Published in N Engl J Med on February 28, 2008
Safety and Efficacy of Acetaminophen in the Intensive Care Unit. (SEA-ICU) | NCT02280239
Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery (VANCSIII) | NCT03483753
Validity Test of Wearable Continuous Blood Pressure Measuring System | NCT04261062
CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ (2010) 28.70
Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82
Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care (2013) 3.40
Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med (2008) 3.28
Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med (2014) 3.02
A multibiomarker-based outcome risk stratification model for adult septic shock*. Crit Care Med (2014) 2.94
Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: a systematic review and meta-analysis. Crit Care Med (2014) 2.45
PCSK9 is a critical regulator of the innate immune response and septic shock outcome. Sci Transl Med (2014) 2.33
Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial. Crit Care (2009) 1.87
Migraine and risk of perioperative ischemic stroke and hospital readmission: hospital based registry study. BMJ (2017) 1.73
Risk factors for acute kidney injury in critically ill patients receiving high intravenous doses of colistin methanesulfonate and/or other nephrotoxic antibiotics: a retrospective cohort study. Crit Care (2013) 1.60
The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med (2014) 1.55
A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock. Am J Respir Crit Care Med (2014) 1.53
Part 10: Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation (2010) 1.50
A Selective V1A Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock. Crit Care Med (2016) 1.49
Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine. Crit Care (2013) 1.46
Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge. Crit Care Med (2008) 1.44
Heparin-binding protein is important for vascular leak in sepsis. Intensive Care Med Exp (2016) 1.38
Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study. Crit Care (2013) 1.31
Therapeutic potential of HMGB1-targeting agents in sepsis. Expert Rev Mol Med (2008) 1.30
WSES consensus conference: Guidelines for first-line management of intra-abdominal infections. World J Emerg Surg (2011) 1.29
Vasopressin and terlipressin in adult vasodilatory shock: a systematic review and meta-analysis of nine randomized controlled trials. Crit Care (2012) 1.24
IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis. Crit Care (2011) 1.23
Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology (2011) 1.21
Sepsis-induced cardiomyopathy. Curr Cardiol Rev (2011) 1.21
Clinical review: The liver in sepsis. Crit Care (2012) 1.21
Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study. Crit Care (2009) 1.20
Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review. Crit Care (2010) 1.18
Bench-to-bedside review: Vasopressin in the management of septic shock. Crit Care (2011) 1.17
Clinical applications of intravenous immunoglobulins (IVIg)--beyond immunodeficiencies and neurology. Clin Exp Immunol (2009) 1.16
Survival after shock requiring high-dose vasopressor therapy. Chest (2013) 1.15
Target blood pressure in sepsis: between a rock and a hard place. Crit Care (2013) 1.13
Septic shock--vasopressin, norepinephrine, and urgency. N Engl J Med (2008) 1.12
Hemodynamic variables and progression of acute kidney injury in critically ill patients with severe sepsis: data from the prospective observational FINNAKI study. Crit Care (2013) 1.10
Reading between the (guide)lines--the KDIGO practice guideline on acute kidney injury in the individual patient. Kidney Int (2013) 1.10
AKI associated with cardiac surgery. Clin J Am Soc Nephrol (2014) 1.08
One size does not fit all in severe infection: obesity alters outcome, susceptibility, treatment, and inflammatory response. Crit Care (2013) 1.06
Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum. Intensive Care Med (2016) 1.05
Timing of vasopressor initiation and mortality in septic shock: a cohort study. Crit Care (2014) 1.05
Early versus delayed administration of norepinephrine in patients with septic shock. Crit Care (2014) 1.04
Surviving sepsis: going beyond the guidelines. Ann Intensive Care (2011) 1.02
Pharmacologic agents for acute hemodynamic instability: Recent advances in the management of perioperative shock- A systematic review. Ann Card Anaesth (2015) 1.01
Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design. Am J Respir Crit Care Med (2016) 1.01
Landmark survival as an end-point for trials in critically ill patients--comparison of alternative durations of follow-up: an exploratory analysis. Crit Care (2009) 1.00
Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental study. Crit Care (2010) 1.00
Targeting HMGB1 in the treatment of sepsis. Expert Opin Ther Targets (2014) 0.99
The Japanese guidelines for the management of sepsis. J Intensive Care (2014) 0.99
Comparison of cardiac, hepatic, and renal effects of arginine vasopressin and noradrenaline during porcine fecal peritonitis: a randomized controlled trial. Crit Care (2009) 0.98
Have we found the prevention for intensive care unit-acquired paresis? Crit Care (2010) 0.98
Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice. Crit Care (2009) 0.97
Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial. Crit Care (2016) 0.96
Early goal-directed resuscitation of patients with septic shock: current evidence and future directions. Crit Care (2015) 0.95
The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients. Intensive Care Med (2010) 0.95
Prevention and treatment of sepsis-induced acute kidney injury: an update. Ann Intensive Care (2015) 0.95
Severe sepsis and septic shock: management and performance improvement. Virulence (2013) 0.94
Initial emergency department diagnosis and management of adult patients with severe sepsis and septic shock. Scand J Trauma Resusc Emerg Med (2012) 0.94
Nonadherence to treatment protocol in published randomised controlled trials: a review. Trials (2012) 0.94
Use of inotropes and vasopressor agents in critically ill patients. Br J Pharmacol (2012) 0.93
Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock? Crit Care (2015) 0.93
Postoperative blood pressure deficit and acute kidney injury progression in vasopressor-dependent cardiovascular surgery patients. Crit Care (2016) 0.92
Control groups in recent septic shock trials: a systematic review. Intensive Care Med (2016) 0.92
Year in review 2010: Critical Care--Multiple organ dysfunction and sepsis. Crit Care (2011) 0.91
Hormonal responses upon return of spontaneous circulation after cardiac arrest: a retrospective cohort study. Crit Care (2011) 0.90
Quantifying the improvement in sepsis diagnosis, documentation, and coding: the marginal causal effect of year of hospitalization on sepsis diagnosis. Ann Epidemiol (2015) 0.90
Guidelines on management of human infection with the novel virus influenza A (H1N1)--a report from the Hospital das Clínicas of the University of São Paulo. Clinics (Sao Paulo) (2009) 0.90
Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure. J Intensive Care (2016) 0.88
A review of sepsis-induced cardiomyopathy. J Intensive Care (2015) 0.88
Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis. PLoS One (2015) 0.88
Procalcitonin levels to guide antibiotic therapy in adults with non-microbiologically proven apparent severe sepsis: a randomised controlled trial. BMJ Open (2013) 0.88
Vasopressin in the pediatric cardiac intensive care unit: Myth or reality. Ann Pediatr Cardiol (2009) 0.88
Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis. Am J Physiol Heart Circ Physiol (2012) 0.88
Intravenous angiotensin II for the treatment of high-output shock (ATHOS trial): a pilot study. Crit Care (2014) 0.87
Clinical trials comparing norepinephrine with vasopressin in patients with septic shock: a meta-analysis. Mil Med Res (2014) 0.87
Personalizing blood pressure management in septic shock. Ann Intensive Care (2015) 0.86
Red blood cell transfusion in septic shock - clinical characteristics and outcome of unselected patients in a prospective, multicentre cohort. Scand J Trauma Resusc Emerg Med (2014) 0.86
Sepsis-induced acute kidney injury. Indian J Crit Care Med (2010) 0.86
Vasopressin in septic shock. N Engl J Med (2008) 0.86
Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Pediatrics (2010) 0.85
Vasopressin for refractory hypotension in extremely low birth weight infants. J Pediatr (2010) 0.85
Cytokines and signaling molecules predict clinical outcomes in sepsis. PLoS One (2013) 0.85
Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85
Attitudes to drug trials among relatives of unconscious intensive care patients. BMC Anesthesiol (2010) 0.84
