Published in EMBO J on March 27, 2008
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International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell (2015) 2.24
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
Mucolipins: Intracellular TRPML1-3 channels. FEBS Lett (2010) 1.49
The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic (2009) 1.44
Transient receptor potential channelopathies. Pflugers Arch (2010) 1.40
Small molecule activators of TRPML3. Chem Biol (2010) 1.37
Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem (2009) 1.32
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J Biol Chem (2011) 1.32
TRP channels of intracellular membranes. J Neurochem (2010) 1.30
TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice. J Physiol (2008) 1.30
TRPMLs: in sickness and in health. Am J Physiol Renal Physiol (2009) 1.26
The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway. Traffic (2009) 1.12
Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1. J Biol Chem (2012) 1.04
The varitint-waddler mouse phenotypes and the TRPML3 ion channel mutation: cause and consequence. Pflugers Arch (2008) 1.04
The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1. Pflugers Arch (2009) 1.04
Constitutive activity of the human TRPML2 channel induces cell degeneration. J Biol Chem (2009) 1.00
The role of TRPMLs in endolysosomal trafficking and function. Cell Calcium (2014) 0.99
Life and death of sensory hair cells expressing constitutively active TRPML3. J Biol Chem (2009) 0.98
Role of TRP channels in the regulation of the endosomal pathway. Physiology (Bethesda) (2011) 0.98
Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1. J Biol Chem (2012) 0.95
Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy. J Cell Sci (2010) 0.94
The intracellular Ca²⁺ channels of membrane traffic. Channels (Austin) (2012) 0.93
Properties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation. J Biol Chem (2010) 0.92
Aberrant Ca2+ handling in lysosomal storage disorders. Cell Calcium (2010) 0.91
Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. J Biol Chem (2013) 0.90
Role of TRP channels in the cardiovascular system. Am J Physiol Heart Circ Physiol (2014) 0.88
TRPML: transporters of metals in lysosomes essential for cell survival? Cell Calcium (2011) 0.88
Mucolipin-3 regulates luminal calcium, acidification, and membrane fusion in the endosomal pathway. J Biol Chem (2011) 0.87
Permeation, regulation and control of expression of TRP channels by trace metal ions. Pflugers Arch (2014) 0.85
Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules. J Biol Chem (2012) 0.84
Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. PLoS One (2010) 0.80
Constitutive activity of TRP channels methods for measuring the activity and its outcome. Methods Enzymol (2010) 0.79
PKD2L1/PKD1L3 channel complex with an alkali-activated mechanism and calcium-dependent inactivation. Eur Biophys J (2015) 0.79
Calcium signaling in membrane repair. Semin Cell Dev Biol (2015) 0.78
Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. PLoS One (2016) 0.78
Opening the TRPML gates. Chem Biol (2010) 0.77
A novel ion channel formed by interaction of TRPML3 with TRPV5. PLoS One (2013) 0.75
Regulation of lysosomal ion homeostasis by channels and transporters. Sci China Life Sci (2016) 0.75
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
TRP channels: an overview. Cell Calcium (2005) 2.98
Permeation and selectivity of TRP channels. Annu Rev Physiol (2006) 2.96
Identification of the gene causing mucolipidosis type IV. Nat Genet (2000) 2.87
Regulation of endocytosis by CUP-5, the Caenorhabditis elegans mucolipin-1 homolog. Nat Genet (2001) 2.23
The pH of the secretory pathway: measurement, determinants, and regulation. Physiology (Bethesda) (2004) 2.16
Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. Proc Natl Acad Sci U S A (2002) 2.03
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A (2007) 1.99
A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. Proc Natl Acad Sci U S A (2007) 1.91
Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. J Biol Chem (2006) 1.90
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types. Proc Natl Acad Sci U S A (2002) 1.62
Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J Biol Chem (2007) 1.56
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc Natl Acad Sci U S A (2007) 1.51
Combined cochleo-saccular and neuroepithelial abnormalities in the Varitint-waddler-J (VaJ) mouse. Hear Res (1998) 1.36
Overexpression of wild-type and mutant mucolipin proteins in mammalian cells: effects on the late endocytic compartment organization. FEBS Lett (2004) 1.35
Diverse and essential roles of mammalian vacuolar-type proton pump ATPase: toward the physiological understanding of inside acidic compartments. Biochim Biophys Acta (2004) 1.33
The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation. Cell Calcium (2003) 1.27
TRPML cation channels regulate the specialized lysosomal compartment of vertebrate B-lymphocytes. Eur J Cell Biol (2006) 1.12
TRPpathies. J Physiol (2006) 1.04
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev (2007) 5.83
STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol (2006) 5.68
SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol (2007) 3.47
Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol (2004) 3.43
The draft genome of a diploid cotton Gossypium raimondii. Nat Genet (2012) 3.18
Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell (2003) 3.11
A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol (2012) 2.54
STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell (2008) 2.30
A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis. EMBO J (2002) 2.11
Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity. Gastroenterology (2005) 2.10
