DNA damage response at functional and dysfunctional telomeres.

The DNA-damage response in human biology and disease. Nature (2009) 17.86

DNA end resection: many nucleases make light work. DNA Repair (Amst) (2009) 3.28

Rif1 and rif2 inhibit localization of tel1 to DNA ends. Mol Cell (2009) 2.09

Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet (2008) 2.00

A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae. Genetics (2008) 1.58

The telosome/shelterin complex and its functions. Genome Biol (2008) 1.57

Human RAP1 inhibits non-homologous end joining at telomeres. EMBO J (2009) 1.49

Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeres. PLoS Genet (2010) 1.42

The DNA damage response at eroded telomeres and tethering to the nuclear pore complex. Nat Cell Biol (2009) 1.36

Rif1 supports the function of the CST complex in yeast telomere capping. PLoS Genet (2011) 1.30

Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects. PLoS Genet (2011) 1.26

Telomeres and immunological diseases of aging. Gerontology (2009) 1.22

Mechanisms and regulation of DNA end resection. EMBO J (2010) 1.22

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase. J Cell Biol (2010) 1.17

Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. DNA Repair (Amst) (2010) 1.17

Taming the tiger by the tail: modulation of DNA damage responses by telomeres. EMBO J (2009) 1.12

Telomere capping in non-dividing yeast cells requires Yku and Rap1. EMBO J (2010) 1.12

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Mol Cell Proteomics (2010) 1.12

Fanconi anemia proteins and endogenous stresses. Mutat Res (2009) 1.11

Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe. EMBO J (2008) 1.07

Large CTG repeats trigger p16-dependent premature senescence in myotonic dystrophy type 1 muscle precursor cells. Am J Pathol (2009) 0.99

Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4. PLoS Genet (2014) 0.93

Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance. J Biol Chem (2008) 0.93

A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection. Genome Biol (2008) 0.93

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. PLoS One (2010) 0.92

Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells. Mol Cell (2012) 0.92

Roles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment. J Biol Chem (2009) 0.92

A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres. Mol Cell Biol (2012) 0.91

The MRX complex plays multiple functions in resection of Yku- and Rif2-protected DNA ends. PLoS One (2010) 0.91

Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond. Front Genet (2013) 0.90

The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis. J Biol Chem (2011) 0.88

ATR contributes to telomere maintenance in human cells. Nucleic Acids Res (2010) 0.88

Loss of the histone variant H2A.Z restores capping to checkpoint-defective telomeres in Drosophila. Genetics (2008) 0.86

Subtelomere-binding protein Tbf1 and telomere-binding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast. Mol Biol Cell (2011) 0.85

The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development. Aging Cell (2010) 0.85

Telomere organization in the ligninolytic basidiomycete Pleurotus ostreatus. Appl Environ Microbiol (2008) 0.84

A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast. PLoS Genet (2010) 0.83

Double-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instability. Cancer Sci (2014) 0.83

Telomere-end processing: mechanisms and regulation. Chromosoma (2013) 0.82

DNA excision repair at telomeres. DNA Repair (Amst) (2015) 0.81

Telomeres, a busy platform for cell signaling. Front Oncol (2013) 0.78

Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance. Cell Cycle (2010) 0.78

To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres? Front Biosci (Landmark Ed) (2010) 0.78

JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein. Cell Death Differ (2015) 0.78

Customizable views on semantically integrated networks for systems biology. Bioinformatics (2011) 0.78

CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase. Cell Cycle (2012) 0.77

The fate of irreparable DNA double-strand breaks and eroded telomeres at the nuclear periphery. Nucleus (2010) 0.77

Structure and function of the telomeric CST complex. Comput Struct Biotechnol J (2016) 0.77

Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clin Exp Gastroenterol (2011) 0.77

Mec1p associates with functionally compromised telomeres. Chromosoma (2012) 0.76

The Telomeric Complex and Metabolic Disease. Genes (Basel) (2017) 0.76

The Leishmania amazonensis TRF (TTAGGG repeat-binding factor) homologue binds and co-localizes with telomeres. BMC Microbiol (2010) 0.75

Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis. Mol Cell Oncol (2014) 0.75

Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance. Biomolecules (2012) 0.75

Sharpening the ends for repair: mechanisms and regulation of DNA resection. Acta Biochim Biophys Sin (Shanghai) (2016) 0.75

Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells. Nucleic Acids Res (2017) 0.75

Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells. Oncotarget (2016) 0.75

Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage. Nucleic Acids Res (2017) 0.75

Alternative arrangements of telomeric recognition sites regulate the binding mode of the DNA-binding domain of yeast Rap1. Biophys Chem (2015) 0.75

Insertion of Retrotransposons at Chromosome Ends: Adaptive Response to Chromosome Maintenance. Front Genet (2016) 0.75

Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis. Environ Res (2017) 0.75

Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex dependent fashion. J Biol Chem (2017) 0.75

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29

Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19

Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12

TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13

Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell (2004) 9.74

DNA damage foci at dysfunctional telomeres. Curr Biol (2003) 9.08

Crystal structure of parallel quadruplexes from human telomeric DNA. Nature (2002) 8.90

A mutant with a defect in telomere elongation leads to senescence in yeast. Cell (1989) 8.69

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell (1998) 8.31

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol (2005) 8.27

Control of telomere length by the human telomeric protein TRF1. Nature (1997) 7.62

ATR and ATRIP: partners in checkpoint signaling. Science (2001) 7.58

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature (2005) 7.45

Recombination proteins in yeast. Annu Rev Genet (2004) 7.04

Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (2001) 6.95

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature (2004) 6.94

An alternative pathway for yeast telomere maintenance rescues est1- senescence. Cell (1993) 6.89

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature (2007) 6.82

Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol Cell Biol (1995) 6.11

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (1999) 5.89

Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science (1996) 5.55

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol (2005) 5.49

POT1 as a terminal transducer of TRF1 telomere length control. Nature (2003) 5.43

Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat Cell Biol (2001) 5.05

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet (1997) 4.95

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell (1997) 4.86

Homologous recombination generates T-loop-sized deletions at human telomeres. Cell (2004) 4.85

A protein-counting mechanism for telomere length regulation in yeast. Science (1997) 4.79

Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell (2004) 4.79

A human telomeric protein. Science (1995) 4.77

The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci (2006) 4.67

TIN2, a new regulator of telomere length in human cells. Nat Genet (1999) 4.66

Control of human telomere length by TRF1 and TRF2. Mol Cell Biol (2000) 4.54

A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev (1992) 4.53

Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature (1997) 4.49

Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell (1993) 4.33

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol Cell Biol (1999) 4.32

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet (2000) 4.30

RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell (1990) 4.25

Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science (1995) 4.23

Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell (2006) 4.13

Identification of human Rap1: implications for telomere evolution. Cell (2000) 4.06

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr Biol (2002) 3.95

Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell (2001) 3.95

Yeast Ku as a regulator of chromosomal DNA end structure. Science (1998) 3.86

Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat Struct Mol Biol (2004) 3.66

A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol Cell (2001) 3.65

Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science (2002) 3.60

The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell (2006) 3.45

Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev (1997) 3.42

RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol (2007) 3.39

Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae. Mol Cell Biol (1994) 3.34

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. EMBO J (2001) 3.28

How telomeres are replicated. Nat Rev Mol Cell Biol (2007) 3.27

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev (2004) 3.25

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol (2005) 3.25

Telomeric localization of TRF2, a novel human telobox protein. Nat Genet (1997) 3.23

Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev (2003) 3.21

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem Cell Biol (2007) 3.13

Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nat Cell Biol (2006) 3.08

A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins. Nat Cell Biol (1999) 3.05

EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev (2002) 3.05

Evidence for a new step in telomere maintenance. Cell (1996) 3.03

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell (2003) 3.01

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.92

Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell (2005) 2.89

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.88

MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans. Nature (2000) 2.86

The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev (2000) 2.82

Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Mol Cell (2003) 2.78

Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem (2006) 2.76

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem (2004) 2.76

Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev (1997) 2.75

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues. Nat Genet (1998) 2.71

Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Mol Cell (2001) 2.70

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69

Telomerase and DNA end replication: no longer a lagging strand problem? Science (1995) 2.67

A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Mol Cell (2007) 2.67

spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr Biol (2001) 2.64

Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes Dev (2002) 2.59

The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr Biol (1998) 2.57

TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem (2004) 2.52

Cell cycle restriction of telomere elongation. Curr Biol (2000) 2.46

The Mre11 nuclease is not required for 5' to 3' resection at multiple HO-induced double-strand breaks. Mol Cell Biol (2004) 2.46

A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr Biol (2004) 2.45

ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. Genes Dev (2003) 2.38

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem (2004) 2.36

Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr Biol (2006) 2.36

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J (2001) 2.36

Cell cycle-dependent regulation of yeast telomerase by Ku. Nat Struct Mol Biol (2004) 2.32

The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell (2006) 2.27

Cdc13 both positively and negatively regulates telomere replication. Genes Dev (2001) 2.24

Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops. Mol Cell Biol (2004) 2.23

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol (2004) 2.23

Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol (2005) 2.20

The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. Nat Genet (2001) 2.19

Regulation of telomere elongation by the cyclin-dependent kinase CDK1. Mol Cell (2006) 2.17

Telomere length homeostasis. Chromosoma (2006) 2.12