskeleton (2006) 1.79

The pharmaceuticalisation of society? A framework for analysis. Sociol Health Illn (2011) 1.75

Molecular caving. Curr Biol (2003) 1.73

Virologic monitoring of hepatitis B virus therapy in clinical trials and practice: recommendations for a standardized approach. Gastroenterology (2007) 1.72

Structures in focus--filopodia. Int J Biochem Cell Biol (2002) 1.63

Dynamic analysis of actin cable function during Drosophila dorsal closure. Curr Biol (2002) 1.62

Animal models of ovarian cancer. Reprod Biol Endocrinol (2003) 1.57

Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Hum Mol Genet (2009) 1.55

Nuclear gene sequences from a late pleistocene sloth coprolite. Curr Biol (2003) 1.55

A multicenter pilot evaluation of the National Institutes of Health chronic graft-versus-host disease (cGVHD) therapeutic response measures: feasibility, interrater reliability, and minimum detectable change. Biol Blood Marrow Transplant (2011) 1.54

Hepatitis C infection and the patient with end-stage renal disease. Hepatology (2002) 1.53

Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. EMBO Rep (2009) 1.51

Prioritization of competing damage and developmental signals by migrating macrophages in the Drosophila embryo. Curr Biol (2010) 1.51

Calcium flashes orchestrate the wound inflammatory response through DUOX activation and hydrogen peroxide release. Curr Biol (2013) 1.50

Targeting connexin43 expression accelerates the rate of wound repair. Curr Biol (2003) 1.48

Safety of transradial cardiac catheterization in patients with end-stage liver disease. Catheter Cardiovasc Interv (2013) 1.47

A treatment algorithm for the management of chronic hepatitis B virus infection in the United States. Clin Gastroenterol Hepatol (2004) 1.47

Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice. Genome Biol (2004) 1.46

Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo. J Cell Biol (2010) 1.45

Hepatitis B virus vaccine in chronic kidney disease: improved immunogenicity by adjuvants? A meta-analysis of randomized trials. Vaccine (2012) 1.43

Analysis of WASp function during the wound inflammatory response--live-imaging studies in zebrafish larvae. J Cell Sci (2008) 1.40

Pathogenomics of Listeria spp. Int J Med Microbiol (2007) 1.39

Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet (2009) 1.37

Relapse of hepatitis B in HBeAg-negative chronic hepatitis B patients who discontinued successful entecavir treatment: the case for continuous antiviral therapy. J Hepatol (2008) 1.36

Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration. J Cell Sci (2006) 1.36

Biodiversity: disease threat to European fish. Nature (2005) 1.33

Rapid virologic response: a new milestone in the management of chronic hepatitis C. Clin Infect Dis (2008) 1.33

Overlap subtype of chronic graft-versus-host disease is associated with an adverse prognosis, functional impairment, and inferior patient-reported outcomes: a Chronic Graft-versus-Host Disease Consortium study. Haematologica (2011) 1.32

A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Dev Cell (2011) 1.31

Chronic liver disease in the Hispanic population of the United States. Clin Gastroenterol Hepatol (2011) 1.30

Hepatitis C virus antibody status and survival after renal transplantation: meta-analysis of observational studies. Am J Transplant (2005) 1.28

Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis. Development (2006) 1.28

The drugs don't work: expectations and the shaping of pharmacogenetics. Soc Stud Sci (2003) 1.24

Hepatitis C virus infection and the dialysis patient. Semin Dial (2007) 1.24

Treatment alternatives for hepatitis B cirrhosis: a cost-effectiveness analysis. Am J Gastroenterol (2006) 1.23

A humanized non-FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease. Blood (2002) 1.22

HLA-matched related hematopoietic cell transplantation for chronic-phase CML using a targeted busulfan and cyclophosphamide preparative regimen. Blood (2003) 1.22

Determination of 210Po in environmental materials: a review of analytical methodology. Appl Radiat Isot (2006) 1.16

Imatinib (Gleevec)-induced hepatotoxicity. J Clin Gastroenterol (2005) 1.14

The standardization of race and ethnicity in biomedical science editorials and UK biobanks. Soc Stud Sci (2008) 1.14

Microtubule remodelling is required for the front-rear polarity switch during contact inhibition of locomotion. J Cell Sci (2011) 1.14

Genetics and Forensics: Making the National DNA Database. Sci Stud (2003) 1.14

Fascin is required for blood cell migration during Drosophila embryogenesis. Development (2009) 1.12

Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol (2008) 1.11

The myth of the biotech revolution. Trends Biotechnol (2004) 1.11

Atrioventricular block after transcatheter balloon expandable aortic valve implantation. JACC Cardiovasc Interv (2008) 1.11

Randomized trial of allogeneic related bone marrow transplantation versus peripheral blood stem cell transplantation for chronic myeloid leukemia. Biol Blood Marrow Transplant (2005) 1.10

Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. Ann Rheum Dis (2009) 1.10

Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos. EMBO Rep (2008) 1.10

Models of ovarian cancer--are we there yet? Mol Cell Endocrinol (2005) 1.08

Cell biology: master regulators of sealing and healing. Curr Biol (2005) 1.07

Role for keratins 6 and 17 during wound closure in embryonic mouse skin. Dev Dyn (2003) 1.07

A small percentage of patients with hepatitis C receive triple therapy with boceprevir or telaprevir. Clin Gastroenterol Hepatol (2013) 1.04

Novel assay using total hepatitis C virus (HCV) core antigen quantification for diagnosis of HCV infection in dialysis patients. J Clin Microbiol (2005) 1.04

The small GTPase Rac plays multiple roles in epithelial sheet fusion--dynamic studies of Drosophila dorsal closure. Dev Biol (2005) 1.04

Biliary complications following liver transplantation. Dig Dis Sci (2010) 1.04

Hepatitis C virus infection, mixed cryoglobulinemia, and kidney disease. Am J Kidney Dis (2012) 1.03

Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse. Dev Dyn (2002) 1.02

Racial categories in medicine: a failure of evidence-based practice? PLoS Med (2007) 1.02

Lamivudine for the treatment of hepatitis B virus-related liver disease after renal transplantation: meta-analysis of clinical trials. Transplantation (2004) 1.02