Published in Nat Rev Mol Cell Biol on May 01, 2008
Adipose Tissue Expandability and Type 2 Diabetes (LIMEX) | NCT03155412
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med (2009) 11.28
Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev (2013) 3.74
The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab (2010) 3.61
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab (2010) 3.11
Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab (2013) 3.00
Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J (2009) 2.83
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity (2012) 2.80
Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest (2011) 2.62
Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med (2015) 2.59
A genome scan for positive selection in thoroughbred horses. PLoS One (2009) 2.42
Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann N Y Acad Sci (2010) 2.16
Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes (2009) 2.11
FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats. J Lipid Res (2009) 1.96
PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis. EMBO J (2009) 1.94
AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol (2010) 1.93
Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metab (2014) 1.86
Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation. Cell Metab (2013) 1.85
High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab (2012) 1.77
Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. FASEB J (2011) 1.72
Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure. J Biol Chem (2009) 1.71
Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr Rev (2011) 1.65
Inflammation induced by RAW macrophages suppresses UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes. Am J Physiol Cell Physiol (2013) 1.59
Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. Diabetes (2009) 1.59
Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions. J Biol Chem (2010) 1.57
MicroRNAs in β-cell biology, insulin resistance, diabetes and its complications. Diabetes (2011) 1.56
Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. Mol Cell Biol (2011) 1.55
Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol (2011) 1.53
Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites. BMC Genomics (2011) 1.52
Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes. BMC Biol (2009) 1.51
Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes. Chem Biol (2012) 1.47
Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity. J Immunol (2011) 1.41
Balancing the fat: lipid droplets and human disease. EMBO Mol Med (2013) 1.40
microRNAs in the regulation of adipogenesis and obesity. Curr Mol Med (2011) 1.39
Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type. Cardiovasc Diabetol (2009) 1.38
Skeletal changes associated with the onset of type 2 diabetes in the ZDF and ZDSD rodent models. Am J Physiol Endocrinol Metab (2009) 1.34
Natural killer T cells in adipose tissue prevent insulin resistance. J Clin Invest (2012) 1.34
Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations. Am J Pathol (2009) 1.33
Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metab Disord (2013) 1.32
Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice. PLoS One (2011) 1.31
Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. Nat Commun (2013) 1.31
FSP27 promotes lipid droplet clustering and then fusion to regulate triglyceride accumulation. PLoS One (2011) 1.30
Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. PLoS Genet (2011) 1.30
Regulation of metabolism by the innate immune system. Nat Rev Endocrinol (2015) 1.29
Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler Thromb Vasc Biol (2012) 1.28
Reversal of small, dense LDL subclass phenotype by normalization of adiposity. Obesity (Silver Spring) (2009) 1.28
Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ. Proc Natl Acad Sci U S A (2013) 1.24
IL-17 in obesity and adipogenesis. Cytokine Growth Factor Rev (2010) 1.23
The skinny on fat: lipolysis and fatty acid utilization in adipocytes. Trends Endocrinol Metab (2009) 1.22
Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations. J Am Heart Assoc (2014) 1.22
Smad3 deficiency in mice protects against insulin resistance and obesity induced by a high-fat diet. Diabetes (2011) 1.21
Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surg Obes Relat Dis (2010) 1.20
Cell biology. On being the right (cell) size. Science (2015) 1.17
A negative regulatory pathway of GLUT4 trafficking in adipocyte: new function of RIP140 in the cytoplasm via AS160. Cell Metab (2009) 1.16
Body composition methods: comparisons and interpretation. J Diabetes Sci Technol (2008) 1.15
The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism. Genome Res (2012) 1.14
Functional analysis of long-chain acyl-CoA synthetase 1 in 3T3-L1 adipocytes. J Biol Chem (2009) 1.14
Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone. Circ Res (2009) 1.13
Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity. Nat Commun (2010) 1.13
Triglycerides and cardiovascular risk. Curr Cardiol Rev (2009) 1.12
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. Proc Natl Acad Sci U S A (2013) 1.12
Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta (2013) 1.12
An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects. J Clin Endocrinol Metab (2011) 1.11
beta3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK. Biochim Biophys Acta (2010) 1.11
MicroRNAs in insulin resistance and obesity. Exp Diabetes Res (2012) 1.10
Adiponectin inhibits lipolysis in mouse adipocytes. Diabetes (2011) 1.10
Ability among adolescents for the metabolic syndrome to predict elevations in factors associated with type 2 diabetes and cardiovascular disease: data from the national health and nutrition examination survey 1999-2006. Metab Syndr Relat Disord (2010) 1.10
Modeling type 2 diabetes in rats using high fat diet and streptozotocin. J Diabetes Investig (2014) 1.09
Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes. Trends Endocrinol Metab (2011) 1.09
Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders. Diabetes (2011) 1.09
From PDE3B to the regulation of energy homeostasis. Curr Opin Pharmacol (2011) 1.09
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet (2016) 1.08
Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats. Hepatology (2009) 1.08
Cytoplasmic receptor-interacting protein 140 (RIP140) interacts with perilipin to regulate lipolysis. Cell Signal (2011) 1.08
Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation. PLoS One (2009) 1.08
Sirtuin-1 regulation of mammalian metabolism. Trends Mol Med (2011) 1.07
Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection. PLoS Pathog (2015) 1.06
Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity. Front Endocrinol (Lausanne) (2013) 1.06
Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. EMBO J (2011) 1.05
The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. Mol Cell Biol (2009) 1.05
Quantitative electron microscopy shows uniform incorporation of triglycerides into existing lipid droplets. Histochem Cell Biol (2009) 1.04
Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes. J Biol Chem (2014) 1.04
Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate. Arterioscler Thromb Vasc Biol (2009) 1.04
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice. Proc Natl Acad Sci U S A (2013) 1.04
Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice. Nat Commun (2015) 1.03
SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL. J Lipid Res (2011) 1.03
Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro. Diabetologia (2012) 1.03
Adipophilin distribution and colocalization with lipid droplets in skeletal muscle. Histochem Cell Biol (2009) 1.02
Interleukin-1β regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability. PLoS One (2013) 1.01
Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice. PLoS One (2011) 1.01
Short-term overeating induces insulin resistance in fat cells in lean human subjects. Mol Med (2009) 1.00
An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism. J Biol Chem (2011) 1.00
Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. Diabetes (2010) 1.00
Adipose tissue deficiency and chronic inflammation in diabetic Goto-Kakizaki rats. PLoS One (2011) 0.99
Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome. J Lipid Res (2010) 0.99
The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. Nutr Metab (Lond) (2010) 0.99
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol (2010) 0.99
Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes (2012) 0.98
Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes. J Biol Chem (2009) 0.98
Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections. J Lipid Res (2012) 0.98
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med (2004) 18.86
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell (1998) 18.32
TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 17.49
A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes (2003) 16.62
Cellular mechanisms of insulin resistance. J Clin Invest (2000) 12.61
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest (2006) 12.32
Adipose tissue as an endocrine organ. J Clin Endocrinol Metab (2004) 11.94
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science (2001) 11.56
Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science (2003) 11.39
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature (1997) 10.53
Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab (2007) 10.40
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem (2002) 9.76
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab (2008) 9.74
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest (1995) 9.59
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
Economic costs of diabetes in the US in 2002. Diabetes Care (2003) 8.92
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science (2004) 8.58
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia (1999) 8.17
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia (2003) 7.88
Leptin-replacement therapy for lipodystrophy. N Engl J Med (2002) 7.78
Obesity-induced inflammatory changes in adipose tissue. J Clin Invest (2003) 7.50
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem (2000) 7.41
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes (1999) 7.14
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest (2006) 6.85
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab (2007) 6.83
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest (1999) 6.73
Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev (2007) 6.53
Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A (2003) 6.06
Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res (2007) 6.03
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes (2005) 5.68
Retracted Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes (2007) 5.67
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes (1997) 5.61
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab (2007) 5.38
Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol (1999) 5.38
Obesity wars: molecular progress confronts an expanding epidemic. Cell (2004) 5.29
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes (2005) 5.22
Life without white fat: a transgenic mouse. Genes Dev (1998) 5.08
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest (2002) 4.96
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes (2006) 4.95
Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem (2004) 4.89
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev (1998) 4.86
Leptin. Annu Rev Physiol (2000) 4.78
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab (2002) 4.64
From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol (2006) 4.58
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science (1996) 4.50
Type 2 diabetes-a matter of beta-cell life and death? Science (2005) 4.46
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes (1995) 4.33
Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology (2003) 4.28
Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev (2007) 4.23
The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem (1994) 4.21
Lipotoxic diseases. Annu Rev Med (2002) 4.16
Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes (1997) 4.15
Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol (2006) 4.07
PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest (2004) 3.86
A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes (2005) 3.84
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem (2002) 3.83
Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci U S A (2004) 3.67
Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat Genet (2000) 3.62
A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett (2006) 3.25
PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol (1995) 3.14
From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes (2004) 3.13
Lipid droplets in lipogenesis and lipolysis. Endocrinology (2008) 3.02
Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem (2007) 2.90
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes (2004) 2.86
Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J Clin Endocrinol Metab (2007) 2.81
Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab (2005) 2.77
OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes (2006) 2.77
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest (2005) 2.69
Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest (1993) 2.68
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem (1998) 2.59
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun (2006) 2.56
Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes (2007) 2.54
Brown fat and thermogenesis. Physiol Rev (1969) 2.50
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A (2004) 2.46
CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J (1998) 2.44
Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol (2007) 2.40
Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase. J Biol Chem (1997) 2.31
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol Cell Biol (1998) 2.28
Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes. Diabetes (2002) 2.28
The role of AMP-activated protein kinase in mitochondrial biogenesis. J Physiol (2006) 2.19
Endocrine and metabolic effects of experimental obesity in man. Recent Prog Horm Res (1973) 2.17
