Published in J Virol on February 20, 2008
Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol (2014) 2.71
Innate immune control and regulation of influenza virus infections. J Leukoc Biol (2009) 1.92
Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice. J Virol (2010) 1.63
MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis. Am J Respir Cell Mol Biol (2009) 1.43
Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses. J Virol (2011) 1.40
Towards a quantitative understanding of the within-host dynamics of influenza A infections. J R Soc Interface (2009) 1.40
Alveolar macrophages are essential for protection from respiratory failure and associated morbidity following influenza virus infection. PLoS Pathog (2014) 1.27
Influenza A virus infection kinetics: quantitative data and models. Wiley Interdiscip Rev Syst Biol Med (2010) 1.18
MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcome. Am J Respir Cell Mol Biol (2011) 1.11
Innate immune response of human alveolar macrophages during influenza A infection. PLoS One (2012) 1.10
Evasion of influenza A viruses from innate and adaptive immune responses. Viruses (2012) 1.06
Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs. J Gen Virol (2011) 1.04
Innate immunity to influenza virus: implications for future therapy. Expert Rev Clin Immunol (2008) 0.99
Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence. PLoS One (2012) 0.99
The hemagglutinin protein of highly pathogenic H5N1 influenza viruses overcomes an early block in the replication cycle to promote productive replication in macrophages. J Virol (2012) 0.94
β-Glucan derived from Aureobasidium pullulans is effective for the prevention of influenza in mice. PLoS One (2012) 0.92
Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity. PLoS One (2011) 0.92
NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein. Proc Natl Acad Sci U S A (2014) 0.90
Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus. PLoS One (2012) 0.89
Strain-dependent effects of PB1-F2 of triple-reassortant H3N2 influenza viruses in swine. J Gen Virol (2012) 0.89
Evaluation of suitable reference genes for gene expression studies in porcine alveolar macrophages in response to LPS and LTA. BMC Res Notes (2012) 0.88
Phenotypic differences in virulence and immune response in closely related clinical isolates of influenza A 2009 H1N1 pandemic viruses in mice. PLoS One (2013) 0.88
Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression. Respir Res (2013) 0.87
MHV68 latency modulates the host immune response to influenza A virus. Inflammation (2013) 0.87
The macrophage galactose-type lectin can function as an attachment and entry receptor for influenza virus. J Virol (2013) 0.86
Epithelial cells, the "switchboard" of respiratory immune defense responses: effects of air pollutants. Swiss Med Wkly (2012) 0.86
Influenza A Virus Panhandle Structure Is Directly Involved in RIG-I Activation and Interferon Induction. J Virol (2015) 0.84
Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages. PLoS One (2014) 0.83
Evasion of natural killer cells by influenza virus. J Leukoc Biol (2010) 0.83
Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection. PLoS Pathog (2015) 0.83
Innate immune sensing and response to influenza. Curr Top Microbiol Immunol (2015) 0.82
Induction of innate immunity and its perturbation by influenza viruses. Protein Cell (2015) 0.82
Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress. PLoS One (2013) 0.81
Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. J Clin Invest (2016) 0.80
PB1-F2 Protein Does Not Impact the Virulence of Triple-Reassortant H3N2 Swine Influenza Virus in Pigs but Alters Pathogenicity and Transmission in Turkeys. J Virol (2015) 0.79
PI3K/Akt signaling pathway modulates influenza virus induced mouse alveolar macrophage polarization to M1/M2b. PLoS One (2014) 0.79
Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle. J Virol (2015) 0.78
Drug Trafficking into Macrophages via the Endocytotic Receptor CD163. Membranes (Basel) (2015) 0.78
Monoclonal antibody specific to HA2 glycopeptide protects mice from H3N2 influenza virus infection. Vet Res (2015) 0.78
Activation of human macrophages by bacterial components relieves the restriction on replication of an interferon-inducing parainfluenza virus 5 (PIV5) P/V mutant. Microbes Infect (2010) 0.77
Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation. Sci Rep (2015) 0.77
Depletion of Alveolar Macrophages Does Not Prevent Hantavirus Disease Pathogenesis in Golden Syrian Hamsters. J Virol (2016) 0.76
Transcriptomic and Epigenetic Profiling of the Lung of Influenza-Infected Pigs: A Comparison of Different Birth Weight and Susceptibility Groups. PLoS One (2015) 0.76
Lethal influenza infection: Is a macrophage to blame? Expert Rev Anti Infect Ther (2015) 0.76
Airborne Influenza A Is Detected in the Personal Breathing Zone of Swine Veterinarians. PLoS One (2016) 0.75
IL-6 ameliorates acute lung injury in influenza virus infection. Sci Rep (2017) 0.75
Viral and bacterial co-infection in severe pneumonia triggers innate immune responses and specifically enhances IP-10: a translational study. Sci Rep (2016) 0.75
Mumps virus inhibits migration of primary human macrophages toward a chemokine gradient through a TNF-alpha dependent mechanism. Virology (2012) 0.75
The effects of H3N2 swine influenza virus infection on TLRs and RLRs signaling pathways in porcine alveolar macrophages. Virol J (2015) 0.75
Influenza and Memory T Cells: How to Awake the Force. Vaccines (Basel) (2016) 0.75
Clodronate treatment significantly depletes macrophages in chickens. Can J Vet Res (2014) 0.75
Lanthionine Synthetase C-Like 2 Modulates Immune Responses to Influenza Virus Infection. Front Immunol (2017) 0.75
