Published in Aging Cell on January 15, 2008
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell (2009) 3.16
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell (2009) 2.79
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
A genome-wide association study of aging. Neurobiol Aging (2011) 1.54
New model of health promotion and disease prevention for the 21st century. BMJ (2008) 1.53
GSK-3α is a central regulator of age-related pathologies in mice. J Clin Invest (2013) 1.25
Dietary interventions to extend life span and health span based on calorie restriction. J Gerontol A Biol Sci Med Sci (2010) 1.23
Human insulin/IGF-1 and familial longevity at middle age. Aging (Albany NY) (2009) 1.16
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. Exp Gerontol (2012) 1.10
Quantitative physiology of Saccharomyces cerevisiae at near-zero specific growth rates. Appl Environ Microbiol (2009) 1.09
Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell (2010) 1.04
Epigenetic control of aging. Antioxid Redox Signal (2010) 1.02
Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context. Mech Ageing Dev (2010) 0.92
Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study. Aging (Albany NY) (2011) 0.91
Inter-chromosomal level of genome organization and longevity-related phenotypes in humans. Age (Dordr) (2012) 0.90
Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity. Int J Mol Sci (2013) 0.89
Mutation and the evolution of ageing: from biometrics to system genetics. Philos Trans R Soc Lond B Biol Sci (2010) 0.87
Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic. BMC Neurosci (2014) 0.84
Mitochondrial polymorphisms are associated both with increased and decreased longevity. Hum Hered (2008) 0.83
Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations. Rejuvenation Res (2013) 0.83
The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway. Evol Bioinform Online (2013) 0.81
Zinc-gene interaction related to inflammatory/immune response in ageing. Genes Nutr (2008) 0.79
The szilard hypothesis on the nature of aging revisited. Genetics (2009) 0.79
Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis. Eur J Hum Genet (2014) 0.79
Exome sequencing of three cases of familial exceptional longevity. Aging Cell (2014) 0.78
Longevity candidate genes and their association with personality traits in the elderly. Am J Med Genet B Neuropsychiatr Genet (2011) 0.78
Association of heat shock proteins with all-cause mortality. Age (Dordr) (2012) 0.78
Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies. PLoS One (2015) 0.77
Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children. J Gerontol A Biol Sci Med Sci (2012) 0.77
Gene activation regresses atherosclerosis, promotes health, and enhances longevity. Lipids Health Dis (2010) 0.77
The decay of stem cell nourishment at the niche. Rejuvenation Res (2013) 0.76
Postmyocardial infarct remodeling and heart failure: potential contributions from pro- and antiaging factors. Cardiol Res Pract (2011) 0.76
GiSAO.db: a database for ageing research. BMC Genomics (2011) 0.75
Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice. Aging (Albany NY) (2016) 0.75
Insulin-like growth factor-1 and insulin-like growth factor binding protein 3 and risk of postoperative cognitive dysfunction. Springerplus (2015) 0.75
Has gene duplication impacted the evolution of Eutherian longevity? Aging Cell (2016) 0.75
Immune aging and challenges for immune protection of the graying population. Aging Dis (2011) 0.75
Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging. Front Immunol (2016) 0.75
Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. Braz J Med Biol Res (2016) 0.75
Physiological underpinnings in life-history trade-offs in man's most popular selection experiment: the dog. J Comp Physiol B (2016) 0.75
Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet (2002) 17.19
Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A (2008) 8.39
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Thyroid status, disability and cognitive function, and survival in old age. JAMA (2004) 5.39
Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA (2010) 5.20
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet (2009) 4.25
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Measuring cognitive function with age: the influence of selection by health and survival. Epidemiology (2008) 3.19
Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet (2007) 3.06
Telomere length predicts survival independent of genetic influences. Aging Cell (2007) 3.01
Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study. Arch Intern Med (2008) 2.90
Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet (2006) 2.89
Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell (2005) 2.83
Predicting survival in oldest old people. Am J Med (2012) 2.81
Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol (2005) 2.81
Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. FASEB J (2010) 2.74
Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol (2002) 2.57
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell (2011) 2.37
Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip. Arthritis Rheum (2004) 2.33
Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. J Am Geriatr Soc (2009) 2.30
External validity of a trial comprised of elderly patients with hormone receptor-positive breast cancer. J Natl Cancer Inst (2014) 2.26
Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med (2012) 2.24
Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One (2009) 2.23
Reduced insulin/IGF-1 signalling and human longevity. Aging Cell (2005) 2.13
Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study. CMAJ (2009) 2.11
Framingham stroke risk score and cognitive impairment for predicting first-time stroke in the oldest old. Stroke (2013) 2.10
In a population-based prospective study, no association between high blood pressure and mortality after age 85 years. J Hypertens (2006) 2.04
Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study. CMAJ (2010) 2.03
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. Arthritis Rheum (2006) 2.00
Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer. JAMA (2012) 2.00
PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data. Bioinformatics (2012) 1.95
Systemic markers of inflammation and cognitive decline in old age. J Am Geriatr Soc (2007) 1.91
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet (2008) 1.91
The continuing value of twin studies in the omics era. Nat Rev Genet (2012) 1.88
Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet (2009) 1.87
Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. Eur J Hum Genet (2007) 1.85
The epigenome: archive of the prenatal environment. Epigenetics (2009) 1.82
Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old. Age Ageing (2010) 1.79
Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Circulation (2012) 1.79
Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study. Diabetes (2002) 1.75
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (2010) 1.75
Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet (2013) 1.72
High blood pressure and resilience to physical and cognitive decline in the oldest old: the Leiden 85-plus Study. J Am Geriatr Soc (2012) 1.70
Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study. J Gerontol A Biol Sci Med Sci (2009) 1.70
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Ann Rheum Dis (2012) 1.66
Serum calcium and cognitive function in old age. J Am Geriatr Soc (2007) 1.66
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. J Gerontol A Biol Sci Med Sci (2010) 1.65
The Netherlands Twin Register biobank: a resource for genetic epidemiological studies. Twin Res Hum Genet (2010) 1.65
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array. Epigenetics Chromatin (2013) 1.62
Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age. Exp Gerontol (2007) 1.62
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity. Proc Natl Acad Sci U S A (2010) 1.60
Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet (2008) 1.60
Adipocytokines and risk of stroke in older people: a nested case-control study. Int J Epidemiol (2008) 1.59
The inverse relationship between alanine aminotransferase in the normal range and adverse cardiovascular and non-cardiovascular outcomes. Int J Epidemiol (2011) 1.58
What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? Mech Ageing Dev (2005) 1.57
Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell (2012) 1.55
Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events? PLoS Med (2009) 1.54
Predictive value of a profile of routine blood measurements on mortality in older persons in the general population: the Leiden 85-plus Study. PLoS One (2013) 1.53
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. PLoS Genet (2013) 1.52
Heritabilities of apolipoprotein and lipid levels in three countries. Twin Res (2002) 1.50
Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population. Clin Nutr (2011) 1.50
The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection. Twin Res Hum Genet (2013) 1.49
Old age mortality and macroeconomic cycles. J Epidemiol Community Health (2013) 1.48
Pravastatin and cognitive function in the elderly. Results of the PROSPER study. J Neurol (2009) 1.47
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol (2014) 1.45
Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. Diabetes (2009) 1.44
C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Circulation (2007) 1.43
Cooler butterflies lay larger eggs: developmental plasticity versus acclimation. Proc Biol Sci (2003) 1.43