Published in J Biol Chem on April 30, 2008
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev (2011) 3.04
Proteolytic networks in cancer. Trends Cell Biol (2011) 2.10
Heparanase: busy at the cell surface. Trends Biochem Sci (2009) 2.07
Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy. Cancer Res (2015) 1.59
Diverse cell signaling events modulated by perlecan. Biochemistry (2008) 1.49
Significance of heparanase in cancer and inflammation. Cancer Microenviron (2011) 1.46
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling. Cancer Res (2009) 1.34
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. J Clin Invest (2011) 1.32
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. J Biol Chem (2010) 1.19
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics. FASEB J (2009) 1.13
Tumorigenic and adhesive properties of heparanase. Semin Cancer Biol (2010) 1.10
The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics. Front Oncol (2014) 1.08
Versatile role of heparanase in inflammation. Matrix Biol (2013) 1.05
The potential of heparanase as a therapeutic target in cancer. Biochem Pharmacol (2014) 1.01
Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides. Endocrinology (2009) 1.01
Role of heparanase in radiation-enhanced invasiveness of pancreatic carcinoma. Cancer Res (2011) 1.00
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis. Oncogene (2009) 0.97
Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability. PLoS Pathog (2016) 0.94
Involvement of heparanase in atherosclerosis and other vessel wall pathologies. Matrix Biol (2013) 0.93
Impact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applications. Rambam Maimonides Med J (2011) 0.92
Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses. Am J Pathol (2015) 0.90
Heparanase in inflammation and inflammation-associated cancer. FEBS J (2013) 0.90
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. Nat Rev Cancer (2015) 0.89
Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis. Mol Immunol (2010) 0.89
Lentiviral miR30-based RNA interference against heparanase suppresses melanoma metastasis with lower liver and lung toxicity. Int J Biol Sci (2013) 0.88
Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells. Clin Exp Metastasis (2013) 0.87
Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin. Cell Mol Life Sci (2014) 0.87
Heparanase and autoimmune diabetes. Front Immunol (2013) 0.86
Heparin enhances serpin inhibition of the cysteine protease cathepsin L. J Biol Chem (2009) 0.85
Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation. J Leukoc Biol (2009) 0.84
Heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantation. PLoS One (2010) 0.82
The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury. Antioxid Redox Signal (2014) 0.81
Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma. J Cell Mol Med (2013) 0.81
Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase. Glycobiology (2016) 0.80
Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response. J Biol Chem (2015) 0.79
Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy. Mol Vis (2016) 0.79
Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice. Cell Mol Life Sci (2013) 0.78
Heparanase Upregulation Contributes to Porcine Reproductive and Respiratory Syndrome Virus Release. J Virol (2017) 0.78
Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545. Oncotarget (2017) 0.75
Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation. PLoS One (2016) 0.75
Nephroprotective effect of heparanase in experimental nephrotic syndrome. PLoS One (2015) 0.75
Heparanase and cancer progression: New directions, new promises. Hum Vaccin Immunother (2016) 0.75
NK cell heparanase controls tumor invasion and immune surveillance. J Clin Invest (2017) 0.75
Emerging Roles of Heparanase in Viral Pathogenesis. Pathogens (2017) 0.75
Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis. Oncotarget (2017) 0.75
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell (2004) 4.38
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat Med (1999) 4.22
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science (1998) 3.98
Exosomes: from biogenesis and secretion to biological function. Immunol Lett (2006) 3.82
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol (2006) 3.24
Lysosomal cysteine proteases: more than scavengers. Biochim Biophys Acta (2000) 2.76
Heparanase: a key enzyme involved in cell invasion. Biochim Biophys Acta (2001) 2.74
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev (2006) 2.74
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis. J Natl Cancer Inst (2004) 2.52
A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol Cell (2004) 2.44
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J (2000) 2.09
Cysteine cathepsin proteases as pharmacological targets in cancer. Trends Pharmacol Sci (2007) 2.07
Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis. Cancer Res (1983) 2.04
Mammalian heparanase: what is the message? J Cell Mol Med (2007) 1.91
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83
