| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Synthesis, insecticidal activity, and QSAR of novel nitromethylene neonicotinoids with tetrahydropyridine fixed cis configuration and exo-ring ether modification.
|
J Agric Food Chem
|
2007
|
2.71
|
|
2
|
Synthesis and antifeedant activity of new oxadiazolyl 3(2H)-pyridazinones.
|
J Agric Food Chem
|
2003
|
1.22
|
|
3
|
A ratiometric fluorescent probe based on FRET for imaging Hg2+ ions in living cells.
|
Angew Chem Int Ed Engl
|
2008
|
1.21
|
|
4
|
Zn2+-triggered amide tautomerization produces a highly Zn2+-selective, cell-permeable, and ratiometric fluorescent sensor.
|
J Am Chem Soc
|
2010
|
1.15
|
|
5
|
cis-Nitromethylene neonicotinoids as new nicotinic family: synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2-alpha]pyridine.
|
Bioorg Med Chem Lett
|
2008
|
1.12
|
|
6
|
A highly selective and sensitive fluorescent chemosensor for Hg2+ in neutral buffer aqueous solution.
|
J Am Chem Soc
|
2004
|
1.10
|
|
7
|
Isomeric boron-fluorine complexes with donor-acceptor architecture: strong solid/liquid fluorescence and large Stokes shift.
|
Org Lett
|
2008
|
0.95
|
|
8
|
M(2)-A induces apoptosis and G(2)-M arrest via inhibiting PI3K/Akt pathway in HL60 cells.
|
Cancer Lett
|
2009
|
0.95
|
|
9
|
Ratiometric and selective fluorescent sensor for CuII based on internal charge transfer (ICT).
|
Org Lett
|
2005
|
0.94
|
|
10
|
Synthesis and herbicidal activity of novel 3-aminocarbonyl-2-oxazolidinethione derivatives containing a substituted pyridine ring.
|
J Agric Food Chem
|
2006
|
0.94
|
|
11
|
A rhodamine-based Hg2+ sensor with high selectivity and sensitivity in aqueous solution: a NS2-containing receptor.
|
J Org Chem
|
2009
|
0.90
|
|
12
|
A highly selective fluorescent probe for fast detection of hydrogen sulfide in aqueous solution and living cells.
|
Chem Commun (Camb)
|
2012
|
0.89
|
|
13
|
A new prodrug-derived ratiometric fluorescent probe for hypoxia: high selectivity of nitroreductase and imaging in tumor cell.
|
Org Lett
|
2011
|
0.88
|
|
14
|
A highly sensitive and selective OFF-ON fluorescent sensor for cadmium in aqueous solution and living cell.
|
J Am Chem Soc
|
2008
|
0.88
|
|
15
|
Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents.
|
Chembiochem
|
2007
|
0.88
|
|
16
|
A novel beta-N-acetyl-D-hexosaminidase from the insect Ostrinia furnacalis (Guenée).
|
FEBS J
|
2008
|
0.88
|
|
17
|
A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor.
|
J Med Chem
|
2009
|
0.87
|
|
18
|
E2F1-dependent pathways are involved in amonafide analogue 7-d-induced DNA damage, G2/M arrest, and apoptosis in p53-deficient K562 cells.
|
J Cell Biochem
|
2012
|
0.87
|
|
19
|
Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies.
|
Bioorg Med Chem
|
2008
|
0.86
|
|
20
|
A red-shift colorimetric and fluorescent sensor for Cu2+ in aqueous solution: unsymmetrical 4,5-diaminonaphthalimide with N-H deprotonation induced by metal ions.
|
Org Biomol Chem
|
2009
|
0.86
|
|
21
|
A new class of long-wavelength fluorophores: strong red fluorescence, convenient synthesis and easy derivation.
|
Chem Commun (Camb)
|
2004
|
0.85
|
|
22
|
The toxic and anti-feedant activity of 2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles against the armyworm Pseudaletia separata (Walker) and other insects and mites.
|
Pest Manag Sci
|
2003
|
0.85
|
|
23
|
A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging.
|
Chem Commun (Camb)
|
2011
|
0.84
|
|
24
|
Isoquino[4,5-bc]acridines: design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability.
|
J Photochem Photobiol B
|
2006
|
0.84
|
|
25
|
The novel anti-tumor agents of 4-triazol-1,8-naphthalimides: synthesis, cytotoxicity, DNA intercalation and photocleavage.
