Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever.

PubWeight™: 1.54‹?› | Rank: Top 4%

🔗 View Article (PMC 2546568)

Published in Virology on May 02, 2008

Authors

Anna P Durbin1, Maria José Vargas, Kimberli Wanionek, Samantha N Hammond, Aubree Gordon, Crisanta Rocha, Angel Balmaseda, Eva Harris

Author Affiliations

1: Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Room 251, Baltimore, MD 21205, USA. adurbin@jhsph.edu

Articles citing this

Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev (2009) 3.61

Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India-Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity. PLoS Negl Trop Dis (2016) 1.56

Dengue viruses - an overview. Infect Ecol Epidemiol (2013) 1.40

Dengue virus-induced hemorrhage in a nonhuman primate model. Blood (2009) 1.29

Antibodies play a greater role than immune cells in heterologous protection against secondary dengue virus infection in a mouse model. Virology (2008) 1.24

Cell type specificity and host genetic polymorphisms influence antibody-dependent enhancement of dengue virus infection. J Virol (2010) 1.23

How innate immune mechanisms contribute to antibody-enhanced viral infections. Clin Vaccine Immunol (2010) 1.23

Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation. Cell Host Microbe (2014) 1.22

Innate immunity to dengue virus infection and subversion of antiviral responses. J Mol Biol (2013) 1.17

Unusual dengue virus 3 epidemic in Nicaragua, 2009. PLoS Negl Trop Dis (2011) 1.10

Cellular and cytokine correlates of severe dengue infection. PLoS One (2012) 1.08

Gene expression patterns of dengue virus-infected children from nicaragua reveal a distinct signature of increased metabolism. PLoS Negl Trop Dis (2010) 1.05

Dendritic cells in dengue virus infection: targets of virus replication and mediators of immunity. Front Immunol (2014) 1.01

Endothelial cells elicit immune-enhancing responses to dengue virus infection. J Virol (2012) 1.00

Dengue virus tropism in humanized mice recapitulates human dengue fever. PLoS One (2011) 0.99

Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus. J Neurovirol (2014) 0.98

Monocyte recruitment to the dermis and differentiation to dendritic cells increases the targets for dengue virus replication. PLoS Pathog (2014) 0.96

Lectin switching during dengue virus infection. J Infect Dis (2011) 0.95

Evaluation of the diagnostic utility of the traditional and revised WHO dengue case definitions. PLoS Negl Trop Dis (2013) 0.95

Defining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody-Enhanced Dengue Virus Infection. MBio (2015) 0.91

Susceptibility and response of human blood monocyte subsets to primary dengue virus infection. PLoS One (2012) 0.91

NK Cells during Dengue Disease and Their Recognition of Dengue Virus-Infected cells. Front Immunol (2014) 0.90

Cells in dengue virus infection in vivo. Adv Virol (2010) 0.90

Dengue hemorrhagic fever-associated immunomediators induced via maturation of dengue virus nonstructural 4B protein in monocytes modulate endothelial cell adhesion molecules and human microvascular endothelial cells permeability. Virology (2011) 0.86

Can non-human primates serve as models for investigating dengue disease pathogenesis? Front Microbiol (2013) 0.86

The NS1 glycoprotein can generate dramatic antibody-enhanced dengue viral replication in normal out-bred mice resulting in lethal multi-organ disease. PLoS One (2011) 0.86

Dengue virus entry as target for antiviral therapy. J Trop Med (2012) 0.86

Maturation of dengue virus nonstructural protein 4B in monocytes enhances production of dengue hemorrhagic fever-associated chemokines and cytokines. Virology (2011) 0.85

Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection. J Biol Chem (2015) 0.84

Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status. PLoS One (2012) 0.84

Low levels of antibody-dependent enhancement in vitro using viruses and plasma from dengue patients. PLoS One (2014) 0.84

Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir. J Virol (2013) 0.84

The battle between infection and host immune responses of dengue virus and its implication in dengue disease pathogenesis. ScientificWorldJournal (2013) 0.83

Dengue virus activates membrane TRAIL relocalization and IFN-α production by human plasmacytoid dendritic cells in vitro and in vivo. PLoS Negl Trop Dis (2013) 0.83

CD8+ T lymphocyte expansion, proliferation and activation in dengue fever. PLoS Negl Trop Dis (2015) 0.83

Antibody-Dependent Enhancement of Dengue Virus Infection in Primary Human Macrophages; Balancing Higher Fusion against Antiviral Responses. Sci Rep (2016) 0.83