Alveolar Macrophages Prevent Lethal Influenza Pneumonia By Inhibiting Infection Of Type-1 Alveolar Epithelial Cells. PLoS Pathog (2017) 0.75
Immune Responses to Influenza Virus and Its Correlation to Age and Inherited Factors. Front Microbiol (2016) 0.75
Increased Plasmodium falciparum Parasitemia in Non-splenectomized Saimiri sciureus Monkeys Treated with Clodronate Liposomes. Front Cell Infect Microbiol (2017) 0.75
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. Nat Commun (2017) 0.75
Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63
Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods (1994) 13.53
On the origin of the human influenza virus subtypes H2N2 and H3N2. Virology (1978) 9.02
Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet (2002) 8.70
Molecular basis for the generation in pigs of influenza A viruses with pandemic potential. J Virol (1998) 8.44
The impact of influenza epidemics on mortality: introducing a severity index. Am J Public Health (1997) 7.81
Virus-specific CD8+ T cells in primary and secondary influenza pneumonia. Immunity (1998) 5.98
The nucleoprotein as a possible major factor in determining host specificity of influenza H3N2 viruses. Virology (1985) 5.65
Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals. Am J Pathol (2007) 4.86
Potential for transmission of avian influenza viruses to pigs. J Gen Virol (1994) 4.24
Replication of avian influenza A viruses in mammals. Infect Immun (1981) 3.69
Role of the B-cell response in recovery of mice from primary influenza virus infection. Immunol Rev (1997) 3.20
Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice. J Exp Med (1989) 3.01
Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol (1996) 2.96
The liposome-mediated macrophage 'suicide' technique. J Immunol Methods (1989) 2.73
Inflammatory responses in influenza A virus infection. Vaccine (2000) 2.21
Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection. J Immunol (2005) 2.13
The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype. J Virol (2002) 2.05
Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease. Drugs (1991) 1.69
Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs. immunity. Eur J Immunol (1991) 1.59
Susceptibility of mononuclear phagocytes to influenza A virus infection and possible role in the antiviral response. J Leukoc Biol (1997) 1.51
Alveolar macrophage in the driver's seat. Immunity (2006) 1.51
Alveolar macrophages regulate the induction of primary cytotoxic T-lymphocyte responses during influenza virus infection. J Virol (1997) 1.32
Regulation of T-cell function in lung tissue by pulmonary alveolar macrophages. Immunology (1993) 1.27
Influenza: pathogenesis and host defense. Semin Respir Infect (1992) 1.27
No apoptotic deaths and different levels of inductions of inflammatory cytokines in alveolar macrophages infected with influenza viruses. Virology (2004) 1.26
Role of free radicals in viral pathogenesis and mutation. Rev Med Virol (2001) 1.14
IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy. J Immunol (2007) 1.13
Interleukin-10 plays an early role in generating virus-specific T cell anergy. BMC Immunol (2007) 1.11
High interleukin-10 production is associated with low antibody response to influenza vaccination in the elderly. J Leukoc Biol (2006) 1.01
Immunoregulatory functions of human alveolar macrophages. Am Rev Respir Dis (1987) 0.97
Mucosal immunoadjuvant activity of liposomes: role of alveolar macrophages. Immunology (1996) 0.80
Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature (2009) 17.96
Oseltamivir resistance during treatment of influenza A (H5N1) infection. N Engl J Med (2005) 15.53
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 14.21
Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol (2005) 9.13
Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. J Mol Biol (2003) 9.09
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest (2007) 9.09
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science (2011) 8.53
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med (2007) 7.87
Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS One (2008) 6.98
Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev (2007) 6.38
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity (2013) 5.47
Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol (2005) 5.40
Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia. Lancet (2004) 5.32
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell (2009) 5.30
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell (2009) 5.22
Reemerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks. J Virol (2004) 5.17
Three Indonesian clusters of H5N1 virus infection in 2005. N Engl J Med (2006) 5.14
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell (2007) 5.09
Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late 2002. Avian Pathol (2004) 5.08
Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003. J Clin Microbiol (2005) 5.04
Lung pathology of fatal severe acute respiratory syndrome. Lancet (2003) 5.02
Adenovirus serotype 5 hexon mediates liver gene transfer. Cell (2008) 5.00
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature (2007) 4.88
Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A (2009) 4.36
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol (2009) 4.28
Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med (2013) 4.14
Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans. J Clin Virol (2009) 4.10
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med (2009) 4.07
Rapid diagnosis of a coronavirus associated with severe acute respiratory syndrome (SARS). Clin Chem (2003) 4.03
Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science (2008) 3.97
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med (2011) 3.88
