Published in Immunity on May 08, 2008
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nat Immunol (2008) 7.18
Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses. J Exp Med (2008) 4.21
Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med (2010) 4.09
Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. J Clin Invest (2011) 3.28
Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer. Nat Rev Cancer (2009) 3.06
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J Exp Med (2010) 2.89
The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response. J Immunol (2009) 2.68
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity (2011) 2.49
Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation. Immunity (2010) 2.38
Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students. J Infect Dis (2012) 2.33
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Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes. J Infect Dis (2008) 2.14
PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells. Int Immunol (2009) 2.10
The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infections. PLoS Pathog (2010) 2.03
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Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. PLoS One (2012) 1.77
Initiation and regulation of T-cell responses in tuberculosis. Mucosal Immunol (2011) 1.77
The precursors of memory: models and controversies. Nat Rev Immunol (2009) 1.75
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Human Ebola virus infection results in substantial immune activation. Proc Natl Acad Sci U S A (2015) 1.49
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature (2017) 1.46
Living in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIV. Immunol Rev (2011) 1.44
The role of mTOR in memory CD8 T-cell differentiation. Immunol Rev (2010) 1.41
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Induction and regulation of T-cell immunity by the novel tuberculosis vaccine M72/AS01 in South African adults. Am J Respir Crit Care Med (2013) 1.31
A systemic neutrophil response precedes robust CD8(+) T-cell activation during natural respiratory syncytial virus infection in infants. J Virol (2009) 1.24
Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth. PLoS One (2009) 1.24
The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus. J Immunol (2009) 1.24
Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies. Clin Immunol (2010) 1.22
Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biol (2010) 1.22
HIV-DNA priming alters T cell responses to HIV-adenovirus vaccine even when responses to DNA are undetectable. J Immunol (2011) 1.21
Primary Epstein-Barr virus infection does not erode preexisting CD8⁺ T cell memory in humans. J Exp Med (2012) 1.20
Systems vaccinology: learning to compute the behavior of vaccine induced immunity. Wiley Interdiscip Rev Syst Biol Med (2011) 1.19
Longitudinal changes in CD4(+) T-cell memory responses induced by BCG vaccination of newborns. J Infect Dis (2013) 1.17
Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques. J Virol (2010) 1.16
Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells. PLoS One (2011) 1.15
Meta-analysis of all immune epitope data in the Flavivirus genus: inventory of current immune epitope data status in the context of virus immunity and immunopathology. Viral Immunol (2010) 1.14
Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART. PLoS One (2010) 1.13
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Role of lymphocytic choriomeningitis virus (LCMV) in understanding viral immunology: past, present and future. Viruses (2012) 1.12
Ex Vivo kinetics of early and long-term multifunctional human leukocyte antigen E-specific CD8+ cells in volunteers immunized with the Ty21a typhoid vaccine. Clin Vaccine Immunol (2010) 1.10
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Immunity (2015) 1.09
Severe pandemic H1N1 2009 infection is associated with transient NK and T deficiency and aberrant CD8 responses. PLoS One (2012) 1.09
Longitudinal analysis of the human T cell response during acute hantavirus infection. J Virol (2011) 1.09
Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age. Proc Natl Acad Sci U S A (2012) 1.08
Immunology taught by humans. Sci Transl Med (2012) 1.08
Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development. Front Immunol (2013) 1.08
A randomized, double-blind, controlled trial of the 17D yellow fever virus vaccine given in combination with immune globulin or placebo: comparative viremia and immunogenicity. Am J Trop Med Hyg (2012) 1.06
The cellular composition of the human immune system is shaped by age and cohabitation. Nat Immunol (2016) 1.04
Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans. PLoS Pathog (2010) 1.03
Universal immunity to influenza must outwit immune evasion. Front Microbiol (2014) 1.03
Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults. J Immunol (2014) 1.02
PD-1 coinhibitory signals: the link between pathogenesis and protection. Semin Immunol (2013) 1.01
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Inhibitory potential of subpopulations of CD8+ T cells in HIV-1-infected elite suppressors. J Virol (2012) 1.00
Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans. Sci Rep (2011) 1.00
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Discovering naturally processed antigenic determinants that confer protective T cell immunity. J Clin Invest (2013) 0.99
Original encounter with antigen determines antigen-presenting cell imprinting of the quality of the immune response in mice. PLoS One (2009) 0.98
Contribution of the immune system to the chemotherapeutic response. Semin Immunopathol (2011) 0.98
CD8 T cell persistence in treated HIV infection. Curr Opin HIV AIDS (2014) 0.97
Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice. J Immunol (2009) 0.97
Humoral and cellular immune responses to measles and tetanus: the importance of elapsed time since last exposure and the nature of the antigen. J Clin Immunol (2010) 0.96