Heparanase expression in primary and metastatic pancreatic cancer. Cancer Res (2001) 1.67
Heparanases and tumor metastasis. J Cell Biochem (1988) 1.64
Heparanase affects adhesive and tumorigenic potential of human glioma cells. Cancer Res (2003) 1.54
Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. J Biol Chem (2004) 1.43
Role of endothelial heparanase in delayed-type hypersensitivity. Blood (2005) 1.35
Mechanism of activation of human heparanase investigated by protein engineering. Biochemistry (2004) 1.21
Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells. Biochem J (2003) 1.19
Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer. J Biol Chem (1999) 1.16
Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase. J Biol Chem (2005) 1.13
Heparanase protein and gene expression in bladder cancer. J Urol (2001) 1.13
Quantification of cathepsins B and L in cells. Biochem J (1998) 1.09
Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L. Int Rev Cytol (2004) 1.07
Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines. J Biol Chem (2003) 0.98
Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans. J Cell Sci (2004) 0.98
Expression of cysteine peptidase cathepsin L and its inhibitors stefins A and B in relation to tumorigenicity of breast cancer cell lines. Cancer Lett (2002) 0.95
Evidence for the proenkephalin processing enzyme prohormone thiol protease (PTP) as a multicatalytic cysteine protease complex: activation by glutathione localized to secretory vesicles. Biochemistry (1999) 0.95
Senescence-initiated reversal of drug resistance: specific role of cathepsin L. Cancer Res (2004) 0.95
Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem (2005) 0.92
Tamoxifen induces heparanase expression in estrogen receptor-positive breast cancer. Clin Cancer Res (2007) 0.92
An alternate targeting pathway for procathepsin L in mouse fibroblasts. Traffic (2002) 0.91
Protease pathways in peptide neurotransmission and neurodegenerative diseases. Cell Mol Neurobiol (2006) 0.86
Involvement of disulfide bond formation in the activation of heparanase. Cancer Res (2007) 0.85
Decreased susceptibility of a 70-kDa protein to cathepsin L after phosphorylation by protein kinase C. Proc Natl Acad Sci U S A (1989) 0.84
Subsite specificity of trypanosomal cathepsin L-like cysteine proteases. Probing the S2 pocket with phenylalanine-derived amino acids. Eur J Biochem (2001) 0.82
Processing properties of recombinant human procathepsin L. Biochem Biophys Res Commun (1997) 0.81
Cathepsins in basal cell carcinomas: activity, immunoreactivity and mRNA staining of cathepsins B, D, H and L. Arch Dermatol Res (2004) 0.81
Purification and characterization of placental heparanase and its expression by cultured cytotrophoblasts. Mol Hum Reprod (1996) 0.81
Carboxydipeptidase activities of recombinant cysteine peptidases. Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana. Eur J Biochem (2004) 0.79
Microenvironmental regulation of tumor progression and metastasis. Nat Med (2013) 8.37
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med (2012) 6.77
CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med (2013) 5.04
IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev (2010) 3.56
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol (2006) 3.24
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev (2011) 3.04
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev (2006) 2.74
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis. J Natl Cancer Inst (2004) 2.52
Non-cell-autonomous tumor suppression by p53. Cell (2013) 2.40
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis. J Biol Chem (2007) 2.25
A novel founder mutation in the RNASEL gene, 471delAAAG, is associated with prostate cancer in Ashkenazi Jews. Am J Hum Genet (2002) 2.24
Cysteine cathepsins and the cutting edge of cancer invasion. Cell Cycle (2007) 2.10
Proteolytic networks in cancer. Trends Cell Biol (2011) 2.10
Heparanase: busy at the cell surface. Trends Biochem Sci (2009) 2.07
Cysteine cathepsin proteases as pharmacological targets in cancer. Trends Pharmacol Sci (2007) 2.07
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res (2006) 2.02
Processing and activation of latent heparanase occurs in lysosomes. J Cell Sci (2004) 1.82
Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem (2004) 1.78
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis. FEBS J (2010) 1.78
Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest. J Cell Sci (2002) 1.75
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J Clin Invest (2009) 1.73
Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. FASEB J (2004) 1.64
Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Circ Res (2008) 1.64
Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development. Semin Cancer Biol (2002) 1.57
Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One (2008) 1.55
Heparanase affects adhesive and tumorigenic potential of human glioma cells. Cancer Res (2003) 1.54
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood (2010) 1.53
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting. J Biol Chem (2005) 1.52
