MPDA: microarray pooled DNA analyzer.

The SNPMaP package for R: a framework for genome-wide association using DNA pooling on microarrays. Bioinformatics (2008) 1.15

Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples. PLoS Genet (2010) 1.14

A genome-wide homozygosity association study identifies runs of homozygosity associated with rheumatoid arthritis in the human major histocompatibility complex. PLoS One (2012) 1.03

GPFrontend and GPGraphics: graphical analysis tools for genetic association studies. BMC Bioinformatics (2010) 0.94

Mitochondrial genetic variants identified to be associated with BMI in adults. PLoS One (2014) 0.83

A new analysis tool for individual-level allele frequency for genomic studies. BMC Genomics (2010) 0.80

The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA. Hum Genet (2011) 0.79

UPDG: utilities package for data analysis of pooled DNA GWAS. BMC Genet (2012) 0.76

Statistical comparison framework and visualization scheme for ranking-based algorithms in high-throughput genome-wide studies. J Comput Biol (2009) 0.75

An integrated analysis tool for analyzing hybridization intensities and genotypes using new-generation population-optimized human arrays. BMC Genomics (2016) 0.75

Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71

Global variation in copy number in the human genome. Nature (2006) 57.50

Large-scale copy number polymorphism in the human genome. Science (2004) 34.64

Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96

A high-resolution survey of deletion polymorphism in the human genome. Nat Genet (2005) 16.99

Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet (2005) 14.30

High-resolution genomic profiling of chromosomal aberrations using Infinium whole-genome genotyping. Genome Res (2006) 10.45

Large-scale genotyping of complex DNA. Nat Biotechnol (2003) 10.00

Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays. Nat Methods (2004) 9.52

Association study designs for complex diseases. Nat Rev Genet (2001) 8.91

An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Res (2004) 8.86

DNA Pooling: a tool for large-scale association studies. Nat Rev Genet (2002) 5.66

Whole genome DNA copy number changes identified by high density oligonucleotide arrays. Hum Genomics (2004) 5.65

The complex interplay among factors that influence allelic association. Nat Rev Genet (2004) 5.26

The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling. Genome Res (1998) 5.11

High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci U S A (2001) 4.31

Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies. Am J Hum Genet (2006) 3.67

Association testing by DNA pooling: an effective initial screen. Proc Natl Acad Sci U S A (2002) 2.79

Algorithms for large-scale genotyping microarrays. Bioinformatics (2003) 2.66

Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design. Ann Hum Genet (2002) 2.51

Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans. Nucleic Acids Res (2006) 2.33

High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools. Proc Natl Acad Sci U S A (2002) 2.32

Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Hum Genet (2000) 2.26

Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am J Hum Genet (2001) 2.26

Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci. Proc Natl Acad Sci U S A (1985) 2.19

Genotyping pooled DNA on microarrays: a systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits. Behav Genet (2004) 2.14

Genome-wide detection of allelic imbalance using human SNPs and high-density DNA arrays. Genome Res (2000) 2.13

Biodiversity of 52 chicken populations assessed by microsatellite typing of DNA pools. Genet Sel Evol (2003) 2.02

Pooled DNA genotyping on Affymetrix SNP genotyping arrays. BMC Genomics (2006) 1.96

Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates. Nucleic Acids Res (2006) 1.88

Identification of disease causing loci using an array-based genotyping approach on pooled DNA. BMC Genomics (2005) 1.83

Allele frequency distributions in pooled DNA samples: applications to mapping complex disease genes. Genome Res (1998) 1.81

Allelic dosage analysis with genotyping microarrays. Biochem Biophys Res Commun (2005) 1.78

Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels. Hum Genomics (2004) 1.71

A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays. Nucleic Acids Res (2005) 1.71

Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs. BMC Genomics (2005) 1.68

Determination of allele frequencies at loci with length polymorphism by quantitative analysis of DNA amplified from pooled samples. PCR Methods Appl (1993) 1.67

Large-scale determination of SNP allele frequencies in DNA pools using MALDI-TOF mass spectrometry. Hum Mutat (2002) 1.65

Identification of frequent chromosome copy-number polymorphisms by use of high-resolution single-nucleotide-polymorphism arrays. Am J Hum Genet (2006) 1.60