Dynamics of the cytotoxic T cell response to a model of acute viral infection. J Virol (2015) 0.96
Immune modulation during latent herpesvirus infection. Immunol Rev (2012) 0.96
Oncolytic viral therapy for pancreatic cancer: current research and future directions. Oncolytic Virother (2014) 0.95
Human immune memory to yellow fever and smallpox vaccination. J Clin Immunol (2008) 0.95
Use it or lose it: establishment and persistence of T cell memory. Front Immunol (2012) 0.95
Approaches to vaccines against Orientia tsutsugamushi. Front Cell Infect Microbiol (2013) 0.94
Viral shedding and immune responses to respiratory syncytial virus infection in older adults. J Infect Dis (2013) 0.93
Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine. PLoS One (2011) 0.93
Progressive vaccinia: case description and laboratory-guided therapy with vaccinia immune globulin, ST-246, and CMX001. J Infect Dis (2012) 0.93
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Unique human immune signature of Ebola virus disease in Guinea. Nature (2016) 0.92
Guiding dengue vaccine development using knowledge gained from the success of the yellow fever vaccine. Cell Mol Immunol (2015) 0.92
Preferential amplification of CD8 effector-T cells after transcutaneous application of an inactivated influenza vaccine: a randomized phase I trial. PLoS One (2010) 0.91
ORFeome approach to the clonal, HLA allele-specific CD4 T-cell response to a complex pathogen in humans. J Immunol Methods (2009) 0.91
Immunology of AAV-Mediated Gene Transfer in the Eye. Front Immunol (2013) 0.90
Yellow fever 17D-vectored vaccines expressing Lassa virus GP1 and GP2 glycoproteins provide protection against fatal disease in guinea pigs. Vaccine (2010) 0.90
Antiviral immunity following smallpox virus infection: a case-control study. J Virol (2010) 0.90
CD4 T Cells Mediate Both Positive and Negative Regulation of the Immune Response to HIV Infection: Complex Role of T Follicular Helper Cells and Regulatory T Cells in Pathogenesis. Front Immunol (2015) 0.90
Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis. Semin Immunol (2014) 0.90
Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. J Clin Invest (2016) 0.89
Regulating cytokine function enhances safety and activity of genetic cancer therapies. Mol Ther (2012) 0.89
Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature (2006) 20.00
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet (2008) 19.65
The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection. Clin Infect Dis (2011) 16.88
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol (2003) 15.51
Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol (2003) 15.51
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol (2003) 11.48
Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity (2007) 10.83
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature (2008) 10.80
mTOR regulates memory CD8 T-cell differentiation. Nature (2009) 10.07
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol (2005) 8.27
Molecular and functional profiling of memory CD8 T cell differentiation. Cell (2002) 8.06
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol (2007) 7.60
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J Exp Med (2011) 7.29
Memory CD8 T-cell differentiation during viral infection. J Virol (2004) 6.75
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med (2005) 6.59
Redefining chronic viral infection. Cell (2009) 6.30
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity (2003) 6.19
Systems biology of vaccination for seasonal influenza in humans. Nat Immunol (2011) 6.09
Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol (2006) 6.00
Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature (2008) 5.94
Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat Immunol (2003) 5.90
Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J Exp Med (2008) 5.71
Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J Exp Med (2002) 5.64
Cutting edge: long-term B cell memory in humans after smallpox vaccination. J Immunol (2003) 5.51
Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science (2004) 5.31
Estimating the precursor frequency of naive antigen-specific CD8 T cells. J Exp Med (2002) 5.16
Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma. J Virol (2002) 4.65
Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system. J Immunol Methods (2004) 4.57
Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A (2004) 4.56
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A (2010) 4.56
Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Nat Med (2008) 4.55
Cutting edge: rapid in vivo killing by memory CD8 T cells. J Immunol (2003) 4.25
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med (2006) 4.23
Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med (2006) 4.17
Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest (2003) 4.14
Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A (2009) 4.12
Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med (2010) 4.09
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity (2010) 4.06
Translating innate immunity into immunological memory: implications for vaccine development. Cell (2006) 3.98
SAP is required for generating long-term humoral immunity. Nature (2003) 3.85
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A Blueprint for HIV Vaccine Discovery. Cell Host Microbe (2012) 3.27
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Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection. Science (2009) 2.64
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Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity (2011) 2.49
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HIV transmission risk behaviors among HIV-infected persons who are successfully linked to care. Clin Infect Dis (2008) 2.44
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