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy. Blood (2007) 1.49
Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. J Biol Chem (2013) 1.49
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. PLoS One (2009) 1.46
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis. Proc Natl Acad Sci U S A (2002) 1.45
Cancer risks in naval divers with multiple exposures to carcinogens. Environ Health Perspect (2003) 1.44
Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46. J Immunol (2004) 1.43
Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. J Biol Chem (2004) 1.43
Heparanase promotes growth, angiogenesis and survival of primary breast tumors. Int J Cancer (2006) 1.42
Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice. Neurosci Lett (2011) 1.41
Non-anticoagulant heparins and inhibition of cancer. Pathophysiol Haemost Thromb (2009) 1.41
A novel protein with similarities to Rb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast. Mol Cell Biol (2004) 1.41
Heparanase mediates cell adhesion independent of its enzymatic activity. FASEB J (2003) 1.41
SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis. Clin Cancer Res (2011) 1.40
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development (2007) 1.40
[Update: adjuvant trastuzumab in HER2 positive breast cancer]. Harefuah (2012) 1.39
Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation. J Neurosci (2009) 1.38
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis. Proc Natl Acad Sci U S A (2005) 1.37
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res (2008) 1.35
Role of endothelial heparanase in delayed-type hypersensitivity. Blood (2005) 1.35
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling. Cancer Res (2009) 1.34
Cellular heparan sulfate participates in the metabolism of prions. J Biol Chem (2003) 1.34
Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. FASEB J (2005) 1.32
Heparan sulfate is a cellular receptor for purified infectious prions. J Biol Chem (2005) 1.32
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. J Clin Invest (2011) 1.32
Heparanase induces VEGF C and facilitates tumor lymphangiogenesis. Int J Cancer (2008) 1.31
Heparanase is essential for the development of diabetic nephropathy in mice. Diabetes (2011) 1.29
The heparanase system and tumor metastasis: is heparanase the seed and soil? Cancer Metastasis Rev (2011) 1.28
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival. Neoplasia (2006) 1.28
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase. J Biol Chem (2005) 1.27
Heparin, heparan sulfate and heparanase in inflammatory reactions. Thromb Haemost (2009) 1.27
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate. Nat Chem Biol (2007) 1.25
Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma. Cancer Res (2003) 1.25
Function of heparanase in prostate tumorigenesis: potential for therapy. Clin Cancer Res (2008) 1.25
Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Res (2007) 1.24
The heparanase/syndecan-1 axis in cancer: mechanisms and therapies. FEBS J (2013) 1.24
Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium. Proc Natl Acad Sci U S A (2002) 1.23
mTOR regulates phagosome and entotic vacuole fission. Mol Biol Cell (2013) 1.22
Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions. Cell Cycle (2010) 1.22
Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants. J Biol Chem (2013) 1.20
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. J Biol Chem (2010) 1.19
Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers. Int J Cancer (2004) 1.18
Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression. PLoS One (2013) 1.18
Heterodimer formation is essential for heparanase enzymatic activity. Biochem Biophys Res Commun (2003) 1.17
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts. J Immunol (2004) 1.16
P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins. FASEB J (2007) 1.14
Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans. PLoS One (2008) 1.14
Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase. J Biol Chem (2005) 1.13
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics. FASEB J (2009) 1.13
Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts. J Cell Sci (2002) 1.12
Role of promoter methylation in regulation of the mammalian heparanase gene. Oncogene (2003) 1.12
Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass. J Cell Physiol (2006) 1.11
Tumorigenic and adhesive properties of heparanase. Semin Cancer Biol (2010) 1.10
Cancer risks in carriers of the BRCA1/2 Ashkenazi founder mutations. J Med Genet (2007) 1.09
Heparanase upregulation by colonic epithelium in inflammatory bowel disease. Mod Pathol (2006) 1.09
Regulation of heparanase gene expression by estrogen in breast cancer. Cancer Res (2003) 1.09
Characterization of mechanisms involved in secretion of active heparanase. J Biol Chem (2006) 1.08
Human heparanase is localized within lysosomes in a stable form. Exp Cell Res (2002) 1.07
Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis. Cancer Res (2009) 1.07