Published in Am J Hum Genet on January 24, 2008
Testing for an unusual distribution of rare variants. PLoS Genet (2011) 9.28
New approaches to population stratification in genome-wide association studies. Nat Rev Genet (2010) 7.97
Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies. Am J Hum Genet (2009) 5.65
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. Am J Hum Genet (2008) 4.79
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Lancet Neurol (2010) 4.19
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet (2009) 3.65
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Genome-wide association study of alcohol dependence. Arch Gen Psychiatry (2009) 3.08
Discovering genetic ancestry using spectral graph theory. Genet Epidemiol (2010) 3.03
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nat Genet (2011) 2.97
ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure. Am J Hum Genet (2010) 2.92
Screen and clean: a tool for identifying interactions in genome-wide association studies. Genet Epidemiol (2010) 2.70
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med (2010) 2.47
Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet (2011) 2.10
Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet (2008) 1.90
Replication in genome-wide association studies. Stat Sci (2009) 1.89
Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies. Annu Rev Public Health (2010) 1.88
Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies. Genet Epidemiol (2009) 1.76
Genome-wide association studies and beyond. Annu Rev Public Health (2010) 1.73
Quantifying missing heritability at known GWAS loci. PLoS Genet (2013) 1.55
Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1. Biol Psychiatry (2015) 1.44
Using principal components of genetic variation for robust and powerful detection of gene-gene interactions in case-control and case-only studies. Am J Hum Genet (2010) 1.41
A comparison of association methods correcting for population stratification in case-control studies. Ann Hum Genet (2011) 1.40
Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. J Invest Dermatol (2009) 1.14
Identifying modifier genes of monogenic disease: strategies and difficulties. Hum Genet (2008) 1.13
Clustering by genetic ancestry using genome-wide SNP data. BMC Genet (2010) 1.12
Overview of techniques to account for confounding due to population stratification and cryptic relatedness in genomic data association analyses. Heredity (Edinb) (2010) 1.11
Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies. Stat Med (2010) 1.11
Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One (2012) 1.11
Sparse principal component analysis for identifying ancestry-informative markers in genome-wide association studies. Genet Epidemiol (2012) 1.10
On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls. Am J Hum Genet (2010) 1.09
Correcting population stratification in genetic association studies using a phylogenetic approach. Bioinformatics (2010) 1.08
Straightforward inference of ancestry and admixture proportions through ancestry-informative insertion deletion multiplexing. PLoS One (2012) 1.08
A population genetic approach to mapping neurological disorder genes using deep resequencing. PLoS Genet (2011) 1.07
Artifact due to differential error when cases and controls are imputed from different platforms. Hum Genet (2011) 1.06
Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat Neurosci (2016) 1.00
A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes. J Allergy Clin Immunol (2014) 0.97
A SPECTRAL GRAPH APPROACH TO DISCOVERING GENETIC ANCESTRY. Ann Appl Stat (2010) 0.94
Control of population stratification by correlation-selected principal components. Biometrics (2010) 0.94
Exploring genetic susceptibility to cancer in diverse populations. Curr Opin Genet Dev (2010) 0.93
Rare and low frequency variant stratification in the UK population: description and impact on association tests. PLoS One (2012) 0.91
Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. Orphanet J Rare Dis (2011) 0.91
Iterative pruning PCA improves resolution of highly structured populations. BMC Bioinformatics (2009) 0.91
Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One (2013) 0.91
No association of psychosis in Alzheimer disease with neurodegenerative pathway genes. Neurobiol Aging (2010) 0.90
β cell ER stress and the implications for immunogenicity in type 1 diabetes. Front Cell Dev Biol (2015) 0.90
Searching for disease susceptibility variants in structured populations. Genomics (2008) 0.86
Application of genetic/genomic approaches to allergic disorders. J Allergy Clin Immunol (2010) 0.86
Linkage analysis of schizophrenia in African-American families. Schizophr Res (2009) 0.86
Stratification-score matching improves correction for confounding by population stratification in case-control association studies. Genet Epidemiol (2012) 0.85
Using public control genotype data to increase power and decrease cost of case-control genetic association studies. Hum Genet (2010) 0.83
The potential for enhancing the power of genetic association studies in African Americans through the reuse of existing genotype data. PLoS Genet (2010) 0.83
Adjusting for population stratification in a fine scale with principal components and sequencing data. Genet Epidemiol (2013) 0.83
A genome-wide analysis of populations from European Russia reveals a new pole of genetic diversity in northern Europe. PLoS One (2013) 0.83
Insight into the peopling of Mainland Southeast Asia from Thai population genetic structure. PLoS One (2013) 0.82
Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Med Genet (2010) 0.81
Association of SERPINE2 with asthma. Chest (2011) 0.81
An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population. Eur J Hum Genet (2009) 0.80
A phylogeny-based sampling strategy and power calculator informs genome-wide associations study design for microbial pathogens. Genome Med (2014) 0.79
Genetics in psychiatry: common variant association studies. Mol Autism (2010) 0.78
KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. Addict Biol (2015) 0.78
Analyzing genetic association studies with an extended propensity score approach. Stat Appl Genet Mol Biol (2012) 0.78
A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies. Am J Hum Genet (2016) 0.78
Genome-wide association study of sporadic brain arteriovenous malformations. J Neurol Neurosurg Psychiatry (2016) 0.76
Novel genetic matching methods for handling population stratification in genome-wide association studies. BMC Bioinformatics (2015) 0.75
On association analysis of rare variants under population substructure: an approach for the detection of subjects that can cause bias in the analysis--T opt: an outlier detection method. Genet Epidemiol (2013) 0.75
Environmental Factors Contribute to β Cell Endoplasmic Reticulum Stress and Neo-Antigen Formation in Type 1 Diabetes. Front Endocrinol (Lausanne) (2017) 0.75
Inference of population structure using multilocus genotype data. Genetics (2000) 147.76
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Genomic control for association studies. Biometrics (1999) 64.39
A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
Population structure and eigenanalysis. PLoS Genet (2006) 37.21
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
A method for quantifying differentiation between populations at multi-allelic loci and its implications for investigating identity and paternity. Genetica (1995) 18.06
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature (1987) 10.70
A genotype calling algorithm for affymetrix SNP arrays. Bioinformatics (2005) 10.43
KORA-gen--resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen (2005) 7.93
Clines, clusters, and the effect of study design on the inference of human population structure. PLoS Genet (2005) 6.73
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature (2007) 6.10
The power of genomic control. Am J Hum Genet (2000) 4.99
PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships. Community Genet (2006) 4.72
On a semiparametric test to detect associations between quantitative traits and candidate genes using unrelated individuals. Genet Epidemiol (2003) 4.67
Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes (2003) 4.44
A simple and improved correction for population stratification in case-control studies. Am J Hum Genet (2007) 4.29
Optimal designs for two-stage genome-wide association studies. Genet Epidemiol (2007) 4.22
Genomic Control to the extreme. Nat Genet (2004) 4.19
Optimal two-stage genotyping designs for genome-wide association scans. Genet Epidemiol (2006) 3.41
Matching strategies for genetic association studies in structured populations. Am J Hum Genet (2004) 3.13
Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes. J Am Soc Nephrol (2006) 3.12
Characterization of multilocus linkage disequilibrium. Genet Epidemiol (2005) 3.03
SNP-based analysis of genetic substructure in the German population. Hum Hered (2006) 2.21
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proc Natl Acad Sci U S A (1988) 2.19
The MONICA Augsburg surveys--basis for prospective cohort studies. Gesundheitswesen (2005) 1.76
Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain. Proc Natl Acad Sci U S A (1990) 1.13
Case-control association studies with matching and genomic controlling. Genet Epidemiol (2004) 1.00
Pyrosequencing-based strategies for improved allele typing of human leukocyte antigen loci. Methods Mol Biol (2007) 0.87
Rehabilitation of adaptive immunity and regeneration of beta cells. Trends Biotechnol (2006) 0.86
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet (2008) 15.51
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71
De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature (2012) 13.61
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Human Gene Mutation Database (HGMD): 2003 update. Hum Mutat (2003) 12.88
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron (2011) 10.61
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol (2005) 10.16
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature (2009) 9.47
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Testing for an unusual distribution of rare variants. PLoS Genet (2011) 9.28
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Mucosal flora in inflammatory bowel disease. Gastroenterology (2002) 8.42
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet (2008) 6.97
Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology (2006) 6.88
The yeast cell-cycle network is robustly designed. Proc Natl Acad Sci U S A (2004) 6.76
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet (2008) 6.75
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet (2006) 6.39
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet (2008) 6.26
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy. Nat Genet (2009) 6.21
Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial. Gut (2011) 6.08
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med (2005) 5.36
Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30