|
Eur J Med Chem
|
2011
|
0.84
|
|
26
|
Actions between neonicotinoids and key residues of insect nAChR based on an ab initio quantum chemistry study: hydrogen bonding and cooperative pi-pi interaction.
|
Bioorg Med Chem
|
2007
|
0.83
|
|
27
|
Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor.
|
Bioorg Med Chem Lett
|
2006
|
0.83
|
|
28
|
A series of polyamide receptor based PET fluorescent sensor molecules: positively cooperative Hg2+ ion binding with high sensitivity.
|
Org Lett
|
2006
|
0.83
|
|
29
|
Syntheses, antifeedant activity, and QSAR analysis of new oxa(thia)diazolyl 3(2H)-pyridazinones.
|
J Agric Food Chem
|
2005
|
0.83
|
|
30
|
Cross-reactive sensor arrays for the detection of peptides in aqueous solution by fluorescence spectroscopy.
|
Chemistry
|
2010
|
0.83
|
|
31
|
Novel benzo-1,2,3-thiadiazole-7-carboxylate derivatives as plant activators and the development of their agricultural applications.
|
J Agric Food Chem
|
2011
|
0.83
|
|
32
|
Selective and ratiometric fluorescent trapping and quantification of protein vicinal dithiols and in situ dynamic tracing in living cells.
|
J Am Chem Soc
|
2014
|
0.83
|
|
33
|
A new class of naphthalimide-based antitumor agents that inhibit topoisomerase II and induce lysosomal membrane permeabilization and apoptosis.
|
J Med Chem
|
2010
|
0.83
|
|
34
|
Trace mercury (II) detection and separation in serum and water samples using a reusable bifunctional fluorescent sensor.
|
Anal Chim Acta
|
2009
|
0.82
|
|
35
|
Synthesis, crystal structure, and insecticidal activities of highly congested hexahydroimidazo[1,2-a]pyridine derivatives: effect of conformation on activities.
|
J Agric Food Chem
|
2010
|
0.82
|
|
36
|
Ratiometric and water-soluble fluorescent zinc sensor of carboxamidoquinoline with an alkoxyethylamino chain as receptor.
|
Org Lett
|
2008
|
0.82
|
|
37
|
Visible study of mercuric ion and its conjugate in living cells of mammals and plants.
|
Chem Res Toxicol
|
2005
|
0.82
|
|
38
|
Novel naphthalimide-amino acid conjugates with flexible leucine moiety as side chain: design, synthesis and potential antitumor activity.
|
Bioorg Med Chem
|
2008
|
0.82
|
|
39
|
A novel synthetic fluoro-containing jasmonate derivative acts as a chemical inducing signal for plant secondary metabolism.
|
Appl Microbiol Biotechnol
|
2005
|
0.82
|
|
40
|
Novel fluorescent pH sensors based on intramolecular hydrogen bonding ability of naphthalimide.
|
Org Lett
|
2004
|
0.82
|
|
41
|
A three-channel fluorescent probe that distinguishes peroxynitrite from hypochlorite.
|
J Am Chem Soc
|
2012
|
0.81
|
|
42
|
Responses of defense signals, biosynthetic gene transcription and taxoid biosynthesis to elicitation by a novel synthetic jasmonate in cell cultures of Taxus chinensis.
|
Biotechnol Bioeng
|
2006
|
0.81
|
|
43
|
7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-κB in LPS-stimulated RAW264.7 macrophages.
|
Int Immunopharmacol
|
2013
|
0.81
|
|
44
|
A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells.
|
Cancer Lett
|
2013
|
0.81
|
|
45
|
A design concept of long-wavelength fluorescent analogs of rhodamine dyes: replacement of oxygen with silicon atom.
|
Chem Commun (Camb)
|
2008
|
0.81
|
|
46
|
Novel nitroheterocyclic hypoxic markers for solid tumor: synthesis and biological evaluation.
|
Bioorg Med Chem
|
2007
|
0.81
|
|
47
|
Versatile nitro-fluorophore as highly effective sensor for hypoxic tumor cells: design, imaging and evaluation.
|
J Fluoresc
|
2008
|
0.81
|
|
48
|
A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: selective detection and quantification.
|
Chem Commun (Camb)
|
2013
|
0.81
|
|
49
|
Discrimination and classification of ginsenosides and ginsengs using bis-boronic acid receptors in dynamic multicomponent indicator displacement sensor arrays.
|
Chemistry
|
2011
|
0.81
|
|
50
|
"Integrated" and "insulated" boronate-based fluorescent probes for the detection of hydrogen peroxide.
