Published in Am J Physiol Lung Cell Mol Physiol on May 02, 2008
Developing multiplexed assays for troponin I and interleukin-33 in plasma by peptide immunoaffinity enrichment and targeted mass spectrometry. Clin Chem (2009) 2.77
Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med (2010) 2.28
Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest (2009) 2.17
Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Clin J Am Soc Nephrol (2010) 1.64
Distinct injury markers for the early detection and prognosis of incident acute kidney injury in critically ill adults with preserved kidney function. Kidney Int (2013) 1.62
A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine. BMC Med Inform Decis Mak (2009) 1.49
Sex and ethnic differences in 47 candidate proteomic markers of cardiovascular disease: the Mayo Clinic proteomic markers of arteriosclerosis study. PLoS One (2010) 1.34
Age-related differences in plasma proteins: how plasma proteins change from neonates to adults. PLoS One (2011) 1.22
Multifunctional core-shell nanoparticles: discovery of previously invisible biomarkers. J Am Chem Soc (2011) 1.11
Biomarkers of HIV-1 associated dementia: proteomic investigation of sera. Proteome Sci (2009) 1.06
Serum protein profiling of systemic lupus erythematosus and systemic sclerosis using recombinant antibody microarrays. Mol Cell Proteomics (2011) 0.98
Candidate serum biomarkers for prostate adenocarcinoma identified by mRNA differences in prostate tissue and verified with protein measurements in tissue and blood. Clin Chem (2012) 0.97
Biomarkers in acute lung injury--marking forward progress. Crit Care Clin (2011) 0.95
Novel effects of hormonal contraceptive use on the plasma proteome. PLoS One (2012) 0.86
Association of serum osteoprotegerin with ankle-brachial index and urine albumin: creatinine ratio in African-Americans and non-Hispanic whites. Atherosclerosis (2009) 0.85
Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis. J Immunol Methods (2012) 0.84
Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Proc Natl Acad Sci U S A (2014) 0.83
Urinary desmosine: a biomarker of structural lung injury during CF pulmonary exacerbation. Pediatr Pulmonol (2012) 0.82
Plasma midregional pro-atrial natriuretic peptide is associated with blood pressure indices and hypertension severity in adults with hypertension. Am J Hypertens (2009) 0.82
Plasma Shh levels reduced in pancreatic cancer patients. Pancreas (2012) 0.80
Plasma levels of apolipoprotein A1 in malaria-exposed primigravidae are associated with severe anemia. PLoS One (2010) 0.80
Redox proteomics identification of oxidatively modified myocardial proteins in human heart failure: implications for protein function. PLoS One (2012) 0.80
Cardiovascular proteomics: implications for clinical applications. Clin Lab Med (2009) 0.79
African-American ethnicity is associated with higher plasma levels of D-dimer in adults with hypertension. J Thromb Haemost (2008) 0.79
Association of serum osteoprotegerin with left ventricular mass in African American adults with hypertension. Am J Hypertens (2010) 0.78
The genetics of congestive heart failure. Heart Fail Clin (2010) 0.76
Beyond fishing: the role of discovery proteomics in mechanistic lung research. Am J Physiol Lung Cell Mol Physiol (2008) 0.76
Application of clinical proteomics in acute respiratory distress syndrome. Clin Transl Med (2014) 0.75
Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease. Circulation (2017) 0.75
Basic local alignment search tool. J Mol Biol (1990) 659.07
Statistical significance for genomewide studies. Proc Natl Acad Sci U S A (2003) 88.64
Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med (2008) 57.29
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003. Nucleic Acids Res (2003) 52.80
NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res (2006) 48.10
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med (2000) 48.03
Systematic determination of genetic network architecture. Nat Genet (1999) 25.45
Use and misuse of the receiver operating characteristic curve in risk prediction. Circulation (2007) 20.44
Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol (1999) 15.63
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Characterizing gene sets with FuncAssociate. Bioinformatics (2003) 14.10
Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol (2006) 10.14
Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution. Mol Cell Proteomics (2007) 6.96
Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites. Glycobiology (2004) 6.13
The limitations of risk factors as prognostic tools. N Engl J Med (2006) 5.90
Mass spectrometric quantitation of peptides and proteins using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA). J Proteome Res (2004) 5.57
The antigenic index: a novel algorithm for predicting antigenic determinants. Comput Appl Biosci (1988) 5.00
The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics (2004) 4.48
