Published in Arch Biochem Biophys on February 14, 2008
The Mtr respiratory pathway is essential for reducing flavins and electrodes in Shewanella oneidensis. J Bacteriol (2009) 1.74
Genetic control of biosynthesis and transport of riboflavin and flavin nucleotides and construction of robust biotechnological producers. Microbiol Mol Biol Rev (2011) 1.38
Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion. J Am Chem Soc (2010) 0.95
An atypical riboflavin pathway is essential for Brucella abortus virulence. PLoS One (2010) 0.91
A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T. BMC Genomics (2012) 0.91
PASS2 version 4: an update to the database of structure-based sequence alignments of structural domain superfamilies. Nucleic Acids Res (2011) 0.86
Riboflavin level manipulates the successive developmental sequences in Aspergillus nidulans. Curr Microbiol (2015) 0.80
Genetic diversity within the genus Francisella as revealed by comparative analyses of the genomes of two North American isolates from environmental sources. BMC Genomics (2012) 0.79
Structural basis for competitive inhibition of 3,4-dihydroxy-2-butanone-4-phosphate synthase from Vibrio cholerae. J Biol Chem (2015) 0.77
An in vitro deletion in ribE encoding lumazine synthase contributes to nitrofurantoin resistance in Escherichia coli. Antimicrob Agents Chemother (2014) 0.76
Carbon-flux distribution within Streptomyces coelicolor metabolism: a comparison between the actinorhodin-producing strain M145 and its non-producing derivative M1146. PLoS One (2013) 0.76
Crystallographic and kinetic study of riboflavin synthase from Brucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility. Acta Crystallogr D Biol Crystallogr (2014) 0.75
Chromobacterium violaceum: important insights for virulence and biotechnological potential by exoproteomic studies. Curr Microbiol (2013) 0.75
Arabidopsis RIBA proteins: two out of three isoforms have lost their bifunctional activity in riboflavin biosynthesis. Int J Mol Sci (2012) 0.75
Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. Proc Natl Acad Sci U S A (2002) 2.14
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein. Proc Natl Acad Sci U S A (2003) 1.80
Probing the reaction mechanism of IspH protein by x-ray structure analysis. Proc Natl Acad Sci U S A (2009) 1.68
Nuphar lutea thioalkaloids inhibit the nuclear factor kappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide. Cancer Biol Ther (2009) 1.62
Biosynthesis of flavocoenzymes. Nat Prod Rep (2005) 1.52
Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction. Angew Chem Int Ed Engl (2009) 1.49
Carbon metabolism of Listeria monocytogenes growing inside macrophages. Mol Microbiol (2008) 1.47
Diagnosis of Toxoplasma gondii infection after allogeneic stem cell transplant can be difficult and requires intensive scrutiny. Leuk Lymphoma (2010) 1.45
IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis. J Am Chem Soc (2004) 1.41
Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. J Biol Chem (2003) 1.40
Pathogenomics of Listeria spp. Int J Med Microbiol (2007) 1.39
Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase. Proc Natl Acad Sci U S A (2002) 1.38
Magnetic-field effect on the photoactivation reaction of Escherichia coli DNA photolyase. Proc Natl Acad Sci U S A (2008) 1.35
Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Eur J Biochem (2003) 1.35
A bicyclic autotrophic CO2 fixation pathway in Chloroflexus aurantiacus. J Biol Chem (2002) 1.34
Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. Bioorg Chem (2004) 1.27
13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA. Proc Natl Acad Sci U S A (2006) 1.21
Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. Eur J Biochem (2004) 1.20
On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin. J Am Chem Soc (2004) 1.18
Biosynthesis of isoprenoids: crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase. Proc Natl Acad Sci U S A (2003) 1.18
New enzymes involved in aerobic benzoate metabolism in Azoarcus evansii. Mol Microbiol (2004) 1.15
Blue light perception in plants. Detection and characterization of a light-induced neutral flavin radical in a C450A mutant of phototropin. J Biol Chem (2003) 1.14
Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis. J Mol Biol (2003) 1.13
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors. Biochemistry (2005) 1.12
Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids. J Mol Biol (2002) 1.11
Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis. J Mol Biol (2011) 1.08
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. Phytochemistry (2009) 1.08
Reductive dehydroxylation of allyl alcohols by IspH protein. Angew Chem Int Ed Engl (2010) 1.07
Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. J Mol Biol (2003) 1.06
Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG. J Mol Biol (2010) 1.05
Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme. Mol Microbiol (2005) 1.02
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation. J Am Chem Soc (2012) 1.02
A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J Mol Biol (2003) 1.02
Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis. J Biol Chem (2004) 1.02
Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine. Structure (2002) 1.01
A metastable prerequisite for the growth of lumazine synthase crystals. J Am Chem Soc (2005) 1.01
Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni. Eur J Biochem (2004) 0.99
Biosynthesis of hyperforin in Hypericum perforatum. J Med Chem (2002) 0.99
The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. J Mol Biol (2002) 0.99
Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I. Proc Natl Acad Sci U S A (2002) 0.98
Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin. J Biol Chem (2004) 0.97
Transcriptional regulation by antitermination. Interaction of RNA with NusB protein and NusB/NusE protein complex of Escherichia coli. J Mol Biol (2002) 0.96
