Published in J Immunol on June 01, 2008
Infections of people with complement deficiencies and patients who have undergone splenectomy. Clin Microbiol Rev (2010) 1.70
Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol (2010) 1.68
Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J Immunol (2012) 1.57
The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis. Proc Natl Acad Sci U S A (2008) 1.51
Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury. J Clin Invest (2010) 1.42
C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells. J Immunol (2009) 1.32
Recent developments in low molecular weight complement inhibitors. Mol Immunol (2009) 1.23
Adenovirus activates complement by distinctly different mechanisms in vitro and in vivo: indirect complement activation by virions in vivo. J Virol (2009) 1.18
Properdin: New roles in pattern recognition and target clearance. Mol Immunol (2008) 1.16
Discrimination between host and pathogens by the complement system. Vaccine (2008) 1.11
Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circ Cardiovasc Imaging (2011) 1.07
Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells. Clin Exp Immunol (2009) 1.07
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein. J Biol Chem (2012) 1.06
Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement. Immunobiology (2010) 1.05
Linkage specificity and role of properdin in activation of the alternative complement pathway by fungal glycans. MBio (2011) 0.99
Determination of severity of murine IgA nephropathy by glomerular complement activation by aberrantly glycosylated IgA and immune complexes. Am J Pathol (2012) 0.96
Properdin in complement activation and tissue injury. Mol Immunol (2013) 0.95
Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement. Front Immunol (2013) 0.94
Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells. J Biol Chem (2009) 0.92
Native properdin binds to Chlamydia pneumoniae and promotes complement activation. Infect Immun (2010) 0.91
The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. PLoS One (2014) 0.87
Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H2O). J Immunol (2013) 0.87
Properdin and factor h: opposing players on the alternative complement pathway "see-saw". Front Immunol (2013) 0.87
The role of properdin in zymosan- and Escherichia coli-induced complement activation. J Immunol (2012) 0.87
Immune complex signatures of patients with active and inactive SLE revealed by multiplex protein binding analysis on antigen microarrays. PLoS One (2012) 0.87
Properdin: a tightly regulated critical inflammatory modulator. Immunol Rev (2016) 0.85
Complement activation by CpG in a human whole blood loop system: mechanisms and immunomodulatory effects. J Immunol (2009) 0.81
Apolipoproteins inhibit the innate immunity activated by necrotic cells or bacterial endotoxin. Immunology (2008) 0.81
Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation. J Immunol (2015) 0.79
On the Functional Overlap between Complement and Anti-Microbial Peptides. Front Immunol (2015) 0.79
Retracted Properdin homeostasis requires turnover of the alternative complement pathway. Proc Natl Acad Sci U S A (2010) 0.78
Properdin binding to complement activating surfaces depends on initial C3b deposition. Proc Natl Acad Sci U S A (2017) 0.76
Quantitative Modeling of the Alternative Pathway of the Complement System. PLoS One (2016) 0.75
Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflammation (2017) 0.75
Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5. J Pathol (2016) 0.75
Functional and structural insight into properdin control of complement alternative pathway amplification. EMBO J (2017) 0.75
Fluid phase recognition molecules in neutrophil-dependent immune responses. Semin Immunol (2016) 0.75
Alternative complement pathway induction by ANCA. Am J Pathol (2008) 0.75
Properdin and factor H production by human dendritic cells modulates their T-cell stimulatory capacity and is regulated by IFN-γ. Eur J Immunol (2017) 0.75
Properdin Levels in Individuals with Chemotherapy-Induced Neutropenia. Open Forum Infect Dis (2016) 0.75
The Murine Factor H-Related Protein FHR-B Promotes Complement Activation. Front Immunol (2017) 0.75
Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury. PLoS One (2017) 0.75
C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions. Front Immunol (2017) 0.75
Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes (2004) 4.24
Structures of complement component C3 provide insights into the function and evolution of immunity. Nature (2005) 4.01
Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases. Nat Immunol (2005) 2.82
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility. J Immunol (2011) 2.44
Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation. Gastroenterology (2005) 2.30
Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation. Hepatology (2010) 2.25
Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. Ann Rheum Dis (2011) 2.11
Allergy is a protective factor against age-related macular degeneration. Invest Ophthalmol Vis Sci (2014) 2.09
Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci U S A (2011) 2.07
Pros and cons for C4d as a biomarker. Kidney Int (2012) 2.03
An outbreak of Pneumocystis jiroveci pneumonia with 1 predominant genotype among renal transplant recipients: interhuman transmission or a common environmental source? Clin Infect Dis (2007) 1.94
Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease. J Am Soc Nephrol (2006) 1.72
Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems. J Biol Chem (2003) 1.68
Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study. Stem Cells Transl Med (2013) 1.68
Biochemical and functional characterization of the interaction between pentraxin 3 and C1q. Eur J Immunol (2003) 1.67
Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy. Kidney Int (2010) 1.66
Mannose-binding lectin engagement with late apoptotic and necrotic cells. Eur J Immunol (2003) 1.66
The complement system in systemic autoimmune disease. J Autoimmun (2009) 1.64
Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells. J Immunol (2004) 1.64
Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis. J Cell Mol Med (2009) 1.59
Anti-carbamylated protein antibodies are present in arthralgia patients and predict the development of rheumatoid arthritis. Arthritis Rheum (2013) 1.54
IL-10-producing macrophages preferentially clear early apoptotic cells. Blood (2006) 1.53
Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid. Arthritis Rheum (2010) 1.53
Direct binding of C1q to apoptotic cells and cell blebs induces complement activation. Eur J Immunol (2002) 1.52
The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells. J Biol Chem (2007) 1.51
Functional characterization of the lectin pathway of complement in human serum. Mol Immunol (2003) 1.48
Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species. Proc Natl Acad Sci U S A (2010) 1.47
Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice. Atherosclerosis (2011) 1.42
Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis. Ann Rheum Dis (2013) 1.37
Central obesity is an independent risk factor for albuminuria in nondiabetic South Asian subjects. Diabetes Care (2007) 1.36
Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells. Amyotroph Lateral Scler Other Motor Neuron Disord (2004) 1.35
The influence of ACPA status and characteristics on the course of RA. Nat Rev Rheumatol (2012) 1.34
Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines. J Clin Invest (2007) 1.33
Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation. Biochemistry (2006) 1.32
Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes. J Clin Invest (2004) 1.31
A functional variant in the CFI gene confers a high risk of age-related macular degeneration. Nat Genet (2013) 1.29
A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study. Cardiovasc Drugs Ther (2006) 1.28
Factor B structure provides insights into activation of the central protease of the complement system. Nat Struct Mol Biol (2007) 1.27
Chronic renal allograft rejection: pathophysiologic considerations. Kidney Int (2005) 1.26
Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. Blood (2002) 1.26
Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion. Am J Pathol (2007) 1.24
Complement activation by (auto-) antibodies. Mol Immunol (2011) 1.22
Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration. Ophthalmology (2011) 1.20
Maturation of dendritic cells abrogates C1q production in vivo and in vitro. Blood (2004) 1.20
The membrane attack complex of complement induces caspase activation and apoptosis. Eur J Immunol (2002) 1.20
Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins. J Immunol (2005) 1.19
Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease. Blood (2013) 1.18
Recognition and clearance of apoptotic cells: a role for complement and pentraxins. Trends Immunol (2003) 1.17
Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin. Transplantation (2008) 1.17
Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the 'AMC-Senshu' method. Ann Rheum Dis (2012) 1.16
Connective tissue growth factor and igf-I are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucose. Diabetes (2003) 1.16
Endothelial activation and circulating markers of endothelial activation in kidney disease. Nat Rev Nephrol (2010) 1.16
Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities. Ann Rheum Dis (2010) 1.15
A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation. Mol Immunol (2006) 1.15
Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiency. Eur J Immunol (2004) 1.15
Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages. Eur J Immunol (2007) 1.14
The spectrum of phenotypes caused by variants in the CFH gene. Mol Immunol (2009) 1.13
Complement activation by tubular cells is mediated by properdin binding. Am J Physiol Renal Physiol (2008) 1.12
Therapeutic targeting of classical and lectin pathways of complement protects from ischemia-reperfusion-induced renal damage. Am J Pathol (2010) 1.12
Mini-review: A pivotal role for innate immunity in the clearance of apoptotic cells. Eur J Immunol (2004) 1.11
Potential for glomerular C4d as an indicator of thrombotic microangiopathy in lupus nephritis. Arthritis Rheum (2008) 1.11
The clinical relevance of a repeat biopsy in lupus nephritis flares. Nephrol Dial Transplant (2009) 1.08
The clearance of apoptotic cells by complement. Immunobiology (2006) 1.08
Haematopoietic stem cells and endothelial progenitor cells in healthy men: effect of aging and training. Aging Cell (2006) 1.07
A novel human IgA monoclonal antibody protects against tuberculosis. J Immunol (2011) 1.07
Evidence that complement protein C1q interacts with C-reactive protein through its globular head region. J Immunol (2006) 1.05
Antibody response against the glomerular basement membrane protein agrin in patients with transplant glomerulopathy. Am J Transplant (2005) 1.05
Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. J Immunol (2006) 1.05
PRAME-specific Allo-HLA-restricted T cells with potent antitumor reactivity useful for therapeutic T-cell receptor gene transfer. Clin Cancer Res (2011) 1.05
MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia. Cardiovasc Res (2011) 1.04
Diagnosis and management of the antiphospholipid syndrome. BMJ (2010) 1.04
Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia. Mol Med (2009) 1.04
Genetic, molecular and functional analyses of complement factor I deficiency. Eur J Immunol (2009) 1.04
The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens. Arthritis Rheum (2011) 1.03
Endothelial progenitor cells: more than an inflammatory response? Arterioscler Thromb Vasc Biol (2004) 1.03
Low pretransplantation mannose-binding lectin levels predict superior patient and graft survival after simultaneous pancreas-kidney transplantation. J Am Soc Nephrol (2007) 1.02
Complement production and regulation by dendritic cells: molecular switches between tolerance and immunity. Mol Immunol (2008) 1.01