p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell (2012) 2.04
TRPC channels as STIM1-regulated store-operated channels. Cell Calcium (2007) 2.04
NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. Mol Cell (2004) 2.02
Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J Biol Chem (2001) 1.97
TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96
Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells. Gastroenterology (2002) 1.91
Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis. Gastroenterology (2010) 1.86
Requirements for efficient correction of ΔF508 CFTR revealed by analyses of evolved sequences. Cell (2012) 1.81
The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda) (2008) 1.76
TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. J Biol Chem (2005) 1.75
Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol (2006) 1.73
Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis. Gastroenterology (2004) 1.72
Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev (2012) 1.71
Hypoxia reprograms calcium signaling and regulates myoglobin expression. Am J Physiol Cell Physiol (2008) 1.69
Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia. Ann Neurol (2005) 1.65
Mitochondrial aberrations in mucolipidosis Type IV. J Biol Chem (2006) 1.61
RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem (2010) 1.58
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J (2006) 1.56
Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J Biol Chem (2007) 1.56
Variability of myocardial ischemic responses to mental versus exercise or adenosine stress in patients with coronary artery disease. J Nucl Cardiol (2008) 1.55
Levodopa improves motor deficits but can further disrupt cognition in a macaque Parkinson model. Mov Disord (2012) 1.51
Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem (2006) 1.50
Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology (2009) 1.50
Effect of prophylaxis on fungal infection and costs for high-risk liver transplant recipients. Liver Transpl (2007) 1.49
Complete genome sequence of the nitrogen-fixing and rhizosphere-associated bacterium Pseudomonas stutzeri strain DSM4166. J Bacteriol (2011) 1.46
Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population. Rheumatol Int (2012) 1.45
Homer proteins in Ca2+ signaling by excitable and non-excitable cells. Cell Calcium (2007) 1.45
The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic (2009) 1.44
TRPC channels as STIM1-regulated SOCs. Channels (Austin) (2009) 1.43
Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3. J Biol Chem (2008) 1.43
L-DOPA impairs proteasome activity in parkinsonism through D1 dopamine receptor. J Neurosci (2012) 1.43
Mental stress-induced myocardial ischemia in coronary artery disease patients with left ventricular dysfunction. J Nucl Cardiol (2007) 1.43
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases. EMBO J (2014) 1.43
Repetitive oocyte donation does not decrease serum anti-Müllerian hormone levels. Fertil Steril (2009) 1.42
TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach. Am J Physiol Gastrointest Liver Physiol (2003) 1.42
The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct. J Physiol (2008) 1.40
Mitochondria and calcium in health and disease. Cell Calcium (2008) 1.39
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39
Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels. Proc Natl Acad Sci U S A (2009) 1.38
Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. Gastroenterology (2009) 1.37
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol (2005) 1.36
Diverse transport modes by the solute carrier 26 family of anion transporters. J Physiol (2008) 1.35
RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease. J Neurosci (2007) 1.35
Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1. J Biol Chem (2009) 1.34
SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol (2007) 1.33
A comparison of the tube forming potentials of early and late endothelial progenitor cells. Exp Cell Res (2007) 1.32
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest (2008) 1.32
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J Biol Chem (2011) 1.32
Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis. J Exp Med (2008) 1.31
Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice. J Biol Chem (2005) 1.30
Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors. EMBO J (2007) 1.29
NOX4 as an oxygen sensor to regulate TASK-1 activity. Cell Signal (2005) 1.28
Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-). J Biol Chem (2004) 1.28
TRPMLs: in sickness and in health. Am J Physiol Renal Physiol (2009) 1.26
Evolution of calcium homeostasis: from birth of the first cell to an omnipresent signalling system. Cell Calcium (2007) 1.26
Retinopathy online challenge: automatic detection of microaneurysms in digital color fundus photographs. IEEE Trans Med Imaging (2009) 1.26
Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. Cancer Sci (2008) 1.24
Calcium signaling complexes in microdomains of polarized secretory cells. Cell Calcium (2006) 1.24
Exosomes containing glycoprotein 350 released by EBV-transformed B cells selectively target B cells through CD21 and block EBV infection in vitro. J Immunol (2010) 1.24
Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease. Sci Transl Med (2010) 1.23
accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA1. Development (2004) 1.23
Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol Appl Pharmacol (2009) 1.23
Pancreatitis: the neglected duct. Gut (2008) 1.22
SLC26A7 is a Cl- channel regulated by intracellular pH. J Biol Chem (2004) 1.22
A mind-body program for older adults with chronic low back pain: results of a pilot study. Pain Med (2009) 1.21