Published in J Clin Invest on July 01, 2008
Genotype imputation. Annu Rev Genomics Hum Genet (2009) 18.64
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci (2010) 3.09
Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants. Int J Epidemiol (2010) 2.91
The emerging genetic architecture of type 2 diabetes. Cell Metab (2008) 2.77
Assessing the potential of glucokinase activators in diabetes therapy. Nat Rev Drug Discov (2009) 2.60
Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet (2008) 2.49
A syndrome with congenital neutropenia and mutations in G6PC3. N Engl J Med (2009) 2.30
Isolated populations and complex disease gene identification. Genome Biol (2008) 1.83
Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) study. Diabetes (2010) 1.71
Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study. PLoS Genet (2008) 1.67
Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. Hum Mol Genet (2008) 1.65
A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. Diabetes (2009) 1.65
Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose. Genet Epidemiol (2010) 1.34
Genomics of type 2 diabetes mellitus: implications for the clinician. Nat Rev Endocrinol (2009) 1.34
Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes (2011) 1.31
Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits. Diabetes (2009) 1.29
Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. Diabetes (2011) 1.29
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun (2015) 1.27
Physiologic characterization of type 2 diabetes-related loci. Curr Diab Rep (2010) 1.24
Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study. Diabetes (2010) 1.20
Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. Diabetologia (2009) 1.20
Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia (2009) 1.13
Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. PLoS One (2010) 1.10
Type 2 Diabetes Genetics: Beyond GWAS. J Diabetes Metab (2012) 1.09
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. PLoS Genet (2015) 1.08
Genome-wide association study identifies two novel Loci with sex-specific effects for type 2 diabetes mellitus and glycemic traits in a korean population. Diabetes Metab J (2014) 1.04
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes (2013) 1.03
Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult population. Diabetes Care (2010) 1.01
PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County. BMC Med Genet (2010) 1.00
Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). Genet Epidemiol (2012) 0.99
Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose. Diabetes (2009) 0.99
A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2. J Assoc Res Otolaryngol (2013) 0.97
Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression. J Mol Endocrinol (2008) 0.93
Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose. Curr Diab Rep (2013) 0.92
G6PC2: a negative regulator of basal glucose-stimulated insulin secretion. Diabetes (2012) 0.92
Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels. Diabetes (2010) 0.92
Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels. Diabetologia (2013) 0.91
Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China. Eur J Epidemiol (2009) 0.90
A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels. Am J Hum Genet (2010) 0.89
The genetics of insulin resistance: Where's Waldo? Curr Diab Rep (2010) 0.89
Associations of common genetic variants with age-related changes in fasting and postload glucose: evidence from 18 years of follow-up of the Whitehall II cohort. Diabetes (2011) 0.89
Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program. PLoS One (2012) 0.87
Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity. Dis Model Mech (2011) 0.87
Genetic determinants of variability in glycated hemoglobin (HbA(1c)) in humans: review of recent progress and prospects for use in diabetes care. Curr Diab Rep (2011) 0.86
Association of a common G6PC2 variant with fasting plasma glucose levels in non-diabetic individuals. Ann Nutr Metab (2009) 0.86
A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro. Diabetes (2008) 0.85
Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study). BMC Med Genet (2011) 0.84
Genetic determinants of cardiometabolic risk: a proposed model for phenotype association and interaction. J Clin Lipidol (2012) 0.84
Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice. J Biol Chem (2012) 0.84
Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets. Diabetes (2014) 0.83
Clinical translation of genetic predictors for type 2 diabetes. Curr Opin Endocrinol Diabetes Obes (2009) 0.81
The hydrodynamic tail vein assay as a tool for the study of liver promoters and enhancers. Methods Mol Biol (2013) 0.81
Single cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes. Genome Res (2016) 0.80
A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX. BMC Genomics (2013) 0.80
Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial. Pharmacogenomics J (2015) 0.76
G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance. Endocrinology (2016) 0.76
Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection. BMC Evol Biol (2017) 0.75
Examining the causal association of fasting glucose with blood pressure in healthy children and adolescents: a Mendelian randomization study employing common genetic variants of fasting glucose. J Hum Hypertens (2014) 0.75
Combined genome-wide linkage and association analyses of fasting glucose level in healthy twins and families of Korea. J Korean Med Sci (2013) 0.75
A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis. Oncotarget (2016) 0.75
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases. J Lipid Res (2017) 0.75
Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study. Trends Cardiovasc Med (2009) 0.75
Effects of G6pc2 deletion on body weight and cholesterol in mice. J Mol Endocrinol (2017) 0.75
Human genetics as a model for target validation: finding new therapies for diabetes. Diabetologia (2017) 0.75
Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes. PLoS One (2017) 0.75
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 101.79
Genomic control for association studies. Biometrics (1999) 64.39
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med (2001) 56.11
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care (1997) 49.11
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet (1998) 40.97
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Banting lecture 1988. Role of insulin resistance in human disease. Diabetes (1988) 33.22
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. National Diabetes Data Group. Diabetes (1979) 12.35
Family-based association tests for genomewide association scans. Am J Hum Genet (2007) 10.67
Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care (1991) 9.95
Allelic discrimination using fluorogenic probes and the 5' nuclease assay. Genet Anal (1999) 9.80
Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19
Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes (1988) 7.80
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
In silico method for inferring genotypes in pedigrees. Nat Genet (2006) 7.08
Diabetes mellitus. Report of a WHO Study Group. World Health Organ Tech Rep Ser (1985) 6.63
Geographical variation in cardiovascular disease, risk factors, and their control in older women: British Women's Heart and Health Study. J Epidemiol Community Health (2003) 4.67
Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care (1998) 3.99
Multipoint oligogenic linkage analysis of quantitative traits. Genet Epidemiol (1997) 3.38
Mapping genes in diabetes. Genetic epidemiological perspective. Diabetes (1990) 3.34
Prevalences of diabetes and impaired glucose regulation in a Danish population: the Inter99 study. Diabetes Care (2003) 2.96
Approved IFCC recommendation on reporting results for blood glucose (abbreviated). Clin Chem (2005) 2.82
Caerphilly and Speedwell collaborative heart disease studies. The Caerphilly and Speedwell Collaborative Group. J Epidemiol Community Health (1984) 2.68
Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods. Ann Epidemiol (2003) 2.51
A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. Diabetes (2004) 2.46
A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet (2006) 2.44
Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish. Hum Hered (2007) 2.26
Coordinate changes in plasma glucose and pancreatic beta-cell function in Latino women at high risk for type 2 diabetes. Diabetes (2006) 2.08
Glucose regulation of gene transcription. J Biol Chem (2000) 1.86
Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators. Hum Hered (1999) 1.76
Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11. Gastroenterology (2004) 1.60
Progression to type 2 diabetes characterized by moderate then rapid glucose increases. Diabetes (2007) 1.51
Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury. Pharmacogenet Genomics (2007) 1.43
Genetic analysis of NIDDM. The study of quantitative traits. Diabetes (1996) 1.40
Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes (1999) 1.39
Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes (2005) 1.38
Bile acid sequestrants and the treatment of type 2 diabetes mellitus. Drugs (2007) 1.34
Transmembrane topology of glucose-6-phosphatase. J Biol Chem (1998) 1.33
Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. Mol Pharmacol (2001) 1.25
Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians. Am J Hum Genet (1997) 1.25
Exploring the genetics of longevity in the Old Order Amish. Mech Ageing Dev (2005) 1.24
Identification of CD4+ T cell-specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein: a novel beta cell autoantigen in type 1 diabetes. J Immunol (2005) 1.24
Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype. Diabetologia (2007) 1.23
Regulation of glucokinase by a fructose-1-phosphate-sensitive protein in pancreatic islets. Eur J Biochem (1990) 1.15
Obesity and central fat pattern among Greenland Inuit and a general population of Denmark (Inter99): relationship to metabolic risk factors. Int J Obes Relat Metab Disord (2003) 1.15
Genome-wide scan of obesity in the Old Order Amish. J Clin Endocrinol Metab (2001) 1.10
Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP). J Biol Chem (2004) 1.06
A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites. Diabetes (2005) 1.04
Partitioning the variability of fasting plasma glucose levels in pedigrees. Genetic and environmental factors. Am J Epidemiol (1987) 0.98
Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas. Diabetologia (2006) 0.97
A variation at position -30 of the beta-cell glucokinase gene promoter is associated with reduced beta-cell function in middle-aged Japanese-American men. Diabetes (1996) 0.96
Evidence for the presence of glucose cycling in pancreatic islets of the ob/ob mouse. J Biol Chem (1989) 0.96
Glucose cycling in islets from healthy and diabetic rats. Diabetes (1990) 0.92
Glucose cycling is markedly enhanced in pancreatic islets of obese hyperglycemic mice. Endocrinology (1990) 0.90
In islet-specific glucose-6-phosphatase-related protein, the beta cell antigenic sequence that is targeted in diabetes is not responsible for the loss of phosphohydrolase activity. Diabetologia (2005) 0.83
The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane. FEBS Lett (2004) 0.82
Glucokinase gene variations in Japanese-Americans with a family history of NIDDM. Diabetes Care (1994) 0.81
Estimating genetic and non-genetic components of variance for fasting glucose levels in pedigrees ascertained through non-insulin dependent diabetes. Ann Hum Genet (1982) 0.80
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res (2010) 97.51
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Finding the missing heritability of complex diseases. Nature (2009) 67.95
A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
The structure of haplotype blocks in the human genome. Science (2002) 50.88
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83