Published in Proteins on November 01, 2008
Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. Chem Biol Drug Des (2011) 1.13
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Human isoprenoid synthase enzymes as therapeutic targets. Front Chem (2014) 0.86
1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase. Org Biomol Chem (2012) 0.84
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Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallogr F Struct Biol Commun (2014) 0.78
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Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase. Biochemistry (2016) 0.75
Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth. ChemMedChem (2016) 0.75
New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase. Bioorg Med Chem (2013) 0.75
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Genomic and proteomic analysis of thirty-nine structural proteins of shrimp white spot syndrome virus. J Virol (2004) 1.65
Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem (2005) 1.62
Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. J Am Chem Soc (2008) 1.57
Bioorganometallic mechanism of action, and inhibition, of IspH. Proc Natl Acad Sci U S A (2010) 1.54
Precise mapping of increased sialylation pattern and the expression of acute phase proteins accompanying murine tumor progression in BALB/c mouse by integrated sera proteomics and glycomics. J Proteome Res (2008) 1.51
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Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins (2006) 1.47
Identification of the nucleocapsid, tegument, and envelope proteins of the shrimp white spot syndrome virus virion. J Virol (2006) 1.42
Diterpene cyclases and the nature of the isoprene fold. Proteins (2010) 1.41
Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation. J Biol Chem (2008) 1.40
The refined crystal structure of an eel pout type III antifreeze protein RD1 at 0.62-A resolution reveals structural microheterogeneity of protein and solvation. Biophys J (2003) 1.36
3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. J Med Chem (2003) 1.35
Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis. J Struct Biol (2010) 1.33
Discovery of virulence factors of pathogenic bacteria. Curr Opin Chem Biol (2008) 1.31
Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies. J Biol Chem (2003) 1.31
Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation. Proc Natl Acad Sci U S A (2004) 1.30
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Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG). Proc Natl Acad Sci U S A (2010) 1.28
Mechanism of the maturation process of SARS-CoV 3CL protease. J Biol Chem (2005) 1.27
Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution. J Biol Chem (2003) 1.26
Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. EMBO J (2006) 1.24
Multitarget drug discovery for tuberculosis and other infectious diseases. J Med Chem (2014) 1.24
Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds. J Biol Chem (2009) 1.23
Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase. J Am Chem Soc (2006) 1.22
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem (2002) 1.22
Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms. J Am Chem Soc (2010) 1.21
A density functional theory investigation of Fe-N-O bonding in heme proteins and model systems. J Am Chem Soc (2003) 1.21
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. J Med Chem (2004) 1.21
(57)Fe Mössbauer isomer shifts of heme protein model systems: electronic structure calculations. J Am Chem Soc (2002) 1.21
Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data. J Med Chem (2008) 1.21
Thermodynamics of bisphosphonates binding to human bone: a two-site model. J Am Chem Soc (2009) 1.21
Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of XC847, a 3'-5' oligoribonuclease from Xanthomonas campestris. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 1.19
Photoaffinity antigens for human gammadelta T cells. J Immunol (2008) 1.19
Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination. J Biol Chem (2006) 1.19
Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons. J Bacteriol (2005) 1.19
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem (2008) 1.18
White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1. J Virol (2006) 1.17
Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates. J Med Chem (2004) 1.16
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The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. J Biol Chem (2007) 1.16
Ultrahigh resolution protein structures using NMR chemical shift tensors. Proc Natl Acad Sci U S A (2011) 1.15
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrob Agents Chemother (2002) 1.14
Protein expression profiling of the shrimp cellular response to white spot syndrome virus infection. Dev Comp Immunol (2006) 1.14
Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. Chem Biol Drug Des (2011) 1.13
Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations. J Med Chem (2005) 1.13
Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton. J Biol Chem (2003) 1.13
Cytochrome P450: an investigation of the Mössbauer spectra of a reaction intermediate and an Fe(IV)[double bond]O model system. J Am Chem Soc (2004) 1.13
Self-cleavage of fusion protein in vivo using TEV protease to yield native protein. Protein Sci (2005) 1.13
Crystal structure of the left-handed archaeal RadA helical filament: identification of a functional motif for controlling quaternary structures and enzymatic functions of RecA family proteins. Nucleic Acids Res (2007) 1.12
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption. J Med Chem (2005) 1.12
Mechanism of action and inhibition of dehydrosqualene synthase. Proc Natl Acad Sci U S A (2010) 1.11
Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem (2002) 1.11
The H(+)-pyrophosphatase of Rhodospirillum rubrum is predominantly located in polyphosphate-rich acidocalcisomes. J Biol Chem (2004) 1.10
A solid state 13C NMR, crystallographic, and quantum chemical investigation of chemical shifts and hydrogen bonding in histidine dipeptides. J Am Chem Soc (2005) 1.10
Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate. J Infect Dis (2002) 1.10
Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi. Int J Antimicrob Agents (2004) 1.10
Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design. J Biol Chem (2007) 1.10
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc Natl Acad Sci U S A (2012) 1.09
Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. J Med Chem (2006) 1.09
NMR investigations of the static and dynamic structures of bisphosphonates on human bone: a molecular model. J Am Chem Soc (2008) 1.09
Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies. Protein Sci (2004) 1.09
Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination. J Biol Chem (2003) 1.08
Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. J Biol Chem (2007) 1.08
On the Mössbauer spectra of isopenicillin N synthase and a model (FeNO)7 (S = 3/2) system. J Am Chem Soc (2004) 1.08
Unusual DNA duplex and hairpin motifs. Nucleic Acids Res (2003) 1.08
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Farnesyl diphosphate synthase inhibitors from in silico screening. Chem Biol Drug Des (2013) 1.02