|
Chem Commun (Camb)
|
2013
|
0.80
|
|
51
|
A general strategy for construction of a difluoromethyl compound library and its application in synthesis of pseudopeptides bearing a terminal difluoromethyl group.
|
Org Biomol Chem
|
2010
|
0.80
|
|
52
|
A dual pH and temperature responsive polymeric fluorescent sensor and its imaging application in living cells.
|
Chem Commun (Camb)
|
2012
|
0.80
|
|
53
|
Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA.
|
Bioorg Med Chem Lett
|
2005
|
0.80
|
|
54
|
2,3,6,7-Tetraamino-9,9-bis(2-ethylhexyl)fluorene: new multifunctional monomer for soluble ladder-conjugated molecules and polymers.
|
Org Lett
|
2008
|
0.80
|
|
55
|
Induction of G2/M phase arrest and apoptosis by potent antitumor APCA in human cervix carcinoma cells.
|
Anticancer Drugs
|
2011
|
0.79
|
|
56
|
Efficient synthesis of regioisomerically pure bis(trifluoromethyl)-substituted 3,4,9,10-perylene tetracarboxylic bis(benzimidazole).
|
Org Lett
|
2009
|
0.79
|
|
57
|
Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor.
|
Eur J Med Chem
|
2011
|
0.79
|
|
58
|
Ratiometric and highly selective fluorescent sensor for cadmium under physiological pH range: a new strategy to discriminate cadmium from zinc.
|
J Org Chem
|
2007
|
0.79
|
|
59
|
A mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products.
|
Mol Divers
|
2009
|
0.79
|
|
60
|
Divalent and oxabridged neonicotinoids constructed by dialdehydes and nitromethylene analogues of imidacloprid: design, synthesis, crystal structure, and insecticidal activities.
|
J Agric Food Chem
|
2010
|
0.79
|
|
61
|
Acenaphtho[1,2-b]pyrrole-based selective fibroblast growth factor receptors 1 (FGFR1) inhibitors: design, synthesis, and biological activity.
|
J Med Chem
|
2011
|
0.79
|
|
62
|
Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding.
|
Bioorg Med Chem
|
2006
|
0.78
|
|
63
|
Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis.
|
Bioorg Med Chem Lett
|
2004
|
0.78
|
|
64
|
Convenient and efficient FRET platform featuring a rigid biphenyl spacer between rhodamine and BODIPY: transformation of 'turn-on' sensors into ratiometric ones with dual emission.
|
Chemistry
|
2011
|
0.78
|
|
65
|
Assessment of 4-nitro-1,8-naphthalic anhydride reductase activity in homogenates of bakers' yeast by reversed-phase high-performance liquid chromatography.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2006
|
0.78
|
|
66
|
Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase.
|
J Med Chem
|
2015
|
0.78
|
|
67
|
Versatile trifunctional chemosensor of rhodamine derivative for Zn2+, Cu2+ and His/Cys in aqueous solution and living cells.
|
Org Biomol Chem
|
2011
|
0.78
|
|
68
|
Design, synthesis, and insecticidal activities of novel analogues of neonicotinoids: replacement of nitromethylene with nitroconjugated system.
|
J Agric Food Chem
|
2009
|
0.78
|
|
69
|
Highly efficient energy transfer in the light harvesting system composed of three kinds of boron-dipyrromethene derivatives.
|
Org Lett
|
2007
|
0.78
|
|
70
|
Design, synthesis, crystal structure analysis, and insecticidal evaluation of phenylazoneonicotinoids.
|
J Agric Food Chem
|
2011
|
0.78
|
|
71
|
Two regioisomeric and exclusively selective Hg(II) sensor molecules composed of a naphthalimide fluorophore and an o-phenylenediamine derived triamide receptor.
|
Chem Commun (Camb)
|
2005
|
0.78
|
|
72
|
Detecting Hg2+ ions with an ICT fluorescent sensor molecule: remarkable emission spectra shift and unique selectivity.
|
J Org Chem
|
2006
|
0.78
|
|
73
|
Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes.
|
Chem Commun (Camb)
|
2015
|
0.78
|
|
74
|
Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites.
|
Appl Microbiol Biotechnol
|
2005
|
0.78
|
|
75
|
Simultaneous quantification of Hg²⁺ and MeHg⁺ in aqueous media with a single fluorescent probe by multiplexing in the time domain.
|
Anal Chem
|
2014
|
0.77
|
|
76
|
Colorimetric and ratiometric fluorescent chemosensor with a large red-shift in emission: Cu(II)-only sensing by deprotonation of secondary amines as receptor conjugated to naphthalimide fluorophore.