New trends in resuscitation. Curr Probl Surg (2011) 0.83
Sepsis and ARDS: The Dark Side of Histones. Mediators Inflamm (2015) 0.83
Critical care trial design and interpretation: a primer. Crit Care Med (2010) 0.83
β2-agonists and acute respiratory distress syndrome. Am J Respir Crit Care Med (2014) 0.83
Therapeutic strategies for high-dose vasopressor-dependent shock. Crit Care Res Pract (2013) 0.82
Copeptin concentration in cord blood in infants with early-onset sepsis, chorioamnionitis and perinatal asphyxia. BMC Pediatr (2011) 0.82
Temporal trends in the utilization of vasopressors in intensive care units: an epidemiologic study. BMC Pharmacol Toxicol (2016) 0.82
Impact of low-dose vasopressin on trauma outcome: prospective randomized study. World J Surg (2011) 0.82
Experimental sepsis in pigs--effects of vasopressin on renal, hepatic, and intestinal dysfunction. Ups J Med Sci (2012) 0.82
[Heart in sepsis : Molecular mechanisms, diagnosis and therapy of septic cardiomyopathy]. Anaesthesist (2017) 0.82
Sensitivity of systemic inflammatory response syndrome for critical illness among ED patients. Am J Emerg Med (2014) 0.81
Vasopressin in hemorrhagic shock: a systematic review and meta-analysis of randomized animal trials. Biomed Res Int (2014) 0.81
Inotropes and vasopressors: more than haemodynamics! Br J Pharmacol (2012) 0.81
The prevention of acute kidney injury an in-depth narrative review: Part 2: Drugs in the prevention of acute kidney injury. NDT Plus (2009) 0.81
Effects of vasopressinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shock. Crit Care (2011) 0.81
Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30
Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA (2009) 13.00
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature (2003) 12.10
One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med (2003) 11.77
Goal-directed resuscitation for patients with early septic shock. N Engl J Med (2014) 11.32
Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med (2011) 9.96
Randomized trials stopped early for benefit: a systematic review. JAMA (2005) 8.43
Transfusion strategies for patients in pediatric intensive care units. N Engl J Med (2007) 7.21
Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med (2011) 6.79
A guide for the design and conduct of self-administered surveys of clinicians. CMAJ (2008) 6.72
High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med (2013) 6.56
The need for an institute of continuing health education. CMAJ (2008) 6.36
Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ (2009) 6.27
Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17
Hypothermia therapy after traumatic brain injury in children. N Engl J Med (2008) 6.10
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90
Comparison of mortality between private for-profit and private not-for-profit hemodialysis centers: a systematic review and meta-analysis. JAMA (2002) 5.57
An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations. Am J Respir Crit Care Med (2006) 5.29
Pulmonary alveolar proteinosis: progress in the first 44 years. Am J Respir Crit Care Med (2002) 5.23
Handheld computing in medicine. J Am Med Inform Assoc (2003) 5.23
A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med (2008) 5.20
Less-tight versus tight control of hypertension in pregnancy. N Engl J Med (2015) 5.03
A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals. CMAJ (2002) 4.84
Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults. N Engl J Med (2015) 4.54
Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med (2007) 4.42
Need for expertise based randomised controlled trials. BMJ (2005) 4.34
An observational study of orthopaedic abstracts and subsequent full-text publications. J Bone Joint Surg Am (2002) 4.25
Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis. Crit Care Med (2014) 4.11
Clinical trial registration--looking back and moving ahead. N Engl J Med (2007) 4.07
No more dithering on e-health: let's keep patients safe instead. CMAJ (2010) 4.01
Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med (2014) 3.96
A randomized trial of protocol-directed sedation management for mechanical ventilation in an Australian intensive care unit. Crit Care Med (2008) 3.65
Clinical consequences of red cell storage in the critically ill. Transfusion (2006) 3.57