Suppression of non-specific binding in serological Luminex assays. J Immunol Methods (2005) 2.96
Protein chip technology. Curr Opin Chem Biol (2003) 2.80
Combining diagnostic test results to increase accuracy. Biostatistics (2000) 2.73
Antibody-based enrichment of peptides on magnetic beads for mass-spectrometry-based quantification of serum biomarkers. Anal Biochem (2006) 2.55
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes. Diabetes (2003) 2.41
Correcting common errors in identifying cancer-specific serum peptide signatures. J Proteome Res (2005) 1.91
Towards a human proteome atlas: high-throughput generation of mono-specific antibodies for tissue profiling. Proteomics (2005) 1.87
Magnetic techniques for the isolation and purification of proteins and peptides. Biomagn Res Technol (2004) 1.62
Comparison of different depletion strategies for improved resolution in proteomic analysis of human serum samples. Proteomics (2005) 1.55
Proton NMR analysis of plasma is a weak predictor of coronary artery disease. Nat Med (2006) 1.49
Sputum biomarkers of inflammation in cystic fibrosis lung disease. Proc Am Thorac Soc (2007) 1.49
Albumin depletion of human plasma also removes low abundance proteins including the cytokines. Proteomics (2005) 1.31
Steroid profiles using liquid chromatography-tandem mass spectrometry with atmospheric pressure photoionization source. Arch Pathol Lab Med (2004) 1.31
Protein arrays: proteomics in multiplex. Nature (2004) 1.18
Reversed-phase high-performance liquid chromatographic prefractionation of immunodepleted human serum proteins to enhance mass spectrometry identification of lower-abundant proteins. J Proteome Res (2005) 1.14
Protein and antibody microarray technology. J Chromatogr B Analyt Technol Biomed Life Sci (2003) 1.08
Effects of preanalytical variables on peptide and protein measurements in human serum and plasma: implications for clinical proteomics. Expert Rev Proteomics (2006) 1.01
Multiplex approaches in protein microarray technology. Expert Rev Proteomics (2005) 0.97
New cardiovascular risk factors exist, but are they clinically useful? Eur Heart J (2008) 0.91
Affinity-capture reagents for protein arrays. Trends Biotechnol (2002) 0.89
Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol (2007) 0.88
Active bead-linked immunoassay on protein microarrays. Anal Chim Acta (2005) 0.84
Proteomics in pediatric research and practice. Adv Pediatr (2007) 0.80
Assay for urinary desmosines in a healthy pre-pubertal population using an improved extraction technique. Ann Clin Biochem (2006) 0.79
Towards a proteome-scale map of the human protein-protein interaction network. Nature (2005) 24.76
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
Comparison of two fluid-management strategies in acute lung injury. N Engl J Med (2006) 19.54
The genetic landscape of a cell. Science (2010) 16.52
A map of the interactome network of the metazoan C. elegans. Science (2004) 15.60
Characterizing gene sets with FuncAssociate. Bioinformatics (2003) 14.10
Evidence for dynamically organized modularity in the yeast protein-protein interaction network. Nature (2004) 13.27
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA (2004) 11.27
High-quality binary protein interaction map of the yeast interactome network. Science (2008) 10.65
Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation (2004) 8.80
Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med (2006) 7.97
DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med (2006) 7.90
Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study. Lancet (2009) 7.27
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation (2007) 6.34
Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med (2007) 6.29
Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA (2003) 6.24
Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet (2007) 6.07
Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med (2005) 5.76
The acute respiratory distress syndrome. J Clin Invest (2012) 5.61
Novel and conventional biomarkers for prediction of incident cardiovascular events in the community. JAMA (2009) 5.52
An experimentally derived confidence score for binary protein-protein interactions. Nat Methods (2008) 5.27
Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. JAMA (2009) 5.22
Quantitative phenotyping via deep barcode sequencing. Genome Res (2009) 5.13
Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease. Circulation (2009) 4.87
Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA (2004) 4.85
A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol (2008) 4.78
Costs associated with delirium in mechanically ventilated patients. Crit Care Med (2004) 4.75
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med (2010) 4.69
Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA (2004) 4.63
A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study. Ann Intern Med (2008) 4.61
Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat Genet (2007) 4.59