Han Chinese cell and genome bank in Taiwan: purpose, design and ethical considerations. Hum Hered (2004) 1.52

Power for genetic association studies with random allele frequencies and genotype distributions. Am J Hum Genet (2004) 1.52

PPC: an algorithm for accurate estimation of SNP allele frequencies in small equimolar pools of DNA using data from high density microarrays. Nucleic Acids Res (2005) 1.50

Allelic imbalance analysis by high-density single-nucleotide polymorphic allele (SNP) array with whole genome amplified DNA. Nucleic Acids Res (2004) 1.46

SNP allele frequency estimation in DNA pools and variance components analysis. Biotechniques (2004) 1.44

Estimation of haplotype frequencies, linkage-disequilibrium measures, and combination of haplotype copies in each pool by use of pooled DNA data. Am J Hum Genet (2003) 1.42

Allelic imbalances in human bladder cancer: genome-wide detection with high-density single-nucleotide polymorphism arrays. J Natl Cancer Inst (2002) 1.34

Simple method to analyze SNP-based association studies using DNA pools. Genet Epidemiol (2003) 1.29

Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA. Proc Natl Acad Sci U S A (2003) 1.27

DNA pooling in mutation detection with reference to sequence analysis. Am J Hum Genet (1999) 1.27

The efficiency of pooling in the detection of rare mutations. Am J Hum Genet (2000) 1.23

Large-scale validation of single nucleotide polymorphisms in gene regions. Genome Res (2004) 1.13

New adjustment factors and sample size calculation in a DNA-pooling experiment with preferential amplification. Genetics (2005) 1.04

Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia. Cancer Res (1997) 0.98

Estimation of relative allele frequencies of single-nucleotide polymorphisms in different populations by microarray hybridization of pooled DNA. Anal Biochem (2004) 0.97

A genome-wide study of preferential amplification/hybridization in microarray-based pooled DNA experiments. Nucleic Acids Res (2006) 0.95

PDA: Pooled DNA analyzer. BMC Bioinformatics (2006) 0.94

Allelotyping of pooled DNA with 250 K SNP microarrays. BMC Genomics (2007) 0.93

Accurate determination of microsatellite allele frequencies in pooled DNA samples. Eur J Hum Genet (2004) 0.92

Association mapping using pooled DNA. Methods Mol Biol (2007) 0.83

Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro. Cancer Res (1999) 0.82

Shortened survival after relapse in T-cell acute lymphoblastic leukemia patients with p16/p15 deletions. Leuk Res (1997) 0.81

A comparison of individual genotyping and pooled DNA analysis for polymorphism validation prior to large-scale genetic studies. Ann Hum Genet (2006) 0.80

Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia. Clin Cancer Res (2000) 0.80

An evaluation of the use of pooled samples in studies of genetic variation. Heredity (Edinb) (1999) 0.79

SNP haplotype tagging from DNA pools of two individuals. BMC Bioinformatics (2003) 0.78

Mapping human genetic diversity in Asia. Science (2009) 7.40

Variant GADL1 and response to lithium therapy in bipolar I disorder. N Engl J Med (2013) 5.71

FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res (2006) 5.60

Medical genetics: a marker for Stevens-Johnson syndrome. Nature (2004) 5.43

Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N Engl J Med (2011) 5.13

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet (2011) 4.04

HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A (2005) 3.82

High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. Clin Cancer Res (2004) 3.66

Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A (2005) 3.37

A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet (2010) 3.25

A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity. Hum Mol Genet (2005) 2.97

Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet (2012) 2.70

Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med (2008) 2.66

Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis. J Bacteriol (2009) 2.64

Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer. Clin Cancer Res (2005) 2.30

Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics (2006) 2.25

PSORS2 is due to mutations in CARD14. Am J Hum Genet (2012) 2.10

Type II collagen gene variants and inherited osteonecrosis of the femoral head. N Engl J Med (2005) 2.08

ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. J Clin Invest (2004) 2.08

The impact of antibodies on clinical outcomes in diseases treated with therapeutic protein: lessons learned from infantile Pompe disease. Genet Med (2011) 2.08

Long contiguous stretches of homozygosity in the human genome. Hum Mutat (2006) 2.07

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat Genet (2012) 2.05

Epidemiologic clues to SARS origin in China. Emerg Infect Dis (2004) 2.03

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet (2011) 1.97

Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex. Curr Mol Med (2002) 1.96

