A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration.

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Published in J Immunol on June 15, 2008

Authors

Shinichi Sekine1, Kosuke Kataoka, Yoshiko Fukuyama, Yasuo Adachi, Julia Davydova, Masato Yamamoto, Ryoki Kobayashi, Keiko Fujihashi, Hideaki Suzuki, David T Curiel, Satoshi Shizukuishi, Jerry R McGhee, Kohtaro Fujihashi

Author Affiliations

1: Department of Pediatric Dentistry and Microbiology, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Dendritic cells and the control of immunity. Nature (1998) 56.54

A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A (1998) 24.58

The dendritic cell system and its role in immunogenicity. Annu Rev Immunol (1991) 23.09

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CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med (1998) 6.12

Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci U S A (1999) 5.66

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med (1996) 5.32

Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine. J Exp Med (2000) 3.43

Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets. J Immunol (2001) 3.39

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Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell (1993) 2.40

Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J Exp Med (1996) 2.38

A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci U S A (1997) 2.07

Origin and differentiation of dendritic cells. Trends Immunol (2001) 2.04

Hematologic effects of flt3 ligand in vivo in mice. Blood (1996) 2.02

Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivo. J Immunol (2000) 1.93

Novel pathways of antigen presentation for the maintenance of memory. Int Immunol (1991) 1.85

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci U S A (1994) 1.67

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Modulating the immune response with dendritic cells and their growth factors. Trends Immunol (2001) 1.66

CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol (2003) 1.54

Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and beta-galactosidase. Hum Gene Ther (1995) 1.48

Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells. Blood (1994) 1.41

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