Published in Lancet Neurol on February 28, 2008
Echoplanar Imaging Thrombolysis Evaluation Trial (EPITHET) | NCT00238537
A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med (2013) 9.97
Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis. Lancet (2012) 4.66
Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol (2008) 3.98
Good clinical outcome after ischemic stroke with successful revascularization is time-dependent. Neurology (2009) 3.45
Real-time diffusion-perfusion mismatch analysis in acute stroke. J Magn Reson Imaging (2010) 3.03
Optimal Tmax threshold for predicting penumbral tissue in acute stroke. Stroke (2008) 2.57
ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes. Neurology (2009) 2.38
Refining the definition of the malignant profile: insights from the DEFUSE-EPITHET pooled data set. Stroke (2011) 2.03
Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev (2014) 1.76
Imaging recommendations for acute stroke and transient ischemic attack patients: A joint statement by the American Society of Neuroradiology, the American College of Radiology, and the Society of NeuroInterventional Surgery. AJNR Am J Neuroradiol (2013) 1.71
Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis. J Cereb Blood Flow Metab (2010) 1.68
The neurovascular unit and combination treatment strategies for stroke. Trends Pharmacol Sci (2012) 1.66
Acute stroke magnetic resonance imaging: current status and future perspective. Neuroradiology (2009) 1.59
Design and rationale of the Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy (MR RESCUE) Trial. Int J Stroke (2012) 1.55
Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials. Stroke (2009) 1.48
The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent. J Cereb Blood Flow Metab (2011) 1.47
Perfusion MRI (Tmax and MTT) correlation with xenon CT cerebral blood flow in stroke patients. Neurology (2009) 1.47
Greater effect of stroke thrombolysis in the presence of arterial obstruction. Ann Neurol (2011) 1.44
Multiparametric MRI and CT models of infarct core and favorable penumbral imaging patterns in acute ischemic stroke. Stroke (2012) 1.43
Perfusion computed tomography to assist decision making for stroke thrombolysis. Brain (2015) 1.41
The value of arterial spin-labeled perfusion imaging in acute ischemic stroke: comparison with dynamic susceptibility contrast-enhanced MRI. Stroke (2012) 1.40
Sensitivity to acute cerebral ischemic injury in migraineurs: A retrospective case-control study. Neurology (2015) 1.39
Failure of collateral blood flow is associated with infarct growth in ischemic stroke. J Cereb Blood Flow Metab (2013) 1.36
Heterogeneity in the penumbra. J Cereb Blood Flow Metab (2011) 1.33
MR mismatch profiles in patients with intracranial atherosclerotic stroke: a comprehensive approach comparing stroke subtypes. J Cereb Blood Flow Metab (2009) 1.20
Effect of collateral blood flow on patients undergoing endovascular therapy for acute ischemic stroke. Stroke (2014) 1.20
Imaging-based treatment selection for intravenous and intra-arterial stroke therapies: a comprehensive review. Expert Rev Cardiovasc Ther (2011) 1.14
Validating imaging biomarkers of cerebral edema in patients with severe ischemic stroke. J Stroke Cerebrovasc Dis (2012) 1.12
The role of the cerebral capillaries in acute ischemic stroke: the extended penumbra model. J Cereb Blood Flow Metab (2013) 1.12
Accuracy and reliability assessment of CT and MR perfusion analysis software using a digital phantom. Radiology (2012) 1.11
Defining an Acidosis-Based Ischemic Penumbra from pH-Weighted MRI. Transl Stroke Res (2011) 1.11
Imaging of acute stroke. Nat Rev Neurol (2010) 1.09
Endovascular therapy for ischemic stroke. J Clin Neurol (2015) 1.09
Relationships between cerebral perfusion and reversibility of acute diffusion lesions in DEFUSE: insights from RADAR. Stroke (2009) 1.09
Prospective study on the mismatch concept in acute stroke patients within the first 24 h after symptom onset - 1000Plus study. BMC Neurol (2009) 1.08
Optimizing prediction scores for poor outcome after intra-arterial therapy in anterior circulation acute ischemic stroke. Stroke (2013) 1.07
Refining the mismatch concept in acute stroke: lessons learned from PET and MRI. J Cereb Blood Flow Metab (2012) 1.07
EPITHET: failed chance or new hope? Lancet Neurol (2008) 1.06
Arterial spin label imaging of acute ischemic stroke and transient ischemic attack. Neuroimaging Clin N Am (2011) 1.05
Geography, structure, and evolution of diffusion and perfusion lesions in Diffusion and perfusion imaging Evaluation For Understanding Stroke Evolution (DEFUSE). Stroke (2009) 1.01
