Published in Sci Signal on May 27, 2008
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med (2010) 4.74
Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol (2014) 4.28
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell Death Differ (2011) 2.60
Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol (2011) 2.53
Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps. J Mol Med (Berl) (2009) 2.33
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. J Exp Med (2010) 1.88
Nitrative and oxidative stress in toxicology and disease. Toxicol Sci (2009) 1.44
Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Semin Immunopathol (2011) 1.26
Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α. Blood (2012) 1.25
M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. J Mol Med (Berl) (2009) 1.17
Experimental selection for Drosophila survival in extremely high O2 environments. PLoS One (2010) 1.05
Reactive oxygen species and mitochondria: A nexus of cellular homeostasis. Redox Biol (2015) 1.03
Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med (Berl) (2011) 1.02
Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps. J Immunol (2012) 0.93
In vivo induction of cutaneous inflammation results in the accumulation of extracellular trap-forming neutrophils expressing RORγt and IL-17. J Invest Dermatol (2013) 0.91
Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Nat Commun (2015) 0.90
Neutrophil extracellular traps as innate immune reaction against the emerging apicomplexan parasite Besnoitia besnoiti. PLoS One (2014) 0.87
Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. J Biol Chem (2010) 0.86
Afa/Dr diffusely adhering Escherichia coli strain C1845 induces neutrophil extracellular traps that kill bacteria and damage human enterocyte-like cells. Infect Immun (2012) 0.86
Capsular polysaccharides from Cryptococcus neoformans modulate production of neutrophil extracellular traps (NETs) by human neutrophils. Sci Rep (2015) 0.85
Increased polyamines alter chromatin and stabilize autoantigens in autoimmune diseases. Front Immunol (2013) 0.85
Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem (2016) 0.84
Modulation of polymorphonuclear neutrophil functions by astrocytes. J Neuroinflammation (2010) 0.84
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques. Neurobiol Dis (2014) 0.84
Therapeutic approaches to preventing cell death in Huntington disease. Prog Neurobiol (2012) 0.84
Social amoebae trap and kill bacteria by casting DNA nets. Nat Commun (2016) 0.82
Key mechanisms governing resolution of lung inflammation. Semin Immunopathol (2016) 0.81
Extracellular traps and macrophages: new roles for the versatile phagocyte. J Leukoc Biol (2015) 0.81
Genetic control of chicken heterophil function in advanced intercross lines: associations with novel and with known Salmonella resistance loci and a likely mechanism for cell death in extracellular trap production. Immunogenetics (2011) 0.80
Programmed cell death and its role in inflammation. Mil Med Res (2015) 0.79
Bone marrow-derived fibrocytes contribute to liver fibrosis. Exp Biol Med (Maywood) (2015) 0.78
Antimicrobial Activity of Mast Cells: Role and Relevance of Extracellular DNA Traps. Front Immunol (2016) 0.77
[Permissive and non-permissive hypercapnia: mechanisms of action and consequences of high carbon dioxide levels]. Arch Bronconeumol (2010) 0.77
Induction of eosinophil apoptosis by hydrogen peroxide promotes the resolution of allergic inflammation. Cell Death Dis (2015) 0.76
NETosis. Autoimmune Dis (2013) 0.76
The role of necrotic cell death in the pathogenesis of immune mediated nephropathies. Clin Immunol (2014) 0.76
Oxidative Stress Facilitates IFN-γ-Induced Mimic Extracellular Trap Cell Death in A549 Lung Epithelial Cancer Cells. PLoS One (2016) 0.76
An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps. Curr Biol (2006) 3.69
Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol (2009) 2.80
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A (2014) 2.63
Bacterial adhesins in host-microbe interactions. Cell Host Microbe (2009) 2.43
Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies. J Exp Med (2007) 2.11
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis. Proc Natl Acad Sci U S A (2006) 2.01
Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps. Cell Microbiol (2007) 1.99
Clinical utility of PCR for common viruses in acute respiratory illness. Pediatrics (2014) 1.86
Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children. J Infect Dis (2013) 1.84
Epidemiology of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol (2008) 1.81
Neutrophil extracellular traps: casting the NET over pathogenesis. Curr Opin Microbiol (2007) 1.80
Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol (2006) 1.62
Emergence of hypervirulent mutants resistant to early clearance during systemic serotype 1 pneumococcal infection in mice and humans. J Infect Dis (2014) 1.62
Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans. J Infect Dis (2005) 1.51