Sensitive and inexpensive molecular test for falciparum malaria: detecting Plasmodium falciparum DNA directly from heat-treated blood by loop-mediated isothermal amplification. Clin Chem (2005) 3.75
Gain-of-function experiments on H7N9. Science (2013) 3.67
Children with respiratory disease associated with metapneumovirus in Hong Kong. Emerg Infect Dis (2003) 3.66
MERS coronaviruses in dromedary camels, Egypt. Emerg Infect Dis (2014) 3.64
The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature (2013) 3.60
H5N1 outbreaks and enzootic influenza. Emerg Infect Dis (2006) 3.49
Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery. J Exp Med (2006) 3.43
Microglia promote the death of developing Purkinje cells. Neuron (2004) 3.42
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol (2009) 3.41
Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus. Emerg Infect Dis (2013) 3.35
Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. Am J Respir Crit Care Med (2002) 3.27
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood (2010) 3.26
Macrophage depletion inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci (2003) 3.17
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J (2005) 3.14
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab (2010) 3.11
Influenza-associated hospitalization in a subtropical city. PLoS Med (2006) 3.07
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol (2007) 3.06
Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations. J Immunol (2008) 3.04
Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res (2010) 2.99
Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China. J Virol (2002) 2.97
Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice. Am J Pathol (2007) 2.84
Distribution of amantadine-resistant H5N1 avian influenza variants in Asia. J Infect Dis (2006) 2.76
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Am J Pathol (2006) 2.70
Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med (2004) 2.68
Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Immunity (2006) 2.62
Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity (2013) 2.61
Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis. Am J Pathol (2011) 2.57
Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004. J Virol (2005) 2.56
Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood (2009) 2.55
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A (2012) 2.54
Treatment with convalescent plasma for influenza A (H5N1) infection. N Engl J Med (2007) 2.53
Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. Hepatology (2010) 2.53
Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol (2011) 2.51
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J Exp Med (2006) 2.51
Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis. Hepatology (2010) 2.48
MERS coronavirus in dromedary camel herd, Saudi Arabia. Emerg Infect Dis (2014) 2.47
Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses. Respir Res (2007) 2.45
Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation (2011) 2.45
Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia. J Infect Dis (2005) 2.43
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature (2012) 2.41
On the pathogenic role of brain-sequestered alphabeta CD8+ T cells in experimental cerebral malaria. J Immunol (2002) 2.40
Long-term evolution and transmission dynamics of swine influenza A virus. Nature (2011) 2.39
Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression. J Clin Invest (2011) 2.37
Human application of a metallic stent covered with a paclitaxel-incorporated membrane for malignant biliary obstruction: multicenter pilot study. Gastrointest Endosc (2007) 2.36
CCR2 promotes hepatic fibrosis in mice. Hepatology (2009) 2.35
Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell (2013) 2.35
Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses. Sci Transl Med (2012) 2.33
Avian flu: Gain-of-function experiments on H7N9. Nature (2013) 2.32
Influenza: emergence and control. J Virol (2004) 2.31
CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med (2013) 2.26
Pause on avian flu transmission research. Science (2012) 2.24
Dual roles for perivascular macrophages in immune-to-brain signaling. Neuron (2010) 2.24
Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. J Neurosci (2008) 2.20
Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell (2013) 2.19
The role of complement in the therapeutic activity of rituximab in a murine B lymphoma model homing in lymph nodes. Haematologica (2006) 2.19
Modulation of dendritic cell trafficking to and from the airways. J Immunol (2006) 2.17
Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP. Blood (2008) 2.16
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis. Am J Respir Crit Care Med (2011) 2.15
Evolutionary dynamics and emergence of panzootic H5N1 influenza viruses. PLoS Pathog (2008) 2.14
Serologic survey of pandemic (H1N1) 2009 virus, Guangxi Province, China. Emerg Infect Dis (2009) 2.13
Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus. J Virol (2010) 2.11
Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. J Immunol (2007) 2.09
Characterization of a human H5N1 influenza A virus isolated in 2003. J Virol (2005) 2.09
Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology (2008) 2.09
Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. Proc Natl Acad Sci U S A (2011) 2.06
Early diagnosis of SARS coronavirus infection by real time RT-PCR. J Clin Virol (2003) 2.05
Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets. Proc Natl Acad Sci U S A (2011) 2.04
Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest (2013) 2.04
Flow-dependent remodeling of small arteries in mice deficient for tissue-type transglutaminase: possible compensation by macrophage-derived factor XIII. Circ Res (2006) 2.03