Early detection of Pompe disease by newborn screening is feasible: results from the Taiwan screening program. Pediatrics (2008) 1.95

PrimerZ: streamlined primer design for promoters, exons and human SNPs. Nucleic Acids Res (2007) 1.91

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat Genet (2012) 1.90

microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Res (2010) 1.76

Complete nucleotide sequence of pK245, a 98-kilobase plasmid conferring quinolone resistance and extended-spectrum-beta-lactamase activity in a clinical Klebsiella pneumoniae isolate. Antimicrob Agents Chemother (2006) 1.76

Human leukocyte antigens and drug hypersensitivity. Curr Opin Allergy Clin Immunol (2007) 1.64

Pompe disease in infants: improving the prognosis by newborn screening and early treatment. Pediatrics (2009) 1.56

Genomewide suggestive linkage of opioid dependence to chromosome 14q. Hum Mol Genet (2007) 1.54

Han Chinese cell and genome bank in Taiwan: purpose, design and ethical considerations. Hum Hered (2004) 1.52

Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics (2010) 1.51

Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome. J Allergy Clin Immunol (2012) 1.51

Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy. J Exp Clin Cancer Res (2013) 1.50

Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. J Allergy Clin Immunol (2011) 1.47

A sliding-window weighted linkage disequilibrium test. Genet Epidemiol (2006) 1.47

Association of the neuronal nicotinic acetylcholine receptor subunit alpha4 polymorphisms with febrile convulsions. Epilepsia (2003) 1.44

Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol (2012) 1.34

A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes. Diabetes (2011) 1.33

Nephrotic syndrome complicating alpha-glucosidase replacement therapy for Pompe disease. Pediatrics (2004) 1.31

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet (2012) 1.30

Genetic diversity of capsular polysaccharide biosynthesis in Klebsiella pneumoniae clinical isolates. Microbiology (2009) 1.26

Genetic determinants of warfarin dosing in the Han-Chinese population. Pharmacogenomics (2009) 1.23

ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci Signal (2010) 1.22

HLA-B*1502-bound peptides: implications for the pathogenesis of carbamazepine-induced Stevens-Johnson syndrome. J Allergy Clin Immunol (2007) 1.20

A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease. Hum Genet (2011) 1.19

AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia. Mol Ther (2008) 1.18

Kernel-based association test. Genetics (2008) 1.17

Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. PLoS One (2009) 1.17

Breast cancer risk associated with genotypic polymorphism of the mitosis-regulating gene Aurora-A/STK15/BTAK. Int J Cancer (2005) 1.12

Analysis of a glucose tetrasaccharide elevated in Pompe disease by stable isotope dilution-electrospray ionization tandem mass spectrometry. Anal Biochem (2003) 1.10

Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study. PLoS One (2011) 1.08

VKORC1 haplotypes in five East-Asian populations and Indians. Pharmacogenomics (2009) 1.08

Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. Alcohol Clin Exp Res (2004) 1.07

Functional analysis of novel SNPs and mutations in human and mouse genomes. BMC Bioinformatics (2008) 1.06

New adjustment factors and sample size calculation in a DNA-pooling experiment with preferential amplification. Genetics (2005) 1.04

Genetic predisposition of life-threatening antiepileptic-induced skin reactions. Expert Opin Drug Saf (2010) 1.04

Clonal expansion of both modern and ancient genotypes of Mycobacterium tuberculosis in southern Taiwan. PLoS One (2012) 1.04

Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. Hypertension (2013) 1.03

A genome-wide homozygosity association study identifies runs of homozygosity associated with rheumatoid arthritis in the human major histocompatibility complex. PLoS One (2012) 1.03

Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. PLoS Genet (2010) 1.02

A promoter sequence variant of ZNF750 is linked with familial psoriasis. J Invest Dermatol (2008) 1.02

Tissue-specific inactivation of murine M6P/IGF2R. Am J Pathol (2003) 1.01

Efficacy of gene therapy for a prototypical lysosomal storage disease (GSD-II) is critically dependent on vector dose, transgene promoter, and the tissues targeted for vector transduction. Mol Ther (2002) 1.00

RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function. Biol Psychiatry (2008) 1.00