Published in J Biol Chem on March 27, 2008
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol (Oxf) (2009) 2.13
AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol (2010) 1.93
Targeting the AMPK pathway for the treatment of Type 2 diabetes. Front Biosci (Landmark Ed) (2009) 1.51
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nat Struct Mol Biol (2012) 1.30
AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol (2009) 1.20
Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila. PLoS One (2010) 1.15
Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem (2010) 1.05
Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res (2014) 1.03
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases. Front Plant Sci (2014) 0.98
Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry. Structure (2013) 0.91
Energy-dependent modulation of glucagon-like signaling in Drosophila via the AMP-activated protein kinase. Genetics (2012) 0.89
AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours. FEBS J (2016) 0.87
Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro. PLoS One (2013) 0.87
ATP induces conformational changes in the carboxyl-terminal region of ClC-5. J Biol Chem (2010) 0.87
Choreography of AMPK activation. Cell Res (2014) 0.86
Perivascular fat, AMP-activated protein kinase and vascular diseases. Br J Pharmacol (2014) 0.86
Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix. J Biol Chem (2009) 0.83
How the ESRF helps industry and how they help the ESRF. Acta Crystallogr D Biol Crystallogr (2013) 0.81
Regulation of AMP-activated protein kinase by natural and synthetic activators. Acta Pharm Sin B (2015) 0.81
The recruitment of AMP-activated protein kinase to glycogen is regulated by autophosphorylation. J Biol Chem (2015) 0.77
Deubiquitination and Activation of AMPK by USP10. Mol Cell (2016) 0.77
Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials. Oncotarget (2017) 0.76
A High Throughput Assay for Discovery of Small Molecules that Bind AMP-activated Protein Kinase (AMPK). Curr Chem Genom Transl Med (2013) 0.75
Architectural plasticity of AMPK revealed by electron microscopy and X-ray crystallography. Sci Rep (2016) 0.75
Metabolic basis for thyroid hormone liver preconditioning: upregulation of AMP-activated protein kinase signaling. ScientificWorldJournal (2012) 0.75
AMP-activated protein kinase - not just an energy sensor. F1000Res (2017) 0.75
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14
Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature (2003) 5.85
Aquaporin water channels--from atomic structure to clinical medicine. J Physiol (2002) 3.70
Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem (2006) 3.31
Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem (2004) 3.00
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles. Science (2005) 2.90
Assumed oxygen consumption frequently results in large errors in the determination of cardiac output. J Thorac Cardiovasc Surg (2005) 2.87
Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose. Proc Natl Acad Sci U S A (2011) 2.65
Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state. J Bacteriol (2008) 2.60
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem (2007) 2.59
A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms. Proc Natl Acad Sci U S A (2003) 2.50
Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation (2008) 2.48
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis. J Biol Chem (2003) 2.45
Recent advances in understanding enteric pathogenic Escherichia coli. Clin Microbiol Rev (2013) 2.43
Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial. Circulation (2002) 2.29
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem (2005) 2.24
Impact of misfit dislocations on the polarization instability of epitaxial nanostructured ferroelectric perovskites. Nat Mater (2004) 2.23
Multiple assembly pathways underlie amyloid-beta fibril polymorphisms. J Mol Biol (2005) 2.14
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Mol Cell (2005) 2.09
Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. J Physiol (2006) 2.06
Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol (2006) 2.03
Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. J Biol Chem (2006) 1.98
PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis. EMBO J (2009) 1.94
A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci (2004) 1.92
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. Nature (2004) 1.86
AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits. Diabetes (2006) 1.85
Conformational changes in surface structures of isolated connexin 26 gap junctions. EMBO J (2002) 1.84
Mitochondrial creatine kinase in human health and disease. Biochim Biophys Acta (2005) 1.82
Exploring the 3D molecular architecture of Escherichia coli type 1 pili. J Mol Biol (2002) 1.81
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation. Structure (2012) 1.73
The creatine kinase system and pleiotropic effects of creatine. Amino Acids (2011) 1.73
Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem (2005) 1.70
Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab (2009) 1.69
Prophylaxis of contrast material-induced nephropathy in patients in intensive care: acetylcysteine, theophylline, or both? A randomized study. Radiology (2006) 1.68
Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol (2009) 1.66
Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem (2004) 1.64
Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expr Purif (2003) 1.62
Structure and assembly of the pseudopilin PulG. Mol Microbiol (2004) 1.61
The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment. Structure (2006) 1.60
Hair bundles are specialized for ATP delivery via creatine kinase. Neuron (2007) 1.60
Yeast two-hybrid, a powerful tool for systems biology. Int J Mol Sci (2009) 1.59
AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem (2006) 1.57
Immunotherapy of peritoneal carcinomatosis with the antibody catumaxomab in colon, gastric, or pancreatic cancer: an open-label, multicenter, phase I/II trial. Onkologie (2011) 1.57
Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem (2004) 1.57
Aquaporins: Phylogeny, Structure, and Physiology of Water Channels. News Physiol Sci (1999) 1.56
Structural engineering of nanoporous anodic aluminium oxide by pulse anodization of aluminium. Nat Nanotechnol (2008) 1.55
Monocrystalline spinel nanotube fabrication based on the Kirkendall effect. Nat Mater (2006) 1.55
Structure and function of water channels. Curr Opin Struct Biol (2002) 1.55
Exploring amyloid formation by a de novo design. Proc Natl Acad Sci U S A (2004) 1.55
Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress. Cardiovasc Res (2012) 1.55
Bacterial outer membrane secretin PulD assembles and inserts into the inner membrane in the absence of its pilotin. EMBO J (2006) 1.52
Structural insights into the secretin PulD and its trypsin-resistant core. J Biol Chem (2005) 1.50
Structure of the dodecameric Yersinia enterocolitica secretin YscC and its trypsin-resistant core. Structure (2013) 1.49
Effect of theophylline on contrast material-nephropathy in patients with chronic renal insufficiency: controlled, randomized, double-blinded study. Radiology (2002) 1.49
Functions and effects of creatine in the central nervous system. Brain Res Bull (2008) 1.48
Molecular architecture of photosynthetic membranes in Rhodobacter sphaeroides: the role of PufX. EMBO J (2004) 1.47
Imaging and manipulation of biological structures with the AFM. Micron (2002) 1.46
Atomic force microscopy and spectroscopy of native membrane proteins. Nat Protoc (2007) 1.46
Five challenges to bringing single-molecule force spectroscopy into living cells. Nat Methods (2011) 1.45
Function and molecular architecture of the Yersinia injectisome tip complex. Mol Microbiol (2007) 1.45
YscU recognizes translocators as export substrates of the Yersinia injectisome. EMBO J (2007) 1.44
Cytotoxin ClyA from Escherichia coli assembles to a 13-meric pore independent of its redox-state. EMBO J (2006) 1.43