Use of magnetic resonance imaging to predict outcome after stroke: a review of experimental and clinical evidence. J Cereb Blood Flow Metab (2010) 1.01
Comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MRI in patients with acute stroke. PLoS One (2013) 0.99
Comparison of arterial spin labeling and bolus perfusion-weighted imaging for detecting mismatch in acute stroke. Stroke (2012) 0.99
Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence. J Cereb Blood Flow Metab (2011) 0.99
Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging. J Cereb Blood Flow Metab (2013) 0.98
Wake-up stroke: clinical and neuroimaging characteristics. Cerebrovasc Dis (2010) 0.97
Worse stroke outcome in atrial fibrillation is explained by more severe hypoperfusion, infarct growth, and hemorrhagic transformation. Int J Stroke (2013) 0.95
Advanced imaging improves prediction of hemorrhage after stroke thrombolysis. Ann Neurol (2013) 0.95
Magnetic resonance imaging in acute ischemic stroke treatment. J Stroke (2014) 0.95
Proteomic Protease Substrate Profiling of tPA Treatment in Acute Ischemic Stroke Patients: A Step Toward Individualizing Thrombolytic Therapy at the Bedside. Transl Stroke Res (2010) 0.94
Therapeutic targets for neuroprotection in acute ischemic stroke: lost in translation? Antioxid Redox Signal (2010) 0.94
Imaging in Endovascular Stroke Trials. J Neuroimaging (2015) 0.93
Hyperintense vessels on acute stroke fluid-attenuated inversion recovery imaging: associations with clinical and other MRI findings. Stroke (2012) 0.93
Age-dependent susceptibility to infarct growth in women. Stroke (2011) 0.92
Periprocedural arterial spin labeling and dynamic susceptibility contrast perfusion in detection of cerebral blood flow in patients with acute ischemic syndrome. Stroke (2013) 0.91
Thrombolytic therapy for acute ischemic stroke beyond three hours. J Emerg Med (2010) 0.90
Imaging stroke patients with unclear onset times. Neuroimaging Clin N Am (2011) 0.90
Quantitative analysis of hypoperfusion in acute stroke: arterial spin labeling versus dynamic susceptibility contrast. Stroke (2013) 0.89
Patients with the malignant profile within 3 hours of symptom onset have very poor outcomes after intravenous tissue-type plasminogen activator therapy. Stroke (2012) 0.89
Recanalization therapies in acute ischemic stroke: pharmacological agents, devices, and combinations. Stroke Res Treat (2009) 0.89
Validating a local Arterial Input Function method for improved perfusion quantification in stroke. J Cereb Blood Flow Metab (2011) 0.89
MR perfusion imaging in acute ischemic stroke. Neuroimaging Clin N Am (2011) 0.89
Susceptibility of Tmax to tracer delay on perfusion analysis: quantitative evaluation of various deconvolution algorithms using digital phantoms. J Cereb Blood Flow Metab (2010) 0.88
Postischemic hyperperfusion on arterial spin labeled perfusion MRI is linked to hemorrhagic transformation in stroke. J Cereb Blood Flow Metab (2015) 0.88
Wake-up stroke: clinical characteristics, imaging findings, and treatment option - an update. Front Neurol (2014) 0.88
Current perspectives on the use of intravenous recombinant tissue plasminogen activator (tPA) for treatment of acute ischemic stroke. Vasc Health Risk Manag (2014) 0.88
Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation. Cerebrovasc Dis (2011) 0.88
Magnetic resonance diffusion-perfusion mismatch in acute ischemic stroke: An update. World J Radiol (2012) 0.87
Prediction of infarct volume and neurologic outcome by using automated multiparametric perfusion-weighted magnetic resonance imaging in a primate model of permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab (2010) 0.87
Magnetic resonance imaging of ischemia viability thresholds and the neurovascular unit. Sensors (Basel) (2013) 0.87
Imaging techniques for acute ischemic stroke: nice gadgets or essential tools for effective treatment? Neuroradiology (2009) 0.87
Favorable vascular profile is an independent predictor of outcome: a post hoc analysis of the safety and efficacy of NeuroFlo Technology in Ischemic Stroke trial. Stroke (2013) 0.86
Detection of ischemic penumbra using combined perfusion and T2* oxygen challenge imaging. Int J Stroke (2014) 0.86
Exploratory analysis of glyburide as a novel therapy for preventing brain swelling. Neurocrit Care (2014) 0.86
Current status and future role of brain PET/MRI in clinical and research settings. Eur J Nucl Med Mol Imaging (2015) 0.86
