Cytokines and atherosclerosis: a comprehensive review of studies in mice.

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Published in Cardiovasc Res on May 16, 2008

Authors

Robert Kleemann1, Susanne Zadelaar, Teake Kooistra

Author Affiliations

1: TNO-BioSciences, Gaubius-Laboratory, Department of Vascular and Metabolic Diseases, PO Box 2215, 2301 CE Leiden, The Netherlands. robert.kleemann@tno.nl

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Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet. Br J Nutr (2012) 0.81

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone. BMC Med Genomics (2014) 0.79

Identification of prognostic and diagnostic biomarkers of glucose intolerance in ApoE3Leiden mice. Physiol Genomics (2012) 0.79

Ritonavir protects against the development of atherosclerosis in APOE*3-Leiden mice. Atherosclerosis (2009) 0.78

A role for the fibrinolytic system in postsurgical adhesion formation. Fertil Steril (2005) 0.78

Beneficial effects of an alternating high- fat dietary regimen on systemic insulin resistance, hepatic and renal inflammation and renal function. PLoS One (2012) 0.78

Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet. Mol Nutr Food Res (2013) 0.78