Published in Biochim Biophys Acta on April 16, 1991
Telomere Associated Variables (TAVs) in Prostate Cancer | NCT04124900
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J (1998) 6.08
Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol (2002) 4.77
TIN2, a new regulator of telomere length in human cells. Nat Genet (1999) 4.66
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci U S A (1998) 4.11
Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci U S A (1994) 3.86
Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res (1995) 3.16
Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol (1994) 2.57
Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells. Mol Cell Biol (1994) 2.26
Role of telomeres and telomerase in cancer. Semin Cancer Biol (2011) 2.20
Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. Proc Natl Acad Sci U S A (2001) 1.87
Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome. Mol Cell Biol (1995) 1.62
Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells. Proc Natl Acad Sci U S A (1998) 1.61
Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discov (2014) 1.59
Telomeres and telomerase in normal and cancer stem cells. FEBS Lett (2010) 1.46
Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor. Mol Cell Biol (1997) 1.37
Generation and Characterization of Vascular Smooth Muscle Cell Lines Derived from a Patient with a Bicuspid Aortic Valve. Cells (2016) 1.37
Telomerase activity is sufficient to allow transformed cells to escape from crisis. Mol Cell Biol (1999) 1.19
Identification of an invasive, N-cadherin-expressing epithelial cell type in endometriosis using a new cell culture model. Am J Pathol (2001) 1.18
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. Mol Cell Biol (2007) 1.16
Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. Cell Div (2010) 1.05
Role of Telomeres and Telomerase in Aging and Cancer. Cancer Discov (2016) 1.03
Ubiquitin-independent proteasomal degradation during oncogenic viral infections. Biochim Biophys Acta (2011) 0.96
Characterisation of telomerase immortalised normal human oesophageal squamous cells. Gut (2003) 0.96
High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis. Mol Cell Biol (2011) 0.92
Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes. J Clin Pathol (1997) 0.92
mTOR Signaling from Cellular Senescence to Organismal Aging. Aging Dis (2013) 0.90
Synergism of BARF1 with Ras induces malignant transformation in primary primate epithelial cells and human nasopharyngeal epithelial cells. Neoplasia (2009) 0.89
Establishment of an immortalised human ovarian surface epithelial cell line without chromosomal instability. Br J Cancer (2005) 0.88
Wnt-signaling and senescence: A tug of war in early neoplasia? Cancer Biol Ther (2008) 0.87
Molecular pathogenesis of aging and cancer: are telomeres and telomerase the connection? J Clin Pathol (1997) 0.86
Allosteric inhibitors of telomerase: oligonucleotide N3'-->P5' phosphoramidates. Nucleic Acids Res (2002) 0.85
Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblasts. Mol Cell Biol (1994) 0.85
hTERT extends the life of human fibroblasts without compromising type I interferon signaling. PLoS One (2013) 0.84
Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Mol Cell Biol (2012) 0.83
The genetics of cellular senescence. Am J Hum Genet (1998) 0.82
Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. Cell Death Differ (2013) 0.82
Modeling platinum sensitive and resistant high-grade serous ovarian cancer: development and applications of experimental systems. Front Oncol (2014) 0.81
Cellular Senescence as the Causal Nexus of Aging. Front Genet (2016) 0.80
Establishment of Hertwig's epithelial root sheath/epithelial rests of Malassez cell line from human periodontium. Mol Cells (2014) 0.79
Telomere function in colorectal cancer. World J Gastrointest Oncol (2009) 0.79
Mammary transplantation of stromal cells and carcinoma cells in C57BL/6J mice. J Vis Exp (2011) 0.78
Oxidative stress under ambient and physiological oxygen tension in tissue culture. Curr Pharmacol Rep (2016) 0.77
Reversal of the temperature-shift-induced growth restriction of a temperature-sensitive simian virus 40 T-antigen-transformed human fibroblast cell line by treatment with retinoic acid. Biochem J (1996) 0.77
Phenotypic and in vivo functional characterization of immortalized human fetal liver cells. Scand J Gastroenterol (2014) 0.76
Nuclear Factor κB1/RelA Mediates Inflammation in Human Lung Epithelial Cells at Atmospheric Oxygen Levels. J Cell Physiol (2015) 0.76
A critical role for TORC1 in cellular senescence. Cell Cycle (2012) 0.76
Improved in situ detection method for telomeric tandem repeats in metaphase spreads and interphase nuclei. Mol Pathol (2000) 0.75
Dancing around the fountain. CMAJ (1993) 0.75
New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression. World J Gastroenterol (2015) 0.75