The growth rate of early DWI lesions is highly variable and associated with penumbral salvage and clinical outcomes following endovascular reperfusion. Int J Stroke (2015) 0.86
Simultaneous PET/MRI in stroke: a case series. J Cereb Blood Flow Metab (2015) 0.85
Imaging for prediction of functional outcome and assessment of recovery in ischemic stroke. Stroke (2014) 0.85
Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke. J Cereb Blood Flow Metab (2012) 0.85
Using longitudinal metamorphosis to examine ischemic stroke lesion dynamics on perfusion-weighted images and in relation to final outcome on T2-w images. Neuroimage Clin (2014) 0.84
Brain edema predicts outcome after nonlacunar ischemic stroke. Stroke (2014) 0.84
The potential roles of 18F-FDG-PET in management of acute stroke patients. Biomed Res Int (2013) 0.84
Defining the ischemic penumbra using magnetic resonance oxygen metabolic index. Stroke (2015) 0.84
Early identification of potentially salvageable tissue with MRI-based predictive algorithms after experimental ischemic stroke. J Cereb Blood Flow Metab (2013) 0.84
The 2012 Feinberg Lecture: treatment swift and treatment sure. Stroke (2012) 0.83
Biomarkers for stroke. J Stroke (2013) 0.83
Sustained reperfusion after blockade of glycoprotein-receptor-Ib in focal cerebral ischemia: an MRI study at 17.6 Tesla. PLoS One (2011) 0.83
Thrombolysis for cerebral ischemia. Front Neurol (2010) 0.83
Assessment of the accuracy of a Bayesian estimation algorithm for perfusion CT by using a digital phantom. Neuroradiology (2013) 0.82
Prominent vessel sign on susceptibility-weighted imaging in acute stroke: prediction of infarct growth and clinical outcome. PLoS One (2015) 0.82
Recanalization and Reperfusion Therapies of Acute Ischemic Stroke: What have We Learned, What are the Major Research Questions, and Where are We Headed? Front Neurol (2014) 0.82
Patients with single distal MCA perfusion lesions have a high rate of good outcome with or without reperfusion. Int J Stroke (2013) 0.82
Clinical relevance and practical implications of trials of perfusion and angiographic imaging in patients with acute ischaemic stroke: a multicentre cohort imaging study. J Neurol Neurosurg Psychiatry (2013) 0.82
Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet (2010) 12.21
Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med (2015) 12.06
Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med (2008) 7.25
1,026 experimental treatments in acute stroke. Ann Neurol (2006) 7.23
Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med (2008) 6.08
Lung cancer susceptibility locus at 5p15.33. Nat Genet (2008) 5.99
Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. Lancet Neurol (2008) 5.40
Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ (2008) 5.14
Critical issues in peripheral arterial disease detection and management: a call to action. Arch Intern Med (2003) 4.72
Pooling of animal experimental data reveals influence of study design and publication bias. Stroke (2004) 4.37
Acute stroke thrombolysis with intravenous tissue plasminogen activator in an Australian tertiary hospital. Med J Aust (2003) 4.24
Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study. Lancet (2008) 4.14
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93
Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke (2008) 3.87
A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med (2012) 3.81
Functional potential in chronic stroke patients depends on corticospinal tract integrity. Brain (2007) 3.74
Very early mobilization after stroke fast-tracks return to walking: further results from the phase II AVERT randomized controlled trial. Stroke (2010) 3.43
Good laboratory practice: preventing introduction of bias at the bench. Stroke (2008) 3.27
Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke. J Cereb Blood Flow Metab (2005) 3.20
Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain (2007) 2.94
Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. J Clin Oncol (2013) 2.87
Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study. Ann Neurol (2002) 2.79
Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol (2012) 2.77
The distinctive movement disorder of ovarian teratoma-associated encephalitis. Mov Disord (2008) 2.48
Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer (2011) 2.43
Cerebral microembolization after protected carotid artery stenting in surgical high-risk patients: results of a 2-year prospective study. J Vasc Surg (2005) 2.41
Clinical practice. Secondary prevention after ischemic stroke or transient ischemic attack. N Engl J Med (2012) 2.39
Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke (2003) 2.25
Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke. Ann Neurol (2002) 2.25
The Stroke Riskometer(TM) App: validation of a data collection tool and stroke risk predictor. Int J Stroke (2014) 2.18
Spectrum of transient focal neurological episodes in cerebral amyloid angiopathy: multicentre magnetic resonance imaging cohort study and meta-analysis. Stroke (2012) 2.13
The Avoid Stroke as Soon as Possible (ASAP) general practice stroke audit. Med J Aust (2002) 2.13
The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke. Brain (2009) 2.12
Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial. Lancet Neurol (2015) 2.09
Opium use and mortality in Golestan Cohort Study: prospective cohort study of 50,000 adults in Iran. BMJ (2012) 2.07
Hematoma growth and outcomes in intracerebral hemorrhage: the INTERACT1 study. Neurology (2012) 2.06
Refining the definition of the malignant profile: insights from the DEFUSE-EPITHET pooled data set. Stroke (2011) 2.03
Should the MATCH results be extrapolated to all stroke patients and affect ongoing trials evaluating clopidogrel plus aspirin? Stroke (2004) 2.02
Retinal microvasculature in acute lacunar stroke: a cross-sectional study. Lancet Neurol (2009) 2.01
Effective prophylaxis for deep venous thrombosis after stroke: both low-dose anticoagulation and stockings for most cases. Stroke (2004) 2.00
Does abnormal circadian blood pressure pattern really matter in patients with transient ischemic attack or minor stroke? Stroke (2014) 1.98
World Stroke Organization global stroke services guidelines and action plan. Int J Stroke (2014) 1.94
Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis. J Cereb Blood Flow Metab (2010) 1.89
Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology (2014) 1.85
The tissue diagnostic instrument. Rev Sci Instrum (2009) 1.82
Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet (2012) 1.81
Insular cortical ischemia is independently associated with acute stress hyperglycemia. Stroke (2004) 1.81
Third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke. Trials (2008) 1.79
Lower treatment blood pressure is associated with greatest reduction in hematoma growth after acute intracerebral hemorrhage. Hypertension (2010) 1.78
Improved survival after stroke: is admission to hospital the major explanation? Trend analyses of the Auckland Regional Community Stroke Studies. Cerebrovasc Dis (2006) 1.75
South Asian patients with ischemic stroke: intracranial large arteries are the predominant site of disease. Stroke (2007) 1.73
Diffusion-weighted imaging and diagnosis of transient ischemic attack. Ann Neurol (2014) 1.72
Advanced breast cancer and breast cancer mortality in randomized controlled trials on mammography screening. J Clin Oncol (2009) 1.71
Tissue plasminogen activator for ischaemic stroke: highly effective, reasonably safe and grossly underused. Med J Aust (2007) 1.71
Tuberculosis recurrence and mortality after successful treatment: impact of drug resistance. PLoS Med (2006) 1.69
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet (2011) 1.68
Spatially and temporally controlled biomineralization is facilitated by interaction between self-assembled dentin matrix protein 1 and calcium phosphate nuclei in solution. Biochemistry (2005) 1.68
Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis. J Cereb Blood Flow Metab (2010) 1.68
Incidence of stroke subtypes in the North East Melbourne Stroke Incidence Study (NEMESIS): differences between men and women. Neuroepidemiology (2008) 1.67
Acute stroke imaging research roadmap. Stroke (2008) 1.66
The physiological significance of the time-to-maximum (Tmax) parameter in perfusion MRI. Stroke (2010) 1.62
Evidence-based care and outcomes of acute stroke managed in hospital specialty units. Med J Aust (2003) 1.61
The PREP algorithm predicts potential for upper limb recovery after stroke. Brain (2012) 1.59
Risk of ischemic stroke among users of the oral contraceptive pill: The Melbourne Risk Factor Study (MERFS) Group. Stroke (2003) 1.59
Quality of life after stroke: the North East Melbourne Stroke Incidence Study (NEMESIS). Stroke (2004) 1.59
Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr (2008) 1.57
Retinal signs and stroke: revisiting the link between the eye and brain. Stroke (2008) 1.54
Frequent early cardiac complications contribute to worse stroke outcome in atrial fibrillation. Cerebrovasc Dis (2011) 1.53
Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core. Stroke (2011) 1.52