Efficient control of population structure in model organism association mapping.

PubWeight™: 12.32‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMC 2278096)

Published in Genetics on March 01, 2008

Authors

Hyun Min Kang1, Noah A Zaitlen, Claire M Wade, Andrew Kirby, David Heckerman, Mark J Daly, Eleazar Eskin

Author Affiliations

1: Department of Computer Science, University of California, Los Angeles, California 90095-1596, USA.

Articles citing this

(truncated to the top 100)

Variance component model to account for sample structure in genome-wide association studies. Nat Genet (2010) 15.52

Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature (2010) 10.66

Mixed linear model approach adapted for genome-wide association studies. Nat Genet (2010) 8.47

Genome-wide efficient mixed-model analysis for association studies. Nat Genet (2012) 6.62

FaST linear mixed models for genome-wide association studies. Nat Methods (2011) 6.52

Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa. Nat Commun (2011) 5.41

Differential confounding of rare and common variants in spatially structured populations. Nat Genet (2012) 5.28

Association mapping: critical considerations shift from genotyping to experimental design. Plant Cell (2009) 4.59

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. Proc Natl Acad Sci U S A (2012) 4.10

A Multiparent Advanced Generation Inter-Cross to fine-map quantitative traits in Arabidopsis thaliana. PLoS Genet (2009) 3.97

The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics (2012) 3.84

A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81

Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots. Genetics (2008) 3.66

A simple genetic architecture underlies morphological variation in dogs. PLoS Biol (2010) 3.46

Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res (2011) 3.25

Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet (2011) 3.23

Recombinational landscape and population genomics of Caenorhabditis elegans. PLoS Genet (2009) 3.14

Correction for hidden confounders in the genetic analysis of gene expression. Proc Natl Acad Sci U S A (2010) 3.08

An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations. Nat Genet (2012) 3.03

Genetic structure and domestication history of the grape. Proc Natl Acad Sci U S A (2011) 2.89

Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nat Genet (2012) 2.85

Linkage and association mapping of Arabidopsis thaliana flowering time in nature. PLoS Genet (2010) 2.76

Using control genes to correct for unwanted variation in microarray data. Biostatistics (2011) 2.70

A mixed-model approach for genome-wide association studies of correlated traits in structured populations. Nat Genet (2012) 2.69

Polygenic modeling with bayesian sparse linear mixed models. PLoS Genet (2013) 2.59

Advantages and pitfalls in the application of mixed-model association methods. Nat Genet (2014) 2.52

Using environmental correlations to identify loci underlying local adaptation. Genetics (2010) 2.52

Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2010) 2.51

Genetic architecture of aluminum tolerance in rice (Oryza sativa) determined through genome-wide association analysis and QTL mapping. PLoS Genet (2011) 2.34

Efficient multivariate linear mixed model algorithms for genome-wide association studies. Nat Methods (2014) 2.33

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag. PLoS Comput Biol (2008) 2.32

Ecological genomics of local adaptation. Nat Rev Genet (2013) 2.20

Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab (2013) 2.17

Effect of natural genetic variation on enhancer selection and function. Nature (2013) 2.10

The advantages and limitations of trait analysis with GWAS: a review. Plant Methods (2013) 2.08

Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome. Proc Natl Acad Sci U S A (2010) 1.96

Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease. Neuroimage (2010) 1.94

Genome-wide association studies in plants: the missing heritability is in the field. Genome Biol (2011) 1.93

Towards identifying genes underlying ecologically relevant traits in Arabidopsis thaliana. Nat Rev Genet (2010) 1.91

Rapid variance components-based method for whole-genome association analysis. Nat Genet (2012) 1.89

Genome-wide association studies for agronomical traits in a world wide spring barley collection. BMC Plant Biol (2012) 1.79

Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat Genet (2015) 1.79

Inferences from genomic models in stratified populations. Genetics (2012) 1.76

Genome-wide association studies in mice. Nat Rev Genet (2012) 1.75

Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci (2011) 1.74

High-resolution mapping of gene expression using association in an outbred mouse stock. PLoS Genet (2008) 1.72

