Published in J Cell Physiol on August 01, 2008
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J Cell Biol (2009) 3.04
Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells. J Biol Chem (2011) 1.67
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. Pflugers Arch (2009) 1.19
TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle. J Biol Chem (2010) 1.10
NAADP receptors. Cold Spring Harb Perspect Biol (2011) 1.08
Lipid raft redox signaling: molecular mechanisms in health and disease. Antioxid Redox Signal (2011) 1.06
Identification of host factors involved in borna disease virus cell entry through a small interfering RNA functional genetic screen. J Virol (2010) 0.94
NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles. Am J Physiol Renal Physiol (2009) 0.94
VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling. Proc Natl Acad Sci U S A (2014) 0.91
The Molecular Basis for Ca(2+) Signalling by NAADP: Two-Pore Channels in a Complex? Messenger (Los Angel) (2012) 0.86
Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor. PLoS One (2014) 0.84
Cyclic ADP-Ribose and NAADP in Vascular Regulation and Diseases. Messenger (Los Angel) (2013) 0.78
Single protein molecule mapping with magnetic atomic force microscopy. Biophys J (2010) 0.77
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs. Cell (2002) 3.16
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes. Med Res Rev (2008) 2.02
Medicinal chemistry of combretastatin A4: present and future directions. J Med Chem (2006) 1.97
Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecol Oncol (2008) 1.79
Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. J Biol Chem (2006) 1.66
AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem (2004) 1.56
Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice. J Cell Biol (2009) 1.53
Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism. Carcinogenesis (2008) 1.48
c-Flip overexpression reduces cardiac hypertrophy in response to pressure overload. J Hypertens (2008) 1.48
In Vitro Validation of a Closed Device Enabling the Purification of the Fluid Portion of Liposuction Aspirates. Plast Reconstr Surg (2016) 1.39
Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis. J Cell Biol (2009) 1.36
Sperm deliver a new second messenger: NAADP. Curr Biol (2003) 1.33
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proc Natl Acad Sci U S A (2007) 1.25
RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. J Biol Chem (2011) 1.23
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. J Med Chem (2013) 1.22
An inflammatory pathway of IFN-gamma production in coronary atherosclerosis. J Immunol (2007) 1.19
Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. PLoS One (2012) 1.18
CD38/CD19: a lipid raft-dependent signaling complex in human B cells. Blood (2007) 1.11
Synthesis and cytotoxic evaluation of combretafurazans. J Med Chem (2005) 1.10
NAD depletion by FK866 induces autophagy. Autophagy (2008) 1.10
Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha. Neoplasia (2010) 1.07
Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. PLoS One (2010) 1.06
DPYD IVS14+1G>A and 2846A>T genotyping for the prediction of severe fluoropyrimidine-related toxicity: a meta-analysis. Pharmacogenomics (2013) 1.02
Emerging functions of extracellular pyridine nucleotides. Mol Med (2007) 0.98
TLR stimulation of prostate tumor cells induces chemokine-mediated recruitment of specific immune cell types. J Immunol (2010) 0.98
Characterization of NAD uptake in mammalian cells. J Biol Chem (2008) 0.97
Nicotinic acid adenine dinucleotide phosphate (NAADP) is present at micromolar concentrations in sea urchin spermatozoa. J Physiol (2002) 0.97
PKC/Raf/MEK/ERK signaling pathway modulates native-LDL-induced E2F-1 gene expression and endothelial cell proliferation. Cardiovasc Res (2003) 0.94
NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells. Blood (2011) 0.93
Toll-like receptor 3 activation induces antiviral immune responses in mouse sertoli cells. Biol Reprod (2008) 0.93
NAADP: an atypical Ca2+-release messenger? Trends Pharmacol Sci (2002) 0.93
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J Med Chem (2010) 0.93
Regulation of arterial-venous differences in tumor necrosis factor responsiveness of endothelial cells by anatomic context. Am J Pathol (2008) 0.92
SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis. J Nat Prod (2005) 0.92
Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARβ and tumor regression. Proc Natl Acad Sci U S A (2013) 0.92
The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation (2012) 0.91
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry. J Med Chem (2006) 0.91
A pivotal role for cADPR-mediated Ca2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cells. FASEB J (2002) 0.90
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents. J Med Chem (2006) 0.90
Common variants of GSTP1, GSTA1, and TGFβ1 are associated with the risk of radiation-induced fibrosis in breast cancer patients. Int J Radiat Oncol Biol Phys (2011) 0.89
Characterization of signaling pathways leading to Fas expression induced by TNF-alpha: pivotal role of NF-kappaB. FASEB J (2004) 0.89
The anti-metastatic agent imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate induces endothelial cell apoptosis by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway. Arch Biochem Biophys (2002) 0.89
Sertoli cells initiate testicular innate immune responses through TLR activation. J Immunol (2006) 0.89
PPADS is a reversible competitive antagonist of the NAADP receptor. Cell Calcium (2006) 0.89
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation. Bioorg Med Chem Lett (2010) 0.88
Plasma membrane microdomains regulate TACE-dependent TNFR1 shedding in human endothelial cells. J Cell Mol Med (2012) 0.88
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells. J Pharmacol Exp Ther (2011) 0.88
Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation. Eur J Biochem (2002) 0.87
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues. J Med Chem (2011) 0.87
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery. J Comb Chem (2008) 0.87
Calcineurin controls the expression of numerous genes in cerebellar granule cells. Mol Cell Neurosci (2003) 0.87
Common variants of eNOS and XRCC1 genes may predict acute skin toxicity in breast cancer patients receiving radiotherapy after breast conserving surgery. Radiother Oncol (2012) 0.87
Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent apoptosis. Apoptosis (2012) 0.86
Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate). Biochem J (2004) 0.86
Platelet-derived growth factor-BB-induced hypertrophy of peritubular smooth muscle cells is mediated by activation of p38 MAP-kinase and of Rho-kinase. J Cell Physiol (2006) 0.86
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. Eur J Med Chem (2012) 0.85
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. ChemMedChem (2008) 0.85
Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB. Glia (2013) 0.85
A concise synthesis of pyrazole analogues of combretastatin A1 as potent anti-tubulin agents. ChemMedChem (2013) 0.85
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry. Bioorg Med Chem (2007) 0.85
Impaired expression of genes coding for reactive oxygen species scavenging enzymes in testes of Mtfr1/Chppr-deficient mice. Reproduction (2007) 0.84
Diagnostic accuracy of HLA-B*57:01 screening for the prediction of abacavir hypersensitivity and clinical utility of the test: a meta-analytic review. Pharmacogenomics (2014) 0.84
Identification of novel antitubulin agents by using a virtual screening approach based on a 7-point pharmacophore model of the tubulin colchi-site. Chem Biol Drug Des (2011) 0.83
Mouse Sertoli cells display phenotypical and functional traits of antigen-presenting cells in response to interferon gamma. Biol Reprod (2007) 0.83
Effect of luminal and extravesicular Ca2+ on NAADP binding and release properties. Biochem Biophys Res Commun (2002) 0.83
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases. J Med Chem (2009) 0.83
Triazine dyes are agonists of the NAADP receptor. Br J Pharmacol (2004) 0.83
Aβ leads to Ca²⁺ signaling alterations and transcriptional changes in glial cells. Neurobiol Aging (2012) 0.83
The effect of CYP3A5 6986A>G and ABCB1 3435C>T on tacrolimus dose-adjusted trough levels and acute rejection rates in renal transplant patients: a systematic review and meta-analysis. Pharmacogenet Genomics (2012) 0.82
Expression profile of a 400-bp Stra8 promoter region during spermatogenesis. Microsc Res Tech (2009) 0.82