Conditional immortalization of primary adipocyte precursor cells. Adipocyte (2015) 0.75
Telomere Restriction Fragment (TRF) Analysis. Bio Protoc (2015) 0.75
One-step immortalization of primary human airway epithelial cells capable of oncogenic transformation. Cell Biosci (2016) 0.75
Derivation of phenobarbital-responsive immortal rat hepatocytes. Am J Pathol (1995) 0.75
Telomere length modulation in human astroglial brain tumors. PLoS One (2013) 0.75
Oncogene-Expressing Senescent Melanocytes Upregulate Mhc Class Ii, A Candidate Melanoma Suppressor Function. J Invest Dermatol (2017) 0.75
Bone regeneration in the stem cell era: safe play for the patient? Clin Rheumatol (2017) 0.75
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet (1997) 6.69
A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol (1992) 6.56
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell (1991) 6.48
Positive autoregulation of the myogenic determination gene MyoD1. Cell (1989) 4.28
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet (1999) 4.22
A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res (1991) 4.07
Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature (1989) 3.73
Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev (1999) 3.19
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev (2001) 3.16
Telomere position effect in human cells. Science (2001) 2.61
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci U S A (1999) 2.36
Telomerase and cancer. Hum Mol Genet (2001) 2.28
E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene (1993) 2.25
Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol (2000) 2.15
Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J Biol Chem (2000) 2.14
Telomerase activity in human cancer. Curr Opin Oncol (1996) 2.13
Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol Cell Biol (1994) 2.00
Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen. Exp Cell Res (1989) 1.96
Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol Cell Biol (1999) 1.96
The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes. Hum Mol Genet (2000) 1.93
Regulation of telomerase activity in immortal cell lines. Mol Cell Biol (1996) 1.82
Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res (2001) 1.73
Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang. J Biol Chem (2000) 1.73
Identification of skeletal muscle precursor cells in vivo by use of MyoD1 and myogenin probes. Cell Tissue Res (1992) 1.67
Biliary excretion of cephalosporins in rats: influence of molecular weight. Antimicrob Agents Chemother (1980) 1.63
Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences. Oncogene (1993) 1.59
Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol Cell Biol (1999) 1.55
Transient expression of human telomerase extends the life span of normal human fibroblasts. Biochem Biophys Res Commun (2000) 1.54
Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc Natl Acad Sci U S A (1985) 1.54
Formation of anucleate and multinucleate cells in normal and SV 40 transformed WI-38 by cytochalasin B. Exp Cell Res (1972) 1.50
An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia (2001) 1.48
Telomerase immortalization of human myometrial cells. Biol Reprod (2002) 1.48
Increasing trends in the use of breast-conserving surgery in California. Am J Public Health (2000) 1.44
Leukaemia in workers exposed to electrical and magnetic fields. Lancet (1982) 1.43
Evidence for a DNA-photoreactivating enzyme in higher plants. Photochem Photobiol (1969) 1.42
Telomeres and telomerase: a simple picture becomes complex. Cell (1996) 1.41
Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor. Proc Natl Acad Sci U S A (1992) 1.41
Pulmonary effects of exposures in silicon carbide manufacturing. Br J Ind Med (1984) 1.39
Multiple myeloma in cosmetologists. Am J Ind Med (1982) 1.38
Induction of muscle genes in neural cells. J Cell Biol (1984) 1.36
Telomeres and telomerase: implications for cancer and aging. Radiat Res (2001) 1.34
Malignant mesothelioma: incidence, asbestos exposure, and reclassification of histopathology. Br J Ind Med (1984) 1.34
Cephaloglycin and its biologically active metabolite desacetylcephaloglycin. Appl Microbiol (1971) 1.34
Hallmarks of telomeres in ageing research. J Pathol (2007) 1.33
A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. Nucleic Acids Res (1999) 1.32
The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen. Exp Cell Res (1993) 1.32
Inhibition of human telomerase activity by peptide nucleic acids. Nat Biotechnol (1996) 1.30
Lack of cell cycle regulation of telomerase activity in human cells. Proc Natl Acad Sci U S A (1997) 1.30
Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells. J Biol Chem (2001) 1.28
Recent trends in mesothelioma incidence in the United States. Am J Ind Med (1986) 1.28
Telomerase activity concentrates in the mitotically active segments of human hair follicles. J Invest Dermatol (1997) 1.25