Fine mapping in 94 inbred mouse strains using a high-density haplotype resource. Genetics (2010) 1.71

Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS Genet (2011) 1.68

Congenic fine-mapping identifies a major causal locus for variation in the native collateral circulation and ischemic injury in brain and lower extremity. Circ Res (2013) 1.68

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet (2011) 1.68

The architecture of parent-of-origin effects in mice. Cell (2014) 1.68

Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss. PLoS Genet (2015) 1.66

Social environment is associated with gene regulatory variation in the rhesus macaque immune system. Proc Natl Acad Sci U S A (2012) 1.63

Inheritance beyond plain heritability: variance-controlling genes in Arabidopsis thaliana. PLoS Genet (2012) 1.58

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A (2012) 1.58

Effectiveness of genomic prediction of maize hybrid performance in different breeding populations and environments. G3 (Bethesda) (2012) 1.57

Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell (2012) 1.57

Combining genome-wide association mapping and transcriptional networks to identify novel genes controlling glucosinolates in Arabidopsis thaliana. PLoS Biol (2011) 1.54

Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell (2013) 1.53

Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. J Clin Invest (2014) 1.53

Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies. PLoS Genet (2016) 1.53

Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects. Neuroimage (2011) 1.48

Genetic adaptation to high altitude in the Ethiopian highlands. Genome Biol (2012) 1.48

Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast. Genome Res (2013) 1.47

QTLRel: an R package for genome-wide association studies in which relatedness is a concern. BMC Genet (2011) 1.46

A population genetic signal of polygenic adaptation. PLoS Genet (2014) 1.46

How can we identify parasite genes that underlie antimalarial drug resistance? Pharmacogenomics (2011) 1.44

Identification of manganese efficiency candidate genes in winter barley (Hordeum vulgare) using genome wide association mapping. BMC Genomics (2016) 1.44

Dissecting the phenotypic components of crop plant growth and drought responses based on high-throughput image analysis. Plant Cell (2014) 1.43

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome (2012) 1.43

Harnessing genomics and genome biology to understand malaria biology. Nat Rev Genet (2012) 1.41

Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide association mapping. Genetics (2009) 1.41

Identifying causal variants at loci with multiple signals of association. Genetics (2014) 1.41

Four loci explain 83% of size variation in the horse. PLoS One (2012) 1.40

Exome genotyping, linkage disequilibrium and population structure in loblolly pine (Pinus taeda L.). BMC Genomics (2016) 1.39

Mapping the genomic architecture of adaptive traits with interspecific introgressive origin: a coalescent-based approach. BMC Genomics (2016) 1.38

Shrinkage estimation of the realized relationship matrix. G3 (Bethesda) (2012) 1.36

Joint modelling of confounding factors and prominent genetic regulators provides increased accuracy in genetical genomics studies. PLoS Comput Biol (2012) 1.36

Novel measures of linkage disequilibrium that correct the bias due to population structure and relatedness. Heredity (Edinb) (2011) 1.32

Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet (2013) 1.30

Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Syst Biol (2011) 1.30

Unraveling the complex trait of harvest index with association mapping in rice (Oryza sativa L.). PLoS One (2012) 1.30

Genome-wide association mapping of salinity tolerance in rice (Oryza sativa). DNA Res (2015) 1.30

Lessons from Dwarf8 on the strengths and weaknesses of structured association mapping. PLoS Genet (2013) 1.30

Altered structural brain connectivity in healthy carriers of the autism risk gene, CNTNAP2. Brain Connect (2011) 1.29

Genetic association mapping identifies single nucleotide polymorphisms in genes that affect abscisic acid levels in maize floral tissues during drought. J Exp Bot (2010) 1.27

Genome-wide association mapping with longitudinal data. Genet Epidemiol (2012) 1.27

The genome sequence of the most widely cultivated cacao type and its use to identify candidate genes regulating pod color. Genome Biol (2013) 1.26

FastMap: fast eQTL mapping in homozygous populations. Bioinformatics (2008) 1.25

Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies. Am J Hum Genet (2014) 1.25

