Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery.

PubWeight™: 0.87‹?›

🔗 View Article (PMID 18311511)

Published in J Clin Immunol on February 29, 2008

Authors

Caroline Baker1, Liliana G Petrich de Marquesini, Amanda J Bishop, Alan J Hedges, Colin M Dayan, F Susan Wong

Author Affiliations

1: Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK.

Articles cited by this

SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics (1999) 14.15

Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet (2001) 6.14

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature (1993) 5.47

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature (1993) 5.10

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A (2003) 3.75

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat Med (1999) 3.45

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest (2004) 3.17

Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J Exp Med (1997) 2.94

Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A (2005) 2.70

Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. Diabetes (1997) 2.65

CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes. Diabetes (2007) 1.98

A comprehensive guide to antibody and T-cell responses in type 1 diabetes. Tissue Antigens (2003) 1.71

Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J Exp Med (1995) 1.67

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol (2006) 1.58

Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes (1999) 1.39

Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci U S A (2005) 1.35

Genes and cellular requirements for autoimmune diabetes susceptibility in nonobese diabetic mice. Curr Dir Autoimmun (2001) 1.32

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide. J Clin Invest (2003) 1.32

Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (2002) 1.31

Identification of a beta-cell-specific HLA class I restricted epitope in type 1 diabetes. Diabetes (2003) 1.30

Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives. Diabetes (2006) 1.21

Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes. Diabetes (2006) 1.20

In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice. Diabetes (2007) 1.13

Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice. J Immunol (2006) 1.08

Identification of naturally processed HLA-A2--restricted proinsulin epitopes by reverse immunology. Diabetes (2005) 1.06

Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients. J Immunol (2007) 1.01

T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading. J Clin Immunol (2004) 0.91

Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice. J Immunol (2005) 0.91

Understanding crypticity is the key to revealing the pathogenesis of autoimmunity. Trends Immunol (2005) 0.87

Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes. Ann N Y Acad Sci (2004) 0.82

CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility. Hum Immunol (1999) 0.81

Peptide-specific cytotoxicity of T lymphocytes against glutamic acid decarboxylase and insulin in type 1 diabetes mellitus. Diabetes Res Clin Pract (2001) 0.81

Articles by these authors

Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature (2008) 12.45

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes (2005) 4.34

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest (2004) 3.17

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest (2008) 3.11

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest (2007) 2.81

Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. J Clin Endocrinol Metab (2009) 2.31

Clinical review: A review of the clinical consequences of variation in thyroid function within the reference range. J Clin Endocrinol Metab (2013) 2.20

Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention. Immunity (2002) 1.74

Therapeutic targeting of Syk in autoimmune diabetes. J Immunol (2010) 1.69

Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells. J Exp Med (2003) 1.52

Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc Natl Acad Sci U S A (2002) 1.40

Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. Diabetes (2011) 1.33

Therapy of endocrine disease: Impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis. Eur J Endocrinol (2013) 1.26

Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture. Diabetes (2008) 1.26

Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism. J Autoimmun (2002) 1.20

Pancreatic volume is reduced in adult patients with recently diagnosed type 1 diabetes. J Clin Endocrinol Metab (2012) 1.20

The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. J Immunol (2004) 1.15

Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells. Diabetes (2012) 1.15

A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab (2008) 1.15

B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes. Diabetes (2008) 1.12

TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. J Clin Invest (2006) 1.09

Partial substitution of thyroxine (T4) with tri-iodothyronine in patients on T4 replacement therapy: results of a large community-based randomized controlled trial. J Clin Endocrinol Metab (2004) 1.01

Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes. Diabetes Metab Res Rev (2003) 1.01

Maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring: data from the Controlled Antenatal Thyroid Study. J Clin Endocrinol Metab (2014) 1.00

Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. J Autoimmun (2009) 1.00

Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity. Diabetes (2007) 0.99

Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells. Proc Natl Acad Sci U S A (2009) 0.97

Increasing readiness to stop smoking in women undergoing cervical screening: evaluation of two leaflets. Nicotine Tob Res (2003) 0.97

Steroid refractory CD4+ T cells in patients with sight-threatening uveitis. Invest Ophthalmol Vis Sci (2009) 0.96

Psychological well-being correlates with free thyroxine but not free 3,5,3'-triiodothyronine levels in patients on thyroid hormone replacement. J Clin Endocrinol Metab (2006) 0.96

CD4+CD25(int) T cells in inflammatory diseases refractory to treatment with glucocorticoids. J Immunol (2007) 0.93

TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes. Am J Physiol Heart Circ Physiol (2012) 0.92

A paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on T4: findings from the HUNT study. Clin Endocrinol (Oxf) (2009) 0.90

IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice. Clin Immunol (2011) 0.90

The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice. J Immunol (2012) 0.89

A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement. Eur J Endocrinol (2011) 0.89

Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells. Diabetes (2013) 0.89

The effects of cytokines on suppression of lymphocyte proliferation by dexamethasone. J Immunol (2009) 0.88

Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes. J Immunol (2007) 0.88

A comparison of Australian and UK obstetricians' and midwives' preferences for screening tests for Down syndrome. Prenat Diagn (2006) 0.88

Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial. Trials (2008) 0.87

TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice. J Immunol (2013) 0.87

Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas. J Biol Chem (2005) 0.86

Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction. J Autoimmun (2007) 0.86

The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity. Rev Endocr Metab Disord (2015) 0.86

Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes. Diabetes (2013) 0.86

Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7. J Immunol (2002) 0.85

Selective immunotargeting of diabetogenic CD4 T cells by genetically redirected T cells. Immunology (2014) 0.84

Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy. J Clin Endocrinol Metab (2011) 0.84

Smoking and strabismus surgery in patients with thyroid eye disease. Ophthalmology (2011) 0.84

Inflammatory regulation by TLR3 in acute hepatitis. J Immunol (2009) 0.84

Basiliximab does not increase efficacy of corticosteroids in patients with steroid-refractory ulcerative colitis. Gastroenterology (2012) 0.83

Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice. Int Immunol (2004) 0.82

The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype. Clin Endocrinol (Oxf) (2011) 0.82

Long-term outcome in patients with severe alcoholic hepatitis can be reliably determined using an in vitro measure of steroid sensitivity. Hepatology (2014) 0.82

An islet-specific pulse of TGF-β abrogates CTL function and promotes β cell survival independent of Foxp3+ T cells. J Immunol (2011) 0.82

CD86 has sustained costimulatory effects on CD8 T cells. J Immunol (2007) 0.82

Immunotargeting of insulin reactive CD8 T cells to prevent diabetes. J Autoimmun (2010) 0.82

Assessment of measurement uncertainty for quantitative methods of analysis: comparative assessment of the precision (uncertainty) of bacterial colony counts. Int J Food Microbiol (2007) 0.82

The role of Gr1+ cells after anti-CD20 treatment in type 1 diabetes in nonobese diabetic mice. J Immunol (2011) 0.81

Dysthyroid optic neuropathy: a clinical diagnosis or a definable entity? Br J Ophthalmol (2007) 0.81

Anti-CD20 treatment prolongs syngeneic islet graft survival and delays the onset of recurrent autoimmune diabetes. Ann N Y Acad Sci (2008) 0.80

Characterization of the T-cell response to coxsackievirus B4: evidence that effector memory cells predominate in patients with type 1 diabetes. Diabetes (2002) 0.80

TSH levels and risk of miscarriage in women on long-term levothyroxine: a community-based study. J Clin Endocrinol Metab (2014) 0.80

A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse. Int Immunol (2003) 0.80

Regulatory T cells in autoimmune endocrine diseases. Trends Endocrinol Metab (2008) 0.80

The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol. BMC Endocr Disord (2014) 0.79

Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis. Int J Exp Pathol (2014) 0.79

Description and evaluation of the first national patient and public involvement day for thyroid eye disease in the United Kingdom. Thyroid (2014) 0.79

Glucocorticoids and the emerging importance of T cell subsets in steroid refractory diseases. Immunopharmacol Immunotoxicol (2009) 0.79

Minimising the between-sample variance in colony counts on foods. Food Microbiol (2010) 0.78

How black African and white British women perceive depression and help-seeking: a pilot vignette study. Int J Soc Psychiatry (2010) 0.78

Developing a novel model system to target insulin-reactive CD8 T cells. Ann N Y Acad Sci (2008) 0.78

Genetic abnormalities in thyroid hormone deiodinases. Curr Opin Endocrinol Diabetes Obes (2015) 0.78

Dendritic cell-based proliferative assays of peripheral T cell responses to tetanus toxoid. Ann N Y Acad Sci (2002) 0.77

T cells recognizing a peptide contaminant undetectable by mass spectrometry. PLoS One (2011) 0.77

Erratum: Whole-genome sequence-based analysis of thyroid function. Nat Commun (2015) 0.77

Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands. Eur J Immunol (2008) 0.77

Dendritic cell-based assays, but not mannosylation of antigen, improves detection of T-cell responses to proinsulin in type 1 diabetes. Immunology (2004) 0.76

Commentary: testosterone and the metabolic syndrome: cause or consequence? Int J Epidemiol (2010) 0.76

An Invitation to Join the Consortium on Thyroid and Pregnancy. Obstet Gynecol (2016) 0.75

Therapy: Immunotherapy for T1DM--targeting innate immunity. Nat Rev Endocrinol (2013) 0.75

Innate and adaptive immune responses are highly interconnected at many levels. Curr Mol Med (2009) 0.75

The effect of the number of sample units tested on the precision of microbial colony counts. Food Microbiol (2011) 0.75

Does changing the order of threat and efficacy information influence the persuasiveness of threat messages? Br J Health Psychol (2006) 0.75

The pancreatic beta-cell: birth, life and death. Biochem Soc Trans (2008) 0.75

Pharmacotherapeutics and the endocrine system: blocking, replacing and exploiting nature's magic bullets. Curr Opin Pharmacol (2002) 0.75

The contribution of sampling uncertainty to total measurement uncertainty in the enumeration of microorganisms in foods. Food Microbiol (2012) 0.75

Measurement uncertainty of the EU methods for microbiological examination of red meat. Food Microbiol (2006) 0.75

Amiodarone-induced thyrotoxicosis, an overview of UK management. Clin Endocrinol (Oxf) (2012) 0.75