Robustness of central carbohydrate metabolism in developing maize kernels. Phytochemistry (2006) 0.96
13CO2 as a universal metabolic tracer in isotopologue perturbation experiments. Phytochemistry (2007) 0.95
Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold. J Mol Biol (2003) 0.95
Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion. J Am Chem Soc (2010) 0.95
Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods. J Org Chem (2006) 0.95
Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda. Proc Natl Acad Sci U S A (2004) 0.94
Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase. J Mol Biol (2003) 0.94
Probing the N(5)-H bond of the isoalloxazine moiety of flavin radicals by X- and W-band pulsed electron-nuclear double resonance. Chemphyschem (2005) 0.94
Isotopolog perturbation techniques for metabolic networks: metabolic recycling of nutritional glucose in Drosophila melanogaster. Proc Natl Acad Sci U S A (2004) 0.94
Advances of high-resolution NMR techniques in the structural and metabolic analysis of plant biochemistry. Phytochemistry (2007) 0.93
Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis. J Org Chem (2009) 0.93
Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli. Acta Crystallogr D Biol Crystallogr (2004) 0.93
Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery. FEBS J (2008) 0.93
Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth. Mol Biol Cell (2004) 0.93
Biochemistry of the non-mevalonate isoprenoid pathway. Cell Mol Life Sci (2011) 0.93
Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design. J Biol Chem (2007) 0.92
Light-induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy. FEBS J (2005) 0.92
Starch biosynthesis and intermediary metabolism in maize kernels. Quantitative analysis of metabolite flux by nuclear magnetic resonance. Plant Physiol (2002) 0.92
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe. Eur J Biochem (2002) 0.91
Structure and properties of an engineered transketolase from maize. Plant Physiol (2003) 0.91
The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods. Acta Crystallogr D Biol Crystallogr (2004) 0.90
13C-, 15N- and 31P-NMR studies of oxidized and reduced low molecular mass thioredoxin reductase and some mutant proteins. Eur J Biochem (2004) 0.90
Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii. Eur J Biochem (2003) 0.90
Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase. J Org Chem (2002) 0.90
Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis. Angew Chem Int Ed Engl (2011) 0.90
Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans. J Mol Biol (2004) 0.89
Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class. J Mol Biol (2004) 0.89
Inhibitors of the herbicidal target IspD: allosteric site binding. Angew Chem Int Ed Engl (2011) 0.88
Multiple assembly states of lumazine synthase: a model relating catalytic function and molecular assembly. J Mol Biol (2006) 0.88
The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution. J Mol Biol (2003) 0.88
Stereochemical studies on the making and unmaking of isopentenyl diphosphate in different biological systems. Chem Biodivers (2004) 0.88
Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications. J Biol Chem (2005) 0.87
Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli. J Org Chem (2005) 0.87
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis. FEBS J (2006) 0.87
The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system. FEBS J (2013) 0.87
Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH. Angew Chem Int Ed Engl (2013) 0.86
Light-induced activation of class II cyclobutane pyrimidine dimer photolyases. DNA Repair (Amst) (2010) 0.86
Evolution of vitamin B2 biosynthesis: 6,7-dimethyl-8-ribityllumazine synthases of Brucella. J Bacteriol (2006) 0.85
Synthesis of Nanophase Iron Oxide in Lumazine Synthase Capsids This work was supported by the BBSRC (W.S.). We thank A. M. Seddon for help with transmission electron microscopy and analytical ultracentrifufation studies and G. D. Ruggiero for the generation of computer images. Angew Chem Int Ed Engl (2001) 0.85
Biosynthesis of gallic acid in Rhus typhina: discrimination between alternative pathways from natural oxygen isotope abundance. Phytochemistry (2004) 0.85
Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism. J Biol Chem (2003) 0.85
Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding. Biochem J (2004) 0.85
Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein. Biochemistry (2011) 0.85
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii. J Mol Biol (2006) 0.84
Changes in flux pattern of the central carbohydrate metabolism during kernel development in maize. Phytochemistry (2005) 0.84
Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. Angew Chem Int Ed Engl (2006) 0.84
A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors. Anal Biochem (2005) 0.84
Evolution of vitamin B2 biosynthesis. A novel class of riboflavin synthase in Archaea. J Mol Biol (2004) 0.84
Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales. J Mol Biol (2007) 0.83
Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. ChemMedChem (2007) 0.83
Stimulation of Vgamma9/Vdelta2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate. Immunobiology (2006) 0.83
Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments. BMC Biochem (2003) 0.83
Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA. J Phys Chem B (2012) 0.83
Rapid preparation of isotopolog libraries by in vivo transformation of 1)C-glucose. Studies on 6,7-dimethyl-8-ribityllumazine, a biosynthetic precursor of vitamin B2. J Org Chem (2004) 0.83
Isoprenoid biosynthesis in plants - 2C-methyl-D-erythritol-4-phosphate synthase (IspC protein) of Arabidopsis thaliana. FEBS J (2006) 0.83
Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase. Eur J Biochem (2004) 0.83