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle. FEBS Lett (2007) 1.50
Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related. J Infect Dis (2008) 1.49
Lysogenic transfer of group A Streptococcus superantigen gene among Streptococci. J Infect Dis (2008) 1.24
LytA, major autolysin of Streptococcus pneumoniae, requires access to nascent peptidoglycan. J Biol Chem (2012) 1.23
Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis. J Bacteriol (2009) 1.23
Sortase-mediated assembly and surface topology of adhesive pneumococcal pili. Mol Microbiol (2008) 1.22
Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel approach in molecular epidemiology. J Clin Microbiol (2007) 1.20
Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression. EMBO Mol Med (2009) 1.19
Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion. J Immunol (2009) 1.18
Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection. PLoS Genet (2013) 1.17
Developmental switch of intestinal antimicrobial peptide expression. J Exp Med (2008) 1.11
Disulfide bond formation and cysteine exclusion in gram-positive bacteria. J Biol Chem (2009) 1.09
Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity. J Mol Biol (2009) 1.05
Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. PLoS One (2009) 1.02
Studies on the antibacterial effects of statins--in vitro and in vivo. PLoS One (2011) 1.00
The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time? FEMS Microbiol Rev (2006) 0.99
Human monocytes promote Th1 and Th17 responses to Streptococcus pneumoniae. Infect Immun (2011) 0.96
Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. Infect Immun (2010) 0.96
Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells. BMC Microbiol (2009) 0.94
Identification of a family of effectors secreted by the type III secretion system that are conserved in pathogenic Chlamydiae. Infect Immun (2010) 0.93
Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis. Proc Natl Acad Sci U S A (2013) 0.93
Resistance to bacitracin in Streptococcus pyogenes from oropharyngeal colonization and noninvasive infections in Portugal was caused by two clones of distinct virulence genotypes. FEMS Microbiol Lett (2009) 0.90
Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. J Bacteriol (2013) 0.90
Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae. MBio (2014) 0.90
Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease. MBio (2012) 0.88
International quality assurance study for characterization of Streptococcus pyogenes. J Clin Microbiol (2007) 0.86
Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-alpha production. Cell Signal (2008) 0.85
The capsule sensitizes Streptococcus pneumoniae to alpha-defensins human neutrophil proteins 1 to 3. Infect Immun (2008) 0.85
Characterization of human invasive isolates of Listeria monocytogenes in Sweden 1986-2007. Foodborne Pathog Dis (2008) 0.85
The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold. Open Biol (2014) 0.85
Immunomodulatory effects of vitamin D on innate and adaptive immune responses to Streptococcus pneumoniae. J Infect Dis (2013) 0.84
Identification of heparin/heparan sulfate interacting protein as a major broad-spectrum antimicrobial protein in lung and small intestine. FASEB J (2008) 0.83
Effects of Streptococcus pneumoniae strain background on complement resistance. PLoS One (2011) 0.83
Comprehensive antigen screening identifies Moraxella catarrhalis proteins that induce protection in a mouse pulmonary clearance model. PLoS One (2013) 0.83
Defense of zebrafish embryos against Streptococcus pneumoniae infection is dependent on the phagocytic activity of leukocytes. Dev Comp Immunol (2011) 0.82
The function and biological role of toll-like receptors in infectious diseases: an update. Curr Opin Infect Dis (2008) 0.82
Influenza A virus-mediated priming enhances cytokine secretion by human dendritic cells infected with Streptococcus pneumoniae. Cell Microbiol (2013) 0.81
Improvement of CRB-65 as a prognostic scoring system in adult patients with bacteraemic pneumococcal pneumonia. Scand J Infect Dis (2011) 0.81
Bacterial evasion of innate defense at epithelial linings. Chem Immunol Allergy (2005) 0.81
Impaired release of antimicrobial peptides into nasal fluid of hyper-IgE and CVID patients. PLoS One (2011) 0.80
Uptake of extracellular DNA: competence induced pili in natural transformation of Streptococcus pneumoniae. Bioessays (2015) 0.80
Adult zebrafish model for pneumococcal pathogenesis. Dev Comp Immunol (2013) 0.79
Secretion of a pneumococcal type II secretion system pilus correlates with DNA uptake during transformation. Proc Natl Acad Sci U S A (2014) 0.79
Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA. J Clin Invest (2016) 0.78
TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection. J Innate Immun (2012) 0.77
Vitamin D Promotes Pneumococcal Killing and Modulates Inflammatory Responses in Primary Human Neutrophils. J Innate Immun (2017) 0.75