Telomerase activity does not always imply telomere maintenance. Biochem Biophys Res Commun (1999) 1.25
The isolation of heterokaryons and hybrids by a selective system using irreversible biochemical inhibitors. Exp Cell Res (1978) 1.25
Expression of differentiated functions in heterokaryons between skeletal myocytes, adrenal cells, fibroblasts and glial cells. Exp Cell Res (1984) 1.24
Breast cancer stage at diagnosis in relation to duration of medicaid enrollment. Med Care (2001) 1.23
Is telomerase a viable target in cancer? Mutat Res (2011) 1.23
Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase. Mol Cell Biol (2000) 1.22
Photoreactivation of UV-irradiated blue-green algal virus LPP-1. Virology (1967) 1.21
Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression. Oncogene (2001) 1.18
Telomerase inhibitors. Trends Biotechnol (2001) 1.18
Use of reiterative selection for defining protein-nucleic acid interactions. Curr Opin Biotechnol (1995) 1.17
Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents. Clin Cancer Res (1996) 1.17
Organic chemicals and malignant melanoma. Am J Ind Med (1983) 1.17
Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation. J Biol Chem (1997) 1.16
Novel DNA binding of p53 mutants and their role in transcriptional activation. Oncogene (1993) 1.16
Refining the telomere-telomerase hypothesis of aging and cancer. Nat Biotechnol (1996) 1.14
Telomerase activity in ordinary meningiomas predicts poor outcome. Hum Pathol (1997) 1.13
The suppression of myogenic functions in heterokaryons formed by fusing chick myocytes to diploid rat fibroblasts. Cell Differ (1983) 1.13
The reactivation of telomerase activity in cancer progression. Trends Genet (1996) 1.13
Evidence that deoxyribonucleic acid photolyase from baker's yeast is a flavoprotein. Biochemistry (1980) 1.13
Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence. Exp Gerontol (1996) 1.09
Purification of a blue-green algal deoxyribonucleic acid photoreactiving enzyme. An enzyme requiring light as a physical cofactor to perform its catalytic function. Biochemistry (1970) 1.08
MyoD, myogenin independent differentiation of primordial myoblasts in mouse somites. J Cell Biol (1992) 1.06
Pancreas cancer is unrelated to the workplace in Los Angeles. Am J Ind Med (1985) 1.05
Respiratory disease in Utah coal miners. Am Rev Respir Dis (1981) 1.05
Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. Oncogene (1996) 1.04
Mitochondrial DNA copy number is proportional to total cell DNA under a variety of growth conditions. J Biol Chem (1990) 1.04
Near-ultraviolet modification of Escherichia coli B ubiquinone in vivo and in vitro. Photochem Photobiol (1974) 1.02
The direct medical costs of osteoporosis for American women aged 45 and older, 1986. Bone (1988) 1.02
New evidence for the insertion of mitochondrial DNA into the human genome: significance for cancer and aging. Mutat Res (1992) 1.02
The orientation of rhodopsin and other pigments in dry films. J Gen Physiol (1972) 1.02
Effects of normal human fibroblast mitochondrial DNA on segregation of HeLaTG Mitochondrial DNA and on tumorigenicity of HeLaTG cells. Cancer Res (1986) 1.02
Sociodemographic factors associated with prostatectomy utilization and concordance with the physician data query for prostate cancer (United States). Cancer Causes Control (1999) 1.01
Synthesis of rat myosin light chains in heterokaryons formed between undifferentiated rat myoblasts and chick skeletal myocytes. J Cell Biol (1981) 1.00
Are mitochondrial DNA mutations involved in the carcinogenic process? Mutat Res (1987) 0.99
Multiple pathways for the regulation of telomerase activity. Eur J Cancer (1997) 0.98
Presence of photoreactivating enzyme in blue-green algal cells. Photochem Photobiol (1968) 0.98
Complexes containing the retinoblastoma gene product recognize different DNA motifs related to the E2F binding site. Oncogene (1992) 0.97
Respiratory effects of borax dust. Br J Ind Med (1985) 0.97
Expression of the RNA component of telomerase during human development and differentiation. Cell Growth Differ (1998) 0.96
Characterisation of telomerase immortalised normal human oesophageal squamous cells. Gut (2003) 0.96
Cytological detection of telomerase activity using an in situ telomeric repeat amplification protocol assay. Cancer Res (1997) 0.96
Noise trauma in the aetiology of acoustic neuromas in men in Los Angeles County, 1978-1985. Br J Cancer (1989) 0.95
Molecular biology of myogenic regulatory factors. Mol Biol Med (1991) 0.95
Alveolar bone necrosis and tooth loss. a rare complication associated with herpes zoster infection of the fifth cranial nerve. Oral Surg Oral Med Oral Pathol (1983) 0.94
Cancer among Hispanic children in California, 1988-1994: comparison with non-Hispanic white children. Cancer (1999) 0.94
Aging. When do telomeres matter? Science (2001) 0.94
Alternative multimeric structures affect myogenin DNA binding activity. J Biol Chem (1992) 0.94