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes (1999) 2.14
Interdomain communication regulating ligand binding by PPAR-gamma. Nature (1998) 2.13
Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation. J Biol Chem (2000) 2.10
Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia (2006) 2.07
Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract Res Clin Endocrinol Metab (2005) 1.98
Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J Biol Chem (2006) 1.96
A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. Diabetes (2005) 1.94
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med (1998) 1.93
Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes (1996) 1.91
The GLUT4 glucose transporter. Cell Metab (2007) 4.30
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest (2004) 4.16
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature (2009) 3.21
Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells. J Clin Invest (2002) 3.13
The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest (2011) 3.12
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A (2003) 3.03
Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem (2007) 2.90
Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A (2008) 2.71
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest (2005) 2.69
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell (2009) 2.61
Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature (2002) 2.51
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med (2013) 2.19
Selective caveolin-1-dependent endocytosis of glycosphingolipids. Mol Biol Cell (2003) 2.05
EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem (2003) 1.99
Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation (2011) 1.97
Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway. Mol Cell Biol (2004) 1.86
Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med (2009) 1.80
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J Biol Chem (2007) 1.80
An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. Proc Natl Acad Sci U S A (2006) 1.78
Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell (2007) 1.76
Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature (2011) 1.74
Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules. EMBO J (2003) 1.64
A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling. J Biol Chem (2001) 1.60
Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol (2011) 1.53
Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes. Mol Cell Biol (2007) 1.50
Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol (2008) 1.47
Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J (2004) 1.43
Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. J Immunol (2004) 1.41
Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. J Biol Chem (2004) 1.38
Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem (2007) 1.35
What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes (2012) 1.35
The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides. J Biol Chem (2001) 1.34
Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes. Mol Cell Biol (2004) 1.32
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev (2004) 1.32
FSP27 promotes lipid droplet clustering and then fusion to regulate triglyceride accumulation. PLoS One (2011) 1.30
PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes. J Biol Chem (2005) 1.29
Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells. J Biol Chem (2007) 1.29
Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem (2005) 1.23
Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations. J Am Heart Assoc (2014) 1.22
Pneumocystis carinii cell wall beta-glucans initiate macrophage inflammatory responses through NF-kappaB activation. J Biol Chem (2003) 1.21
Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surg Obes Relat Dis (2010) 1.20
Glucosylceramide modulates membrane traffic along the endocytic pathway. J Lipid Res (2002) 1.17
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol (2008) 1.15
KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling. J Biol Chem (2004) 1.12
Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J (2008) 1.10
Dicer is required for the formation of white but not brown adipose tissue. J Cell Physiol (2011) 1.09
Lipid droplets: FSP27 knockout enhances their sizzle. J Clin Invest (2008) 1.09
RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin. J Biol Chem (2004) 1.09
Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. J Biol Chem (2008) 1.05
The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes. J Biol Chem (2005) 1.05
FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes. Biochem Biophys Res Commun (2013) 1.04
Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor. J Biol Chem (2004) 1.04
Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes. J Biol Chem (2014) 1.04
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice. Proc Natl Acad Sci U S A (2013) 1.04
Micromanaging insulin secretion. Nat Med (2004) 1.04
C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab (2011) 1.03
Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Biochem J (2011) 1.03
Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes. J Lipid Res (2010) 1.01
Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes. J Biol Chem (2009) 0.98
RNAi-based gene silencing in primary mouse and human adipose tissues. J Lipid Res (2006) 0.98
Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning. J Clin Invest (2016) 0.97
Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation. Mol Cell Biol (2012) 0.96
β3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation. J Biol Chem (2012) 0.96
Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction. Proc Natl Acad Sci U S A (2009) 0.95
Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by suppressing the mammalian target of rapamycin (mTOR) signaling pathway in cultured adipocytes. J Biol Chem (2009) 0.94
A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem (2010) 0.93
Identification of the lipid droplet targeting domain of the Cidea protein. J Lipid Res (2010) 0.92
CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. Am J Physiol Endocrinol Metab (2013) 0.92
Macrophage internalization of fungal beta-glucans is not necessary for initiation of related inflammatory responses. Infect Immun (2005) 0.91
Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization. Mol Biol Cell (2003) 0.91
Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans. PLoS One (2012) 0.89
Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling. J Lipid Res (2013) 0.85
Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha. J Biol Chem (2005) 0.84
Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues. Mol Cell Biol (2015) 0.84
CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone. PLoS One (2012) 0.83
ARNT misbehavin' in diabetic beta cells. Nat Med (2006) 0.81
Prolonged efficiency of siRNA-mediated gene silencing in primary cultures of human preadipocytes and adipocytes. Obesity (Silver Spring) (2013) 0.80
Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism. Cell Immunol (2009) 0.79
Tensions rise and blood flows over dysfunctional fat. Circulation (2011) 0.77