MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2.

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Published in Leukemia on February 14, 2008

Authors

L Gu1, N Zhu, H W Findley, M Zhou

Author Affiliations

1: Division of Hematology/Oncology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

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Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation. Neuron (1994) 3.67

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Sodium channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro. Proc Natl Acad Sci U S A (1994) 2.45

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Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science (2000) 2.29

Two EGF molecules contribute additively to stabilization of the EGFR dimer. EMBO J (1997) 2.16

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Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal. Proc Natl Acad Sci U S A (1995) 2.08

Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J Biol Chem (1992) 2.08

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nat Neurosci (1999) 1.93

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Nonlinear theory for relativistic plasma wakefields in the blowout regime. Phys Rev Lett (2006) 1.30

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The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology. Structure (1997) 1.25

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Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood (2001) 1.21

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Lipid peroxides induce expression of catalase in cultured vascular cells. J Lipid Res (2000) 1.16

Crystal structure of bovine low molecular weight phosphotyrosyl phosphatase complexed with the transition state analog vanadate. Biochemistry (1997) 1.15

Recombinant nucleocapsid protein is potentially an inexpensive, effective serodiagnostic reagent for infectious bronchitis virus. J Virol Methods (1998) 1.15

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Ageing alters the myosin heavy chain composition of single fibres from human skeletal muscle. Acta Physiol Scand (1990) 1.14

Kit receptor dimerization is driven by bivalent binding of stem cell factor. J Biol Chem (1997) 1.14

Novel activity of a phycobiliprotein lyase: both the attachment of phycocyanobilin and the isomerization to phycoviolobilin are catalyzed by the proteins PecE and PecF encoded by the phycoerythrocyanin operon. FEBS Lett (2000) 1.12

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Hormonal control of protein expression and mRNA levels of the MaxiK channel alpha subunit in myometrium. FEBS Lett (1999) 1.11

Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence. Proc Natl Acad Sci U S A (1998) 1.11

Dual role of fibronectin in hematopoietic differentiation. Blood (1989) 1.11

Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues. Biochemistry (1998) 1.10

Chromophore attachment to biliproteins: specificity of PecE/PecF, a lyase-isomerase for the photoactive 3(1)-cys-alpha 84-phycoviolobilin chromophore of phycoerythrocyanin. Biochemistry (2001) 1.10

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Release of the neuregulin functional polypeptide requires its cytoplasmic tail. J Biol Chem (1998) 1.07

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Cloning and sequence analysis of a protective M-like protein gene from Streptococcus equi subsp. zooepidemicus. Infect Immun (1995) 1.05

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Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2. J Biol Chem (1994) 1.03

Intracrine and autocrine effects of basic fibroblast growth factor in vascular smooth muscle cells. J Mol Cell Cardiol (1997) 1.02

Norepinephrine-induced hepatocellular dysfunction in early sepsis is mediated by activation of alpha2-adrenoceptors. Am J Physiol Gastrointest Liver Physiol (2001) 1.02

Effects of different antigenic microenvironments on the course of CD8+ T cell responses in vivo. Int Immunol (1996) 1.00

Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases. J Immunol (2001) 1.00

In vivo imaging of rat cortical bone porosity by synchrotron phase contrast micro computed tomography. Phys Med Biol (2014) 1.00

Improving return rates for health-care outcome. Psychol Rep (2000) 0.99

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Magnet used for protein crystallization: novel attempts to improve the crystal quality. Biochem Biophys Res Commun (2000) 0.99

The tax protein from the primate T-cell lymphotropic virus type 3 is expressed in vivo and is functionally related to HTLV-1 Tax rather than HTLV-2 Tax. Oncogene (2006) 0.99

Antidiabetic effects of 11beta-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis. Diabetes Obes Metab (2009) 0.98

Congenital fistula of the palate. J Craniomaxillofac Surg (1998) 0.98

In vitro selection of sequence contexts which enhance bypass of abasic sites and tetrahydrofuran by T4 DNA polymerase holoenzyme. J Mol Biol (1999) 0.97

A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis. J Immunol (1995) 0.97

A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation. J Biol Chem (1998) 0.97