Liposome-mediated delivery of iminosugars enhances efficacy against dengue virus in vivo. Antimicrob Agents Chemother (2012) 0.82

Hyperferritinaemia in dengue virus infected patients is associated with immune activation and coagulation disturbances. PLoS Negl Trop Dis (2014) 0.82

Mosquito Saliva Increases Endothelial Permeability in the Skin, Immune Cell Migration, and Dengue Pathogenesis during Antibody-Dependent Enhancement. PLoS Pathog (2016) 0.80

Biologic Evidence Required for Zika Disease Enhancement by Dengue Antibodies. Emerg Infect Dis (2017) 0.79

Utility of humanized BLT mice for analysis of dengue virus infection and antiviral drug testing. J Virol (2013) 0.78

Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection. PLoS Negl Trop Dis (2015) 0.78

Vascular leakage in dengue hemorrhagic Fever is associated with dengue infected monocytes, monocyte activation/exhaustion, and cytokines production. Int J Vasc Med (2015) 0.78

Potential biomarkers for the clinical prognosis of severe dengue. Mem Inst Oswaldo Cruz (2013) 0.77

Down-regulation of complement receptors on the surface of host monocyte even as in vitro complement pathway blocking interferes in dengue infection. PLoS One (2014) 0.77

Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response. Genome Med (2016) 0.76

Dengue virus induces mitochondrial elongation through impairment of Drp1-triggered mitochondrial fission. Virology (2016) 0.76

Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model. PLoS One (2015) 0.75

Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection. Front Immunol (2016) 0.75

Differentiating between dengue fever and malaria using hematological parameters in endemic areas of Thailand. Infect Dis Poverty (2017) 0.75

Immunogenicity of a novel tetravalent vaccine formulation with four recombinant lipidated dengue envelope protein domain IIIs in mice. Sci Rep (2016) 0.75

Genomic approaches for understanding dengue: insights from the virus, vector, and host. Genome Biol (2016) 0.75

Monocyte-plasmablast crosstalk during dengue. Cell Host Microbe (2014) 0.75

High-dimensional CyTOF analysis of dengue virus-infected human DCs reveals distinct viral signatures. JCI Insight (2017) 0.75

Articles cited by this

Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis (2000) 11.44

A prospective study of dengue infections in Bangkok. Am J Trop Med Hyg (1988) 8.54

Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody. J Exp Med (1977) 7.01

Dengue: an escalating problem. BMJ (2002) 6.09

Human skin Langerhans cells are targets of dengue virus infection. Nat Med (2000) 5.74

Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever. Am J Trop Med Hyg (1989) 4.79

DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. J Exp Med (2003) 4.69

Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua. Am J Trop Med Hyg (2001) 4.32

In vivo enhancement of dengue virus infection in rhesus monkeys by passively transferred antibody. J Infect Dis (1979) 3.90

Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization. J Infect Dis (2004) 3.81

Immunopathogenesis of Dengue hemorrhagic fever. Virology (1999) 3.16

Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua. Am J Trop Med Hyg (2005) 3.12

Murine model for dengue virus-induced lethal disease with increased vascular permeability. J Virol (2006) 3.07

Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. J Infect Dis (1999) 2.96

Dengue viruses and mononuclear phagocytes. II. Identity of blood and tissue leukocytes supporting in vitro infection. J Exp Med (1977) 2.84

Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention. Proc Natl Acad Sci U S A (2007) 2.69

High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua. Trop Med Int Health (2006) 2.67

Immunological enhancement of dengue virus replication. Nat New Biol (1973) 2.61

Human IgG Fc receptor II mediates antibody-dependent enhancement of dengue virus infection. J Immunol (1990) 2.47

Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. J Infect Dis (2004) 2.43

Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue. J Clin Invest (1991) 2.37

Immunity and immunopathology in dengue virus infections. Semin Immunol (1992) 2.32

Serological diagnosis of dengue by an ELISA inhibition method (EIM). Mem Inst Oswaldo Cruz (1992) 2.12

Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996-1997 dengue-2 outbreak in French Polynesia. J Med Virol (2000) 2.02

Human dendritic cells as targets of dengue virus infection. J Investig Dermatol Symp Proc (2001) 1.96

Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells. J Med Virol (2008) 1.85

Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. J Infect Dis (1999) 1.82

Gamma interferon augments Fc gamma receptor-mediated dengue virus infection of human monocytic cells. J Virol (1988) 1.71

Dengue virus infects macrophages and dendritic cells in a mouse model of infection. J Infect Dis (2007) 1.71