Nonmetric multidimensional scaling corrects for population structure in association mapping with different sample types. Genetics (2009) 1.25

A kernel of truth: statistical advances in polygenic variance component models for complex human pedigrees. Adv Genet (2013) 1.25

Mapping quantitative trait loci by controlling polygenic background effects. Genetics (2013) 1.24

Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene. Proc Natl Acad Sci U S A (2012) 1.24

Genome-wide association reveals genetic basis for the propensity to migrate in wild populations of rainbow and steelhead trout. Mol Ecol (2012) 1.23

Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. PLoS One (2012) 1.23

Association studies identify natural variation at PHYC linked to flowering time and morphological variation in pearl millet. Genetics (2009) 1.22

Identification of novel genes that mediate innate immunity using inbred mice. Genetics (2009) 1.22

Genome-wide delineation of natural variation for pod shatter resistance in Brassica napus. PLoS One (2014) 1.21

Robust identification of local adaptation from allele frequencies. Genetics (2013) 1.21

Articles cited by this

Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71

Statistical significance for genomewide studies. Proc Natl Acad Sci U S A (2003) 88.64

Evolutionary trees from DNA sequences: a maximum likelihood approach. J Mol Evol (1981) 67.56

Genomic control for association studies. Biometrics (1999) 64.39

Population structure and eigenanalysis. PLoS Genet (2006) 37.21

Construction of phylogenetic trees. Science (1967) 23.69

A unified mixed-model method for association mapping that accounts for multiple levels of relatedness. Nat Genet (2005) 20.97

Association mapping in structured populations. Am J Hum Genet (2000) 16.79

Evaluation of the maximum likelihood estimate of the evolutionary tree topologies from DNA sequence data, and the branching order in hominoidea. J Mol Evol (1989) 16.24

The pattern of polymorphism in Arabidopsis thaliana. PLoS Biol (2005) 10.13

Arabidopsis map-based cloning in the post-genome era. Plant Physiol (2002) 9.26

A Hidden Markov Model approach to variation among sites in rate of evolution. Mol Biol Evol (1996) 8.35

Estimation of pairwise relatedness with molecular markers. Genetics (1999) 7.60

An Arabidopsis example of association mapping in structured samples. PLoS Genet (2006) 7.03

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat Genet (2005) 6.91

A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature (2007) 6.77

Haplotype reconstruction from genotype data using Imperfect Phylogeny. Bioinformatics (2004) 6.02

Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet (2005) 5.57

Founder effects in the assessment of HIV polymorphisms and HLA allele associations. Science (2007) 4.60

Maize association population: a high-resolution platform for quantitative trait locus dissection. Plant J (2005) 4.59

Genome-wide association mapping in Arabidopsis identifies previously known flowering time and pathogen resistance genes. PLoS Genet (2005) 4.25

Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol (2004) 4.08

An estimator for pairwise relatedness using molecular markers. Genetics (2002) 3.69

The mouse as a model for human biology: a resource guide for complex trait analysis. Nat Rev Genet (2007) 3.55

A comparison of microsatellite-based pairwise relatedness estimators. Mol Ecol (2001) 2.80

Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains. Behav Genet (1998) 2.73

A quick method for computing approximate thresholds for quantitative trait loci detection. Genetics (2001) 2.57

Estimating quantitative genetic parameters using sibships reconstructed from marker data. Genetics (2000) 2.32

A mixed-model approach to association mapping using pedigree information with an illustration of resistance to Phytophthora infestans in potato. Genetics (2006) 2.22

Estimation of effects of single genes on quantitative traits. J Anim Sci (1992) 2.20

Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains. J Neurosci (2004) 2.03

Genomewide association analysis in diverse inbred mice: power and population structure. Genetics (2007) 2.01

Statistical framework for phylogenomic analysis of gene family expression profiles. Genetics (2004) 2.01

Comparative methods for the analysis of gene-expression evolution: an example using yeast functional genomic data. Mol Biol Evol (2004) 1.88