|
Org Lett
|
2005
|
0.77
|
|
77
|
Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe.
|
Chem Commun (Camb)
|
2010
|
0.77
|
|
78
|
Rationally designed multitarget anticancer agents.
|
Curr Med Chem
|
2013
|
0.77
|
|
79
|
Unique tri-output optical probe for specific and ultrasensitive detection of hydrazine.
|
Anal Chem
|
2014
|
0.77
|
|
80
|
Induction of apoptosis and suppression of ERCC1 expression by the potent amonafide analogue 8-c in human colorectal carcinoma cells.
|
Anticancer Drugs
|
2013
|
0.77
|
|
81
|
Hydrazine detection in the gas state and aqueous solution based on the Gabriel mechanism and its imaging in living cells.
|
Chem Commun (Camb)
|
2014
|
0.77
|
|
82
|
Highly selective fluorescent probe for vicinal-dithiol-containing proteins and in situ imaging in living cells.
|
Angew Chem Int Ed Engl
|
2011
|
0.77
|
|
83
|
B1-induced caspase-independent apoptosis in MCF-7 cells is mediated by down-regulation of Bcl-2 via p53 binding to P2 promoter TATA box.
|
Toxicol Appl Pharmacol
|
2011
|
0.77
|
|
84
|
Novel naphthalimide derivatives as potential apoptosis-inducing agents: design, synthesis and biological evaluation.
|
Eur J Med Chem
|
2009
|
0.77
|
|
85
|
B1, a novel amonafide analogue, overcomes the resistance conferred by Bcl-2 in human promyelocytic leukemia HL60 cells.
|
Mol Cancer Res
|
2010
|
0.77
|
|
86
|
Novel, unnatural benzo-1,2,3-thiadiazole-7-carboxylate elicitors of taxoid biosynthesis.
|
J Agric Food Chem
|
2006
|
0.77
|
|
87
|
Naphthalimide intercalators with chiral amino side chains: effects of chirality on DNA binding, photodamage and antitumor cytotoxicity.
|
Bioorg Med Chem Lett
|
2008
|
0.77
|
|
88
|
Novel fluorescent fluorine-boron complexes: synthesis, crystal structure, photoluminescence, and electrochemistry properties.
|
J Org Chem
|
2008
|
0.77
|
|
89
|
Thiadiazole: a new family of intercalative photonuclease with electron transfer and radical mechanisms.
|
Bioorg Med Chem Lett
|
2003
|
0.77
|
|
90
|
Highly efficient strategy for enhancing taxoid production by repeated elicitation with a newly synthesized jasmonate in fed-batch cultivation of Taxus chinensis cells.
|
Biotechnol Bioeng
|
2005
|
0.76
|
|
91
|
Bulky 4-tritylphenylethynyl substituted boradiazaindacene: pure red emission, relatively large Stokes shift and inhibition of self-quenching.
|
Chem Commun (Camb)
|
2008
|
0.76
|
|
92
|
PTID: an integrated web resource and computational tool for agrochemical discovery.
|
Bioinformatics
|
2012
|
0.76
|
|
93
|
In situ visualization and detection of protein sulfenylation responses in living cells through a dimedone-based fluorescent probe.
|
Org Biomol Chem
|
2013
|
0.76
|
|
94
|
Highly selective and sensitive near-infrared fluorescent sensors for cadmium in aqueous solution.
|
Org Lett
|
2010
|
0.76
|
|
95
|
Study on the interaction between 4-(2-diethylamino-ethylamino)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile and DNA by molecular spectra.
|
Int J Biol Macromol
|
2006
|
0.76
|
|
96
|
A thioether-rich crown-based highly selective fluorescent sensor for Hg(2+) and Ag(+) in aqueous solution.
|
Dalton Trans
|
2009
|
0.76
|
|
97
|
Versatile probes for the selective detection of vicinal-dithiol-containing proteins: design, synthesis, and application in living cells.
|
Chemistry
|
2013
|
0.76
|
|
98
|
A simple assay for the fluorometric detection of lithium ions in aqueous solution.
|
Chemistry
|
2010
|
0.76
|
|
99
|
New artificial fluoro-cofactor of hydride transfer with novel fluorescence assay for redox biocatalysis.
|
Chem Commun (Camb)
|
2016
|
0.76
|
|
100
|
Synthesis, antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains.
|
Bioorg Med Chem Lett
|
2005
|
0.76
|
|
101
|
A turn-on fluorescent probe for tumor hypoxia imaging in living cells.