Dengue. Curr Opin Infect Dis (2002) 1.54

Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases. N Engl J Med (1996) 1.52

Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. J Infect Dis (1998) 1.44

Isolation of dengue viruses from peripheral blood leukocytes of patients with hemorrhagic fever. J Infect Dis (1980) 1.42

Anti-TNF antibody treatment reduces mortality in experimental dengue virus infection. FEMS Immunol Med Microbiol (2003) 1.41

Characterisation of lymphocyte response and cytokine patterns in patients with dengue fever. Immunobiology (2001) 1.33

Dendritic cell precursors are permissive to dengue virus and human immunodeficiency virus infection. J Virol (2005) 1.26

Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which influence the development of T helper cell phenotype. Eur J Immunol (1996) 1.25

B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties. Immunol Lett (2005) 1.24

High levels of sTNFR p75 and TNF alpha in dengue-infected patients. Microbiol Immunol (1996) 1.19

Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures. J Med Virol (1999) 1.16

Growth of dengue type 2 virus isolates in human peripheral blood leukocytes correlates with severe and mild dengue disease. Am J Trop Med Hyg (1991) 1.13

In vitro assessment of human endothelial cell permeability: effects of inflammatory cytokines and dengue virus infection. J Virol Methods (2004) 1.11

B cells are the principal circulating mononuclear cells infected by dengue virus. Southeast Asian J Trop Med Public Health (1999) 1.09

RECENT EPIDEMICS OF HEMORRHAGIC FEVER IN THAILAND. OBSERVATIONS RELATED TO PATHOGENESIS OF A "NEW" DENGUE DISEASE. Am J Public Health Nations Health (1965) 1.04

Increased pro-inflammatory cytokines (TNF-alpha and IL-6) and anti-inflammatory compounds (sTNFRp55 and sTNFRp75) in Brazilian patients during exanthematic dengue fever. Mem Inst Oswaldo Cruz (1999) 1.03

T cell activation in vivo by dengue virus infection. J Clin Lab Immunol (1995) 0.95

Low rates of antigen detection and virus isolation from the peripheral blood leukocytes of dengue fever patients. Am J Trop Med Hyg (1985) 0.93

Articles by these authors

Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study. Lancet Infect Dis (2012) 8.02

Global spread and persistence of dengue. Annu Rev Microbiol (2008) 6.44

Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis. Lancet (2011) 5.43

Emergence and global spread of a dengue serotype 3, subtype III virus. Emerg Infect Dis (2003) 4.29

The WHO dengue classification and case definitions: time for a reassessment. Lancet (2006) 3.69

The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity. Cell Host Microbe (2010) 3.48

Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification. PLoS Pathog (2010) 3.16

Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua. Am J Trop Med Hyg (2005) 3.12

Murine model for dengue virus-induced lethal disease with increased vascular permeability. J Virol (2006) 3.07

Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical. J Virol (2004) 2.83

Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua. J Infect Dis (2010) 2.80

Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis. J Virol (2006) 2.76

High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua. Trop Med Int Health (2006) 2.67

Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog (2010) 2.62

Multicentre prospective study on dengue classification in four South-east Asian and three Latin American countries. Trop Med Int Health (2011) 2.60

A single dose of any of four different live attenuated tetravalent dengue vaccines is safe and immunogenic in flavivirus-naive adults: a randomized, double-blind clinical trial. J Infect Dis (2013) 2.51

Short report: assessment of the World Health Organization scheme for classification of dengue severity in Nicaragua. Am J Trop Med Hyg (2005) 2.49

Serotype-specific differences in clinical manifestations of dengue. Am J Trop Med Hyg (2006) 2.39

Multi-country evaluation of the sensitivity and specificity of two commercially-available NS1 ELISA assays for dengue diagnosis. PLoS Negl Trop Dis (2010) 2.33

Human enterovirus 109: a novel interspecies recombinant enterovirus isolated from a case of acute pediatric respiratory illness in Nicaragua. J Virol (2010) 2.31

Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. Sci Transl Med (2011) 2.29

Evaluation of the traditional and revised WHO classifications of Dengue disease severity. PLoS Negl Trop Dis (2011) 2.26

Diagnosis of dengue virus infection by detection of specific immunoglobulin M (IgM) and IgA antibodies in serum and saliva. Clin Diagn Lab Immunol (2003) 2.22

Association between pentavalent rotavirus vaccine and severe rotavirus diarrhea among children in Nicaragua. JAMA (2009) 2.16

Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2. J Virol (2010) 2.14

The Nicaraguan pediatric dengue cohort study: study design, methods, use of information technology, and extension to other infectious diseases. Am J Epidemiol (2009) 2.14

Evaluation of immunological markers in serum, filter-paper blood spots, and saliva for dengue diagnosis and epidemiological studies. J Clin Virol (2008) 2.10

Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. Am J Trop Med Hyg (2009) 1.87

Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA. Virology (2002) 1.81

Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice. J Immunol (2005) 1.79

Dengue virus infects macrophages and dendritic cells in a mouse model of infection. J Infect Dis (2007) 1.71

High dengue case capture rate in four years of a cohort study in Nicaragua compared to national surveillance data. PLoS Negl Trop Dis (2010) 1.70

Integration of information technologies in clinical studies in Nicaragua. PLoS Med (2007) 1.69

A novel magnetic bead bioassay platform using a microchip-based sensor for infectious disease diagnosis. J Immunol Methods (2006) 1.69

Convergent antibody signatures in human dengue. Cell Host Microbe (2013) 1.64

Early activation of natural killer and B cells in response to primary dengue virus infection in A/J mice. Virology (2004) 1.61

Animal models of dengue virus infection. Viruses (2012) 1.60

Single-reaction, multiplex, real-time rt-PCR for the detection, quantitation, and serotyping of dengue viruses. PLoS Negl Trop Dis (2013) 1.57

Prevalence and seasonality of influenza-like illness in children, Nicaragua, 2005-2007. Emerg Infect Dis (2009) 1.55

Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure. Virology (2005) 1.55

Mouse STAT2 restricts early dengue virus replication. Cell Host Microbe (2010) 1.53

Virus identification in unknown tropical febrile illness cases using deep sequencing. PLoS Negl Trop Dis (2012) 1.52

Symptomatic versus inapparent outcome in repeat dengue virus infections is influenced by the time interval between infections and study year. PLoS Negl Trop Dis (2013) 1.51

Quantitative assessment of the benefits of specific information technologies applied to clinical studies in developing countries. Am J Trop Med Hyg (2008) 1.49

Ultrasound measurement of gallbladder wall thickening as a diagnostic test and prognostic indicator for severe dengue in pediatric patients. Pediatr Infect Dis J (2007) 1.42

Clinical attack rate and presentation of pandemic H1N1 influenza versus seasonal influenza A and B in a pediatric cohort in Nicaragua. Clin Infect Dis (2010) 1.40

Dominant cross-reactive B cell response during secondary acute dengue virus infection in humans. PLoS Negl Trop Dis (2012) 1.39

RNA secondary structure in the coding region of dengue virus type 2 directs translation start codon selection and is required for viral replication. J Virol (2006) 1.38

Y box-binding protein-1 binds to the dengue virus 3'-untranslated region and mediates antiviral effects. J Biol Chem (2007) 1.37

A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface. EMBO Mol Med (2014) 1.37

rDEN2/4Delta30(ME), a live attenuated chimeric dengue serotype 2 vaccine is safe and highly immunogenic in healthy dengue-naïve adults. Hum Vaccin (2006) 1.36

Comparison of the FDA-approved CDC DENV-1-4 real-time reverse transcription-PCR with a laboratory-developed assay for dengue virus detection and serotyping. J Clin Microbiol (2013) 1.35

Fluid intake and decreased risk for hospitalization for dengue fever, Nicaragua. Emerg Infect Dis (2003) 1.32

The capsid-coding region hairpin element (cHP) is a critical determinant of dengue virus and West Nile virus RNA synthesis. Virology (2008) 1.31

Interplay of RNA elements in the dengue virus 5' and 3' ends required for viral RNA replication. J Virol (2010) 1.31

Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domain. Virology (2004) 1.30

Development of an internally controlled real-time reverse transcriptase PCR assay for pan-dengue virus detection and comparison of four molecular dengue virus detection assays. J Clin Microbiol (2013) 1.29

Sequential immunization with vesicles prepared from heterologous Neisseria meningitidis strains elicits broadly protective serum antibodies to group B strains. Infect Immun (2002) 1.29

Dendritic cell precursors are permissive to dengue virus and human immunodeficiency virus infection. J Virol (2005) 1.26

Early clinical features of dengue virus infection in nicaraguan children: a longitudinal analysis. PLoS Negl Trop Dis (2012) 1.25

Genome-wide patterns of intrahuman dengue virus diversity reveal associations with viral phylogenetic clade and interhost diversity. J Virol (2012) 1.25