Generalized analysis of molecular variance. PLoS Genet (2007) 1.85

Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations. Genetics (2005) 1.80

Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Nat Genet (2006) 1.77

An integrated in silico gene mapping strategy in inbred mice. Genetics (2006) 1.60

Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice. Physiol Genomics (2002) 1.57

Leveraging hierarchical population structure in discrete association studies. PLoS One (2007) 1.48

A large-sample QTL study in mice: II. Body composition. Mamm Genome (2004) 1.31

Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F(2) mice. Funct Integr Genomics (2002) 1.18

Power of mixed-model QTL mapping from phenotypic, pedigree and marker data in self-pollinated crops. Theor Appl Genet (2006) 1.05

Quantitative trait loci for body weight in the intercross between SM/J and A/J mice. Exp Anim (2001) 1.00

Articles by these authors

PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70

The structure of haplotype blocks in the human genome. Science (2002) 50.88

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96

Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30

The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49

Efficiency and power in genetic association studies. Nat Genet (2005) 25.56

Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04

Whole-genome patterns of common DNA variation in three human populations. Science (2005) 21.22

Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71

Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron (2011) 18.73

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13

Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet (2008) 15.89

Common deletion polymorphisms in the human genome. Nat Genet (2006) 15.66

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63

Variance component model to account for sample structure in genome-wide association studies. Nat Genet (2010) 15.52

Genetic mapping in human disease. Science (2008) 15.12

Calibrating a coalescent simulation of human genome sequence variation. Genome Res (2005) 15.04

Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat Genet (2006) 14.76

Assessing computational tools for the discovery of transcription factor binding sites. Nat Biotechnol (2005) 14.29

Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

A comparison of phasing algorithms for trios and unrelated individuals. Am J Hum Genet (2006) 12.45

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07

Methods for high-density admixture mapping of disease genes. Am J Hum Genet (2004) 12.02

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol (2008) 11.28

Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet (2008) 10.49

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nat Med (2006) 10.34

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (2010) 9.61

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet (2008) 9.52

Testing for an unusual distribution of rare variants. PLoS Genet (2011) 9.28

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet (2007) 8.74

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet (2009) 8.39

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98

New approaches to population stratification in genome-wide association studies. Nat Rev Genet (2010) 7.97

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature (2007) 7.91

Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet (2006) 7.49

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16

Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07

Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. N Engl J Med (2010) 6.84

A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature (2007) 6.77

The mosaic structure of variation in the laboratory mouse genome. Nature (2002) 6.54

FaST linear mixed models for genome-wide association studies. Nat Methods (2011) 6.52

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet (2008) 6.42

Parental phenotypes in family-based association analysis. Am J Hum Genet (2004) 6.35

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet (2011) 6.20

Ascertainment through family history of disease often decreases the power of family-based association studies. Behav Genet (2007) 6.06

Haplotype reconstruction from genotype data using Imperfect Phylogeny. Bioinformatics (2004) 6.02

Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet (2007) 5.99

Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet (2012) 5.99

Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet (2010) 5.79

Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). Genome Res (2005) 5.71

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet (2011) 5.58

Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis. Nature (2006) 5.52

Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genet (2008) 5.08

Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet (2008) 5.04

The spectrum kernel: a string kernel for SVM protein classification. Pac Symp Biocomput (2002) 4.90

Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet (2006) 4.78

A genome-wide linkage and association scan reveals novel loci for autism. Nature (2009) 4.76

Whole population, genome-wide mapping of hidden relatedness. Genome Res (2008) 4.72

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci U S A (2007) 4.71

Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65

Founder effects in the assessment of HIV polymorphisms and HLA allele associations. Science (2007) 4.60

Validating, augmenting and refining genome-wide association signals. Nat Rev Genet (2009) 4.56

Ipr1 gene mediates innate immunity to tuberculosis. Nature (2005) 4.53

Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes (2006) 4.36

Adaptation of HIV-1 to human leukocyte antigen class I. Nature (2009) 4.24

Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat Genet (2007) 4.23

Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Lancet Neurol (2010) 4.19

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet (2009) 4.11