The effect of selenium therapy on mortality in patients with sepsis syndrome: a systematic review and meta-analysis of randomized controlled trials. Crit Care Med (2013) 3.43
High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults: a randomized, controlled trial. Am J Respir Crit Care Med (2002) 3.43
Family satisfaction with care in the intensive care unit: results of a multiple center study. Crit Care Med (2002) 3.36
Barriers to full-text publication following presentation of abstracts at annual orthopaedic meetings. J Bone Joint Surg Am (2003) 3.36
Quality of care in for-profit and not-for-profit nursing homes: systematic review and meta-analysis. BMJ (2009) 3.22
Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet (2010) 3.15
Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary team. Crit Care Med (2006) 3.15
Patient and healthcare professional factors influencing end-of-life decision-making during critical illness: a systematic review. Crit Care Med (2011) 3.07
Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial. JAMA (2013) 3.06
Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med (2006) 3.06
The H1N1 vaccine race: can we beat the pandemic? CMAJ (2009) 3.01
A multibiomarker-based outcome risk stratification model for adult septic shock*. Crit Care Med (2014) 2.94
Methodologic issues in systematic reviews and meta-analyses. Clin Orthop Relat Res (2003) 2.90
Derivation and validation of a simplified predictive index for renal replacement therapy after cardiac surgery. JAMA (2007) 2.89
Rationing critical care beds: a systematic review. Crit Care Med (2004) 2.86
Binge drinking: all too prevalent and hazardous. CMAJ (2011) 2.85
The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis. Crit Care Med (2015) 2.85
The Very Elderly Admitted to ICU: A Quality Finish? Crit Care Med (2015) 2.77
Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock. Crit Care Med (2009) 2.77
Is it time for another medical curriculum revolution? CMAJ (2008) 2.76
Payments for care at private for-profit and private not-for-profit hospitals: a systematic review and meta-analysis. CMAJ (2004) 2.76
Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review. JAMA (2003) 2.73
Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med (2008) 2.64
End-of-life care for the critically ill: A national intensive care unit survey. Crit Care Med (2006) 2.61
Frequency of colorectal cancer screening and the impact of family physicians on screening behaviour. CMAJ (2007) 2.60
Beneficial effects of short-term vasopressin infusion during severe septic shock. Anesthesiology (2002) 2.59
Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Crit Care Med (2011) 2.59
S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res (2008) 2.54
Age of transfused blood in critically ill adults. N Engl J Med (2015) 2.52
Uniform format for disclosure of competing interests in ICMJE journals. N Engl J Med (2009) 2.46
Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ (2007) 2.44
Measuring performance is essential to patient-centred care. CMAJ (2010) 2.42
Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med (2006) 2.39
Epidemiology and 12-month outcomes from traumatic brain injury in australia and new zealand. J Trauma (2008) 2.39
The design and interpretation of pilot trials in clinical research in critical care. Crit Care Med (2009) 2.38
The need for public engagement in choosing health priorities. CMAJ (2010) 2.35
Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ (2007) 2.33
Treatment of new-onset atrial fibrillation in noncardiac intensive care unit patients: a systematic review of randomized controlled trials. Crit Care Med (2008) 2.33
Tissue plasminogen activator in cardiac arrest with pulseless electrical activity. N Engl J Med (2002) 2.31
Mortality predictions in the intensive care unit: comparing physicians with scoring systems. Crit Care Med (2006) 2.29
Written informed consent and selection bias in observational studies using medical records: systematic review. BMJ (2009) 2.27
A systematic review of studies comparing health outcomes in Canada and the United States. Open Med (2007) 2.26
Dying in the ICU: perspectives of family members. Chest (2003) 2.25
Can erythropoietin eradicate red cell transfusions in the critically ill? Crit Care Med (2006) 2.21
Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis (2008) 2.20