The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol (2011) 4.57
Metal chelation and inhibition of bacterial growth in tissue abscesses. Science (2008) 4.55
Assessing experimentally derived interactions in a small world. Proc Natl Acad Sci U S A (2003) 4.53
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature (2012) 4.35
Literature-curated protein interaction datasets. Nat Methods (2009) 4.21
MALDI imaging mass spectrometry: molecular snapshots of biochemical systems. Nat Methods (2007) 4.20
Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study. Circulation (2005) 4.08
Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology (2006) 4.03
Proteomic patterns of tumour subsets in non-small-cell lung cancer. Lancet (2003) 4.01
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome. Crit Care Med (2002) 3.87
Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med (2005) 3.85
Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci (2010) 3.84
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol (2008) 3.82
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet (2009) 3.81
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science (2011) 3.72
Defining genetic interaction. Proc Natl Acad Sci U S A (2008) 3.67
Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans. Nat Biotechnol (2007) 3.65
Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis. Nature (2005) 3.62
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Predicting gene function from patterns of annotation. Genome Res (2003) 3.55
Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute. Circulation (2009) 3.55
Long-term trends in the incidence of heart failure after myocardial infarction. Circulation (2008) 3.52
Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study. Arterioscler Thromb Vasc Biol (2006) 3.48
A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury. Crit Care Med (2005) 3.44
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med (2014) 3.39
Clinical risk factors for primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med (2013) 3.38
Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med (2006) 3.38
Cardiac arrest during long-distance running races. N Engl J Med (2012) 3.34
Intensity-based protein identification by machine learning from a library of tandem mass spectra. Nat Biotechnol (2004) 3.30
Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study. Crit Care Med (2013) 3.30
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest (2011) 3.23
Functional specificity among ribosomal proteins regulates gene expression. Cell (2007) 3.22
A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity. Genes Dev (2008) 3.19
Combining biological networks to predict genetic interactions. Proc Natl Acad Sci U S A (2004) 3.18
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation (2005) 3.16
Validation of an atrial fibrillation risk algorithm in whites and African Americans. Arch Intern Med (2010) 3.05
Attitudes and perceptions of patients towards methods of establishing a DNA biobank. Cell Tissue Bank (2007) 3.05
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet (2007) 3.04
Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal Chem (2006) 3.03
Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Am J Physiol Lung Cell Mol Physiol (2003) 3.02
Next generation software for functional trend analysis. Bioinformatics (2009) 3.01
Postobstructive pulmonary edema: a case for hydrostatic mechanisms. Chest (2007) 2.97
Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. BMC Med Genet (2007) 2.93
Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med (2012) 2.92
Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med (2010) 2.86
Absolute quantification of the model biomarker prostate-specific antigen in serum by LC-Ms/MS using protein cleavage and isotope dilution mass spectrometry. J Proteome Res (2004) 2.85
Direct tissue analysis using matrix-assisted laser desorption/ionization mass spectrometry: practical aspects of sample preparation. J Mass Spectrom (2003) 2.84
Automated acoustic matrix deposition for MALDI sample preparation. Anal Chem (2006) 2.83
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82
Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med (2015) 2.80
Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med (2007) 2.79
Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med (2009) 2.77
Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J Am Soc Nephrol (2009) 2.77
Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit Care Med (2015) 2.77
Findings on the portable chest radiograph correlate with fluid balance in critically ill patients. Chest (2002) 2.77
Judging the quality of gene expression-based clustering methods using gene annotation. Genome Res (2002) 2.76
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
Large-scale implementation of sedation and delirium monitoring in the intensive care unit: a report from two medical centers. Crit Care Med (2005) 2.72