|
Chem Commun (Camb)
|
2015
|
0.76
|
|
102
|
A modeling study for structure features of β-N-acetyl-D-hexosaminidase from Ostrinia furnacalis and its novel inhibitor allosamidin: species selectivity and multi-target characteristics.
|
Chem Biol Drug Des
|
2012
|
0.76
|
|
103
|
Advanced research on cis-Neonicotinoids.
|
Chimia (Aarau)
|
2011
|
0.76
|
|
104
|
B1, a novel naphthalimide-based DNA intercalator, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation.
|
Invest New Drugs
|
2010
|
0.76
|
|
105
|
Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: various DNA binding geometry and interesting antitumor capacity.
|
Bioorg Med Chem
|
2006
|
0.76
|
|
106
|
Novel chemically synthesized salicylate derivative as an effective elicitor for inducing the biosynthesis of plant secondary metabolites.
|
Biotechnol Prog
|
2006
|
0.75
|
|
107
|
Short and scalable synthesis of an anhydride precursor of the environment-sensitive fluorophore 6-dimethylaminonaphthalimide.
|
Nat Protoc
|
2011
|
0.75
|
|
108
|
DNA double helix unwinding triggers transcription block-dependent apoptosis: a semiquantitative probe of the response of ATM, RNAPII, and p53 to two DNA intercalators.
|
Chem Res Toxicol
|
2009
|
0.75
|
|
109
|
Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.
|
Eur J Med Chem
|
2013
|
0.75
|
|
110
|
Fluorescent imaging of acute mercuric chloride exposure on cultured human kidney tubular epithelial cells.
|
Kidney Int
|
2004
|
0.75
|
|
111
|
Selective and sensitive chromo- and fluorogenic dual detection of anionic surfactants in water based on a pair of "on-off-on" fluorescent sensors.
|
Chemistry
|
2009
|
0.75
|
|
112
|
Novel dimer based descriptors with solvational computation for QSAR study of oxadiazoylbenzoyl-ureas as novel insect-growth regulators.
|
J Comput Chem
|
2010
|
0.75
|
|
113
|
Practical assay for nitrite and nitrosothiol as an alternative to the Griess assay or the 2,3-diaminonaphthalene assay.
|
Anal Chem
|
2014
|
0.75
|
|
114
|
5-Non-amino aromatic substituted naphthalimides as potential antitumor agents: Synthesis via Suzuki reaction, antiproliferative activity, and DNA-binding behavior.
|
Bioorg Med Chem
|
2010
|
0.75
|
|
115
|
Highly chemoselective reduction of aromatic nitro compounds to the corresponding hydroxylamines catalysed by plant cells from a grape (Vitis vinifera L.).
|
Chem Commun (Camb)
|
2005
|
0.75
|
|
116
|
Novel angular furoquinolinones bearing flexible chain as antitumor agent: design, synthesis, cytotoxic evaluation, and DNA-binding studies.
|
Bioorg Med Chem
|
2008
|
0.75
|
|
117
|
Discovery of a novel family of polycyclic aromatic molecules with unique reactivity and members valuable for fluorescent sensing and medicinal chemistry.
|
Chem Commun (Camb)
|
2015
|
0.75
|
|
118
|
Novel 2-aminothiazonaphthalimides as visible light activatable photonucleases: effects of intercalation, heterocyclic-fused area and side chains.
|
Bioorg Med Chem Lett
|
2005
|
0.75
|
|
119
|
Multiple molecular logic functions and molecular calculations facilitated by surfactant's versatility.
|
Chem Commun (Camb)
|
2008
|
0.75
|
|
120
|
Recent progress of highly efficient in vivo biological screening for novel agrochemicals in China.
|
Pest Manag Sci
|
2010
|
0.75
|
|
121
|
A fluorescent sensor for pyrophosphate based on a Pd(II) complex.
|
Dalton Trans
|
2010
|
0.75
|
|
122
|
Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells.
|
Bioorg Med Chem
|
2008
|
0.75
|
|
123
|
7b, a novel amonafide analog, inhibited proliferation and phorbol 12-myristate 13-acetate/phytohemagglutinin-induced inflammatory responses of Jurkat T cells via p73-dependent pathway and decrease of nuclear factor-κB DNA-binding, respectively.
|
Leuk Lymphoma
|
2012
|
0.75
|
|
124
|
Novel antitumor agent family of 1H-benzo[c,d]indol-2-one with flexible basic side chains: synthesis and biological evaluation.
|
Bioorg Med Chem
|
2006
|
0.75
|
|
125
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